ULTRAGENYX PHARMACEUTICAL IN RARE
COM · Common Stock · CUSIP 90400D108 · ISIN US90400D1081
Biopharmaceutical company based in Novato, California, United States
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNovato, CA
- Websiteultragenyx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($10.0m this quarter). Holder counts are more reliable. Shares outstanding: 98.5m as of 2026-05-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $20.93. Options: 12 managers hold calls ($27.9m notional), 11 hold puts ($25.8m).
Trends to Q1 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 233 |
| Q4 2022 | 228 |
| Q1 2023 | 230 |
| Q2 2023 | 243 |
| Q3 2023 | 222 |
| Q4 2023 | 238 |
| Q1 2024 | 271 |
| Q2 2024 | 275 |
| Q3 2024 | 303 |
| Q4 2024 | 316 |
| Q1 2025 | 304 |
| Q2 2025 | 313 |
| Q3 2025 | 304 |
| Q4 2025 | 289 |
| Q1 2026 | 298 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2024 | 161 | 120 |
| Q3 2024 | 163 | 120 |
| Q4 2024 | 149 | 151 |
| Q1 2025 | 155 | 148 |
| Q2 2025 | 167 | 151 |
| Q3 2025 | 181 | 145 |
| Q4 2025 | 153 | 155 |
| Q1 2026 | 180 | 132 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2025 | $148.5m | $87.7m | 0.59 |
| Q3 2025 | $88.8m | $34.0m | 0.38 |
| Q4 2025 | $75.9m | $47.6m | 0.63 |
| Q1 2026 | $27.9m | $25.8m | 0.93 |
Biggest buyers
| AQR CAPITAL MANAGEMENT LLC | Added | +3.2m |
| Sofinnova Investments, Inc. | Added | +3.1m |
| Bellevue Group AG | Added | +2.4m |
| Assenagon Asset Management S.A. | Added | +2.1m |
| TWO SIGMA INVESTMENTS, LP | Added | +1.8m |
| D. E. Shaw & Co., Inc. | Added | +916.3k |
| Qube Research & Technologies Ltd | New | +914.8k |
| Point72 Asset Management, L.P. | New | +893.3k |
| MILLENNIUM MANAGEMENT LLC | Added | +891.5k |
| Eagle Health Investments LP | New | +884.1k |
Biggest sellers
| JPMORGAN CHASE & CO | Reduced | -3.7m |
| BAKER BROS. ADVISORS LP | Sold out | -2.8m |
| FMR LLC | Reduced | -2.4m |
| MONTANOVA CAPITAL, LLC | Sold out | -2.0m |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | Reduced | -1.5m |
| Aberdeen Group plc | Reduced | -1.4m |
| JANE STREET GROUP, LLC | Reduced | -847.8k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -750.3k |
| Pictet Asset Management Holding SA | Reduced | -627.8k |
| Polar Capital Holdings Plc | Sold out | -556.6k |
Biggest calls
| Sofinnova Investments, Inc. | New | $7.3m350.0k shares |
| Caption Management, LLC | Added | $7.1m340.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $5.1m243.9k shares |
| CITADEL ADVISORS LLC | Added | $2.7m128.1k shares |
| JANE STREET GROUP, LLC | Added | $2.6m124.1k shares |
| IMC-Chicago, LLC | Added | $894.6k42.7k shares |
| Walleye Capital LLC | Reduced | $685.1k32.7k shares |
| ADAR1 Capital Management, LLC | Added | $419.0k20.0k shares |
| GROUP ONE TRADING LLC | Reduced | $349.9k16.7k shares |
| SIMPLEX TRADING, LLC | New | $324.7k15.5k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $7.7m367.1k shares |
| Caption Management, LLC | Reduced | $6.1m290.0k shares |
| GROUP ONE TRADING LLC | Added | $3.2m151.7k shares |
| HRT FINANCIAL LP | New | $2.8m135.0k shares |
| CITADEL ADVISORS LLC | Reduced | $2.7m127.8k shares |
| JANE STREET GROUP, LLC | Reduced | $1.6m76.9k shares |
| IMC-Chicago, LLC | Added | $798.2k38.1k shares |
| GOLDMAN SACHS GROUP INC | Added | $366.6k17.5k shares |
| Walleye Capital LLC | Reduced | $270.3k12.9k shares |
| SIMPLEX TRADING, LLC | New | $196.9k9.4k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution +3.2 pts · filed 2026-07-30 | 8.3% |
| RTW INVESTMENTS, LP 13G · institution new · filed 2026-08-14 | 7.9% |
| VANGUARD PORTFOLIO MANAGEMENT LLC 13G · institution +1.5 pts · filed 2026-07-31 | 7.0% |
| AQR CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-08-13 | 6.7% |
| Madison Avenue Partners, LP 13G · passive investor new · filed 2026-10-20 | 6.4% |
| STATE STREET CORP 13G · institution +1.2 pts · filed 2026-08-07 | 6.3% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-07-31 | 5.1% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD PORTFOLIO MANAGEMENT LLC), FMR LLC (3.5%, 2026-02-05)
Insider purchases and sales in Q1 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2024 | 0 | — | 3 | $534.4k | $512.7k |
| Q3 2024 | 0 | — | 3 | $2.1m | $2.1m |
| Q4 2024 | 0 | — | 2 | $1.3m | $908.9k |
| Q1 2025 | 0 | — | 8 | $6.8m | $4.2m |
| Q2 2025 | 0 | — | 2 | $118.8k | $89.9k |
| Q3 2025 | 0 | — | 2 | $80.9k | — |
| Q4 2025 | 0 | — | 2 | $365.3k | $112.1k |
| Q1 2026 | 0 | — | 7 | $2.7m | $371.6k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-03-10 | Parschauer Karah Herdman EVP and Chief Legal Officer | Sold | $79.5k3.5k shares |
| 2026-03-06 | Parschauer Karah Herdman EVP and Chief Legal Officer | Sold | $128.8k6.0k shares |
| 2026-03-03 | Horn Howard Chief Financial Officer | Sold plan | $36.6k1.6k shares |
| 2026-03-02 | KAKKIS EMIL D President & CEO, director | Sold | $1.2m54.4k shares |
| 2026-03-02 | Harris Erik EVP & Chief Commercial Officer | Sold | $240.3k10.5k shares |
| 2026-03-02 | Pinion John Richard Officer | Sold | $228.7k10.0k shares |
| 2026-03-02 | Horn Howard Chief Financial Officer | Sold plan | $190.9k8.4k shares |
| 2026-03-02 | Parschauer Karah Herdman EVP and Chief Legal Officer | Sold | $185.5k8.1k shares |
| 2026-03-02 | Crombez Eric EVP and Chief Medical Officer | Sold | $160.3k7.0k shares |
| 2026-03-02 | Huizenga Theodore Alan SVP, Chief Accounting Officer | Sold | $37.2k1.6k shares |
| 2026-02-02 | Horn Howard Chief Financial Officer | Sold plan | $72.1k3.1k shares |
| 2026-01-02 | Horn Howard Chief Financial Officer | Sold plan | $71.9k3.1k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2026
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.00% of their portfolio | 7.3m $152.9m | Added +668.0k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.01% of their portfolio | 5.4m $112.8m | First filing |
| STATE STREET CORP 0.00% of their portfolio | 5.0m $105.2m | Added +718.4k |
| AQR CAPITAL MANAGEMENT LLC 0.04% of their portfolio | 4.6m $95.9m | Added +3.2m |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 4.2m $87.8m | First filing |
| RTW INVESTMENTS, LP 0.76% of their portfolio | 3.6m $76.4m | Added +648.7k |
| SANDS CAPITAL MANAGEMENT, LLC 0.26% of their portfolio | 3.2m $67.3m | Reduced -271.2k |
| Sofinnova Investments, Inc. 3.30% of their portfolio | 3.1m $65.9m | Added +3.1m |
| WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio | 2.6m $55.3m | Added +178.9k |
| Bellevue Group AG 1.19% of their portfolio | 2.4m $49.9m | Added +2.4m |
| Assenagon Asset Management S.A. 0.08% of their portfolio | 2.3m $47.3m | Added +2.1m |
| TWO SIGMA INVESTMENTS, LP 0.04% of their portfolio | 2.2m $46.2m | Added +1.8m |
| FRONTIER CAPITAL MANAGEMENT CO LLC 0.47% of their portfolio | 2.2m $45.9m | Added +226.1k |
| CITADEL ADVISORS LLC 0.03% of their portfolio | 2.1m $44.3m | Reduced -210.6k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.8m $38.8m | Added +11.2k |
| MILLENNIUM MANAGEMENT LLC 0.03% of their portfolio | 1.8m $37.1m | Added +891.5k |
| GW&K Investment Management, LLC 0.30% of their portfolio | 1.6m $33.8m | Added +240.0k |
| MORGAN STANLEY 0.00% of their portfolio | 1.5m $31.4m | Reduced -325.8k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.13% of their portfolio | 1.4m $30.0m | Reduced -318.2k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.12% of their portfolio | 1.4m $29.9m | Added +783.5k |
| D. E. Shaw & Co., Inc. 0.02% of their portfolio | 1.3m $26.4m | Added +916.3k |
| Rock Springs Capital Management LP 1.50% of their portfolio | 1.2m $25.5m | Reduced -48.5k |
| Jones Hill Capital LP 5.23% of their portfolio | 1.2m $24.4m | First filing |
| Candriam S.C.A. 0.12% of their portfolio | 1.1m $23.0m | Added +296.8k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.0m $21.9m | Reduced -167.4k |
| Qube Research & Technologies Ltd 0.03% of their portfolio | 914.8k $19.2m | New |
| Point72 Asset Management, L.P. 0.03% of their portfolio | 893.3k $18.7m | New |
| Eagle Health Investments LP 3.89% of their portfolio | 884.1k $18.5m | New |
| Catalio Capital Management, LP 3.72% of their portfolio | 850.8k $17.8m | Added +688.2k |
| UBS Group AG 0.00% of their portfolio | 832.7k $17.4m | Added +163.9k |
| SPHERA FUNDS MANAGEMENT LTD. 2.92% of their portfolio | 809.3k $17.0m | Added +508.7k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 804.1k $16.8m | Reduced -750.3k |
| Nuveen, LLC 0.00% of their portfolio | 662.1k $13.9m | Reduced -139.4k |
| HRT FINANCIAL LP 0.05% of their portfolio | 613.2k $12.8m | Added +111.5k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 608.2k $12.7m | First filing |
| Pictet Asset Management Holding SA 0.01% of their portfolio | 603.6k $11.7m | Reduced -627.8k |
| Palo Alto Investors LP 1.91% of their portfolio | 596.5k $12.5m | Added +135.2k |
| Legal & General Group Plc 0.00% of their portfolio | 590.3k $12.4m | Added +179.0k |
| RENAISSANCE TECHNOLOGIES LLC 0.02% of their portfolio | 561.7k $11.8m | Added +195.6k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 558.5k $11.7m | Reduced -40.4k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 535.6k $11.2m | Added +8.9k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 524.8k $11.0m | Added +372.5k |
| Jump Financial, LLC 0.16% of their portfolio | 504.1k $10.6m | Added +388.2k |
| Connor, Clark & Lunn Investment Management Ltd. 0.02% of their portfolio | 500.9k $10.5m | Added +237.1k |
| Schonfeld Strategic Advisors LLC 0.08% of their portfolio | 494.7k $10.4m | Reduced -246.9k |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 490.8k $10.3m | Reduced -412.3k |
| Ikarian Capital, LLC 1.45% of their portfolio | 482.6k $10.1m | Added +469.9k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.02% of their portfolio | 480.0k $10.1m | Added +200.0k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio | 451.1k $9.5m | Added +120.0k |
| Squarepoint Ops LLC 0.02% of their portfolio | 444.5k $9.3m | Added +53.9k |
| ALGERT GLOBAL LLC 0.14% of their portfolio | 428.5k $9.0m | Added +209.3k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.01% of their portfolio | 418.1k $8.8m | Reduced -1.5m |
| Russell Investments Group, Ltd. 0.01% of their portfolio | 403.0k $8.4m | Reduced -437.9k |
| Newtyn Management, LLC 0.90% of their portfolio | 400.0k $8.4m | Added +104.1k |
| Krensavage Asset Management, LLC 3.20% of their portfolio | 390.9k $8.2m | Added +241.2k |
| Trexquant Investment LP 0.06% of their portfolio | 389.5k $8.2m | Added +224.4k |
| Balyasny Asset Management L.P. 0.02% of their portfolio | 384.4k $8.1m | Reduced -135.7k |
| Privium Fund Management B.V. 1.59% of their portfolio | 364.8k $7.6m | Added +7.3k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 353.1k $7.4m | Reduced -47.3k |
| SummitTX Capital, L.P. 0.23% of their portfolio | 347.8k $7.3m | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 341.1k $7.1m | Added +42.4k |
| CITIGROUP INC 0.00% of their portfolio | 315.4k $6.6m | Added +245.9k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 312.6k $6.5m | Added +3.6k |
| Blue Owl Capital Holdings LP 1.74% of their portfolio | 302.6k $6.3m | Added +90.0k |
| FRED ALGER MANAGEMENT, LLC 0.03% of their portfolio | 298.0k $6.2m | Reduced -113.8k |
| Invesco Ltd. 0.00% of their portfolio | 289.6k $6.1m | Added +59.3k |
| GordonMD Global Investments LP 4.22% of their portfolio | 289.1k $6.1m | Reduced -40.0k |
| FMR LLC 0.00% of their portfolio | 287.3k $6.0m | Reduced -2.4m |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.00% of their portfolio | 260.4k $5.5m | Reduced -49.7k |
| BARCLAYS PLC 0.00% of their portfolio | 249.8k $5.2m | Reduced -109.3k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 245.9k $4.7m | Reduced -3.7m |
| Parkman Healthcare Partners LLC 0.51% of their portfolio | 235.0k $4.9m | Added +173.0k |
| Longaeva Partners L.P. 0.23% of their portfolio | 228.1k $4.8m | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 223.0k $4.7m | Added +18.9k |
| Motley Fool Wealth Management, LLC 0.53% of their portfolio | 223.0k $4.7m | Reduced -74.5k |
| KENNEDY CAPITAL MANAGEMENT LLC 0.10% of their portfolio | 219.3k $4.6m | New |
| Y-Intercept (Hong Kong) Ltd 0.09% of their portfolio | 218.4k $4.6m | New |
| Brevan Howard Capital Management LP 0.05% of their portfolio | 215.8k $4.5m | Added +107.9k |
| Man Group plc 0.01% of their portfolio | 213.4k $4.5m | Added +135.0k |
| Quantinno Capital Management LP 0.01% of their portfolio | 187.5k $3.9m | Added +137.8k |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.01% of their portfolio | 181.8k $3.8m | Reduced -1.0k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 179.1k $3.5m | Added +3.5k |
| Ishara Investments LP 3.69% of their portfolio | 174.2k $3.7m | Added +124.2k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 173.7k $3.6m | Reduced -847.8k |
| Woodline Partners LP 0.01% of their portfolio | 171.8k $3.6m | Unchanged |
| Swiss National Bank 0.00% of their portfolio | 171.1k $3.6m | Unchanged |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 165.4k $3.5m | Added +8.4k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 157.5k $3.3m | Added +85.4k |
| MOORE CAPITAL MANAGEMENT, LP 0.12% of their portfolio | 157.1k $3.3m | Reduced -42.9k |
| WORLDQUANT MILLENNIUM ADVISORS LLC 0.01% of their portfolio | 150.6k $3.2m | Added +53.7k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.07% of their portfolio | 142.0k $3.0m | New |
| GROUP ONE TRADING LLC 0.10% of their portfolio | 140.2k $2.9m | Added +117.0k |
| SR One Capital Management, LP 0.32% of their portfolio | 137.8k $2.9m | Unchanged |
| Corient Private Wealth LP 0.00% of their portfolio | 136.5k $2.9m | New |
| B Group, Inc. 2.10% of their portfolio | 135.0k $2.8m | Unchanged |
| CAPITAL FUND MANAGEMENT S.A. 0.02% of their portfolio | 121.4k $2.5m | Reduced -28.8k |
| Walleye Capital LLC 0.02% of their portfolio | 119.7k $2.5m | Added +83.2k |
| FIFTH THIRD BANCORP 0.00% of their portfolio | 110.3k $2.3m | New |
| Caption Management, LLC 0.11% of their portfolio | 110.0k $2.3m | Reduced -109.5k |
| Entropy Technologies, LP 0.11% of their portfolio | 109.7k $2.3m | Added +49.1k |