ULTRAGENYX PHARMACEUTICAL IN RARE
COM · Common Stock · CUSIP 90400D108 · ISIN US90400D1081
Biopharmaceutical company based in Novato, California, United States
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNovato, CA
- Websiteultragenyx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($13.1m this quarter). Holder counts are more reliable. Shares outstanding: 92.3m as of 2024-10-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $55.52. Options: 16 managers hold calls ($29.9m notional), 10 hold puts ($25.6m).
Trends to Q3 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 233 |
| Q4 2022 | 228 |
| Q1 2023 | 230 |
| Q2 2023 | 243 |
| Q3 2023 | 222 |
| Q4 2023 | 238 |
| Q1 2024 | 271 |
| Q2 2024 | 275 |
| Q3 2024 | 303 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 135 | 100 |
| Q1 2023 | 120 | 99 |
| Q2 2023 | 129 | 110 |
| Q3 2023 | 116 | 106 |
| Q4 2023 | 134 | 98 |
| Q1 2024 | 150 | 96 |
| Q2 2024 | 161 | 120 |
| Q3 2024 | 163 | 120 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q4 2023 | $23.1m | $23.3m | 1.01 |
| Q1 2024 | $33.1m | $18.5m | 0.56 |
| Q2 2024 | $24.2m | $16.4m | 0.68 |
| Q3 2024 | $29.9m | $25.6m | 0.86 |
Biggest buyers
| Alyeska Investment Group, L.P. | Added | +1.1m |
| AQR CAPITAL MANAGEMENT LLC | Added | +947.3k |
| ALKEON CAPITAL MANAGEMENT LLC | Added | +769.9k |
| TWO SIGMA ADVISERS, LP | Added | +545.6k |
| Invesco Ltd. | Added | +406.0k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Added | +400.7k |
| BANK OF AMERICA CORP /DE/ | Added | +378.1k |
| Driehaus Capital Management LLC | Added | +255.8k |
| Frazier Life Sciences Management, L.P. | Added | +208.7k |
| Nuveen Asset Management, LLC | Added | +188.5k |
Biggest sellers
| RTW INVESTMENTS, LP | Reduced | -1.3m |
| MILLENNIUM MANAGEMENT LLC | Reduced | -1.1m |
| Vestal Point Capital, LP | Reduced | -1.1m |
| MONTANOVA CAPITAL, LLC | Reduced | -910.1k |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Reduced | -536.4k |
| AXA S.A. | Reduced | -425.3k |
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -390.7k |
| Walleye Capital LLC | Reduced | -341.5k |
| Schonfeld Strategic Advisors LLC | Reduced | -316.1k |
| MARSHALL WACE, LLP | Reduced | -311.1k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $10.8m194.4k shares |
| MOORE CAPITAL MANAGEMENT, LP | Unchanged | $5.6m100.0k shares |
| TORNO CAPITAL, LLC | Not comparable | $3.3m60.0k shares |
| CITADEL ADVISORS LLC | Added | $1.9m34.8k shares |
| LMR Partners LLP | New | $1.7m30.0k shares |
| Caption Management, LLC | New | $1.7m30.0k shares |
| JANE STREET GROUP, LLC | Reduced | $1.5m26.6k shares |
| CITIGROUP INC | New | $888.8k16.0k shares |
| WOLVERINE TRADING, LLC | New | $843.7k15.5k shares |
| PEAK6 Investments LLC | New | $472.2k8.5k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $10.0m180.7k shares |
| JANE STREET GROUP, LLC | Added | $6.5m117.9k shares |
| TORNO CAPITAL, LLC | Not comparable | $3.3m60.0k shares |
| Caption Management, LLC | New | $1.7m30.0k shares |
| CITADEL ADVISORS LLC | Reduced | $1.2m22.5k shares |
| CITIGROUP INC | New | $888.8k16.0k shares |
| GROUP ONE TRADING LLC | Unchanged | $833.2k15.0k shares |
| SIMPLEX TRADING, LLC | Added | $555.0k10.0k shares |
| Walleye Capital LLC | Unchanged | $483.3k8.7k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution +3.2 pts · filed 2026-07-30 | 8.3% |
| RTW INVESTMENTS, LP 13G · institution new · filed 2026-08-14 | 7.9% |
| VANGUARD PORTFOLIO MANAGEMENT LLC 13G · institution +1.5 pts · filed 2026-07-31 | 7.0% |
| AQR CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-08-13 | 6.7% |
| Madison Avenue Partners, LP 13G · passive investor new · filed 2026-10-20 | 6.4% |
| STATE STREET CORP 13G · institution +1.2 pts · filed 2026-08-07 | 6.3% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-07-31 | 5.1% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD PORTFOLIO MANAGEMENT LLC), FMR LLC (3.5%, 2026-02-05)
Insider purchases and sales in Q3 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2022 | 0 | — | 3 | $1.2m | — |
| Q1 2023 | 0 | — | 7 | $793.5k | — |
| Q2 2023 | 0 | — | 4 | $416.4k | — |
| Q3 2023 | 0 | — | 2 | $352.0k | — |
| Q4 2023 | 0 | — | 2 | $4.3m | $1.3m |
| Q1 2024 | 0 | — | 8 | $3.4m | $620.4k |
| Q2 2024 | 0 | — | 3 | $534.4k | $512.7k |
| Q3 2024 | 0 | — | 3 | $2.1m | $2.1m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-09-03 | KAKKIS EMIL D President & CEO, director · See FN | Sold plan | $1.1m20.0k shares |
| 2024-09-03 | Huizenga Theodore Alan SVP, Chief Accounting Officer | Sold | $5.1k91 shares |
| 2024-08-06 | KAKKIS EMIL D President & CEO, director · See FN | Sold plan | $1.0m20.0k shares |
| 2024-07-02 | Sanders Corazon (Corsee) D. Director | Sold plan | $23.9k584 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q3 2024
| Manager | Shares | Change |
|---|---|---|
| VANGUARD GROUP INC 0.01% of their portfolio | 9.9m $552.5m | Added +165.0k |
| BlackRock, Inc. 0.01% of their portfolio | 5.8m $323.8m | First filing |
| SANDS CAPITAL MANAGEMENT, LLC 0.86% of their portfolio | 5.1m $284.3m | Reduced -236.5k |
| WELLINGTON MANAGEMENT GROUP LLP 0.04% of their portfolio | 4.2m $231.4m | Reduced -390.7k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio | 3.1m $170.5m | Added +76.7k |
| ALKEON CAPITAL MANAGEMENT LLC 0.92% of their portfolio | 3.0m $167.3m | Added +769.9k |
| STATE STREET CORP 0.01% of their portfolio | 2.7m $148.0m | Reduced -33.0k |
| Clearbridge Investments, LLC 0.11% of their portfolio | 2.4m $134.8m | Added +73.2k |
| FEDERATED HERMES, INC. 0.26% of their portfolio | 2.1m $117.2m | Added +3.7k |
| Rock Springs Capital Management LP 3.58% of their portfolio | 2.0m $109.9m | Added +54.2k |
| RTW INVESTMENTS, LP 1.58% of their portfolio | 2.0m $109.3m | Reduced -1.3m |
| DEUTSCHE BANK AG\ 0.04% of their portfolio | 1.7m $93.8m | Reduced -93.4k |
| Invesco Ltd. 0.02% of their portfolio | 1.7m $93.0m | Added +406.0k |
| BAKER BROS. ADVISORS LP 0.91% of their portfolio | 1.6m $87.6m | Added +109.6k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 1.6m $87.3m | Added +65.6k |
| ALLIANCEBERNSTEIN L.P. 0.03% of their portfolio | 1.5m $85.9m | Added +18.4k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.15% of their portfolio | 1.5m $84.8m | Added +400.7k |
| Alyeska Investment Group, L.P. 0.33% of their portfolio | 1.2m $65.0m | Added +1.1m |
| MONTANOVA CAPITAL, LLC 2.30% of their portfolio | 1.2m $64.0m | Reduced -910.1k |
| AQR CAPITAL MANAGEMENT LLC 0.08% of their portfolio | 1.0m $57.8m | Added +947.3k |
| TWO SIGMA ADVISERS, LP 0.13% of their portfolio | 987.8k $54.9m | Added +545.6k |
| NORGES BANK 0.01% of their portfolio | 940.6k $52.3m | Reduced -61.8k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 925.9k $51.4m | Added +378.1k |
| Avoro Capital Advisors LLC 0.67% of their portfolio | 830.0k $46.1m | Unchanged |
| MARSHALL WACE, LLP 0.06% of their portfolio | 822.0k $45.7m | Reduced -311.1k |
| Driehaus Capital Management LLC 0.37% of their portfolio | 783.9k $43.5m | Added +255.8k |
| Bank of New York Mellon Corp 0.01% of their portfolio | 772.1k $42.9m | Reduced -9.9k |
| TWO SIGMA INVESTMENTS, LP 0.09% of their portfolio | 755.7k $42.0m | Added +187.4k |
| First Light Asset Management, LLC 3.49% of their portfolio | 755.1k $41.9m | Reduced -208.0k |
| Avidity Partners Management LP 2.13% of their portfolio | 752.0k $41.8m | Reduced -208.0k |
| Vestal Point Capital, LP 3.29% of their portfolio | 750.0k $41.7m | Reduced -1.1m |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.10% of their portfolio | 724.2k $40.2m | Reduced -106.2k |
| Candriam S.C.A. 0.23% of their portfolio | 713.1k $39.6m | Added +24.1k |
| MILLENNIUM MANAGEMENT LLC 0.03% of their portfolio | 710.7k $39.5m | Reduced -1.1m |
| Point72 Asset Management, L.P. 0.13% of their portfolio | 653.7k $36.3m | Added +113.9k |
| FMR LLC 0.00% of their portfolio | 637.8k $35.4m | Reduced -9.8k |
| Frazier Life Sciences Management, L.P. 1.41% of their portfolio | 633.7k $35.2m | Added +208.7k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 594.5k $33.0m | Added +56.9k |
| EMERALD ADVISERS, LLC 1.22% of their portfolio | 569.8k $31.7m | Added +83.1k |
| Eagle Health Investments LP 6.01% of their portfolio | 561.7k $31.2m | Added +37.2k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.01% of their portfolio | 542.4k $30.1m | Added +172.1k |
| FRED ALGER MANAGEMENT, LLC 0.14% of their portfolio | 536.3k $29.8m | Reduced -12.6k |
| Pictet Asset Management Holding SA 0.03% of their portfolio | 520.5k $28.3m | Reduced -36.3k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 506.5k $28.1m | Reduced -123.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 473.3k $26.3m | Added +91.4k |
| MORGAN STANLEY 0.00% of their portfolio | 467.8k $26.0m | Reduced -30.1k |
| GW&K Investment Management, LLC 0.22% of their portfolio | 466.6k $25.9m | Added +60.0k |
| EMERALD MUTUAL FUND ADVISERS TRUST 1.24% of their portfolio | 429.3k $23.8m | Added +38.8k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 426.4k $23.7m | Reduced -15.6k |
| AXA S.A. 0.07% of their portfolio | 425.4k $23.6m | Reduced -425.3k |
| Schonfeld Strategic Advisors LLC 0.18% of their portfolio | 400.8k $22.3m | Reduced -316.1k |
| Nuveen Asset Management, LLC 0.01% of their portfolio | 392.8k $21.8m | Added +188.5k |
| MPM BIOIMPACT LLC 2.75% of their portfolio | 329.7k $18.3m | Reduced -50.8k |
| Man Group plc 0.05% of their portfolio | 327.2k $18.2m | Reduced -301.5k |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main 0.02% of their portfolio | 294.7k $16.4m | Unchanged |
| Cutter Capital Management, LP 4.70% of their portfolio | 286.8k $15.9m | Reduced -78.2k |
| MACQUARIE GROUP LTD 0.02% of their portfolio | 275.9k $15.3m | Added +46.4k |
| Woodline Partners LP 0.13% of their portfolio | 267.6k $14.9m | Added +765 |
| D. E. Shaw & Co., Inc. 0.02% of their portfolio | 261.6k $14.5m | Added +58.2k |
| Aberdeen Group plc 0.03% of their portfolio | 253.3k $14.1m | Reduced -31.4k |
| MOORE CAPITAL MANAGEMENT, LP 0.39% of their portfolio | 245.0k $13.6m | Unchanged |
| Privium Fund Management B.V. 3.35% of their portfolio | 242.5k $13.5m | Reduced -9.1k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio | 238.1k $13.2m | Reduced -9.1k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 218.9k $12.3m | Reduced -75.0k |
| GREAT LAKES ADVISORS, LLC 0.09% of their portfolio | 199.3k $11.1m | Added +166.7k |
| SPHERA FUNDS MANAGEMENT LTD. 1.78% of their portfolio | 195.3k $10.9m | Reduced -98.5k |
| Hudson Bay Capital Management LP 0.07% of their portfolio | 195.0k $10.8m | Reduced -220.0k |
| Cubist Systematic Strategies, LLC 0.15% of their portfolio | 183.5k $10.2m | New |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio | 182.9k $10.0m | Reduced -174.6k |
| RENAISSANCE TECHNOLOGIES LLC 0.02% of their portfolio | 182.1k $10.1m | New |
| Ikarian Capital, LLC 3.09% of their portfolio | 179.0k $9.9m | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 177.8k $9.9m | Added +947 |
| Granite Investment Partners, LLC 0.42% of their portfolio | 175.0k $9.7m | New |
| TD Asset Management Inc 0.01% of their portfolio | 169.1k $9.2m | Added +20.0k |
| Motley Fool Wealth Management, LLC 0.47% of their portfolio | 168.0k $9.3m | Reduced -2.4k |
| Trexquant Investment LP 0.12% of their portfolio | 167.3k $9.3m | Added +148.5k |
| Blue Owl Capital Holdings LP 1.76% of their portfolio | 163.2k $9.1m | Reduced -105.0k |
| VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 162.1k $9.0m | Added +75.2k |
| Swiss National Bank 0.01% of their portfolio | 159.2k $8.8m | Added +13.3k |
| Assenagon Asset Management S.A. 0.02% of their portfolio | 145.4k $8.1m | Added +3.3k |
| WCM INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio | 145.3k $7.9m | Reduced -9.3k |
| Motley Fool Asset Management LLC 0.47% of their portfolio | 141.6k $8.0m | Added +360 |
| PEREGRINE CAPITAL MANAGEMENT LLC 0.23% of their portfolio | 134.2k $7.5m | Reduced -14.6k |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 131.4k $7.3m | Reduced -53.6k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 120.3k $6.7m | Added +95.5k |
| PINNACLE ASSOCIATES LTD 0.10% of their portfolio | 119.4k $5.7m | Reduced -41.7k |
| SEI INVESTMENTS CO 0.01% of their portfolio | 116.1k $6.5m | Added +24.3k |
| California Public Employees Retirement System 0.00% of their portfolio | 114.1k $6.3m | Added +6.0k |
| RHUMBLINE ADVISERS 0.01% of their portfolio | 110.3k $6.1m | Added +13.6k |
| Parkman Healthcare Partners LLC 0.78% of their portfolio | 109.5k $6.1m | Added +9.5k |
| EFG Asset Management (North America) Corp. 1.02% of their portfolio | 109.4k $6.1m | Reduced -16.2k |
| Crestwood Advisors Group, LLC 0.11% of their portfolio | 100.3k $5.6m | Unchanged |
| Rafferty Asset Management, LLC 0.02% of their portfolio | 98.4k $5.5m | Reduced -27.8k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.02% of their portfolio | 98.0k $5.4m | Reduced -536.4k |
| UBS Group AG 0.00% of their portfolio | 93.1k $5.2m | Reduced -102.8k |
| Legal & General Group Plc 0.00% of their portfolio | 92.8k $5.2m | Added +7.5k |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.01% of their portfolio | 89.6k $5.0m | Unchanged |
| Russell Investments Group, Ltd. 0.01% of their portfolio | 88.6k $4.9m | Reduced -67.4k |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 86.4k $4.8m | Added +76.2k |
| Duquesne Family Office LLC 0.17% of their portfolio | 85.4k $4.7m | New |