TWIST BIOSCIENCE CORP TWST
COM · Common Stock · CUSIP 90184D100 · ISIN US90184D1000
Biotechnology company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSouth San Francisco, CA
- Founded2013
- Websitetwistbioscience.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($60.9m this quarter). Holder counts are more reliable. Shares outstanding: 61.3m as of 2026-01-27, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $31.72. Options: 7 managers hold calls ($4.6m notional), 5 hold puts ($3.2m).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 222 |
| Q4 2022 | 199 |
| Q1 2023 | 202 |
| Q2 2023 | 194 |
| Q3 2023 | 197 |
| Q4 2023 | 220 |
| Q1 2024 | 240 |
| Q2 2024 | 265 |
| Q3 2024 | 247 |
| Q4 2024 | 248 |
| Q1 2025 | 264 |
| Q2 2025 | 245 |
| Q3 2025 | 239 |
| Q4 2025 | 244 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 121 | 99 |
| Q2 2024 | 147 | 112 |
| Q3 2024 | 120 | 128 |
| Q4 2024 | 111 | 112 |
| Q1 2025 | 135 | 105 |
| Q2 2025 | 112 | 140 |
| Q3 2025 | 132 | 96 |
| Q4 2025 | 116 | 115 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $3.4m | $2.1m | 0.63 |
| Q2 2025 | $3.5m | $2.4m | 0.69 |
| Q3 2025 | $4.7m | $2.5m | 0.53 |
| Q4 2025 | $4.6m | $3.2m | 0.70 |
Biggest buyers
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | Added | +1.8m |
| EdgePoint Investment Group Inc. | Added | +1.3m |
| ARK Investment Management LLC | Added | +832.7k |
| STATE STREET CORP | Added | +538.8k |
| STEMPOINT CAPITAL LP | New | +518.4k |
| WELLINGTON MANAGEMENT GROUP LLP | Added | +513.3k |
| Freshford Capital Management, LLC | New | +420.2k |
| Blue Water Life Science Advisors, LP | New | +383.0k |
| Balyasny Asset Management L.P. | Added | +333.1k |
| CITIGROUP INC | Added | +307.8k |
Biggest sellers
| JPMORGAN CHASE & CO | Reduced | -1.8m |
| MORGAN STANLEY | Reduced | -625.8k |
| Artisan Partners Limited Partnership | Reduced | -580.7k |
| Point72 Asset Management, L.P. | Sold out | -530.0k |
| Invesco Ltd. | Reduced | -504.9k |
| Qube Research & Technologies Ltd | Reduced | -400.5k |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Reduced | -394.0k |
| Bank of New York Mellon Corp | Reduced | -315.3k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -296.1k |
| BlackRock, Inc. | Reduced | -283.4k |
Biggest calls
| CITADEL ADVISORS LLC | Added | $1.6m49.5k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $1.2m39.1k shares |
| PEAK6 LLC | New | $634.4k20.0k shares |
| JANE STREET GROUP, LLC | Reduced | $488.5k15.4k shares |
| GROUP ONE TRADING LLC | Added | $282.3k8.9k shares |
| Walleye Capital LLC | New | $231.6k7.3k shares |
| SIMPLEX TRADING, LLC | Reduced | $171.3k5.4k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $2.1m64.8k shares |
| CITADEL ADVISORS LLC | Reduced | $1.0m32.2k shares |
| SIMPLEX TRADING, LLC | Reduced | $95.2k3.0k shares |
| Walleye Capital LLC | New | $47.6k1.5k shares |
| GROUP ONE TRADING LLC | Added | $25.4k800 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +5.6 pts · filed 2026-09-08 | 13.2% |
| BlackRock, Inc. 13G · institution filed 2025-04-17 | 8.3% |
| Artisan Partners Limited Partnership 13G · institution -2.4 pts · filed 2026-08-13 | 7.7% |
| PRICE T ROWE ASSOCIATES INC /MD/ 13G · institution new · filed 2026-08-14 | 5.8% |
| ARK Investment Management LLC 13G · institution -2.2 pts · filed 2026-09-08 | 5.1% |
| STATE STREET CORP 13G · institution +0.8 pts · filed 2025-11-10 | 5.1% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.0% |
Fell to 5% or below in the last year: EdgePoint Investment Group Inc. (4.2%, 2026-08-14), WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC (3.5%, 2026-08-11), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 0 | — | 6 | $329.6k | — |
| Q2 2024 | 0 | — | 7 | $945.5k | — |
| Q3 2024 | 0 | — | 6 | $957.9k | — |
| Q4 2024 | 0 | — | 7 | $4.9m | $351.8k |
| Q1 2025 | 0 | — | 7 | $1.9m | $250.0k |
| Q2 2025 | 0 | — | 6 | $1.8m | — |
| Q3 2025 | 0 | — | 6 | $879.3k | — |
| Q4 2025 | 0 | — | 7 | $5.8m | $176.3k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-12-22 | Leproust Emily M. Chief Executive Officer, director | Sold | $55.5k1.6k shares |
| 2025-12-22 | Cho Dennis Officer | Sold | $11.2k324 shares |
| 2025-12-22 | Green Paula SVP of Human Resources | Sold | $9.4k273 shares |
| 2025-12-08 | Leproust Emily M. Chief Executive Officer, director | Sold | $74.1k2.3k shares |
| 2025-12-08 | Green Paula SVP of Human Resources | Sold | $28.8k877 shares |
| 2025-12-08 | Cho Dennis Officer | Sold | $13.1k398 shares |
| 2025-12-08 | WERNER ROBERT F. Chief Accounting Officer | Sold | $7.6k230 shares |
| 2025-11-24 | WERNER ROBERT F. Chief Accounting Officer | Sold | $23.6k822 shares |
| 2025-11-21 | Leproust Emily M. Chief Executive Officer, director | Sold | $70.6k2.7k shares |
| 2025-11-21 | Finn Patrick John President and COO | Sold | $47.1k1.8k shares |
| 2025-11-21 | Laponis Adam Chief Financial Officer | Sold | $23.5k887 shares |
| 2025-11-21 | Cho Dennis Officer | Sold | $20.1k757 shares |
| 2025-11-21 | Green Paula SVP of Human Resources | Sold | $15.8k598 shares |
| 2025-11-21 | WERNER ROBERT F. Chief Accounting Officer | Sold | $6.1k229 shares |
| 2025-11-18 | JOHANNESSEN JAN Director | Sold | $174.5k7.0k shares |
| 2025-11-03 | Leproust Emily M. Chief Executive Officer, director | Sold | $156.8k4.9k shares |
| 2025-11-03 | Finn Patrick John President and COO | Sold | $88.4k2.8k shares |
| 2025-11-03 | Green Paula SVP of Human Resources | Sold | $34.8k1.1k shares |
| 2025-11-03 | Cho Dennis Officer | Sold | $32.7k1.0k shares |
| 2025-11-03 | WERNER ROBERT F. Chief Accounting Officer | Sold | $5.1k160 shares |
| 2025-10-30 | Leproust Emily M. Chief Executive Officer, director | Sold | $986.6k31.4k shares |
| 2025-10-30 | Finn Patrick John President and COO | Sold | $553.5k17.6k shares |
| 2025-10-30 | Green Paula SVP of Human Resources | Sold | $217.6k6.9k shares |
| 2025-10-30 | Cho Dennis Officer | Sold | $204.8k6.5k shares |
| 2025-10-30 | Laponis Adam Chief Financial Officer | Sold | $173.5k5.5k shares |
| 2025-10-30 | WERNER ROBERT F. Chief Accounting Officer | Sold | $31.9k1.0k shares |
| 2025-10-23 | Finn Patrick John President and COO | Sold | $69.2k2.2k shares |
| 2025-10-09 | Laponis Adam Chief Financial Officer | Sold plan | $82.9k2.5k shares |
| 2025-10-08 | Laponis Adam Chief Financial Officer | Sold plan | $93.5k3.0k shares |
| 2025-10-06 | Leproust Emily M. Chief Executive Officer, director | Sold | $1.0m31.3k shares |
The latest 30 of 39 trades.
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| ARK Investment Management LLC 1.59% of their portfolio | 7.6m $239.8m | Added +832.7k |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC 0.53% of their portfolio | 6.0m $188.9m | Added +1.8m |
| BlackRock, Inc. 0.00% of their portfolio | 5.9m $187.0m | Reduced -283.4k |
| Artisan Partners Limited Partnership 0.28% of their portfolio | 5.8m $184.9m | Reduced -580.7k |
| VANGUARD GROUP INC 0.00% of their portfolio | 5.8m $183.2m | Added +8.0k |
| EdgePoint Investment Group Inc. 1.40% of their portfolio | 5.4m $170.6m | Added +1.3m |
| STATE STREET CORP 0.00% of their portfolio | 3.6m $115.1m | Added +538.8k |
| Sumitomo Mitsui Trust Group, Inc. 0.04% of their portfolio | 1.9m $60.4m | Reduced -217.4k |
| Amova Asset Management Americas, Inc. 0.70% of their portfolio | 1.9m $60.3m | Reduced -217.4k |
| Soleus Capital Management, L.P. 2.51% of their portfolio | 1.9m $59.1m | Reduced -4.4k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 1.7m $53.8m | Added +69.6k |
| MILLENNIUM MANAGEMENT LLC 0.03% of their portfolio | 1.5m $47.5m | Reduced -296.1k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.5m $46.3m | Added +10.9k |
| Thrivent Financial for Lutherans 0.08% of their portfolio | 1.4m $43.2m | Reduced -101.7k |
| Invesco Ltd. 0.00% of their portfolio | 1.3m $40.9m | Reduced -504.9k |
| BAILLIE GIFFORD & CO 0.03% of their portfolio | 1.3m $40.5m | Added +13.5k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio | 1.2m $37.2m | Added +49.4k |
| First Light Asset Management, LLC 2.77% of their portfolio | 1.1m $36.2m | Reduced -54.1k |
| MORGAN STANLEY 0.00% of their portfolio | 866.4k $27.5m | Reduced -625.8k |
| AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio | 865.6k $27.5m | Added +27.6k |
| Tao Capital Management LP 22.63% of their portfolio | 828.8k $26.3m | Unchanged |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 815.4k $25.9m | Added +24.5k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 813.1k $25.8m | Added +513.3k |
| UBS Group AG 0.00% of their portfolio | 662.3k $21.0m | Added +147.4k |
| JENNISON ASSOCIATES LLC 0.01% of their portfolio | 618.9k $19.6m | Reduced -15.7k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.03% of their portfolio | 591.2k $18.8m | Added +6.5k |
| Balyasny Asset Management L.P. 0.03% of their portfolio | 579.4k $18.4m | Added +333.1k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 548.4k $17.4m | Reduced -25.2k |
| STEMPOINT CAPITAL LP 2.82% of their portfolio | 518.4k $16.4m | New |
| NORTHERN TRUST CORP 0.00% of their portfolio | 504.8k $16.0m | Reduced -20.2k |
| Freshford Capital Management, LLC 5.35% of their portfolio | 420.2k $13.3m | New |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 415.6k $13.2m | Added +294.1k |
| CITIGROUP INC 0.01% of their portfolio | 401.3k $12.7m | Added +307.8k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 399.4k $12.7m | Reduced -51.0k |
| Blue Water Life Science Advisors, LP 7.63% of their portfolio | 383.0k $12.1m | New |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd 0.81% of their portfolio | 371.6k $11.8m | Added +105.7k |
| Aberdeen Group plc 0.02% of their portfolio | 308.1k $9.8m | Reduced -12.2k |
| Nuveen, LLC 0.00% of their portfolio | 290.6k $9.2m | Reduced -261.6k |
| PEREGRINE CAPITAL MANAGEMENT LLC 0.28% of their portfolio | 288.3k $9.1m | Reduced -3.9k |
| SEI INVESTMENTS CO 0.01% of their portfolio | 270.1k $8.6m | Reduced -26.8k |
| SILVERCREST ASSET MANAGEMENT GROUP LLC 0.06% of their portfolio | 269.1k $8.5m | Added +767 |
| OSTERWEIS CAPITAL MANAGEMENT INC 0.34% of their portfolio | 256.9k $8.1m | New |
| JUPITER ASSET MANAGEMENT LTD 0.06% of their portfolio | 243.7k $7.7m | Reduced -1.4k |
| Pictet Asset Management Holding SA 0.01% of their portfolio | 222.6k $7.3m | Added +115.9k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 215.1k $6.8m | Reduced -1.8m |
| Ensign Peak Advisors, Inc 0.01% of their portfolio | 212.6k $6.7m | Reduced -13.7k |
| Trexquant Investment LP 0.06% of their portfolio | 198.5k $6.3m | Reduced -134.2k |
| BARCLAYS PLC 0.00% of their portfolio | 194.1k $6.2m | Reduced -32.6k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 182.9k $5.8m | Reduced -315.3k |
| Qube Research & Technologies Ltd 0.01% of their portfolio | 172.0k $5.5m | Reduced -400.5k |
| Legal & General Group Plc 0.00% of their portfolio | 171.2k $5.4m | Added +45.9k |
| STATE OF MICHIGAN RETIREMENT SYSTEM 0.02% of their portfolio | 153.2k $4.9m | Unchanged |
| Schonfeld Strategic Advisors LLC 0.02% of their portfolio | 139.9k $4.4m | Added +74.4k |
| ODDO BHF ASSET MANAGEMENT SAS 0.16% of their portfolio | 135.7k $4.3m | Reduced -36.1k |
| NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio | 135.6k $4.3m | Reduced -25.6k |
| Vestmark Advisory Solutions, Inc. 0.06% of their portfolio | 130.0k $4.1m | Added +12.7k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 129.6k $4.1m | Reduced -78.4k |
| Swiss National Bank 0.00% of their portfolio | 119.0k $3.8m | Added +2.9k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 114.3k $3.6m | Reduced -10 |
| NATIXIS 0.01% of their portfolio | 103.7k $3.3m | New |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.01% of their portfolio | 103.1k $3.3m | Reduced -394.0k |
| FRED ALGER MANAGEMENT, LLC 0.01% of their portfolio | 94.1k $3.0m | Reduced -3.0k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 91.1k $2.9m | Reduced -4.1k |
| BLAIR WILLIAM & CO/IL 0.01% of their portfolio | 81.6k $2.6m | Added +22.5k |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.00% of their portfolio | 80.6k $2.6m | First filing |
| Aquatic Capital Management LLC 0.07% of their portfolio | 78.5k $2.5m | Added +56.2k |
| SG Americas Securities, LLC 0.00% of their portfolio | 76.5k $2.4m | Added +59.5k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 76.3k $2.4m | Added +855 |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 74.8k $2.4m | Added +28.1k |
| HRT FINANCIAL LP 0.01% of their portfolio | 73.1k $2.3m | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 70.8k $2.2m | Added +53.8k |
| FMR LLC 0.00% of their portfolio | 68.9k $2.2m | Reduced -150.6k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 66.5k $2.1m | Reduced -76 |
| LAZARD ASSET MANAGEMENT LLC 0.00% of their portfolio | 66.0k $2.1m | Reduced -12.3k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.00% of their portfolio | 65.1k $2.1m | Reduced -468 |
| CANADA PENSION PLAN INVESTMENT BOARD 0.00% of their portfolio | 60.2k $1.9m | Added +11.3k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 59.0k $1.9m | Added +5.1k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 58.3k $1.9m | Reduced -8 |
| Conestoga Capital Advisors, LLC 0.03% of their portfolio | 56.8k $1.8m | Added +1.2k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 55.7k $1.8m | Reduced -44.8k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 53.9k $1.7m | Reduced -204.8k |
| LPL Financial LLC 0.00% of their portfolio | 53.0k $1.7m | Added +17.6k |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 51.3k $1.6m | Added +51 |
| Clarius Group, LLC 0.09% of their portfolio | 49.6k $1.6m | Unchanged |
| Mitsubishi UFJ Asset Management Co., Ltd. 0.00% of their portfolio | 44.7k $1.4m | Added +4.7k |
| PROFUND ADVISORS LLC 0.04% of their portfolio | 42.4k $1.3m | Added +17.7k |
| ALGERT GLOBAL LLC 0.02% of their portfolio | 40.6k $1.3m | Reduced -19.7k |
| HighMark Wealth Management LLC 0.51% of their portfolio | 39.5k $1.3m | Unchanged |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 38.6k $1.2m | Reduced -11.2k |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 37.6k $1.2m | Reduced -9.7k |
| Squarepoint Ops LLC 0.00% of their portfolio | 35.7k $1.1m | Reduced -40.1k |
| Maxi Investments CY Ltd 0.20% of their portfolio | 35.0k $1.1m | New |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 34.5k $1.1m | Reduced -2.6k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 33.3k $1.1m | Reduced -62.9k |
| MetLife Investment Management, LLC 0.01% of their portfolio | 33.2k $1.1m | Reduced -1.5k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 33.2k $1.1m | Reduced -95.3k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 32.0k $1.0m | Reduced -83.2k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 31.4k $996.0k | Added +5.4k |
| BENJAMIN EDWARDS INC 0.01% of their portfolio | 29.6k $939.8k | Added +1.3k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 27.6k $874.9k | New |