TWIST BIOSCIENCE CORP TWST
COM · Common Stock · CUSIP 90184D100 · ISIN US90184D1000
Biotechnology company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSouth San Francisco, CA
- Founded2013
- Websitetwistbioscience.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($64.9m this quarter). Holder counts are more reliable. Shares outstanding: 61.1m as of 2025-11-13, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $28.14. Options: 5 managers hold calls ($4.7m notional), 4 hold puts ($2.5m).
Trends to Q3 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 222 |
| Q4 2022 | 199 |
| Q1 2023 | 202 |
| Q2 2023 | 194 |
| Q3 2023 | 197 |
| Q4 2023 | 220 |
| Q1 2024 | 240 |
| Q2 2024 | 265 |
| Q3 2024 | 247 |
| Q4 2024 | 248 |
| Q1 2025 | 264 |
| Q2 2025 | 245 |
| Q3 2025 | 239 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2023 | 95 | 94 |
| Q1 2024 | 121 | 99 |
| Q2 2024 | 147 | 112 |
| Q3 2024 | 120 | 128 |
| Q4 2024 | 111 | 112 |
| Q1 2025 | 135 | 105 |
| Q2 2025 | 112 | 140 |
| Q3 2025 | 132 | 96 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q4 2024 | $6.0m | $2.0m | 0.34 |
| Q1 2025 | $3.4m | $2.1m | 0.63 |
| Q2 2025 | $3.5m | $2.4m | 0.69 |
| Q3 2025 | $4.7m | $2.5m | 0.53 |
Biggest buyers
| EdgePoint Investment Group Inc. | Added | +1.7m |
| Soleus Capital Management, L.P. | Added | +1.5m |
| Artisan Partners Limited Partnership | Added | +1.3m |
| MILLENNIUM MANAGEMENT LLC | Added | +1.1m |
| JPMORGAN CHASE & CO | Added | +597.3k |
| STATE STREET CORP | Added | +588.1k |
| BAILLIE GIFFORD & CO | Added | +487.1k |
| ARK Investment Management LLC | Added | +326.4k |
| UBS Group AG | Added | +298.3k |
| MORGAN STANLEY | Added | +291.7k |
Biggest sellers
| Point72 Asset Management, L.P. | Reduced | -1.6m |
| CITADEL ADVISORS LLC | Reduced | -1.4m |
| Invesco Ltd. | Reduced | -552.8k |
| ExodusPoint Capital Management, LP | Sold out | -471.8k |
| Iron Triangle Partners LP | Sold out | -424.4k |
| Balyasny Asset Management L.P. | Reduced | -382.0k |
| VICTORY CAPITAL MANAGEMENT INC | Reduced | -313.5k |
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -277.2k |
| BANK OF AMERICA CORP /DE/ | Reduced | -238.0k |
| HAWK RIDGE CAPITAL MANAGEMENT LP | Sold out | -234.3k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $3.0m105.9k shares |
| CITADEL ADVISORS LLC | Added | $664.1k23.6k shares |
| JANE STREET GROUP, LLC | Added | $574.1k20.4k shares |
| SIMPLEX TRADING, LLC | Added | $402.0k14.3k shares |
| GROUP ONE TRADING LLC | Added | $115.4k4.1k shares |
Biggest puts
| CITADEL ADVISORS LLC | Added | $1.1m38.5k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $1.1m38.1k shares |
| SIMPLEX TRADING, LLC | Added | $343.0k12.2k shares |
| GROUP ONE TRADING LLC | Reduced | $14.1k500 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +5.6 pts · filed 2026-09-08 | 13.2% |
| BlackRock, Inc. 13G · institution filed 2025-04-17 | 8.3% |
| Artisan Partners Limited Partnership 13G · institution -2.4 pts · filed 2026-08-13 | 7.7% |
| PRICE T ROWE ASSOCIATES INC /MD/ 13G · institution new · filed 2026-08-14 | 5.8% |
| ARK Investment Management LLC 13G · institution -2.2 pts · filed 2026-09-08 | 5.1% |
| STATE STREET CORP 13G · institution +0.8 pts · filed 2025-11-10 | 5.1% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.0% |
Fell to 5% or below in the last year: EdgePoint Investment Group Inc. (4.2%, 2026-08-14), WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC (3.5%, 2026-08-11), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q3 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 6 | $329.6k | — |
| Q2 2024 | 0 | — | 7 | $945.5k | — |
| Q3 2024 | 0 | — | 6 | $957.9k | — |
| Q4 2024 | 0 | — | 7 | $4.9m | $351.8k |
| Q1 2025 | 0 | — | 7 | $1.9m | $250.0k |
| Q2 2025 | 0 | — | 6 | $1.8m | — |
| Q3 2025 | 0 | — | 6 | $879.3k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-09-22 | Leproust Emily M. Chief Executive Officer, director | Sold | $47.0k1.7k shares |
| 2025-09-22 | Green Paula SVP of Human Resources | Sold | $8.1k295 shares |
| 2025-09-22 | Cho Dennis Officer | Sold | $6.4k233 shares |
| 2025-09-15 | Cho Dennis Officer | Sold | $2.4k94 shares |
| 2025-09-08 | Leproust Emily M. Chief Executive Officer, director | Sold | $58.3k2.3k shares |
| 2025-09-08 | Green Paula SVP of Human Resources | Sold | $23.0k892 shares |
| 2025-09-08 | Cho Dennis Officer | Sold | $6.9k269 shares |
| 2025-09-08 | WERNER ROBERT F. Chief Accounting Officer | Sold | $6.1k235 shares |
| 2025-08-25 | WERNER ROBERT F. Chief Accounting Officer | Sold | $23.6k853 shares |
| 2025-08-21 | Leproust Emily M. Chief Executive Officer, director | Sold | $70.5k2.7k shares |
| 2025-08-21 | Finn Patrick John President and COO | Sold | $47.8k1.8k shares |
| 2025-08-21 | Laponis Adam Chief Financial Officer | Sold | $23.8k918 shares |
| 2025-08-21 | Green Paula SVP of Human Resources | Sold | $16.1k619 shares |
| 2025-08-21 | Cho Dennis Officer | Sold | $13.5k521 shares |
| 2025-08-21 | WERNER ROBERT F. Chief Accounting Officer | Sold | $6.2k238 shares |
| 2025-08-04 | Leproust Emily M. Chief Executive Officer, director | Sold | $158.4k5.6k shares |
| 2025-08-04 | Finn Patrick John President and COO | Sold | $90.4k3.2k shares |
| 2025-08-04 | Green Paula SVP of Human Resources | Sold | $35.6k1.3k shares |
| 2025-08-04 | Cho Dennis Officer | Sold | $22.3k785 shares |
| 2025-08-04 | WERNER ROBERT F. Chief Accounting Officer | Sold | $5.3k186 shares |
| 2025-07-23 | Finn Patrick John President and COO | Sold | $79.8k2.2k shares |
| 2025-07-09 | Laponis Adam Chief Financial Officer | Sold | $93.4k2.4k shares |
| 2025-07-02 | Leproust Emily M. Chief Executive Officer, director | Sold | $17.2k476 shares |
| 2025-07-02 | Finn Patrick John President and COO | Sold | $7.6k209 shares |
| 2025-07-02 | Green Paula SVP of Human Resources | Sold | $5.1k142 shares |
| 2025-07-02 | Cho Dennis Officer | Sold | $4.5k125 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q3 2025
| Manager | Shares | Change |
|---|---|---|
| ARK Investment Management LLC 1.13% of their portfolio | 6.7m $189.3m | Added +326.4k |
| Artisan Partners Limited Partnership 0.26% of their portfolio | 6.4m $180.4m | Added +1.3m |
| BlackRock, Inc. 0.00% of their portfolio | 6.2m $173.9m | Reduced -98.1k |
| VANGUARD GROUP INC 0.00% of their portfolio | 5.8m $162.3m | Reduced -63.2k |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC 0.30% of their portfolio | 4.1m $116.6m | Added +235.7k |
| EdgePoint Investment Group Inc. 0.86% of their portfolio | 4.1m $114.9m | Added +1.7m |
| STATE STREET CORP 0.00% of their portfolio | 3.1m $86.9m | Added +588.1k |
| Sumitomo Mitsui Trust Group, Inc. 0.03% of their portfolio | 2.1m $59.7m | Reduced -179.2k |
| Amova Asset Management Americas, Inc. 0.58% of their portfolio | 2.1m $59.6m | Reduced -179.2k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 2.0m $57.3m | Added +597.3k |
| Soleus Capital Management, L.P. 2.81% of their portfolio | 1.9m $52.5m | Added +1.5m |
| Invesco Ltd. 0.01% of their portfolio | 1.8m $50.5m | Reduced -552.8k |
| MILLENNIUM MANAGEMENT LLC 0.04% of their portfolio | 1.8m $50.5m | Added +1.1m |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 1.6m $45.8m | Added +102.0k |
| MORGAN STANLEY 0.00% of their portfolio | 1.5m $42.0m | Added +291.7k |
| Thrivent Financial for Lutherans 0.08% of their portfolio | 1.5m $41.2m | Added +184.7k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.4m $40.8m | Added +24.0k |
| BAILLIE GIFFORD & CO 0.03% of their portfolio | 1.3m $35.5m | Added +487.1k |
| First Light Asset Management, LLC 3.17% of their portfolio | 1.2m $33.6m | Added +249.8k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio | 1.1m $31.6m | Reduced -95.7k |
| AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio | 838.1k $23.6m | Reduced -26.3k |
| Tao Capital Management LP 17.64% of their portfolio | 828.8k $23.3m | Unchanged |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 790.9k $22.3m | Added +62.3k |
| JENNISON ASSOCIATES LLC 0.01% of their portfolio | 634.6k $17.9m | Added +16.4k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.02% of their portfolio | 584.7k $16.5m | Added +71.8k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 573.6k $16.1m | Reduced -20.4k |
| Qube Research & Technologies Ltd 0.02% of their portfolio | 572.4k $16.1m | Added +241.3k |
| Nuveen, LLC 0.00% of their portfolio | 552.1k $15.5m | Added +41.2k |
| Point72 Asset Management, L.P. 0.03% of their portfolio | 530.0k $14.9m | Reduced -1.6m |
| NORTHERN TRUST CORP 0.00% of their portfolio | 525.0k $14.8m | Reduced -4.1k |
| UBS Group AG 0.00% of their portfolio | 514.9k $14.5m | Added +298.3k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 498.3k $14.0m | Reduced -29.9k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.06% of their portfolio | 497.1k $14.0m | Added +134.9k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 450.4k $12.7m | Reduced -238.0k |
| Trexquant Investment LP 0.10% of their portfolio | 332.7k $9.4m | Added +99.4k |
| Aberdeen Group plc 0.01% of their portfolio | 320.3k $9.0m | Added +158.9k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 299.8k $8.4m | Reduced -277.2k |
| SEI INVESTMENTS CO 0.01% of their portfolio | 296.9k $8.4m | Added +13.7k |
| PEREGRINE CAPITAL MANAGEMENT LLC 0.25% of their portfolio | 292.2k $8.2m | Added +75.6k |
| SILVERCREST ASSET MANAGEMENT GROUP LLC 0.05% of their portfolio | 268.3k $7.6m | Reduced -6.4k |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd 0.51% of their portfolio | 265.9k $7.5m | Added +126.3k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 258.7k $7.3m | Added +5.3k |
| Balyasny Asset Management L.P. 0.01% of their portfolio | 246.2k $6.9m | Reduced -382.0k |
| JUPITER ASSET MANAGEMENT LTD 0.06% of their portfolio | 245.1k $6.9m | Added +192.1k |
| BARCLAYS PLC 0.00% of their portfolio | 226.7k $6.4m | Added +16.1k |
| Ensign Peak Advisors, Inc 0.01% of their portfolio | 226.3k $6.4m | Added +61.0k |
| FMR LLC 0.00% of their portfolio | 219.5k $6.2m | Added +2.4k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 207.9k $5.9m | Added +59.4k |
| ODDO BHF ASSET MANAGEMENT SAS 0.18% of their portfolio | 171.8k $4.8m | Added +64.6k |
| NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio | 161.2k $4.5m | Added +40.8k |
| STATE OF MICHIGAN RETIREMENT SYSTEM 0.02% of their portfolio | 153.2k $4.3m | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 128.5k $3.6m | Reduced -226.1k |
| Legal & General Group Plc 0.00% of their portfolio | 125.3k $3.5m | Added +15.0k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 121.5k $3.4m | Added +59.5k |
| Vestmark Advisory Solutions, Inc. 0.06% of their portfolio | 117.2k $3.3m | Reduced -80.3k |
| Swiss National Bank 0.00% of their portfolio | 116.1k $3.3m | Added +2.2k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 115.2k $3.2m | Reduced -1.4m |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 114.3k $3.2m | Added +38.6k |
| Pictet Asset Management Holding SA 0.00% of their portfolio | 106.8k $2.9m | Reduced -3.0k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 100.5k $2.8m | Added +5.2k |
| FRED ALGER MANAGEMENT, LLC 0.01% of their portfolio | 97.1k $2.7m | Added +96 |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 96.3k $2.7m | Reduced -34.6k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 95.2k $2.7m | Reduced -4.2k |
| CITIGROUP INC 0.00% of their portfolio | 93.5k $2.6m | Reduced -30.2k |
| Cubist Systematic Strategies, LLC 0.03% of their portfolio | 87.5k $2.5m | New |
| MACQUARIE GROUP LTD 0.00% of their portfolio | 82.2k $2.3m | Added +21.5k |
| LAZARD ASSET MANAGEMENT LLC 0.00% of their portfolio | 78.3k $2.2m | Added +20.0k |
| Man Group plc 0.00% of their portfolio | 76.1k $2.1m | Reduced -30.4k |
| Squarepoint Ops LLC 0.00% of their portfolio | 75.8k $2.1m | Added +4.1k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 75.5k $2.1m | Reduced -3.5k |
| Prosight Management, LP 0.51% of their portfolio | 75.0k $2.1m | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 73.8k $2.1m | Reduced -42.2k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 66.6k $1.9m | Added +76 |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.00% of their portfolio | 65.6k $1.8m | Added +58.5k |
| Schonfeld Strategic Advisors LLC 0.01% of their portfolio | 65.4k $1.8m | Added +35.3k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 63.9k $1.8m | Reduced -58.0k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.01% of their portfolio | 60.5k $1.7m | Reduced -91.9k |
| ALGERT GLOBAL LLC 0.03% of their portfolio | 60.3k $1.7m | Added +8.5k |
| BLAIR WILLIAM & CO/IL 0.00% of their portfolio | 59.1k $1.7m | Reduced -642 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 58.3k $1.6m | Added +4.2k |
| Conestoga Capital Advisors, LLC 0.03% of their portfolio | 55.6k $1.6m | Added +27.2k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 53.9k $1.5m | Added +4.6k |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 51.3k $1.4m | Added +50 |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 49.8k $1.4m | Added +8.2k |
| Clarius Group, LLC 0.08% of their portfolio | 49.6k $1.4m | Unchanged |
| CANADA PENSION PLAN INVESTMENT BOARD 0.00% of their portfolio | 48.9k $1.4m | Unchanged |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 47.2k $1.3m | Reduced -313.5k |
| Campbell & CO Investment Adviser LLC 0.10% of their portfolio | 47.2k $1.3m | Added +32.8k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 46.8k $1.3m | Added +5.8k |
| Perbak Capital Partners LLP 0.23% of their portfolio | 46.4k $1.3m | Added +22.8k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 44.1k $1.2m | New |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 41.8k $1.2m | Reduced -3.7k |
| Engineers Gate Manager LP 0.01% of their portfolio | 40.1k $1.1m | New |
| Mitsubishi UFJ Asset Management Co., Ltd. 0.00% of their portfolio | 40.0k $1.1m | Reduced -1.6k |
| HighMark Wealth Management LLC 0.49% of their portfolio | 39.5k $1.1m | Added +947 |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 37.2k $1.0m | Added +147 |
| JBF Capital, Inc. 0.15% of their portfolio | 37.1k $1.0m | New |
| LPL Financial LLC 0.00% of their portfolio | 35.4k $996.1k | Added +6.7k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 34.7k $977.2k | Unchanged |
| Tower Research Capital LLC (TRC) 0.03% of their portfolio | 34.3k $964.8k | Added +16.1k |