TWIST BIOSCIENCE CORP TWST
COM · Common Stock · CUSIP 90184D100 · ISIN US90184D1000
Biotechnology company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSouth San Francisco, CA
- Founded2013
- Websitetwistbioscience.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($90.4m this quarter). Holder counts are more reliable. Shares outstanding: 60.4m as of 2025-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $36.79. Options: 7 managers hold calls ($3.5m notional), 5 hold puts ($2.4m).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 222 |
| Q4 2022 | 199 |
| Q1 2023 | 202 |
| Q2 2023 | 194 |
| Q3 2023 | 197 |
| Q4 2023 | 220 |
| Q1 2024 | 240 |
| Q2 2024 | 265 |
| Q3 2024 | 247 |
| Q4 2024 | 248 |
| Q1 2025 | 264 |
| Q2 2025 | 245 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 83 | 92 |
| Q4 2023 | 95 | 94 |
| Q1 2024 | 121 | 99 |
| Q2 2024 | 147 | 112 |
| Q3 2024 | 120 | 128 |
| Q4 2024 | 111 | 112 |
| Q1 2025 | 135 | 105 |
| Q2 2025 | 112 | 140 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $5.9m | $2.0m | 0.34 |
| Q4 2024 | $6.0m | $2.0m | 0.34 |
| Q1 2025 | $3.4m | $2.1m | 0.63 |
| Q2 2025 | $3.5m | $2.4m | 0.69 |
Biggest buyers
| EdgePoint Investment Group Inc. | Added | +1.3m |
| Point72 Asset Management, L.P. | Added | +725.5k |
| BlackRock, Inc. | Added | +643.6k |
| GOLDMAN SACHS GROUP INC | Added | +592.1k |
| MORGAN STANLEY | Added | +589.7k |
| Balyasny Asset Management L.P. | Added | +567.5k |
| CITADEL ADVISORS LLC | Added | +432.3k |
| BANK OF AMERICA CORP /DE/ | Added | +405.6k |
| MILLENNIUM MANAGEMENT LLC | Added | +404.9k |
| Soleus Capital Management, L.P. | New | +354.4k |
Biggest sellers
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | Reduced | -1.2m |
| Invesco Ltd. | Reduced | -1.0m |
| Artisan Partners Limited Partnership | Reduced | -790.3k |
| MARSHALL WACE, LLP | Sold out | -318.2k |
| VOYA INVESTMENT MANAGEMENT LLC | Reduced | -307.1k |
| Nuveen, LLC | Reduced | -303.1k |
| First Light Asset Management, LLC | Reduced | -273.7k |
| MPM BIOIMPACT LLC | Sold out | -261.2k |
| FRED ALGER MANAGEMENT, LLC | Reduced | -241.3k |
| Thrivent Financial for Lutherans | Reduced | -230.8k |
Biggest calls
| BNP PARIBAS FINANCIAL MARKETS | New | $1.1m306 shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $1.0m28.2k shares |
| CITADEL ADVISORS LLC | Reduced | $761.6k20.7k shares |
| JANE STREET GROUP, LLC | Added | $437.8k11.9k shares |
| SIMPLEX TRADING, LLC | Reduced | $73.0k2.0k shares |
| GROUP ONE TRADING LLC | Reduced | $36.8k1.0k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CITADEL ADVISORS LLC | Added | $1.0m27.8k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $945.5k25.7k shares |
| SIMPLEX TRADING, LLC | Reduced | $419.0k11.4k shares |
| GROUP ONE TRADING LLC | Reduced | $25.8k700 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +5.6 pts · filed 2026-09-08 | 13.2% |
| BlackRock, Inc. 13G · institution filed 2025-04-17 | 8.3% |
| Artisan Partners Limited Partnership 13G · institution -2.4 pts · filed 2026-08-13 | 7.7% |
| PRICE T ROWE ASSOCIATES INC /MD/ 13G · institution new · filed 2026-08-14 | 5.8% |
| ARK Investment Management LLC 13G · institution -2.2 pts · filed 2026-09-08 | 5.1% |
| STATE STREET CORP 13G · institution +0.8 pts · filed 2025-11-10 | 5.1% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.0% |
Fell to 5% or below in the last year: EdgePoint Investment Group Inc. (4.2%, 2026-08-14), WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC (3.5%, 2026-08-11), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 6 | $329.6k | — |
| Q2 2024 | 0 | — | 7 | $945.5k | — |
| Q3 2024 | 0 | — | 6 | $957.9k | — |
| Q4 2024 | 0 | — | 7 | $4.9m | $351.8k |
| Q1 2025 | 0 | — | 7 | $1.9m | $250.0k |
| Q2 2025 | 0 | — | 6 | $1.8m | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-06-20 | Leproust Emily M. Chief Executive Officer, director | Sold | $60.0k1.7k shares |
| 2025-06-20 | Green Paula SVP of Human Resources | Sold | $10.4k292 shares |
| 2025-06-20 | Cho Dennis Officer | Sold | $8.2k230 shares |
| 2025-06-16 | Cho Dennis Officer | Sold | $3.1k94 shares |
| 2025-06-06 | Leproust Emily M. Chief Executive Officer, director | Sold | $68.9k2.2k shares |
| 2025-06-06 | Green Paula SVP of Human Resources | Sold | $27.1k853 shares |
| 2025-06-06 | Cho Dennis Officer | Sold | $8.2k257 shares |
| 2025-06-06 | WERNER ROBERT F. Chief Accounting Officer | Sold | $7.1k225 shares |
| 2025-05-23 | WERNER ROBERT F. Chief Accounting Officer | Sold | $23.3k839 shares |
| 2025-05-21 | Leproust Emily M. Chief Executive Officer, director | Sold | $83.4k2.8k shares |
| 2025-05-21 | Finn Patrick John President and COO | Sold | $55.8k1.9k shares |
| 2025-05-21 | Laponis Adam Chief Financial Officer | Sold | $27.8k936 shares |
| 2025-05-21 | Green Paula SVP of Human Resources | Sold | $18.8k632 shares |
| 2025-05-21 | Cho Dennis Officer | Sold | $15.8k531 shares |
| 2025-05-21 | WERNER ROBERT F. Chief Accounting Officer | Sold | $7.2k242 shares |
| 2025-05-08 | Finn Patrick John President and COO | Sold | $646.2k20.0k shares |
| 2025-05-07 | Cho Dennis Officer | Sold | $163.6k5.0k shares |
| 2025-05-05 | Leproust Emily M. Chief Executive Officer, director | Sold | $189.8k5.0k shares |
| 2025-05-05 | Finn Patrick John President and COO | Sold | $105.4k2.8k shares |
| 2025-05-05 | Green Paula SVP of Human Resources | Sold | $41.5k1.1k shares |
| 2025-05-05 | Cho Dennis Officer | Sold | $25.9k689 shares |
| 2025-05-05 | WERNER ROBERT F. Chief Accounting Officer | Sold | $6.1k162 shares |
| 2025-04-23 | Finn Patrick John President and COO | Sold | $82.3k2.1k shares |
| 2025-04-09 | Laponis Adam Chief Financial Officer | Sold | $88.9k2.5k shares |
| 2025-04-02 | Leproust Emily M. Chief Executive Officer, director | Sold | $19.1k492 shares |
| 2025-04-02 | Finn Patrick John President and COO | Sold | $8.0k206 shares |
| 2025-04-02 | Green Paula SVP of Human Resources | Sold | $5.4k140 shares |
| 2025-04-02 | Cho Dennis Officer | Sold | $4.8k124 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| ARK Investment Management LLC 1.73% of their portfolio | 6.4m $235.5m | Added +158.8k |
| BlackRock, Inc. 0.00% of their portfolio | 6.3m $230.9m | Added +643.6k |
| VANGUARD GROUP INC 0.00% of their portfolio | 5.8m $214.5m | Reduced -36.1k |
| Artisan Partners Limited Partnership 0.28% of their portfolio | 5.1m $186.2m | Reduced -790.3k |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC 0.38% of their portfolio | 3.9m $143.7m | Added +99.7k |
| STATE STREET CORP 0.00% of their portfolio | 2.5m $92.0m | Reduced -192.7k |
| EdgePoint Investment Group Inc. 0.66% of their portfolio | 2.4m $87.8m | Added +1.3m |
| Invesco Ltd. 0.01% of their portfolio | 2.3m $86.4m | Reduced -1.0m |
| Sumitomo Mitsui Trust Group, Inc. 0.05% of their portfolio | 2.3m $84.6m | Reduced -116.4k |
| Amova Asset Management Americas, Inc. 0.84% of their portfolio | 2.3m $84.5m | Reduced -116.4k |
| Point72 Asset Management, L.P. 0.19% of their portfolio | 2.2m $79.4m | Added +725.5k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 1.5m $56.1m | Added +592.1k |
| CITADEL ADVISORS LLC 0.05% of their portfolio | 1.5m $55.3m | Added +432.3k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.4m $52.9m | Reduced -13.0k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.4m $52.4m | Added +4.4k |
| Thrivent Financial for Lutherans 0.10% of their portfolio | 1.3m $47.0m | Reduced -230.8k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio | 1.2m $44.9m | Reduced -1.2m |
| MORGAN STANLEY 0.00% of their portfolio | 1.2m $44.2m | Added +589.7k |
| First Light Asset Management, LLC 4.51% of their portfolio | 945.0k $34.8m | Reduced -273.7k |
| AMERICAN CENTURY COMPANIES INC 0.02% of their portfolio | 864.4k $31.8m | Added +101.0k |
| Tao Capital Management LP 22.36% of their portfolio | 828.8k $30.5m | Unchanged |
| BAILLIE GIFFORD & CO 0.02% of their portfolio | 775.7k $28.5m | Added +43.7k |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 728.6k $26.8m | Reduced -6.6k |
| MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio | 713.1k $26.2m | Added +404.9k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 688.3k $25.3m | Added +405.6k |
| Balyasny Asset Management L.P. 0.05% of their portfolio | 628.2k $23.1m | Added +567.5k |
| JENNISON ASSOCIATES LLC 0.01% of their portfolio | 618.2k $22.7m | Added +41.5k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 594.1k $21.9m | Added +81.7k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 577.1k $21.2m | Reduced -183.9k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 529.1k $19.5m | Reduced -87.8k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 528.1k $19.4m | Reduced -13.1k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.03% of their portfolio | 512.9k $18.9m | Added +60.2k |
| Nuveen, LLC 0.01% of their portfolio | 511.0k $18.8m | Reduced -303.1k |
| ExodusPoint Capital Management, LP 0.21% of their portfolio | 471.8k $17.4m | Added +43.1k |
| Iron Triangle Partners LP 2.47% of their portfolio | 424.4k $15.6m | Added +442 |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.05% of their portfolio | 362.2k $13.3m | Added +319.9k |
| VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio | 360.7k $13.3m | Reduced -4.7k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 354.6k $13.0m | Added +314.2k |
| Soleus Capital Management, L.P. 0.90% of their portfolio | 354.4k $13.0m | New |
| Qube Research & Technologies Ltd 0.02% of their portfolio | 331.2k $12.2m | Added +91.8k |
| SEI INVESTMENTS CO 0.01% of their portfolio | 283.2k $10.4m | Reduced -31.9k |
| SILVERCREST ASSET MANAGEMENT GROUP LLC 0.07% of their portfolio | 274.7k $10.1m | Added +78.2k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 253.4k $9.3m | Reduced -65.4k |
| HAWK RIDGE CAPITAL MANAGEMENT LP 0.36% of their portfolio | 234.3k $8.6m | Added +75.6k |
| Trexquant Investment LP 0.10% of their portfolio | 233.3k $8.6m | Added +83.7k |
| FMR LLC 0.00% of their portfolio | 217.1k $8.0m | Added +940 |
| UBS Group AG 0.00% of their portfolio | 216.6k $8.0m | Reduced -58.4k |
| PEREGRINE CAPITAL MANAGEMENT LLC 0.24% of their portfolio | 216.6k $8.0m | New |
| BARCLAYS PLC 0.00% of their portfolio | 210.6k $7.7m | Added +96.2k |
| Vestmark Advisory Solutions, Inc. 0.10% of their portfolio | 197.6k $7.3m | Added +106.5k |
| Ensign Peak Advisors, Inc 0.01% of their portfolio | 165.3k $6.1m | Reduced -35.6k |
| Aberdeen Group plc 0.01% of their portfolio | 161.4k $5.9m | New |
| STATE OF MICHIGAN RETIREMENT SYSTEM 0.03% of their portfolio | 153.2k $5.6m | Unchanged |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio | 152.4k $5.6m | New |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 148.5k $5.5m | Reduced -117.1k |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd 0.46% of their portfolio | 139.6k $5.1m | Added +91.5k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 130.9k $4.8m | Added +1.8k |
| CITIGROUP INC 0.00% of their portfolio | 123.7k $4.6m | Reduced -82.8k |
| Russell Investments Group, Ltd. 0.01% of their portfolio | 121.9k $4.5m | Added +13.1k |
| NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio | 120.4k $4.4m | Added +111.6k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 116.0k $4.3m | Reduced -24.7k |
| Swiss National Bank 0.00% of their portfolio | 113.9k $4.2m | Reduced -1.3k |
| Legal & General Group Plc 0.00% of their portfolio | 110.3k $4.1m | Added +19.9k |
| Pictet Asset Management Holding SA 0.00% of their portfolio | 109.8k $4.0m | Reduced -6.7k |
| ODDO BHF ASSET MANAGEMENT SAS 0.15% of their portfolio | 107.2k $3.9m | Reduced -286 |
| Man Group plc 0.01% of their portfolio | 106.5k $3.9m | Added +5.3k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 99.4k $3.7m | Added +3.4k |
| FRED ALGER MANAGEMENT, LLC 0.02% of their portfolio | 97.0k $3.6m | Reduced -241.3k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 95.3k $3.5m | Reduced -61.2k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.01% of their portfolio | 79.0k $2.9m | Added +8.7k |
| Hillsdale Investment Management Inc. 0.11% of their portfolio | 77.6k $2.9m | Reduced -3.2k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 77.5k $2.9m | Reduced -6.4k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 75.7k $2.8m | Reduced -23.6k |
| Squarepoint Ops LLC 0.01% of their portfolio | 71.7k $2.6m | Added +47.2k |
| CAPITAL FUND MANAGEMENT S.A. 0.03% of their portfolio | 68.2k $2.5m | New |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 66.8k $2.5m | Reduced -68.0k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 66.5k $2.4m | Unchanged |
| Aquatic Capital Management LLC 0.05% of their portfolio | 62.3k $2.3m | New |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 62.0k $2.3m | Reduced -50.1k |
| MACQUARIE GROUP LTD 0.00% of their portfolio | 60.8k $2.2m | Added +16.6k |
| BLAIR WILLIAM & CO/IL 0.01% of their portfolio | 59.7k $2.2m | Reduced -2.2k |
| LAZARD ASSET MANAGEMENT LLC 0.00% of their portfolio | 58.3k $2.1m | Reduced -837 |
| FIRST TRUST ADVISORS LP 0.00% of their portfolio | 56.7k $2.1m | Added +2.0k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 54.2k $2.0m | Added +442 |
| Graham Capital Management, L.P. 0.06% of their portfolio | 53.9k $2.0m | Added +30.4k |
| JUPITER ASSET MANAGEMENT LTD 0.02% of their portfolio | 53.0k $2.0m | New |
| ALGERT GLOBAL LLC 0.04% of their portfolio | 51.8k $1.9m | Added +27.2k |
| IEQ CAPITAL, LLC 0.01% of their portfolio | 51.2k $1.9m | Reduced -35.6k |
| Clarius Group, LLC 0.11% of their portfolio | 49.6k $1.8m | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 49.3k $1.8m | Added +3.5k |
| CANADA PENSION PLAN INVESTMENT BOARD 0.00% of their portfolio | 48.9k $1.8m | Unchanged |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 45.5k $1.7m | Reduced -110 |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 45.4k $1.7m | Reduced -52.5k |
| Mitsubishi UFJ Asset Management Co., Ltd. 0.00% of their portfolio | 41.6k $1.5m | Reduced -6.7k |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 41.6k $1.5m | Reduced -28.7k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 41.0k $1.5m | Added +3.9k |
| HighMark Wealth Management LLC 0.69% of their portfolio | 38.5k $1.4m | Added +38.2k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 37.0k $1.4m | Reduced -566 |
| XTX Topco Ltd 0.05% of their portfolio | 35.3k $1.3m | Added +20.2k |
| MetLife Investment Management, LLC 0.01% of their portfolio | 34.7k $1.3m | Unchanged |