TWIST BIOSCIENCE CORP TWST
COM · Common Stock · CUSIP 90184D100 · ISIN US90184D1000
Biotechnology company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSouth San Francisco, CA
- Founded2013
- Websitetwistbioscience.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($127.8m this quarter). Holder counts are more reliable. Shares outstanding: 59.7m as of 2025-01-30, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $46.47. Options: 9 managers hold calls ($6.0m notional), 7 hold puts ($2.0m).
Trends to Q4 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 222 |
| Q4 2022 | 199 |
| Q1 2023 | 202 |
| Q2 2023 | 194 |
| Q3 2023 | 197 |
| Q4 2023 | 220 |
| Q1 2024 | 240 |
| Q2 2024 | 265 |
| Q3 2024 | 247 |
| Q4 2024 | 248 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2023 | 112 | 77 |
| Q2 2023 | 103 | 84 |
| Q3 2023 | 83 | 92 |
| Q4 2023 | 95 | 94 |
| Q1 2024 | 121 | 99 |
| Q2 2024 | 147 | 112 |
| Q3 2024 | 120 | 128 |
| Q4 2024 | 111 | 112 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2024 | $8.7m | $8.0m | 0.92 |
| Q2 2024 | $12.4m | $7.2m | 0.58 |
| Q3 2024 | $5.9m | $2.0m | 0.34 |
| Q4 2024 | $6.0m | $2.0m | 0.34 |
Biggest buyers
| First Light Asset Management, LLC | New | +1.2m |
| MARSHALL WACE, LLP | Added | +840.8k |
| Thrivent Financial for Lutherans | Added | +532.0k |
| JENNISON ASSOCIATES LLC | Added | +302.9k |
| AMERICAN CENTURY COMPANIES INC | Added | +293.8k |
| HAWK RIDGE CAPITAL MANAGEMENT LP | New | +287.5k |
| ARK Investment Management LLC | Added | +237.8k |
| VANGUARD GROUP INC | Added | +189.8k |
| RENAISSANCE TECHNOLOGIES LLC | Added | +184.4k |
| MILLENNIUM MANAGEMENT LLC | Added | +178.2k |
Biggest sellers
| JPMORGAN CHASE & CO | Reduced | -3.2m |
| STATE STREET CORP | Reduced | -623.4k |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | Reduced | -527.6k |
| BANK OF AMERICA CORP /DE/ | Reduced | -451.3k |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | Reduced | -333.0k |
| Sumitomo Mitsui Trust Group, Inc. | Reduced | -248.7k |
| Amova Asset Management Americas, Inc. | Reduced | -247.9k |
| Squarepoint Ops LLC | Reduced | -245.7k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | Reduced | -173.0k |
| Artisan Partners Limited Partnership | Reduced | -125.2k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $2.5m53.1k shares |
| CITADEL ADVISORS LLC | Added | $1.4m29.8k shares |
| MILLENNIUM MANAGEMENT LLC | New | $929.4k20.0k shares |
| GROUP ONE TRADING LLC | Added | $264.9k5.7k shares |
| JANE STREET GROUP, LLC | Reduced | $250.9k5.4k shares |
| SIMPLEX TRADING, LLC | Added | $246.0k5.3k shares |
| Walleye Trading LLC | New | $227.7k4.9k shares |
| Walleye Capital LLC | New | $213.8k4.6k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $1.1m23.9k shares |
| CITADEL ADVISORS LLC | Added | $422.9k9.1k shares |
| SIMPLEX TRADING, LLC | Added | $315.0k6.8k shares |
| Walleye Trading LLC | New | $79.0k1.7k shares |
| GROUP ONE TRADING LLC | New | $46.5k1.0k shares |
| Walleye Capital LLC | New | $46.5k1.0k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +5.6 pts · filed 2026-09-08 | 13.2% |
| BlackRock, Inc. 13G · institution filed 2025-04-17 | 8.3% |
| Artisan Partners Limited Partnership 13G · institution -2.4 pts · filed 2026-08-13 | 7.7% |
| PRICE T ROWE ASSOCIATES INC /MD/ 13G · institution new · filed 2026-08-14 | 5.8% |
| ARK Investment Management LLC 13G · institution -2.2 pts · filed 2026-09-08 | 5.1% |
| STATE STREET CORP 13G · institution +0.8 pts · filed 2025-11-10 | 5.1% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.0% |
Fell to 5% or below in the last year: EdgePoint Investment Group Inc. (4.2%, 2026-08-14), WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC (3.5%, 2026-08-11), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q4 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2023 | 0 | — | 3 | $52.9k | — |
| Q2 2023 | 1 | $132.0k | 0 | — | — |
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 6 | $329.6k | — |
| Q2 2024 | 0 | — | 7 | $945.5k | — |
| Q3 2024 | 0 | — | 6 | $957.9k | — |
| Q4 2024 | 0 | — | 7 | $4.9m | $351.8k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-12-20 | Leproust Emily M. Chief Executive Officer, director | Sold | $74.3k1.7k shares |
| 2024-12-20 | Cho Dennis Officer | Sold | $14.2k316 shares |
| 2024-12-20 | Green Paula SVP of Human Resources | Sold | $12.7k282 shares |
| 2024-12-16 | Cho Dennis Officer | Sold | $6.2k133 shares |
| 2024-12-06 | Leproust Emily M. Chief Executive Officer, director | Sold | $116.8k2.2k shares |
| 2024-12-06 | Green Paula SVP of Human Resources | Sold | $45.3k860 shares |
| 2024-12-06 | Cho Dennis Officer | Sold | $19.3k367 shares |
| 2024-12-06 | WERNER ROBERT F. Chief Accounting Officer | Sold | $11.9k226 shares |
| 2024-12-05 | CHESS ROBERT Director | Sold plan | $181.7k3.5k shares |
| 2024-11-25 | WERNER ROBERT F. Chief Accounting Officer | Sold | $34.9k789 shares |
| 2024-11-11 | Finn Patrick John President and COO | Sold | $496.3k10.3k shares |
| 2024-11-11 | Leproust Emily M. Chief Executive Officer, director | Sold | $382.5k8.0k shares |
| 2024-11-11 | CHESS ROBERT Director | Sold plan | $170.1k3.6k shares |
| 2024-11-11 | Cho Dennis Officer | Sold | $72.3k1.5k shares |
| 2024-11-11 | Green Paula SVP of Human Resources | Sold | $64.7k1.3k shares |
| 2024-11-06 | Leproust Emily M. Chief Executive Officer, director | Sold | $639.4k14.3k shares |
| 2024-11-06 | Finn Patrick John President and COO | Sold | $278.3k6.2k shares |
| 2024-11-06 | Green Paula SVP of Human Resources | Sold | $246.2k5.5k shares |
| 2024-11-06 | Laponis Adam Chief Financial Officer | Sold | $185.6k4.2k shares |
| 2024-11-06 | Cho Dennis Officer | Sold | $80.8k1.8k shares |
| 2024-11-06 | WERNER ROBERT F. Chief Accounting Officer | Sold | $64.6k1.4k shares |
| 2024-11-04 | Leproust Emily M. Chief Executive Officer, director | Sold | $201.2k4.8k shares |
| 2024-11-04 | Finn Patrick John President and COO | Sold | $111.4k2.7k shares |
| 2024-11-04 | Green Paula SVP of Human Resources | Sold | $43.9k1.1k shares |
| 2024-11-04 | Cho Dennis Officer | Sold | $27.4k659 shares |
| 2024-11-04 | WERNER ROBERT F. Chief Accounting Officer | Sold | $6.5k156 shares |
| 2024-10-23 | Finn Patrick John President and COO | Sold | $97.4k2.3k shares |
| 2024-10-09 | Laponis Adam Chief Financial Officer | Sold | $35.8k856 shares |
| 2024-10-02 | Leproust Emily M. Chief Executive Officer, director | Sold | $587.9k13.6k shares |
| 2024-10-02 | Finn Patrick John President and COO | Sold | $296.6k6.9k shares |
The latest 30 of 32 trades.
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2024
| Manager | Shares | Change |
|---|---|---|
| Artisan Partners Limited Partnership 0.42% of their portfolio | 5.9m $273.9m | Reduced -125.2k |
| VANGUARD GROUP INC 0.00% of their portfolio | 5.8m $269.9m | Added +189.8k |
| ARK Investment Management LLC 2.17% of their portfolio | 5.6m $260.0m | Added +237.8k |
| BlackRock, Inc. 0.01% of their portfolio | 5.6m $259.3m | Added +101.8k |
| Invesco Ltd. 0.03% of their portfolio | 3.6m $166.6m | Reduced -58.0k |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC 0.33% of their portfolio | 2.9m $137.1m | Reduced -527.6k |
| Sumitomo Mitsui Trust Group, Inc. 0.08% of their portfolio | 2.6m $121.4m | Reduced -248.7k |
| Amova Asset Management Americas, Inc. 1.32% of their portfolio | 2.6m $121.4m | Reduced -247.9k |
| STATE STREET CORP 0.00% of their portfolio | 2.5m $118.2m | Reduced -623.4k |
| JPMORGAN CHASE & CO 0.01% of their portfolio | 1.8m $83.6m | Reduced -3.2m |
| Thrivent Financial for Lutherans 0.14% of their portfolio | 1.5m $70.0m | Added +532.0k |
| CITADEL ADVISORS LLC 0.06% of their portfolio | 1.4m $65.2m | Reduced -80.3k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.4m $63.9m | Added +6.9k |
| First Light Asset Management, LLC 5.45% of their portfolio | 1.2m $57.0m | New |
| MORGAN STANLEY 0.00% of their portfolio | 899.2k $41.8m | Reduced -92.0k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 895.4k $41.6m | Reduced -26.0k |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 879.0k $40.8m | Reduced -83.2k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio | 853.7k $39.7m | Reduced -26.5k |
| MARSHALL WACE, LLP 0.05% of their portfolio | 846.1k $39.3m | Added +840.8k |
| Tao Capital Management LP 26.88% of their portfolio | 828.8k $38.5m | Unchanged |
| WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio | 786.3k $36.5m | Reduced -11.4k |
| BAILLIE GIFFORD & CO 0.03% of their portfolio | 777.5k $36.1m | Reduced -56.8k |
| FRED ALGER MANAGEMENT, LLC 0.17% of their portfolio | 761.2k $35.4m | Reduced -5.9k |
| AMERICAN CENTURY COMPANIES INC 0.02% of their portfolio | 756.4k $35.1m | Added +293.8k |
| JENNISON ASSOCIATES LLC 0.02% of their portfolio | 680.8k $31.6m | Added +302.9k |
| MILLENNIUM MANAGEMENT LLC 0.03% of their portfolio | 634.2k $29.5m | Added +178.2k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 627.6k $29.2m | Added +51.9k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 579.6k $26.9m | Reduced -35.4k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 542.8k $25.2m | Added +17.9k |
| Iron Triangle Partners LP 2.67% of their portfolio | 492.5k $22.9m | Reduced -17.5k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.03% of their portfolio | 442.0k $20.5m | Reduced -40.6k |
| RENAISSANCE TECHNOLOGIES LLC 0.03% of their portfolio | 398.7k $18.5m | Added +184.4k |
| PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio | 374.6k $17.4m | Added +168.7k |
| VICTORY CAPITAL MANAGEMENT INC 0.02% of their portfolio | 372.3k $17.3m | Added +40.5k |
| TWO SIGMA INVESTMENTS, LP 0.04% of their portfolio | 347.5k $16.1m | Reduced -72.1k |
| Ensign Peak Advisors, Inc 0.03% of their portfolio | 329.0k $15.3m | Reduced -1.9k |
| SEI INVESTMENTS CO 0.02% of their portfolio | 296.4k $13.8m | Reduced -13.3k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 292.6k $13.6m | Added +89.2k |
| HAWK RIDGE CAPITAL MANAGEMENT LP 0.64% of their portfolio | 287.5k $13.4m | New |
| MPM BIOIMPACT LLC 1.76% of their portfolio | 267.5k $12.4m | Reduced -27.4k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 233.6k $10.9m | Reduced -18.5k |
| UBS Group AG 0.00% of their portfolio | 227.6k $10.6m | Added +77.3k |
| FMR LLC 0.00% of their portfolio | 226.2k $10.5m | Added +7.6k |
| Qube Research & Technologies Ltd 0.02% of their portfolio | 219.9k $10.2m | Added +29.1k |
| TWO SIGMA ADVISERS, LP 0.02% of their portfolio | 215.6k $10.0m | Reduced -64.9k |
| MACQUARIE GROUP LTD 0.01% of their portfolio | 202.5k $9.4m | Added +101.2k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 184.5k $8.6m | Reduced -451.3k |
| SILVERCREST ASSET MANAGEMENT GROUP LLC 0.05% of their portfolio | 172.3k $8.0m | Reduced -1.6k |
| Trexquant Investment LP 0.09% of their portfolio | 168.2k $7.8m | Added +11.7k |
| NORGES BANK 0.00% of their portfolio | 163.2k $7.6m | Reduced -20.5k |
| AQR CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 160.8k $7.5m | Reduced -26.8k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 159.8k $7.4m | Added +12.9k |
| VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 158.0k $7.3m | Reduced -7.1k |
| STATE OF MICHIGAN RETIREMENT SYSTEM 0.04% of their portfolio | 153.2k $7.1m | Unchanged |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio | 140.0k $6.5m | Reduced -173.0k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 139.1k $6.5m | Reduced -19.1k |
| BARCLAYS PLC 0.00% of their portfolio | 126.4k $5.9m | Reduced -26.7k |
| Swiss National Bank 0.00% of their portfolio | 115.2k $5.4m | Added +1.2k |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 107.3k $5.0m | Added +98.2k |
| Vestmark Advisory Solutions, Inc. 0.15% of their portfolio | 102.9k $4.5m | Added +40.2k |
| Man Group plc 0.01% of their portfolio | 102.0k $4.7m | Reduced -27.6k |
| PRUDENTIAL FINANCIAL INC 0.01% of their portfolio | 99.1k $4.6m | Reduced -22.0k |
| Rafferty Asset Management, LLC 0.02% of their portfolio | 93.3k $4.3m | Reduced -45.8k |
| CITIGROUP INC 0.00% of their portfolio | 92.1k $4.3m | Added +41.7k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 91.4k $4.2m | Added +2.3k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 90.5k $4.2m | Added +52.5k |
| Legal & General Group Plc 0.00% of their portfolio | 87.2k $4.1m | Reduced -3.9k |
| FIRST TRUST ADVISORS LP 0.00% of their portfolio | 83.4k $3.9m | Reduced -93.1k |
| Hillsdale Investment Management Inc. 0.18% of their portfolio | 78.0k $3.6m | Added +300 |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 73.2k $3.4m | Added +17.9k |
| BLAIR WILLIAM & CO/IL 0.01% of their portfolio | 67.9k $3.2m | Reduced -19.4k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.01% of their portfolio | 67.1k $3.1m | Reduced -2.6k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 66.5k $3.1m | Added +820 |
| IEQ CAPITAL, LLC 0.03% of their portfolio | 62.0k $2.9m | Added +10.8k |
| Aquatic Capital Management LLC 0.08% of their portfolio | 61.1k $2.8m | Added +7.1k |
| Schonfeld Strategic Advisors LLC 0.02% of their portfolio | 57.6k $2.7m | New |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 55.2k $2.6m | Added +19.3k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 54.8k $2.5m | Reduced -259 |
| ODDO BHF ASSET MANAGEMENT SAS 0.12% of their portfolio | 52.8k $2.5m | Reduced -20.3k |
| State of New Jersey Common Pension Fund D 0.01% of their portfolio | 50.8k $2.4m | Added +5.7k |
| LPL Financial LLC 0.00% of their portfolio | 49.9k $2.3m | Reduced -6.5k |
| Clarius Group, LLC 0.16% of their portfolio | 49.6k $2.3m | Unchanged |
| CANADA PENSION PLAN INVESTMENT BOARD 0.00% of their portfolio | 48.9k $2.3m | New |
| Mitsubishi UFJ Asset Management Co., Ltd. 0.00% of their portfolio | 48.2k $2.3m | Reduced -3.5k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 47.9k $2.2m | First filing |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 42.4k $2.0m | Added +9.6k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 41.4k $1.9m | Added +5.6k |
| ExodusPoint Capital Management, LP 0.02% of their portfolio | 39.3k $1.8m | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 37.9k $1.8m | Added +9.7k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 36.8k $1.7m | Reduced -1.1k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 36.1k $1.7m | Added +10.0k |
| XTX Topco Ltd 0.14% of their portfolio | 35.4k $1.6m | Added +19.9k |
| MetLife Investment Management, LLC 0.01% of their portfolio | 35.2k $1.6m | Added +2.0k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 29.9k $1.4m | Reduced -57 |
| ALGERT GLOBAL LLC 0.03% of their portfolio | 29.5k $1.4m | Reduced -14.1k |
| Corebridge Financial, Inc. 0.01% of their portfolio | 29.0k $1.3m | Reduced -1.8k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.00% of their portfolio | 28.5k $1.3m | Reduced -849 |
| LAZARD ASSET MANAGEMENT LLC 0.00% of their portfolio | 27.9k $1.3m | Added +7.8k |
| Squarepoint Ops LLC 0.00% of their portfolio | 27.8k $1.3m | Reduced -245.7k |
| Comprehensive Financial Management LLC 0.03% of their portfolio | 26.3k $1.2m | Unchanged |