TWIST BIOSCIENCE CORP TWST
COM · Common Stock · CUSIP 90184D100 · ISIN US90184D1000
Biotechnology company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSouth San Francisco, CA
- Founded2013
- Websitetwistbioscience.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($184.4m this quarter). Holder counts are more reliable. Shares outstanding: 58.6m as of 2024-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $49.27. Options: 9 managers hold calls ($12.4m notional), 6 hold puts ($7.2m).
Trends to Q2 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 222 |
| Q4 2022 | 199 |
| Q1 2023 | 202 |
| Q2 2023 | 194 |
| Q3 2023 | 197 |
| Q4 2023 | 220 |
| Q1 2024 | 240 |
| Q2 2024 | 265 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 103 | 96 |
| Q1 2023 | 112 | 77 |
| Q2 2023 | 103 | 84 |
| Q3 2023 | 83 | 92 |
| Q4 2023 | 95 | 94 |
| Q1 2024 | 121 | 99 |
| Q2 2024 | 147 | 112 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2023 | $2.9m | $5.3m | 1.84 |
| Q4 2023 | $11.8m | $15.0m | 1.27 |
| Q1 2024 | $8.7m | $8.0m | 0.92 |
| Q2 2024 | $12.4m | $7.2m | 0.58 |
Biggest buyers
| Artisan Partners Limited Partnership | Added | +1.4m |
| Invesco Ltd. | Added | +965.7k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | Added | +869.4k |
| Point72 Asset Management, L.P. | New | +673.1k |
| FRED ALGER MANAGEMENT, LLC | Added | +575.1k |
| Iron Triangle Partners LP | New | +526.5k |
| GOLDMAN SACHS GROUP INC | Added | +366.1k |
| TWO SIGMA INVESTMENTS, LP | Added | +315.1k |
| VICTORY CAPITAL MANAGEMENT INC | Added | +300.9k |
| TWO SIGMA ADVISERS, LP | Added | +252.7k |
Biggest sellers
| MORGAN STANLEY | Reduced | -1.9m |
| MILLENNIUM MANAGEMENT LLC | Reduced | -1.4m |
| JPMORGAN CHASE & CO | Reduced | -1.4m |
| ARK Investment Management LLC | Reduced | -814.6k |
| STATE STREET CORP | Reduced | -798.0k |
| Bank of New York Mellon Corp | Reduced | -466.4k |
| Amova Asset Management Americas, Inc. | Reduced | -387.9k |
| Sumitomo Mitsui Trust Group, Inc. | Reduced | -387.9k |
| BlackRock Inc. | Reduced | -351.2k |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | Reduced | -324.8k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $5.9m120.4k shares |
| Affinity Asset Advisors, LLC | New | $2.2m45.0k shares |
| CITADEL ADVISORS LLC | Reduced | $2.1m41.6k shares |
| JANE STREET GROUP, LLC | New | $1.0m21.0k shares |
| GROUP ONE TRADING LLC | Added | $527.3k10.7k shares |
| JPMORGAN CHASE & CO | New | $414.0k8.4k shares |
| SIMPLEX TRADING, LLC | Reduced | $128.0k2.6k shares |
| Walleye Capital LLC | New | $113.3k2.3k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $4.6m93.5k shares |
| SIMPLEX TRADING, LLC | Added | $1.0m20.8k shares |
| JANE STREET GROUP, LLC | Added | $995.5k20.2k shares |
| CITADEL ADVISORS LLC | Reduced | $556.9k11.3k shares |
| Walleye Capital LLC | New | $64.1k1.3k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +5.6 pts · filed 2026-09-08 | 13.2% |
| BlackRock, Inc. 13G · institution filed 2025-04-17 | 8.3% |
| Artisan Partners Limited Partnership 13G · institution -2.4 pts · filed 2026-08-13 | 7.7% |
| PRICE T ROWE ASSOCIATES INC /MD/ 13G · institution new · filed 2026-08-14 | 5.8% |
| ARK Investment Management LLC 13G · institution -2.2 pts · filed 2026-09-08 | 5.1% |
| STATE STREET CORP 13G · institution +0.8 pts · filed 2025-11-10 | 5.1% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.0% |
Fell to 5% or below in the last year: EdgePoint Investment Group Inc. (4.2%, 2026-08-14), WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC (3.5%, 2026-08-11), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q2 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2022 | 0 | — | 3 | $1.1m | — |
| Q4 2022 | 0 | — | 1 | $54.4k | — |
| Q1 2023 | 0 | — | 3 | $52.9k | — |
| Q2 2023 | 1 | $132.0k | 0 | — | — |
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 6 | $329.6k | — |
| Q2 2024 | 0 | — | 7 | $945.5k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-06-20 | Leproust Emily M. Chief Executive Officer, director | Sold | $85.6k1.7k shares |
| 2024-06-20 | Green Paula SVP of Human Resources | Sold | $14.7k297 shares |
| 2024-06-20 | Cho Dennis Officer | Sold | $11.6k234 shares |
| 2024-06-14 | Cho Dennis Officer | Sold | $4.8k95 shares |
| 2024-06-06 | Leproust Emily M. Chief Executive Officer, director | Sold | $123.6k2.4k shares |
| 2024-06-06 | Green Paula SVP of Human Resources | Sold | $47.1k918 shares |
| 2024-06-06 | Cho Dennis Officer | Sold | $14.2k276 shares |
| 2024-06-06 | WERNER ROBERT F. Chief Accounting Officer | Sold | $12.4k242 shares |
| 2024-05-23 | WERNER ROBERT F. Chief Accounting Officer | Sold | $142.2k3.4k shares |
| 2024-05-03 | Leproust Emily M. Chief Executive Officer, director | Sold | $154.6k4.2k shares |
| 2024-05-03 | Finn Patrick John President and COO | Sold | $85.8k2.3k shares |
| 2024-05-03 | Green Paula SVP of Human Resources | Sold | $33.8k910 shares |
| 2024-05-03 | Banyai William Officer | Sold | $29.6k798 shares |
| 2024-05-03 | Cho Dennis Officer | Sold | $21.1k568 shares |
| 2024-05-03 | WERNER ROBERT F. Chief Accounting Officer | Sold | $4.9k132 shares |
| 2024-04-23 | Finn Patrick John President and COO | Sold | $65.5k2.2k shares |
| 2024-04-09 | Laponis Adam Chief Financial Officer | Sold | $18.4k556 shares |
| 2024-04-02 | Leproust Emily M. Chief Executive Officer, director | Sold | $37.1k1.1k shares |
| 2024-04-02 | Finn Patrick John President and COO | Sold | $16.1k492 shares |
| 2024-04-02 | Banyai William Officer | Sold | $10.7k327 shares |
| 2024-04-02 | Green Paula SVP of Human Resources | Sold | $7.5k229 shares |
| 2024-04-02 | Cho Dennis Officer | Sold | $4.2k129 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2024
| Manager | Shares | Change |
|---|---|---|
| ARK Investment Management LLC 2.68% of their portfolio | 6.1m $302.1m | Reduced -814.6k |
| Artisan Partners Limited Partnership 0.45% of their portfolio | 6.1m $299.1m | Added +1.4m |
| JPMORGAN CHASE & CO 0.01% of their portfolio | 5.9m $288.4m | Reduced -1.4m |
| VANGUARD GROUP INC 0.01% of their portfolio | 5.6m $275.6m | Added +130.1k |
| BlackRock Inc. 0.01% of their portfolio | 5.4m $267.3m | Reduced -351.2k |
| Invesco Ltd. 0.04% of their portfolio | 3.4m $168.6m | Added +965.7k |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC 0.41% of their portfolio | 3.2m $156.9m | Reduced -324.8k |
| Sumitomo Mitsui Trust Group, Inc. 0.12% of their portfolio | 3.2m $155.9m | Reduced -387.9k |
| Amova Asset Management Americas, Inc. 1.80% of their portfolio | 3.2m $155.9m | Reduced -387.9k |
| STATE STREET CORP 0.01% of their portfolio | 2.6m $130.2m | Reduced -798.0k |
| CITADEL ADVISORS LLC 0.07% of their portfolio | 1.4m $70.4m | Reduced -284.6k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 1.3m $66.1m | Added +8.8k |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 1.0m $49.8m | Reduced -245.2k |
| BAILLIE GIFFORD & CO 0.04% of their portfolio | 984.3k $48.5m | Reduced -243.2k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio | 961.2k $47.4m | Added +869.4k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 845.0k $41.6m | Added +366.1k |
| Tao Capital Management LP 33.48% of their portfolio | 828.8k $40.8m | Unchanged |
| MORGAN STANLEY 0.00% of their portfolio | 815.0k $40.2m | Reduced -1.9m |
| MILLENNIUM MANAGEMENT LLC 0.03% of their portfolio | 782.4k $38.6m | Reduced -1.4m |
| LORD, ABBETT & CO. LLC 0.06% of their portfolio | 708.5k $34.9m | Added +105.5k |
| Bank of New York Mellon Corp 0.01% of their portfolio | 689.0k $34.0m | Reduced -466.4k |
| Point72 Asset Management, L.P. 0.11% of their portfolio | 673.1k $33.2m | New |
| FRED ALGER MANAGEMENT, LLC 0.16% of their portfolio | 654.9k $32.3m | Added +575.1k |
| TWO SIGMA INVESTMENTS, LP 0.07% of their portfolio | 579.2k $28.5m | Added +315.1k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 558.7k $27.5m | Reduced -14.6k |
| Iron Triangle Partners LP 2.72% of their portfolio | 526.5k $25.9m | New |
| AMERICAN CENTURY COMPANIES INC 0.02% of their portfolio | 506.4k $25.0m | Reduced -275.7k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 500.4k $24.7m | Added +42.4k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.03% of their portfolio | 474.1k $23.4m | Added +95.3k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.07% of their portfolio | 409.5k $20.2m | Reduced -302.2k |
| Driehaus Capital Management LLC 0.19% of their portfolio | 388.6k $19.2m | Added +150.3k |
| TWO SIGMA ADVISERS, LP 0.04% of their portfolio | 340.0k $16.8m | Added +252.7k |
| Ensign Peak Advisors, Inc 0.03% of their portfolio | 331.4k $16.3m | Added +141.6k |
| SEI INVESTMENTS CO 0.02% of their portfolio | 314.7k $15.5m | Added +91.1k |
| VICTORY CAPITAL MANAGEMENT INC 0.02% of their portfolio | 308.2k $15.2m | Added +300.9k |
| JENNISON ASSOCIATES LLC 0.01% of their portfolio | 291.5k $14.4m | Added +141.5k |
| Cubist Systematic Strategies, LLC 0.24% of their portfolio | 282.8k $13.9m | Added +34.7k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 276.5k $13.6m | Added +248.4k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 243.8k $12.0m | Reduced -17.6k |
| NORGES BANK 0.00% of their portfolio | 239.5k $11.8m | Reduced -29.1k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 207.7k $10.2m | Added +15.6k |
| FMR LLC 0.00% of their portfolio | 206.2k $10.2m | Added +22.0k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 203.8k $10.0m | Added +28.4k |
| INTRINSIC EDGE CAPITAL MANAGEMENT LLC 0.94% of their portfolio | 197.2k $9.7m | Added +97.2k |
| Man Group plc 0.03% of their portfolio | 193.1k $9.5m | Reduced -35.4k |
| PRUDENTIAL FINANCIAL INC 0.01% of their portfolio | 192.8k $9.5m | Reduced -87.2k |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 0.06% of their portfolio | 192.0k $9.5m | Not comparable |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 172.7k $8.5m | Added +14.1k |
| Trexquant Investment LP 0.12% of their portfolio | 160.9k $7.9m | Added +77.7k |
| VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 160.2k $7.9m | Added +141.3k |
| CASTLEARK MANAGEMENT LLC 0.32% of their portfolio | 157.4k $7.8m | Added +10.8k |
| UBS Group AG 0.00% of their portfolio | 155.5k $7.7m | Reduced -53.4k |
| STATE OF MICHIGAN RETIREMENT SYSTEM 0.04% of their portfolio | 153.2k $7.5m | Unchanged |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 138.5k $6.8m | Reduced -25.3k |
| SILVERCREST ASSET MANAGEMENT GROUP LLC 0.05% of their portfolio | 138.2k $6.8m | Added +4.0k |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 133.4k $6.6m | Added +90.3k |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 122.9k $6.1m | Added +83.3k |
| Swiss National Bank 0.00% of their portfolio | 114.0k $5.6m | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 110.7k $5.5m | Added +92.0k |
| Rafferty Asset Management, LLC 0.02% of their portfolio | 103.1k $5.1m | Reduced -141.0k |
| FIRST TRUST ADVISORS LP 0.00% of their portfolio | 96.0k $4.7m | Reduced -30.8k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 92.9k $4.6m | Reduced -8.1k |
| Allspring Global Investments Holdings, LLC 0.01% of their portfolio | 84.2k $4.1m | New |
| Legal & General Group Plc 0.00% of their portfolio | 83.3k $4.1m | Reduced -2.1k |
| Global IMC LLC 0.92% of their portfolio | 83.3k $4.1m | New |
| Vestmark Advisory Solutions, Inc. 0.17% of their portfolio | 80.8k $4.0m | Reduced -33.6k |
| Gotham Asset Management, LLC 0.05% of their portfolio | 79.1k $3.9m | Added +18.2k |
| Hillsdale Investment Management Inc. 0.30% of their portfolio | 77.6k $3.8m | New |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.01% of their portfolio | 75.4k $3.7m | First filing |
| Balyasny Asset Management L.P. 0.01% of their portfolio | 73.8k $3.6m | Added +19.1k |
| Raymond James Financial Services Advisors, Inc. 0.00% of their portfolio | 68.3k $3.4m | New |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 65.7k $3.2m | Reduced -550 |
| Informed Momentum Co LLC 0.52% of their portfolio | 64.8k $3.2m | New |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 61.4k $3.0m | Added +28.0k |
| QRG CAPITAL MANAGEMENT, INC. 0.03% of their portfolio | 59.4k $2.9m | Added +5.0k |
| MACQUARIE GROUP LTD 0.00% of their portfolio | 58.0k $2.9m | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 56.4k $2.8m | Reduced -1.3k |
| Mitsubishi UFJ Asset Management Co., Ltd. 0.00% of their portfolio | 54.3k $2.7m | Added +44.8k |
| Clarius Group, LLC 0.17% of their portfolio | 49.6k $2.4m | Unchanged |
| BARCLAYS PLC 0.00% of their portfolio | 48.6k $2.4m | Reduced -84.1k |
| State of New Jersey Common Pension Fund D 0.01% of their portfolio | 46.5k $2.3m | Reduced -22.2k |
| Knights of Columbus Asset Advisors LLC 0.14% of their portfolio | 42.2k $2.1m | Added +592 |
| Eisler Capital (US) LLC 0.38% of their portfolio | 40.4k $2.0m | New |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 37.8k $1.9m | Reduced -2.0k |
| LPL Financial LLC 0.00% of their portfolio | 34.9k $1.7m | Added +5.9k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 34.7k $1.7m | Added +2.6k |
| MetLife Investment Management, LLC 0.01% of their portfolio | 33.2k $1.6m | Added +3.2k |
| Scientech Research LLC 0.32% of their portfolio | 31.4k $1.5m | Added +15.9k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 31.1k $1.5m | Added +1.1k |
| Corebridge Financial, Inc. 0.01% of their portfolio | 30.9k $1.5m | First filing |
| JANUS HENDERSON GROUP PLC 0.00% of their portfolio | 29.9k $1.5m | Reduced -288 |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 29.8k $1.5m | Added +5.6k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 29.5k $1.5m | Added +18.5k |
| MERCER GLOBAL ADVISORS INC /ADV 0.00% of their portfolio | 28.9k $1.4m | Added +3.8k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 28.3k $1.4m | Added +21.1k |
| ALGERT GLOBAL LLC 0.04% of their portfolio | 27.3k $1.3m | Added +14.6k |
| CITIGROUP INC 0.00% of their portfolio | 27.1k $1.3m | Reduced -198.0k |
| Legacy Capital Group California, Inc. 0.48% of their portfolio | 27.0k $1.3m | Reduced -1.2k |
| Comprehensive Financial Management LLC 0.05% of their portfolio | 26.3k $1.3m | Unchanged |
| Simplify Asset Management Inc. 0.11% of their portfolio | 25.5k $1.3m | New |