Vault-13

2SEVENTY BIO INC TSVT

COMMON STOCK · Common Stock · CUSIP 901384107 · ISIN US9013841070

151 institutional holders +3 vs Q1 2023
49,877,32249.9m shares reported held*
$504.8mreported value*
24 new 60 added 31 reduced 20 sold out net sold ≈ $412.4k (-40.7k shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $10.12. Options: 5 managers hold calls ($1.2m notional), 5 hold puts ($406.5k).

Trends to Q2 2023

Institutional holders

Managers reporting a position, each quarter

0100200Q3 22: 134Q4 22: 143Q1 23: 148Q2 23: 151151Q3 22Q4 22Q1 23Q2 23
Numbers
QuarterHolders
Q3 2022134
Q4 2022143
Q1 2023148
Q2 2023151

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q4 22: 67 bought or addedQ4 22: 50 cut or sold outQ4 22Q1 23: 86 bought or addedQ1 23: 45 cut or sold outQ1 23Q2 23: 84 bought or addedQ2 23: 51 cut or sold outQ2 23
Numbers
QuarterBought or addedCut or sold out
Q4 20226750
Q1 20238645
Q2 20238451

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$1m$2m$3mQ3 22 calls: $2.3mQ3 22 puts: $552.0kQ3 22P/C 0.24Q4 22 calls: $499.5kQ4 22 puts: $202.4kQ4 22P/C 0.41Q1 23 calls: $655.6kQ1 23 puts: $364.0kQ1 23P/C 0.56Q2 23 calls: $1.2mQ2 23 puts: $406.5kQ2 23P/C 0.35
Numbers
QuarterCallsPutsP/C
Q3 2022$2.3m$552.0k0.24
Q4 2022$499.5k$202.4k0.41
Q1 2023$655.6k$364.0k0.56
Q2 2023$1.2m$406.5k0.35

Biggest buyers

Avidity Partners Management LP New +1,342,000+1.3m
Kynam Capital Management, LP Added +1,151,734+1.2m
Point72 Asset Management, L.P. Added +1,065,673+1.1m
BlackRock Inc. Added +974,661+974.7k
MILLENNIUM MANAGEMENT LLC Added +952,858+952.9k
VANGUARD GROUP INC Added +573,640+573.6k
DAFNA Capital Management LLC New +496,416+496.4k
ExodusPoint Capital Management, LP Added +428,350+428.4k
JACOBS LEVY EQUITY MANAGEMENT, INC Added +405,084+405.1k
DIMENSIONAL FUND ADVISORS LP New +311,246+311.2k

Biggest sellers

CITADEL ADVISORS LLC Reduced -2,162,130-2.2m
Balyasny Asset Management L.P. Sold out -1,437,302-1.4m
Iron Triangle Partners LP Sold out -868,939-868.9k
Newtyn Management, LLC Reduced -767,256-767.3k
Artal Group S.A. Sold out -750,000-750.0k
PRICE T ROWE ASSOCIATES INC /MD/ Reduced -586,826-586.8k
JPMORGAN CHASE & CO Reduced -411,467-411.5k
MORGAN STANLEY Reduced -388,205-388.2k
Deep Track Capital, LP Sold out -350,000-350.0k
FMR LLC Reduced -294,564-294.6k

Biggest calls

GROUP ONE TRADING LLC Added $545.5k53.9k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP New $362.3k35.8k shares
CITADEL ADVISORS LLC Reduced $210.0k20.7k shares
SIMPLEX TRADING, LLC Reduced $37.0k3.7k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

MILLENNIUM MANAGEMENT LLC New $357.2k35.3k shares
CITADEL ADVISORS LLC Reduced $23.3k2.3k shares
SIMPLEX TRADING, LLC Added $20.0k2.0k shares
Cutler Group LLC / CA New $6.0k3.0k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
VANGUARD GROUP INC 13G · institution filed 2025-04-30 5.4% 2.8m 2025-04-30

Holders, Q2 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Kynam Capital Management, LP 7.59% of their portfolio PRINCETON, NJ 4,890,7064.9m $49.5m $49.5m 7.59% Added +1.2m +1,151,734
2 BlackRock Inc. 0.00% of their portfolio New York, NY 4,135,1844.1m $41.8m $41.8m 0.00% Added +974.7k +974,661
3 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 3,477,6743.5m $35.2m $35.2m 0.00% Added +573.6k +573,640
4 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 3,060,2063.1m $31.0m $31.0m 0.00% Reduced -87.2k -87,183
5 MILLENNIUM MANAGEMENT LLC 0.03% of their portfolio NEW YORK, NY 2,895,4762.9m $29.3m $29.3m 0.03% Added +952.9k +952,858
6 WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio Boston, MA 2,879,9222.9m $29.1m $29.1m 0.01% Added +110.5k +110,480
7 BAKER BROS. ADVISORS LP 0.15% of their portfolio NEW YORK, NY 2,497,5262.5m $25.3m $25.3m 0.15% Unchanged
8 ORBIMED ADVISORS LLC 0.44% of their portfolio New York, NY 2,391,6282.4m $24.2m $24.2m 0.44% Unchanged
9 Casdin Capital, LLC 1.79% of their portfolio New York, NY 2,023,9132.0m $20.5m $20.5m 1.79% Unchanged
10 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 1,624,2521.6m $16.4m $16.4m 0.00% Reduced -123.3k -123,270
11 ExodusPoint Capital Management, LP 0.17% of their portfolio NEW YORK, NY 1,457,3901.5m $14.7m $14.7m 0.17% Added +428.4k +428,350
12 Bain Capital Life Sciences Investors, LLC 1.47% of their portfolio Boston, MA 1,408,9011.4m $14.3m $14.3m 1.47% Unchanged
13 Avidity Partners Management LP 0.47% of their portfolio DALLAS, TX 1,342,0001.3m $13.6m $13.6m 0.47% New
14 Point72 Asset Management, L.P. 0.04% of their portfolio STAMFORD, CT 1,276,9521.3m $12.9m $12.9m 0.04% Added +1.1m +1,065,673
15 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 1,172,2141.2m $11.9m $11.9m 0.00% Reduced -411.5k -411,467
16 CREDIT SUISSE AG/ 0.01% of their portfolio ZURICH, V8 1,020,9531.0m $10.3m $10.3m 0.01% Added +3.0k +2,979
17 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 983,226983.2k $10.0m $10.0m 0.00% Added +241.8k +241,754
18 CHI Advisors LLC 2.62% of their portfolio NEW YORK, NY 852,007852.0k $8.6m $8.6m 2.62% Reduced -3.0k -2,993
19 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 777,121777.1k $7.9m $7.9m 0.00% Reduced -388.2k -388,205
20 Newtyn Management, LLC 1.76% of their portfolio NEW YORK, NY 737,744737.7k $7.5m $7.5m 1.76% Reduced -767.3k -767,256
21 CLOUGH CAPITAL PARTNERS L P 0.54% of their portfolio Boston, MA 529,110529.1k $5.4m $5.4m 0.54% Added +280.5k +280,500
22 JACOBS LEVY EQUITY MANAGEMENT, INC 0.03% of their portfolio FLORHAM PARK, NJ 521,264521.3k $5.3m $5.3m 0.03% Added +405.1k +405,084
23 DAFNA Capital Management LLC 1.37% of their portfolio LOS ANGELES, CA 496,416496.4k $5.0m $5.0m 1.37% New
24 SECTORAL ASSET MANAGEMENT INC 0.78% of their portfolio MONTREAL, A8 462,485462.5k $4.7m $4.7m 0.78% Reduced -13.5k -13,515
25 Boxer Capital, LLC 0.22% of their portfolio San Diego, CA 459,836459.8k $4.7m $4.7m 0.22% Unchanged
26 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 457,854457.9k $4.6m $4.6m 0.00% Added +107.9k +107,856
27 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 417,829417.8k $4.2m $4.2m 0.00% Added +97.8k +97,836
28 FMR LLC 0.00% of their portfolio BOSTON, MA 317,910317.9k $3.2m $3.2m 0.00% Reduced -294.6k -294,564
29 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 311,246311.2k $3.1m $3.1m 0.00% New
30 Bleichroeder LP 0.52% of their portfolio NEW YORK, NY 255,230255.2k $2.6m $2.6m 0.52% Added +89.8k +89,823
31 TANG CAPITAL MANAGEMENT LLC 0.37% of their portfolio SAN DIEGO, CA 250,000250.0k $2.5m $2.5m 0.37% Unchanged
32 Rafferty Asset Management, LLC 0.01% of their portfolio New York, NY 230,938230.9k $2.3m $2.3m 0.01% Added +9.0k +8,967
33 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 221,490221.5k $2.2m $2.2m 0.00% Added +64.1k +64,090
34 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 204,109204.1k $2.1m $2.1m 0.00% Reduced -2.2m -2,162,130
35 MOORE CAPITAL MANAGEMENT, LP 0.05% of their portfolio NEW YORK, NY 200,000200.0k $2.0m $2.0m 0.05% New
36 Polar Asset Management Partners Inc. 0.04% of their portfolio TORONTO, A6 198,300198.3k $2.0m $2.0m 0.04% New
37 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 184,220184.2k $1.9m $1.9m 0.00% Added +43.9k +43,917
38 AlphaCentric Advisors LLC 1.01% of their portfolio SAN JUAN, PR 180,000180.0k $1.8m $1.8m 1.01% Reduced -122.5k -122,500
39 Weiss Asset Management LP 0.21% of their portfolio BOSTON, MA 161,943161.9k $1.6m $1.6m 0.21% Unchanged
40 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 150,027150.0k $1.5m $1.5m 0.00% Reduced -249.9k -249,909
41 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 122,778122.8k $1.2m $1.2m 0.00% Reduced -271.3k -271,348
42 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 115,446115.4k $1.2m $1.2m 0.00% New
43 Lion Point Capital, LP 0.84% of their portfolio NEW YORK, NY 111,667111.7k $1.1m $1.1m 0.84% Reduced -58.3k -58,333
44 PRUDENTIAL FINANCIAL INC 0.00% of their portfolio NEWARK, NJ 99,966100.0k $1.0m $1.0m 0.00% Added +46.9k +46,910
45 Swiss National Bank 0.00% of their portfolio ZURICH, V8 98,30298.3k $994.8k $994.8k 0.00% Added +3.6k +3,600
46 Jackson Creek Investment Advisors LLC 0.40% of their portfolio CASTLE ROCK, CO 97,94697.9k $991.0k $991.0k 0.40% Added +5.3k +5,323
47 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 97,91297.9k $990.9k $990.9k 0.00% Added +23.2k +23,231
48 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 89,33889.3k $904.1k $904.1k 0.00% Reduced -78.9k -78,878
49 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 85,45085.5k $864.8k $864.8k 0.00% Reduced -177.5k -177,526
50 UBS Group AG 0.00% of their portfolio ZURICH, V8 82,43282.4k $834.2k $834.2k 0.00% Reduced -108.3k -108,344
51 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 80,05780.1k $810.2k $810.2k 0.00% Added +20.0k +19,967
52 Walleye Capital LLC 0.01% of their portfolio NEW YORK, NY 75,30775.3k $762.1k $762.1k 0.01% New
53 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 73,67173.7k $745.5k $745.5k 0.00% Added +63.1k +63,145
54 HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.00% of their portfolio TORONTO, A6 68,00068.0k $688.2k $688.2k 0.00% New
55 Birchview Capital, LP 0.45% of their portfolio BURLINGTON, VT 59,83359.8k $605.5k $605.5k 0.45% Unchanged
56 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 59,45659.5k $601.7k $601.7k 0.00% Added +14.0k +14,017
57 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 57,39957.4k $580.9k $580.9k 0.00% Added +22.2k +22,224
58 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 56,44156.4k $571.2k $571.2k 0.00% Added +4.0k +3,969
59 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 51,23151.2k $518.5k $518.5k 0.00% New
60 Trexquant Investment LP 0.01% of their portfolio STAMFORD, CT 51,16651.2k $517.8k $517.8k 0.01% New
61 COLONY GROUP LLC 0.01% of their portfolio Boston, MA 50,63050.6k $512.0k $512.0k 0.01% Added +29.4k +29,428
62 SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.02% of their portfolio BALA CYNWYD, PA 49,33849.3k $499.3k $499.3k 0.02% Reduced -18.2k -18,155
63 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 43,86843.9k $447.5k $447.5k 0.00% Unchanged
64 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 43,84643.8k $443.7k $443.7k 0.00% Reduced -398 -398
65 PROFUND ADVISORS LLC 0.02% of their portfolio BETHESDA, MD 42,01442.0k $425.2k $425.2k 0.02% Added +943 +943
66 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 41,18941.2k $416.8k $416.8k 0.00% Added +415 +415
67 Legal & General Group Plc 0.00% of their portfolio London, X0 40,16740.2k $406.5k $406.5k 0.00% Added +21.2k +21,199
68 PUTNAM INVESTMENTS LLC 0.00% of their portfolio BOSTON, MA 40,07840.1k $405.6k $405.6k 0.00% Added +2.8k +2,795
69 PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 0.00% of their portfolio COLUMBUS, OH 39,86239.9k $403.0k $403.0k 0.00% Added +4.5k +4,450
70 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 36,25936.3k $366.9k $366.9k 0.00% Added +5.6k +5,575
71 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 34,61234.6k $350.3k $350.3k 0.00% Added +4.8k +4,775
72 VIRTUS ADVISERS, LLC 0.19% of their portfolio HARTFORD, CT 31,96532.0k $323.5k $323.5k 0.19% Added +6.9k +6,923
73 CAPTRUST FINANCIAL ADVISORS 0.00% of their portfolio RALEIGH, NC 30,50230.5k $308.7k $308.7k 0.00% Reduced -7 -7
74 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 27,08327.1k $274.1k $274.1k 0.00% Added +6.4k +6,365
75 Graham Capital Management, L.P. 0.01% of their portfolio ROWAYTON, CT 25,72525.7k $260.3k $260.3k 0.01% New
76 Tower Research Capital LLC (TRC) 0.01% of their portfolio NEW YORK, NY 25,42625.4k $257.3k $257.3k 0.01% Added +23.4k +23,396
77 Pale Fire Capital SE 0.02% of their portfolio Prague, 2N 24,28824.3k $245.8k $245.8k 0.02% New
78 AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio New York, NY 24,17524.2k $244.7k $244.7k 0.00% Added +6.1k +6,130
79 Mitsubishi UFJ Asset Management Co., Ltd. 0.00% of their portfolio TOKYO, M0 23,98124.0k $242.7k $242.7k 0.00% Added +6.7k +6,722
80 JANUS HENDERSON GROUP PLC 0.00% of their portfolio LONDON, X0 23,18423.2k $234.7k $234.7k 0.00% Added +9.8k +9,830
81 AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio KANSAS CITY, MO 23,02423.0k $233.0k $233.0k 0.00% Added +11.7k +11,744
82 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 22,59722.6k $228.7k $228.7k 0.00% Reduced -3.5k -3,482
83 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 20,02720.0k $202.7k $202.7k 0.00% Reduced -33.4k -33,357
84 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 19,92819.9k $202.0k $202.0k 0.00% Reduced -586.8k -586,826
85 Hennion & Walsh Asset Management, Inc. 0.01% of their portfolio Parsippany, NJ 19,44419.4k $197.0k $197.0k 0.01% Reduced -14.0k -14,015
86 HORIZON KINETICS ASSET MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 18,00018.0k $182.2k $182.2k 0.00% Unchanged
87 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 17,21017.2k $174.2k $174.2k 0.00% Reduced -46 -46
88 PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio DES MOINES, IA 16,76316.8k $169.6k $169.6k 0.00% Added +4.5k +4,471
89 AXQ CAPITAL, LP 0.21% of their portfolio JERSEY CITY, NJ 16,60016.6k $168.0k $168.0k 0.21% New
90 Fiduciary Trust Co 0.00% of their portfolio Boston, MA 15,10315.1k $152.8k $152.8k 0.00% Unchanged
91 AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio Greenwich, CT 14,71114.7k $148.9k $148.9k 0.00% Added +896 +896
92 VIRGINIA RETIREMENT SYSTEMS ET Al 0.00% of their portfolio RICHMOND, VA 14,30014.3k $144.7k $144.7k 0.00% New
93 STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio TALLAHASSEE, FL 14,26314.3k $144.3k $144.3k 0.00% Added +10 +10
94 Green Alpha Advisors, LLC 0.09% of their portfolio NIWOT, CO 13,83713.8k $140.0k $140.0k 0.09% Added +1.6k +1,612
95 Integrated Advisors Network LLC 0.01% of their portfolio DALLAS, TX 13,57513.6k $137.4k $137.4k 0.01% New
96 Mariner, LLC 0.00% of their portfolio Overland Park, KS 13,16113.2k $133.2k $133.2k 0.00% Reduced -5.3k -5,308
97 ARIZONA STATE RETIREMENT SYSTEM 0.00% of their portfolio PHOENIX, AZ 12,68812.7k $128.4k $128.4k 0.00% Added +2.3k +2,251
98 FRANKLIN RESOURCES INC 0.00% of their portfolio San Mateo, CA 12,66112.7k $128.1k $128.1k 0.00% Added +20 +20
99 Walleye Trading LLC 0.01% of their portfolio NEW YORK, NY 12,55512.6k $127.1k $127.1k 0.01% New
100 E Fund Management Co., Ltd. 0.01% of their portfolio GUANGZHOU, F4 12,42012.4k $126.0k $126.0k 0.01% Reduced -181 -181