TREVI THERAPEUTICS INC TRVI
COM · Common Stock · CUSIP 89532M101
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNew Haven, CT
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($92.5k this quarter). Holder counts are more reliable. Shares outstanding: 128.2m as of 2025-10-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $12.52. Options: 9 managers hold calls ($5.3m notional), 6 hold puts ($7.5m).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 41 |
| Q4 2022 | 38 |
| Q1 2023 | 37 |
| Q2 2023 | 54 |
| Q3 2023 | 56 |
| Q4 2023 | 64 |
| Q1 2024 | 81 |
| Q2 2024 | 78 |
| Q3 2024 | 94 |
| Q4 2024 | 111 |
| Q1 2025 | 138 |
| Q2 2025 | 155 |
| Q3 2025 | 164 |
| Q4 2025 | 185 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 38 | 32 |
| Q2 2024 | 40 | 25 |
| Q3 2024 | 48 | 21 |
| Q4 2024 | 67 | 31 |
| Q1 2025 | 95 | 43 |
| Q2 2025 | 103 | 55 |
| Q3 2025 | 100 | 65 |
| Q4 2025 | 103 | 63 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $10.7m | $2.2m | 0.21 |
| Q2 2025 | $7.8m | $3.7m | 0.48 |
| Q3 2025 | $8.4m | $16.4m | 1.94 |
| Q4 2025 | $5.3m | $7.5m | 1.41 |
Biggest buyers
| FMR LLC | Added | +3.2m |
| EMERALD ADVISERS, LLC | New | +1.9m |
| Pictet Asset Management Holding SA | Added | +1.5m |
| EMERALD MUTUAL FUND ADVISERS TRUST | New | +1.3m |
| EVENTIDE ASSET MANAGEMENT, LLC | Added | +1.2m |
| FRONTIER CAPITAL MANAGEMENT CO LLC | New | +1.1m |
| Woodline Partners LP | Added | +900.0k |
| Soleus Capital Management, L.P. | Added | +875.0k |
| NAN FUNG TRINITY (HK) LTD | Added | +827.9k |
| VANGUARD GROUP INC | Added | +607.7k |
Biggest sellers
| Rubric Capital Management LP | Reduced | -4.8m |
| MORGAN STANLEY | Reduced | -3.3m |
| VIKING GLOBAL INVESTORS LP | Reduced | -1.9m |
| ALLIANCEBERNSTEIN L.P. | Reduced | -1.2m |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -775.2k |
| BANK OF AMERICA CORP /DE/ | Reduced | -742.0k |
| Logos Global Management LP | Reduced | -650.0k |
| Affinity Asset Advisors, LLC | Reduced | -649.8k |
| Qube Research & Technologies Ltd | Reduced | -629.1k |
| Balyasny Asset Management L.P. | Reduced | -451.8k |
Biggest calls
| RAYMOND JAMES FINANCIAL INC | New | $1.2m150.0k shares |
| GROUP ONE TRADING LLC | Reduced | $1.0m80.9k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $940.3k75.1k shares |
| CITADEL ADVISORS LLC | Added | $662.3k52.9k shares |
| JANE STREET GROUP, LLC | Added | $540.9k43.2k shares |
| Velan Capital Investment Management LP | New | $482.0k38.5k shares |
| DLD Asset Management, LP | New | $317.8k25.4k shares |
| J. Goldman & Co LP | New | $83.9k6.7k shares |
| SIMPLEX TRADING, LLC | Reduced | $8.8k700 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $3.2m255.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $1.4m113.8k shares |
| CITADEL ADVISORS LLC | Reduced | $1.1m90.0k shares |
| JANE STREET GROUP, LLC | Reduced | $865.1k69.1k shares |
| GROUP ONE TRADING LLC | Reduced | $455.7k36.4k shares |
| IMC-Chicago, LLC | Reduced | $386.9k30.9k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
New Enterprise Associates 16, L.P.
13D · may seek influence
-1.1 pts · filed 2026-05-07
Stated purposeThe Funds acquired the Firm Shares for investment purposes. Depending on market conditions, its continuing evaluation of the business and prospects of the Issuer and other factors, the Funds and other Reporting Persons may dispose of or acquire additional shares of the Issuer, including shares that may be acquired upon exercise of the NEA 16 Warrants prior to expiration. Except as set forth above, none of the Reporting Persons has any present plans which relate to or would result in: (a) The acquisition by any person of additional securities of the Issuer, or the disposition of securities of the Issuer; (b) An extraordinary corporate transaction, such as a merger, reorganization or liquidation, involving the Issuer or any of its subsidiaries; (c) A sale or transfer of a material amount … Full filing |
10.5% |
| FMR LLC 13G · institution +2.5 pts · filed 2026-08-06 | 8.8% |
| Frazier Life Sciences Public Fund, L.P. 13G · passive investor -3.6 pts · filed 2025-11-14 | 7.0% |
| BlackRock, Inc. 13G · institution +1.3 pts · filed 2026-10-27 | 6.9% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27), Rubric Capital Management LP (2.9%, 2026-02-13), VIKING GLOBAL INVESTORS LP (4.2%, 2025-11-14)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 0 | — | 3 | $232.5k | — |
| Q3 2024 | 0 | — | 3 | $338.0k | — |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 3 | $601.1k | $549.1k |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 0 | — | — |
None reported in Q4 2025.
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| NEA Management Company, LLC 8.44% of their portfolio | 13.2m $165.5m | Unchanged |
| Frazier Life Sciences Management, L.P. 3.45% of their portfolio | 10.3m $128.4m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 10.1m $126.8m | Added +225.1k |
| FMR LLC 0.00% of their portfolio | 6.5m $81.4m | Added +3.2m |
| VANGUARD GROUP INC 0.00% of their portfolio | 6.4m $80.6m | Added +607.7k |
| Vivo Capital, LLC 4.12% of their portfolio | 5.1m $63.8m | Unchanged |
| MARSHALL WACE, LLP 0.06% of their portfolio | 4.6m $57.3m | Reduced -261.2k |
| Rubric Capital Management LP 0.56% of their portfolio | 3.8m $47.2m | Reduced -4.8m |
| WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio | 3.4m $42.6m | Added +150.1k |
| MPM BIOIMPACT LLC 4.71% of their portfolio | 3.3m $41.2m | Reduced -119.9k |
| VIKING GLOBAL INVESTORS LP 0.11% of their portfolio | 3.2m $40.0m | Reduced -1.9m |
| ORBIMED ADVISORS LLC 0.82% of their portfolio | 3.2m $39.9m | Reduced -117.7k |
| ALLIANCEBERNSTEIN L.P. 0.01% of their portfolio | 3.1m $38.6m | Reduced -1.2m |
| Octagon Capital Advisors LP 4.41% of their portfolio | 2.8m $35.2m | Unchanged |
| EVENTIDE ASSET MANAGEMENT, LLC 0.51% of their portfolio | 2.6m $32.8m | Added +1.2m |
| STATE STREET CORP 0.00% of their portfolio | 2.4m $30.5m | Added +215.6k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 2.4m $30.2m | Added +192.0k |
| Siren, L.L.C. 0.85% of their portfolio | 2.3m $28.6m | Reduced -250.0k |
| Affinity Asset Advisors, LLC 1.93% of their portfolio | 2.2m $26.9m | Reduced -649.8k |
| ACORN CAPITAL ADVISORS, LLC 9.10% of their portfolio | 2.1m $26.9m | Unchanged |
| Artia Global Partners LP 4.05% of their portfolio | 2.0m $25.2m | Added +13.9k |
| EMERALD ADVISERS, LLC 0.73% of their portfolio | 1.9m $23.7m | New |
| RAYMOND JAMES FINANCIAL INC 0.01% of their portfolio | 1.8m $22.1m | Added +355.9k |
| Logos Global Management LP 1.29% of their portfolio | 1.6m $19.4m | Reduced -650.0k |
| Pictet Asset Management Holding SA 0.02% of their portfolio | 1.5m $19.2m | Added +1.5m |
| EMERALD MUTUAL FUND ADVISERS TRUST 0.78% of their portfolio | 1.3m $15.9m | New |
| Pivotal bioVenture Partners Investment Advisor LLC 6.08% of their portfolio | 1.3m $15.7m | Unchanged |
| FRONTIER CAPITAL MANAGEMENT CO LLC 0.15% of their portfolio | 1.1m $13.9m | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.1m $13.7m | Reduced -742.0k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 1.1m $13.2m | Added +269.4k |
| FLPUTNAM INVESTMENT MANAGEMENT CO 0.19% of their portfolio | 1.1m $13.2m | Added +5.3k |
| MORGAN STANLEY 0.00% of their portfolio | 1.1m $13.1m | Reduced -3.3m |
| Woodline Partners LP 0.05% of their portfolio | 1.0m $12.5m | Added +900.0k |
| Point72 Asset Management, L.P. 0.02% of their portfolio | 1.0m $12.5m | Added +58.1k |
| NAN FUNG TRINITY (HK) LTD 0.91% of their portfolio | 917.5k $11.5m | Added +827.9k |
| Soleus Capital Management, L.P. 0.48% of their portfolio | 900.0k $11.3m | Added +875.0k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 836.8k $10.5m | Added +30.5k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 825.5k $10.3m | Reduced -775.2k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 762.0k $9.5m | Added +25.0k |
| PANAGORA ASSET MANAGEMENT INC 0.03% of their portfolio | 693.0k $8.7m | Added +122.5k |
| SPHERA FUNDS MANAGEMENT LTD. 1.57% of their portfolio | 598.5k $7.5m | Reduced -45.4k |
| BARCLAYS PLC 0.00% of their portfolio | 582.7k $7.3m | Added +365.8k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 570.2k $7.1m | Reduced -157.4k |
| PRUDENTIAL FINANCIAL INC 0.01% of their portfolio | 549.2k $6.9m | Reduced -53.4k |
| Informed Momentum Co LLC 0.75% of their portfolio | 541.2k $6.8m | Reduced -8.2k |
| SILVERARC CAPITAL MANAGEMENT, LLC 0.98% of their portfolio | 541.2k $6.8m | Reduced -47.5k |
| Burkehill Global Management, LP 0.43% of their portfolio | 525.0k $6.6m | Unchanged |
| PEREGRINE CAPITAL MANAGEMENT LLC 0.19% of their portfolio | 507.7k $6.4m | Reduced -112.8k |
| Invesco Ltd. 0.00% of their portfolio | 498.9k $6.2m | Added +15.9k |
| J. Goldman & Co LP 0.22% of their portfolio | 444.4k $5.6m | Reduced -348.4k |
| KVP Capital Advisors, LP 5.35% of their portfolio | 414.0k $5.2m | First filing |
| STEMPOINT CAPITAL LP 0.86% of their portfolio | 399.6k $5.0m | Added +48.8k |
| Opaleye Management Inc. 0.57% of their portfolio | 345.1k $4.3m | Reduced -44.9k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 324.2k $4.1m | New |
| UBS Group AG 0.00% of their portfolio | 274.6k $3.4m | Reduced -24.0k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 260.6k $3.3m | Added +34.2k |
| F/m Investments LLC 0.11% of their portfolio | 241.5k $3.0m | New |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 226.2k $2.8m | Added +211.0k |
| Velan Capital Investment Management LP 1.49% of their portfolio | 205.0k $2.6m | Unchanged |
| Nuveen, LLC 0.00% of their portfolio | 183.3k $2.3m | Unchanged |
| Balyasny Asset Management L.P. 0.00% of their portfolio | 174.6k $2.2m | Reduced -451.8k |
| Swiss National Bank 0.00% of their portfolio | 168.2k $2.1m | Added +6.5k |
| FRED ALGER MANAGEMENT, LLC 0.01% of their portfolio | 158.0k $2.0m | Reduced -33.1k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 152.9k $1.9m | Added +50.3k |
| SUPERSTRING CAPITAL MANAGEMENT LP 0.99% of their portfolio | 148.3k $1.9m | New |
| SEI INVESTMENTS CO 0.00% of their portfolio | 147.9k $1.9m | Added +62.1k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 141.3k $1.8m | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 140.7k $1.8m | Added +24.3k |
| BIT Capital GmbH 0.07% of their portfolio | 130.0k $1.6m | Added +123.3k |
| HRT FINANCIAL LP 0.01% of their portfolio | 125.1k $1.6m | New |
| SG Americas Securities, LLC 0.00% of their portfolio | 124.6k $1.6m | Added +60.0k |
| CITIGROUP INC 0.00% of their portfolio | 123.5k $1.5m | Added +96.6k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 120.6k $1.5m | Reduced -2.7k |
| HighVista Strategies LLC 0.34% of their portfolio | 106.2k $1.3m | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 105.9k $1.3m | Reduced -9.1k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 101.3k $1.3m | Added +45.6k |
| OPPENHEIMER & CO INC 0.02% of their portfolio | 100.7k $1.3m | Added +2.0k |
| LMR Partners LLP 0.01% of their portfolio | 100.0k $1.3m | Unchanged |
| Rosalind Advisors, Inc. 0.46% of their portfolio | 100.0k $1.3m | Unchanged |
| DIADEMA PARTNERS LP 0.72% of their portfolio | 97.2k $1.2m | Added +11.4k |
| Erste Asset Management GmbH 0.01% of their portfolio | 90.0k $1.2m | New |
| SECTORAL ASSET MANAGEMENT INC 0.85% of their portfolio | 84.3k $1.1m | Reduced -21.7k |
| XTX Topco Ltd 0.03% of their portfolio | 83.8k $1.0m | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 83.8k $1.0m | Added +2.1k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 83.8k $1.0m | Reduced -36.2k |
| COMERICA BANK 0.00% of their portfolio | 83.0k $1.0m | Added +82.6k |
| WEXFORD CAPITAL LP 0.26% of their portfolio | 82.0k $1.0m | New |
| Legal & General Group Plc 0.00% of their portfolio | 81.7k $1.0m | Reduced -299 |
| PFS Partners, LLC 0.45% of their portfolio | 79.0k $989.1k | Unchanged |
| MAI Capital Management 0.01% of their portfolio | 77.8k $973.7k | Reduced -20.7k |
| Hudson Bay Capital Management LP 0.01% of their portfolio | 75.0k $939.0k | New |
| Campbell & CO Investment Adviser LLC 0.04% of their portfolio | 71.1k $890.1k | Added +46.2k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 70.8k $886.8k | Added +19.2k |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 68.5k $857.4k | New |
| WealthTrust Axiom LLC 0.20% of their portfolio | 61.5k $770.0k | Unchanged |
| OPTIMIZE FINANCIAL INC. 0.39% of their portfolio | 61.5k $769.8k | Added +884 |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 59.5k $744.6k | Reduced -58.2k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 59.4k $744.2k | Added +3.0k |
| KENNEDY CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 56.3k $704.5k | Added +1.3k |
| LPL Financial LLC 0.00% of their portfolio | 53.0k $663.1k | Added +12.5k |