TAYSHA GENE THERAPIES INC TSHA
COM SHS · Common Stock · CUSIP 877619106 · ISIN US8776191061
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersDallas, TX
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($23.8k this quarter). Holder counts are more reliable. Shares outstanding: 204.9m as of 2024-08-12, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $2.24. Options: 5 managers hold calls ($208.5k notional), 5 hold puts ($98.8k).
Trends to Q2 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 54 |
| Q4 2022 | 53 |
| Q1 2023 | 45 |
| Q2 2023 | 40 |
| Q3 2023 | 64 |
| Q4 2023 | 88 |
| Q1 2024 | 110 |
| Q2 2024 | 108 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 34 | 24 |
| Q1 2023 | 18 | 26 |
| Q2 2023 | 12 | 18 |
| Q3 2023 | 49 | 17 |
| Q4 2023 | 58 | 19 |
| Q1 2024 | 65 | 41 |
| Q2 2024 | 63 | 60 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2023 | $785.0k | $663.3k | 0.84 |
| Q4 2023 | $259.4k | $60.5k | 0.23 |
| Q1 2024 | $453.0k | $462.4k | 1.02 |
| Q2 2024 | $208.5k | $98.8k | 0.47 |
Biggest buyers
| BlackRock Inc. | Added | +9.1m |
| JPMORGAN CHASE & CO | Added | +5.7m |
| STATE STREET CORP | Added | +3.0m |
| DEUTSCHE BANK AG\ | New | +2.5m |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +1.9m |
| Octagon Capital Advisors LP | Added | +1.5m |
| VANGUARD GROUP INC | Added | +1.2m |
| FMR LLC | Added | +1.1m |
| Nuveen Asset Management, LLC | New | +1.1m |
| Woodline Partners LP | New | +1.0m |
Biggest sellers
| MORGAN STANLEY | Reduced | -8.0m |
| MILLENNIUM MANAGEMENT LLC | Reduced | -2.8m |
| Eversept Partners, LP | Sold out | -2.3m |
| COWEN AND COMPANY, LLC | Sold out | -1.6m |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -1.2m |
| Point72 Asset Management, L.P. | Sold out | -1.1m |
| STEMPOINT CAPITAL LP | Sold out | -1.1m |
| ACUTA CAPITAL PARTNERS, LLC | Reduced | -1.0m |
| Soleus Capital Management, L.P. | Sold out | -925.0k |
| Qube Research & Technologies Ltd | Reduced | -439.6k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $110.9k49.5k shares |
| SIMPLEX TRADING, LLC | Added | $38.0k17.2k shares |
| CITADEL ADVISORS LLC | Reduced | $35.6k15.9k shares |
| GROUP ONE TRADING LLC | Reduced | $24.0k10.7k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $50.2k22.4k shares |
| CITADEL ADVISORS LLC | Added | $43.2k19.3k shares |
| GROUP ONE TRADING LLC | Reduced | $5.4k2.4k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
| SIMPLEX TRADING, LLC | New | $0400 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor no change · filed 2026-08-14 | 9.9% |
| Manning Paul B 13D · may seek influence filed 2025-06-03 | 9.8% |
| RTW INVESTMENTS, LP 13G · institution -1.3 pts · filed 2026-05-15 | 7.0% |
| BlackRock, Inc. 13G · institution +1.3 pts · filed 2026-01-21 | 6.5% |
| Vestal Point Capital, LP 13G · institution +1.3 pts · filed 2026-05-15 | 6.3% |
| MORGAN STANLEY 13G · institution -1.6 pts · filed 2026-08-13 | 5.1% |
| GOLDMAN SACHS GROUP INC 13G · passive investor new · filed 2025-07-03 | 5.1% |
Fell to 5% or below in the last year: FMR LLC (4.9%, 2026-02-05), Octagon Capital Advisors LP (3.3%, 2025-11-14)
Insider purchases and sales in Q2 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2022 | 0 | — | 2 | $249.6k | — |
| Q4 2022 | 1 | $3.0m | 0 | — | — |
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 1 | $3.4k | 0 | — | — |
| Q3 2023 | 3 | $1.2m | 1 | $76.9k | $76.9k |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 0 | — | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-06-27 | Manning Paul B 10% owner | Bought | $3.0m1.3m shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2024
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.00% of their portfolio | 21.2m $47.5m | Added +1.1m |
| RTW INVESTMENTS, LP 0.65% of their portfolio | 18.8m $42.1m | Added +207.1k |
| Avoro Capital Advisors LLC 0.56% of their portfolio | 18.6m $41.8m | Unchanged |
| BlackRock Inc. 0.00% of their portfolio | 11.7m $26.3m | Added +9.1m |
| RA CAPITAL MANAGEMENT, L.P. 0.32% of their portfolio | 10.9m $24.4m | Unchanged |
| Venrock Adviser, LLC 1.28% of their portfolio | 9.0m $20.2m | Unchanged |
| MORGAN STANLEY 0.00% of their portfolio | 7.5m $16.7m | Reduced -8.0m |
| VANGUARD GROUP INC 0.00% of their portfolio | 7.2m $16.1m | Added +1.2m |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 5.9m $13.3m | Added +5.7m |
| Octagon Capital Advisors LP 1.69% of their portfolio | 4.6m $10.2m | Added +1.5m |
| Artal Group S.A. 0.25% of their portfolio | 4.4m $9.8m | Added +666.7k |
| BAKER BROS. ADVISORS LP 0.11% of their portfolio | 4.0m $9.0m | Unchanged |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD 1.69% of their portfolio | 3.7m $8.3m | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 3.3m $7.4m | Added +3.0m |
| Polar Capital Holdings Plc 0.04% of their portfolio | 3.0m $6.8m | Added +506.1k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 2.9m $6.5m | Added +1.9m |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 2.5m $5.7m | New |
| ACUTA CAPITAL PARTNERS, LLC 4.40% of their portfolio | 2.3m $5.2m | Reduced -1.0m |
| EAGLE ASSET MANAGEMENT INC 0.02% of their portfolio | 1.7m $3.9m | Reduced -66.8k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 1.3m $2.9m | Added +177.2k |
| Ghost Tree Capital, LLC 0.97% of their portfolio | 1.2m $2.8m | Added +300.0k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 1.1m $2.4m | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 1.0m $2.3m | Reduced -31.9k |
| Woodline Partners LP 0.02% of their portfolio | 1.0m $2.3m | New |
| Palo Alto Investors LP 0.21% of their portfolio | 811.3k $1.8m | Unchanged |
| Granahan Investment Management, LLC 0.07% of their portfolio | 809.7k $1.8m | New |
| MARSHALL WACE, LLP 0.00% of their portfolio | 786.1k $1.8m | Reduced -244.6k |
| Schonfeld Strategic Advisors LLC 0.01% of their portfolio | 769.2k $1.7m | Added +216.6k |
| Quantum Private Wealth, LLC 0.58% of their portfolio | 730.5k $1.6m | Added +32.0k |
| Sands Capital Alternatives, LLC 0.54% of their portfolio | 724.9k $1.6m | Unchanged |
| Alphabet Inc. 0.07% of their portfolio | 640.9k $1.4m | Unchanged |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 632.5k $1.4m | Reduced -439.6k |
| Diametric Capital, LP 0.62% of their portfolio | 512.4k $1.1m | Added +358.9k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 454.5k $1.0m | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 429.7k $962.6k | Added +378.3k |
| Invesco Ltd. 0.00% of their portfolio | 397.8k $891.0k | New |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 340.7k $763.2k | Reduced -2.8m |
| NorthCoast Asset Management LLC 0.01% of their portfolio | 292.8k $655.8k | Added +15.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 270.8k $606.5k | Added +59.4k |
| Jefferies Financial Group Inc. 0.01% of their portfolio | 257.7k $577.2k | Added +209.6k |
| ADAR1 Capital Management, LLC 0.11% of their portfolio | 250.8k $561.8k | Added +207.3k |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.04% of their portfolio | 186.6k $418.0k | Added +130.7k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 184.3k $412.8k | New |
| TD Asset Management Inc 0.00% of their portfolio | 175.6k $393.3k | Unchanged |
| Alpine Global Management, LLC 0.06% of their portfolio | 151.5k $339.3k | New |
| GSA CAPITAL PARTNERS LLP 0.02% of their portfolio | 141.8k $318.0k | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 133.2k $298.4k | Added +69.5k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 129.2k $289.4k | Reduced -1.2m |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 128.1k $287.0k | Added +69.2k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 124.0k $277.7k | Reduced -1.7k |
| Chicago Partners Investment Group LLC 0.01% of their portfolio | 116.9k $263.0k | Reduced -8.4k |
| Privium Fund Management B.V. 0.05% of their portfolio | 98.5k $212.8k | New |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 95.6k $214.1k | New |
| Corebridge Financial, Inc. 0.00% of their portfolio | 86.1k $193.6k | First filing |
| Squarepoint Ops LLC 0.00% of their portfolio | 80.3k $179.8k | Reduced -133.7k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 69.7k $156.2k | Added +62.3k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 64.8k $145.2k | New |
| Virtu Financial LLC 0.01% of their portfolio | 57.2k $128.0k | New |
| UBS Group AG 0.00% of their portfolio | 56.1k $125.6k | Reduced -133.2k |
| BARCLAYS PLC 0.00% of their portfolio | 54.2k $117.4k | New |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 53.9k $120.8k | New |
| Leonteq Securities AG 0.02% of their portfolio | 53.0k $118.7k | Added +25.0k |
| LPL Financial LLC 0.00% of their portfolio | 48.1k $107.7k | Added +6.0k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 46.9k $105.0k | Added +46.7k |
| Redwood Wealth Management Group, LLC 0.08% of their portfolio | 46.4k $103.9k | New |
| Marathon Trading Investment Management LLC 0.03% of their portfolio | 45.3k $101.6k | Reduced -178.6k |
| Dynamic Advisor Solutions LLC 0.00% of their portfolio | 45.0k $100.8k | Unchanged |
| Williams & Novak, LLC 0.09% of their portfolio | 45.0k $100.8k | Unchanged |
| CITIGROUP INC 0.00% of their portfolio | 43.9k $98.4k | Reduced -211.3k |
| Scientech Research LLC 0.02% of their portfolio | 43.4k $97.1k | New |
| MetLife Investment Management, LLC 0.00% of their portfolio | 41.8k $93.6k | New |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 41.1k $92.1k | Reduced -287.4k |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 27.3k $61.0k | Unchanged |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 26.6k $59.7k | New |
| China Universal Asset Management Co., Ltd. 0.01% of their portfolio | 22.0k $49.2k | Reduced -13.9k |
| VIRTUS ADVISERS, LLC 0.02% of their portfolio | 21.7k $48.6k | New |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 21.6k $48.4k | New |
| Lee Financial Co 0.01% of their portfolio | 20.0k $44.8k | Unchanged |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 18.1k $40.5k | Added +1.1k |
| Legal & General Group Plc 0.00% of their portfolio | 17.9k $40.2k | New |
| Cambridge Investment Research Advisors, Inc. 0.00% of their portfolio | 16.5k $37.0k | Reduced -785 |
| US BANCORP \DE\ 0.00% of their portfolio | 16.1k $36.0k | Reduced -1.6k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 15.7k $35.0k | New |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 15.7k $35.1k | New |
| Howard Capital Management, LLC 0.00% of their portfolio | 14.2k $31.7k | Unchanged |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 13.0k $29.2k | Reduced -11.1k |
| Marex Group Ltd 0.00% of their portfolio | 12.5k $28.0k | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 11.6k $26.0k | New |
| ProShare Advisors LLC 0.00% of their portfolio | 11.5k $25.9k | Reduced -1.6k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 11.2k $25.1k | Reduced -7.9k |
| Camelot Portfolios, LLC 0.01% of their portfolio | 11.0k $24.6k | New |
| Schechter Investment Advisors, LLC 0.00% of their portfolio | 10.6k $23.8k | New |
| Capital Investment Advisors, LLC 0.00% of their portfolio | 10.0k $22.4k | Unchanged |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 5.6k $12.1k | New |
| AMALGAMATED BANK 0.00% of their portfolio | 5.5k $12.0k | New |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC 0.00% of their portfolio | 2.0k $4.5k | New |
| State of Wyoming 0.00% of their portfolio | 1.8k $4.0k | New |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 1.0k $2.2k | New |
| Allworth Financial LP 0.00% of their portfolio | 1.0k $2.1k | Unchanged |
| Daiwa Securities Group Inc. 0.00% of their portfolio | 691 $2.0k | Unchanged |