TANGO THERAPEUTICS INC TNGX
COM · Common Stock · CUSIP 87583X109
Company in Cambridge, United States
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersBoston, MA
- Founded2017
- Websitetangotx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($62.3k this quarter). Holder counts are more reliable. Shares outstanding: 142.7m as of 2026-02-26, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $8.86. Options: 4 managers hold calls ($840.8k notional), 2 hold puts ($265.8k).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 87 |
| Q4 2022 | 83 |
| Q1 2023 | 93 |
| Q2 2023 | 90 |
| Q3 2023 | 101 |
| Q4 2023 | 122 |
| Q1 2024 | 127 |
| Q2 2024 | 121 |
| Q3 2024 | 122 |
| Q4 2024 | 139 |
| Q1 2025 | 123 |
| Q2 2025 | 116 |
| Q3 2025 | 141 |
| Q4 2025 | 170 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 58 | 56 |
| Q2 2024 | 56 | 59 |
| Q3 2024 | 54 | 51 |
| Q4 2024 | 74 | 55 |
| Q1 2025 | 57 | 68 |
| Q2 2025 | 62 | 59 |
| Q3 2025 | 85 | 45 |
| Q4 2025 | 124 | 49 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $1.5k | $0 | 0.00 |
| Q2 2025 | $1.3m | $96.8k | 0.07 |
| Q3 2025 | $1.6m | $172.8k | 0.11 |
| Q4 2025 | $840.8k | $265.8k | 0.32 |
Biggest buyers
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Added | +8.1m |
| TCG Crossover Management, LLC | Added | +4.2m |
| Woodline Partners LP | Added | +4.0m |
| Bellevue Group AG | New | +3.9m |
| Caligan Partners LP | New | +3.7m |
| GOLDMAN SACHS GROUP INC | Added | +3.4m |
| Logos Global Management LP | Added | +3.2m |
| DEERFIELD MANAGEMENT COMPANY, L.P. | New | +2.9m |
| BlackRock, Inc. | Added | +2.9m |
| FMR LLC | Added | +2.9m |
Biggest sellers
| EcoR1 Capital, LLC | Sold out | -10.6m |
| TRV GP IV, LLC | Reduced | -6.0m |
| GILEAD SCIENCES, INC. | Sold out | -4.9m |
| Paradigm Biocapital Advisors LP | Sold out | -3.1m |
| T. Rowe Price Investment Management, Inc. | Reduced | -2.7m |
| Bain Capital Life Sciences Investors, LLC | Reduced | -2.1m |
| RA CAPITAL MANAGEMENT, L.P. | Sold out | -2.0m |
| Commodore Capital LP | Sold out | -1.5m |
| MARSHALL WACE, LLP | Reduced | -1.2m |
| Point72 Asset Management, L.P. | Reduced | -945.4k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $370.3k41.8k shares |
| SIMPLEX TRADING, LLC | Added | $358.8k40.5k shares |
| CITADEL ADVISORS LLC | New | $102.8k11.6k shares |
| GROUP ONE TRADING LLC | Reduced | $8.9k1.0k shares |
Biggest puts
| JANE STREET GROUP, LLC | New | $262.3k29.6k shares |
| SIMPLEX TRADING, LLC | Reduced | $3.5k400 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
BCTG Holdings, LLC
13D · may seek influence
filed 2025-01-02
Stated purposeItem 4 is hereby amended by the addition of the following: The disclosure set forth above in Item 3 is hereby incorporated herein. Full filing |
10.0% |
| FARALLON PARTNERS L L C/CA 13G · passive investor filed 2026-02-06 | 10.0% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 13G · institution filed 2026-08-14 | 9.8% |
| RTW INVESTMENTS, LP 13G · institution new · filed 2026-05-15 | 9.3% |
| Farallon Capital Partners, L.P. 13G · passive investor -1.9 pts · filed 2026-05-11 | 7.8% |
| TCG Crossover GP II, LLC 13G · passive investor -1.1 pts · filed 2026-08-14 | 7.0% |
| FMR LLC 13G · institution +6.9 pts · filed 2026-05-06 | 6.9% |
| BlackRock, Inc. 13G · institution +1.3 pts · filed 2026-01-21 | 6.3% |
| GOLDMAN SACHS GROUP INC 13G · institution new · filed 2026-08-14 | 6.0% |
Fell to 5% or below in the last year: Woodline Partners LP (2.5%, 2026-08-14), Nextech Crossover I GP S.a r.l. (0.0%, 2026-08-14), Adage Capital Management, L.P. (3.4%, 2026-08-12), Invus Global Management, LLC (4.0%, 2026-05-04), VANGUARD GROUP INC (0.0%, 2026-03-27), EcoR1 Capital, LLC (0.0%, 2026-02-17), Third Rock Ventures IV, L.P. (4.7%, 2026-02-10)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 0 | — | 4 | $302.3k | — |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 1 | $74.0k | 0 | — | — |
| Q1 2025 | 0 | — | 4 | $143.2k | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-10-23 | TRV GP IV, LLC +2 10% owner | Sold | $4.8m477.4k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| FARALLON CAPITAL MANAGEMENT, L.L.C. 0.60% of their portfolio | 13.1m $115.7m | Added +2.3m |
| TCG Crossover Management, LLC 3.74% of their portfolio | 12.8m $113.1m | Added +4.2m |
| Boxer Capital Management, LLC 21.09% of their portfolio | 10.9m $96.4m | Added +1.1m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.14% of their portfolio | 10.6m $94.0m | Added +8.1m |
| Woodline Partners LP 0.35% of their portfolio | 10.1m $89.2m | Added +4.0m |
| BlackRock, Inc. 0.00% of their portfolio | 8.5m $75.7m | Added +2.9m |
| Siren, L.L.C. 2.16% of their portfolio | 8.2m $72.3m | Added +2.3m |
| TRV GP IV, LLC 27.35% of their portfolio | 7.9m $69.8m | Reduced -6.0m |
| Nextech Invest Ltd. 6.22% of their portfolio | 7.3m $64.4m | Added +1.7m |
| VANGUARD GROUP INC 0.00% of their portfolio | 6.8m $59.8m | Added +1.7m |
| STATE STREET CORP 0.00% of their portfolio | 6.2m $55.1m | Added +2.9m |
| Balyasny Asset Management L.P. 0.09% of their portfolio | 5.3m $46.8m | Added +1.8m |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 4.9m $43.8m | Added +3.4m |
| Logos Global Management LP 2.48% of their portfolio | 4.2m $37.2m | Added +3.2m |
| Bellevue Group AG 0.66% of their portfolio | 3.9m $34.8m | New |
| Caligan Partners LP 3.03% of their portfolio | 3.7m $33.0m | New |
| Nantahala Capital Management, LLC 1.89% of their portfolio | 3.6m $31.7m | Added +1.8m |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.33% of their portfolio | 2.9m $25.8m | New |
| FMR LLC 0.00% of their portfolio | 2.9m $25.4m | Added +2.9m |
| MONTANOVA CAPITAL, LLC 0.59% of their portfolio | 2.7m $23.6m | New |
| JANUS HENDERSON GROUP PLC 0.01% of their portfolio | 2.6m $23.5m | Added +342.0k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 2.6m $22.6m | Added +670.9k |
| Deep Track Capital, LP 0.50% of their portfolio | 2.5m $21.7m | Added +1.0m |
| Vivo Capital, LLC 1.23% of their portfolio | 2.2m $19.1m | Added +1.4m |
| Point72 Asset Management, L.P. 0.03% of their portfolio | 2.0m $17.5m | Reduced -945.4k |
| RTW INVESTMENTS, LP 0.13% of their portfolio | 1.5m $13.2m | New |
| MORGAN STANLEY 0.00% of their portfolio | 1.4m $12.6m | Added +1.2m |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 1.4m $12.4m | Added +471.2k |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 1.0m $9.1m | Added +595.2k |
| Affinity Asset Advisors, LLC 0.64% of their portfolio | 1.0m $8.9m | New |
| UBS Group AG 0.00% of their portfolio | 990.5k $8.8m | Added +830.0k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.22% of their portfolio | 957.3k $8.5m | New |
| T. Rowe Price Investment Management, Inc. 0.00% of their portfolio | 845.8k $7.5m | Reduced -2.7m |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 841.0k $7.5m | Added +182.7k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 803.2k $7.1m | Added +197.6k |
| Candriam S.C.A. 0.03% of their portfolio | 708.8k $6.3m | Unchanged |
| BESSEMER GROUP INC 0.01% of their portfolio | 708.4k $6.3m | Unchanged |
| ArrowMark Colorado Holdings LLC 0.14% of their portfolio | 708.4k $6.3m | Unchanged |
| Bain Capital Life Sciences Investors, LLC 0.44% of their portfolio | 653.5k $5.8m | Reduced -2.1m |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 593.0k $5.3m | Reduced -702.4k |
| SPHERA FUNDS MANAGEMENT LTD. 1.01% of their portfolio | 544.6k $4.8m | New |
| PERCEPTIVE ADVISORS LLC 0.08% of their portfolio | 513.0k $4.5m | New |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 487.1k $4.3m | Reduced -185.7k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 478.1k $4.2m | Added +322.6k |
| Rock Springs Capital Management LP 0.18% of their portfolio | 386.9k $3.4m | New |
| BARCLAYS PLC 0.00% of their portfolio | 368.2k $3.3m | Added +2.5k |
| Mass General Brigham, Inc 0.39% of their portfolio | 354.2k $3.1m | First filing |
| Bank of New York Mellon Corp 0.00% of their portfolio | 343.8k $3.0m | Added +151.5k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 329.2k $2.9m | Reduced -1.2m |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 318.7k $2.8m | New |
| Nuveen, LLC 0.00% of their portfolio | 300.4k $2.7m | Reduced -627.6k |
| GREAT LAKES ADVISORS, LLC 0.02% of their portfolio | 294.3k $2.6m | Reduced -129.5k |
| ACUTA CAPITAL PARTNERS, LLC 1.70% of their portfolio | 282.7k $2.5m | New |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.01% of their portfolio | 255.1k $2.3m | Reduced -129.1k |
| CONGRESS ASSET MANAGEMENT CO 0.01% of their portfolio | 234.6k $2.1m | Added +6.5k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 233.9k $2.1m | Reduced -19.4k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 226.6k $2.0m | Added +81.3k |
| Seven Fleet Capital Management LP 1.29% of their portfolio | 215.2k $1.9m | First filing |
| Integral Health Asset Management, LLC 0.09% of their portfolio | 200.0k $1.8m | New |
| TRV GP VI, LLC 1.16% of their portfolio | 194.2k $1.7m | Unchanged |
| Fisher Asset Management, LLC 0.00% of their portfolio | 187.7k $1.7m | Reduced -22.7k |
| Invesco Ltd. 0.00% of their portfolio | 177.6k $1.6m | Reduced -854.3k |
| Squarepoint Ops LLC 0.00% of their portfolio | 173.9k $1.5m | New |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 151.9k $1.3m | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 144.4k $1.3m | Unchanged |
| ADAR1 Capital Management, LLC 0.09% of their portfolio | 140.0k $1.2m | New |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 129.5k $1.1m | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 129.1k $1.1m | Added +21.3k |
| Verition Fund Management LLC 0.01% of their portfolio | 121.8k $1.1m | Added +97.0k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 121.2k $1.1m | Added +66.2k |
| GSA CAPITAL PARTNERS LLP 0.09% of their portfolio | 118.6k $1.1m | New |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 106.5k $943.5k | Added +4.2k |
| Trexquant Investment LP 0.01% of their portfolio | 105.3k $932.7k | Reduced -93.8k |
| Swiss National Bank 0.00% of their portfolio | 87.8k $777.9k | New |
| PROFUND ADVISORS LLC 0.02% of their portfolio | 83.8k $742.1k | Added +52.5k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 82.2k $728.6k | Added +3.1k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 74.2k $657.4k | Added +15.1k |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 68.3k $604.7k | Added +14.7k |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 64.2k $512.0k | Added +47.1k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 62.6k $551.9k | Added +22.2k |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 60.0k $502.0k | Unchanged |
| MetLife Investment Management, LLC 0.00% of their portfolio | 59.7k $528.9k | Added +12.0k |
| Y-Intercept (Hong Kong) Ltd 0.01% of their portfolio | 59.3k $525.7k | Added +22.4k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 58.4k $518.0k | Added +17.8k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 56.8k $503.6k | Reduced -11.0k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 53.9k $477.8k | Added +43.9k |
| Graham Capital Management, L.P. 0.02% of their portfolio | 51.3k $454.7k | New |
| CANADA PENSION PLAN INVESTMENT BOARD 0.00% of their portfolio | 50.4k $446.5k | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 48.2k $427.1k | Added +43.4k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 47.8k $423.6k | Added +34.3k |
| SmartHarvest Portfolios, LLC 0.14% of their portfolio | 46.1k $408.6k | First filing |
| Creative Planning 0.00% of their portfolio | 41.9k $371.3k | Added +6.7k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 41.5k $367.3k | New |
| Legal & General Group Plc 0.00% of their portfolio | 39.4k $349.4k | Added +33.0k |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 38.9k $345.0k | Added +10.8k |
| XTX Topco Ltd 0.01% of their portfolio | 37.8k $335.2k | New |
| CITIGROUP INC 0.00% of their portfolio | 36.2k $321.1k | Added +18.1k |
| Janney Montgomery Scott LLC 0.00% of their portfolio | 36.0k $319.0k | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 35.2k $312.0k | Reduced -53.6k |
| Philadelphia Financial Management of San Francisco, LLC 0.06% of their portfolio | 33.3k $295.0k | New |