TANGO THERAPEUTICS INC TNGX
COM · Common Stock · CUSIP 87583X109
Company in Cambridge, United States
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersBoston, MA
- Founded2017
- Websitetangotx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($2.1m this quarter). Holder counts are more reliable. Shares outstanding: 134.6m as of 2025-10-28, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $8.40. Options: 4 managers hold calls ($1.6m notional), 3 hold puts ($172.8k).
Trends to Q3 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 87 |
| Q4 2022 | 83 |
| Q1 2023 | 93 |
| Q2 2023 | 90 |
| Q3 2023 | 101 |
| Q4 2023 | 122 |
| Q1 2024 | 127 |
| Q2 2024 | 121 |
| Q3 2024 | 122 |
| Q4 2024 | 139 |
| Q1 2025 | 123 |
| Q2 2025 | 116 |
| Q3 2025 | 141 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2023 | 73 | 36 |
| Q1 2024 | 58 | 56 |
| Q2 2024 | 56 | 59 |
| Q3 2024 | 54 | 51 |
| Q4 2024 | 74 | 55 |
| Q1 2025 | 57 | 68 |
| Q2 2025 | 62 | 59 |
| Q3 2025 | 85 | 45 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q4 2024 | $4.3k | $13.6k | 3.14 |
| Q1 2025 | $1.5k | $0 | 0.00 |
| Q2 2025 | $1.3m | $96.8k | 0.07 |
| Q3 2025 | $1.6m | $172.8k | 0.11 |
Biggest buyers
| Paradigm Biocapital Advisors LP | New | +3.1m |
| Point72 Asset Management, L.P. | New | +2.9m |
| Siren, L.L.C. | Added | +2.5m |
| JANUS HENDERSON GROUP PLC | New | +2.3m |
| STATE STREET CORP | Added | +2.0m |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | Added | +1.6m |
| Deep Track Capital, LP | New | +1.5m |
| GOLDMAN SACHS GROUP INC | Added | +1.4m |
| VANGUARD GROUP INC | Added | +1.0m |
| Logos Global Management LP | New | +950.0k |
Biggest sellers
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Reduced | -3.4m |
| TRV GP IV, LLC | Reduced | -3.0m |
| TCG Crossover Management, LLC | Reduced | -2.2m |
| Nantahala Capital Management, LLC | Reduced | -1.6m |
| Blue Owl Capital Holdings LP | Reduced | -695.0k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -476.9k |
| Soleus Capital Management, L.P. | Reduced | -430.0k |
| MORGAN STANLEY | Reduced | -282.8k |
| MARSHALL WACE, LLP | Reduced | -253.2k |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Sold out | -218.8k |
Biggest calls
| J. Goldman & Co LP | New | $907.2k108.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $519.1k61.8k shares |
| SIMPLEX TRADING, LLC | Added | $92.0k11.0k shares |
| GROUP ONE TRADING LLC | New | $33.6k4.0k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $120.1k14.3k shares |
| Belvedere Trading LLC | Added | $27.7k3.3k shares |
| SIMPLEX TRADING, LLC | New | $25.0k3.0k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
BCTG Holdings, LLC
13D · may seek influence
filed 2025-01-02
Stated purposeItem 4 is hereby amended by the addition of the following: The disclosure set forth above in Item 3 is hereby incorporated herein. Full filing |
10.0% |
| FARALLON PARTNERS L L C/CA 13G · passive investor filed 2026-02-06 | 10.0% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 13G · institution filed 2026-08-14 | 9.8% |
| RTW INVESTMENTS, LP 13G · institution new · filed 2026-05-15 | 9.3% |
| Farallon Capital Partners, L.P. 13G · passive investor -1.9 pts · filed 2026-05-11 | 7.8% |
| TCG Crossover GP II, LLC 13G · passive investor -1.1 pts · filed 2026-08-14 | 7.0% |
| FMR LLC 13G · institution +6.9 pts · filed 2026-05-06 | 6.9% |
| BlackRock, Inc. 13G · institution +1.3 pts · filed 2026-01-21 | 6.3% |
| GOLDMAN SACHS GROUP INC 13G · institution new · filed 2026-08-14 | 6.0% |
Fell to 5% or below in the last year: Woodline Partners LP (2.5%, 2026-08-14), Nextech Crossover I GP S.a r.l. (0.0%, 2026-08-14), Adage Capital Management, L.P. (3.4%, 2026-08-12), Invus Global Management, LLC (4.0%, 2026-05-04), VANGUARD GROUP INC (0.0%, 2026-03-27), EcoR1 Capital, LLC (0.0%, 2026-02-17), Third Rock Ventures IV, L.P. (4.7%, 2026-02-10)
Insider purchases and sales in Q3 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2023 | 0 | — | 1 | $63.0k | — |
| Q1 2024 | 0 | — | 4 | $302.3k | — |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 1 | $74.0k | 0 | — | — |
| Q1 2025 | 0 | — | 4 | $143.2k | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-09-25 | TRV GP IV, LLC +2 10% owner | Sold | $4.0m500.0k shares |
| 2025-09-16 | TRV GP IV, LLC +2 10% owner | Sold | $2.6m363.5k shares |
| 2025-09-08 | TRV GP IV, LLC +2 10% owner | Sold | $608.7k86.5k shares |
| 2025-09-05 | TRV GP IV, LLC +2 10% owner | Sold | $4.5m642.9k shares |
| 2025-08-22 | TRV GP IV, LLC +2 10% owner | Sold | $2.1m302.2k shares |
| 2025-08-19 | TRV GP IV, LLC +2 10% owner | Sold | $7.7m1.1m shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q3 2025
| Manager | Shares | Change |
|---|---|---|
| TRV GP IV, LLC 42.51% of their portfolio | 13.9m $116.5m | Reduced -3.0m |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 0.51% of their portfolio | 10.8m $90.4m | Added +1.6m |
| EcoR1 Capital, LLC 4.29% of their portfolio | 10.6m $89.3m | Unchanged |
| Boxer Capital Management, LLC 26.16% of their portfolio | 9.8m $82.1m | Unchanged |
| TCG Crossover Management, LLC 3.53% of their portfolio | 8.5m $71.7m | Reduced -2.2m |
| Woodline Partners LP 0.24% of their portfolio | 6.0m $50.7m | Added +22 |
| Siren, L.L.C. 1.93% of their portfolio | 5.9m $49.4m | Added +2.5m |
| BlackRock, Inc. 0.00% of their portfolio | 5.6m $47.4m | Added +183.7k |
| Nextech Invest Ltd. 7.08% of their portfolio | 5.5m $46.5m | Unchanged |
| VANGUARD GROUP INC 0.00% of their portfolio | 5.1m $42.4m | Added +1.0m |
| GILEAD SCIENCES, INC. 2.28% of their portfolio | 4.9m $40.8m | Unchanged |
| T. Rowe Price Investment Management, Inc. 0.02% of their portfolio | 3.5m $29.6m | Added +357.1k |
| Balyasny Asset Management L.P. 0.06% of their portfolio | 3.5m $29.2m | Added +224.7k |
| STATE STREET CORP 0.00% of their portfolio | 3.4m $28.3m | Added +2.0m |
| Paradigm Biocapital Advisors LP 0.77% of their portfolio | 3.1m $25.9m | New |
| Point72 Asset Management, L.P. 0.05% of their portfolio | 2.9m $24.5m | New |
| Bain Capital Life Sciences Investors, LLC 1.51% of their portfolio | 2.7m $22.8m | Unchanged |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.03% of their portfolio | 2.5m $21.1m | Reduced -3.4m |
| JANUS HENDERSON GROUP PLC 0.01% of their portfolio | 2.3m $19.3m | New |
| RA CAPITAL MANAGEMENT, L.P. 0.21% of their portfolio | 2.0m $16.8m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.9m $15.8m | Added +113.9k |
| Nantahala Capital Management, LLC 0.94% of their portfolio | 1.8m $15.2m | Reduced -1.6m |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 1.5m $12.7m | Added +1.4m |
| Commodore Capital LP 0.62% of their portfolio | 1.5m $12.6m | Unchanged |
| MARSHALL WACE, LLP 0.01% of their portfolio | 1.5m $12.5m | Reduced -253.2k |
| Deep Track Capital, LP 0.34% of their portfolio | 1.5m $12.2m | New |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 1.3m $10.9m | Reduced -476.9k |
| Invesco Ltd. 0.00% of their portfolio | 1.0m $8.7m | Added +936.6k |
| Logos Global Management LP 0.79% of their portfolio | 950.0k $8.0m | New |
| Nuveen, LLC 0.00% of their portfolio | 928.0k $7.8m | Added +485.0k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 926.9k $7.8m | Added +801.7k |
| Vivo Capital, LLC 0.53% of their portfolio | 776.7k $6.5m | Added +176.7k |
| Candriam S.C.A. 0.03% of their portfolio | 708.8k $6.0m | Unchanged |
| BESSEMER GROUP INC 0.01% of their portfolio | 708.4k $6.0m | Added +14 |
| ArrowMark Colorado Holdings LLC 0.11% of their portfolio | 708.4k $6.0m | Unchanged |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 672.7k $5.7m | Added +147.6k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 658.3k $5.5m | Added +56.8k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 605.6k $5.1m | Added +5.1k |
| Avoro Capital Advisors LLC 0.06% of their portfolio | 545.0k $4.6m | New |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 430.4k $3.6m | New |
| GREAT LAKES ADVISORS, LLC 0.03% of their portfolio | 423.9k $3.6m | New |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.01% of their portfolio | 384.2k $3.2m | New |
| BARCLAYS PLC 0.00% of their portfolio | 365.7k $3.1m | Added +227.0k |
| Soleus Capital Management, L.P. 0.13% of their portfolio | 300.0k $2.5m | Reduced -430.0k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 287.5k $2.4m | Reduced -217.0k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 253.3k $2.1m | New |
| MORGAN STANLEY 0.00% of their portfolio | 251.8k $2.1m | Reduced -282.8k |
| STEMPOINT CAPITAL LP 0.42% of their portfolio | 245.4k $2.1m | Added +36.6k |
| READYSTATE ASSET MANAGEMENT LP 0.10% of their portfolio | 245.1k $2.1m | Reduced -173.4k |
| Cubist Systematic Strategies, LLC 0.03% of their portfolio | 240.7k $2.0m | New |
| FRED ALGER MANAGEMENT, LLC 0.01% of their portfolio | 230.3k $1.9m | Added +39.0k |
| CONGRESS ASSET MANAGEMENT CO 0.01% of their portfolio | 228.1k $1.9m | Added +926 |
| Fisher Asset Management, LLC 0.00% of their portfolio | 210.4k $1.8m | Reduced -13.7k |
| Trexquant Investment LP 0.02% of their portfolio | 199.1k $1.7m | New |
| TRV GP VI, LLC 1.49% of their portfolio | 194.2k $1.6m | Unchanged |
| Bank of New York Mellon Corp 0.00% of their portfolio | 192.3k $1.6m | Added +4.4k |
| UBS Group AG 0.00% of their portfolio | 160.5k $1.3m | Reduced -116.6k |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.05% of their portfolio | 157.2k $1.3m | Reduced -2.6k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 155.4k $1.3m | Added +108.3k |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 145.3k $1.2m | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 144.4k $1.2m | Added +122.2k |
| Blue Owl Capital Holdings LP 0.31% of their portfolio | 119.4k $1.0m | Reduced -695.0k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 107.8k $905.8k | Reduced -4.4k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 102.3k $859.1k | Reduced -3.7k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 94.1k $790.4k | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 88.8k $746.2k | Reduced -153.6k |
| ExodusPoint Capital Management, LP 0.01% of their portfolio | 81.2k $682.4k | New |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 79.2k $665.1k | Added +229 |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 67.8k $569.8k | Added +1.2k |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 60.0k $497.0k | Unchanged |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 59.1k $496.9k | Added +6.5k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 55.3k $464.5k | Reduced -10.2k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 55.0k $462.0k | Added +5.8k |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 53.6k $450.0k | New |
| MetLife Investment Management, LLC 0.00% of their portfolio | 47.7k $400.9k | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 40.7k $343.0k | Added +2.3k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 40.4k $339.6k | Reduced -1.6k |
| Y-Intercept (Hong Kong) Ltd 0.01% of their portfolio | 37.0k $310.5k | New |
| Quadrature Capital Ltd 0.00% of their portfolio | 36.2k $303.3k | New |
| Janney Montgomery Scott LLC 0.00% of their portfolio | 36.0k $302.0k | Reduced -3.5k |
| Creative Planning 0.00% of their portfolio | 35.2k $296.1k | New |
| Harvest Investment Services, LLC 0.05% of their portfolio | 31.8k $267.5k | New |
| PROFUND ADVISORS LLC 0.01% of their portfolio | 31.3k $262.8k | New |
| Clear Harbor Asset Management, LLC 0.02% of their portfolio | 30.3k $254.5k | Added +1 |
| J. Goldman & Co LP 0.01% of their portfolio | 29.0k $243.9k | New |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 28.2k $236.5k | Reduced -17.5k |
| Simplicity Wealth,LLC 0.01% of their portfolio | 27.0k $226.5k | Unchanged |
| EverSource Wealth Advisors, LLC 0.01% of their portfolio | 26.7k $223.9k | Added +22 |
| Verition Fund Management LLC 0.00% of their portfolio | 24.8k $207.9k | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 22.7k $190.6k | Reduced -6.1k |
| Virtus Investment Advisers, LLC 0.05% of their portfolio | 22.5k $189.3k | Added +3.9k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 21.5k $180.6k | Reduced -103.5k |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 20.5k $172.6k | Added +2.9k |
| Vanguard Personalized Indexing Management, LLC 0.00% of their portfolio | 20.2k $169.8k | Reduced -156 |
| China Universal Asset Management Co., Ltd. 0.01% of their portfolio | 19.5k $163.8k | Reduced -2.3k |
| CITIGROUP INC 0.00% of their portfolio | 18.1k $152.1k | Reduced -12.2k |
| TD Asset Management Inc 0.00% of their portfolio | 18.1k $151.8k | New |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 17.2k $144.4k | Added +6.9k |
| ProShare Advisors LLC 0.00% of their portfolio | 16.2k $136.3k | Reduced -3.5k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 15.6k $130.8k | Added +9.0k |