TANGO THERAPEUTICS INC TNGX
COM · Common Stock · CUSIP 87583X109
Company in Cambridge, United States
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersBoston, MA
- Founded2017
- Websitetangotx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($39.7k this quarter). Holder counts are more reliable. Shares outstanding: 107.4m as of 2024-11-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $3.09. Options: 3 managers hold calls ($4.3k notional), 2 hold puts ($13.6k).
Trends to Q4 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 87 |
| Q4 2022 | 83 |
| Q1 2023 | 93 |
| Q2 2023 | 90 |
| Q3 2023 | 101 |
| Q4 2023 | 122 |
| Q1 2024 | 127 |
| Q2 2024 | 121 |
| Q3 2024 | 122 |
| Q4 2024 | 139 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2023 | 44 | 30 |
| Q2 2023 | 31 | 46 |
| Q3 2023 | 55 | 37 |
| Q4 2023 | 73 | 36 |
| Q1 2024 | 58 | 56 |
| Q2 2024 | 56 | 59 |
| Q3 2024 | 54 | 51 |
| Q4 2024 | 74 | 55 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2024 | $19.1k | $12.7k | 0.67 |
| Q2 2024 | $22.3k | $8.6k | 0.38 |
| Q3 2024 | $23.9k | $16.6k | 0.69 |
| Q4 2024 | $4.3k | $13.6k | 3.14 |
Biggest buyers
| TCG Crossover Management, LLC | New | +10.7m |
| Nantahala Capital Management, LLC | New | +2.8m |
| Blue Owl Capital Holdings LP | New | +1.7m |
| SCHRODER INVESTMENT MANAGEMENT GROUP | New | +655.2k |
| Balyasny Asset Management L.P. | Added | +592.0k |
| ORBIMED ADVISORS LLC | New | +550.0k |
| JACOBS LEVY EQUITY MANAGEMENT, INC | New | +517.4k |
| ACADIAN ASSET MANAGEMENT LLC | New | +495.1k |
| Woodline Partners LP | New | +394.4k |
| VANGUARD GROUP INC | Added | +339.9k |
Biggest sellers
| FMR LLC | Reduced | -9.4m |
| Boxer Capital, LLC | Sold out | -8.2m |
| Southpoint Capital Advisors LP | Sold out | -5.0m |
| EcoR1 Capital, LLC | Reduced | -2.7m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Sold out | -2.3m |
| T. Rowe Price Investment Management, Inc. | Reduced | -1.7m |
| DEERFIELD MANAGEMENT COMPANY, L.P. | Sold out | -1.5m |
| STATE STREET CORP | Reduced | -1.1m |
| CITADEL ADVISORS LLC | Reduced | -1.1m |
| BAKER BROS. ADVISORS LP | Sold out | -750.0k |
Biggest calls
| CITADEL ADVISORS LLC | Reduced | $4.3k1.4k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
| SIMPLEX TRADING, LLC | New | $0100 shares |
Biggest puts
| CITADEL ADVISORS LLC | Added | $13.6k4.4k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
BCTG Holdings, LLC
13D · may seek influence
filed 2025-01-02
Stated purposeItem 4 is hereby amended by the addition of the following: The disclosure set forth above in Item 3 is hereby incorporated herein. Full filing |
10.0% |
| FARALLON PARTNERS L L C/CA 13G · passive investor filed 2026-02-06 | 10.0% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 13G · institution filed 2026-08-14 | 9.8% |
| RTW INVESTMENTS, LP 13G · institution new · filed 2026-05-15 | 9.3% |
| Farallon Capital Partners, L.P. 13G · passive investor -1.9 pts · filed 2026-05-11 | 7.8% |
| TCG Crossover GP II, LLC 13G · passive investor -1.1 pts · filed 2026-08-14 | 7.0% |
| FMR LLC 13G · institution +6.9 pts · filed 2026-05-06 | 6.9% |
| BlackRock, Inc. 13G · institution +1.3 pts · filed 2026-01-21 | 6.3% |
| GOLDMAN SACHS GROUP INC 13G · institution new · filed 2026-08-14 | 6.0% |
Fell to 5% or below in the last year: Woodline Partners LP (2.5%, 2026-08-14), Nextech Crossover I GP S.a r.l. (0.0%, 2026-08-14), Adage Capital Management, L.P. (3.4%, 2026-08-12), Invus Global Management, LLC (4.0%, 2026-05-04), VANGUARD GROUP INC (0.0%, 2026-03-27), EcoR1 Capital, LLC (0.0%, 2026-02-17), Third Rock Ventures IV, L.P. (4.7%, 2026-02-10)
Insider purchases and sales in Q4 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 0 | — | — |
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 0 | — | 1 | $63.0k | — |
| Q1 2024 | 0 | — | 4 | $302.3k | — |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 1 | $74.0k | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-11-18 | Rothenberg Mace Director | Bought | $37.8k10.0k shares |
| 2024-11-14 | Rothenberg Mace Director | Bought | $36.2k10.0k shares |
| 2024-11-07 | EcoR1 Capital, LLC 10% owner · See Note | Sold | $3.5m1.2m shares |
| 2024-11-06 | Davis Aaron I. +1 See remarks · See footnote | Sold | $9.7m3.1m shares |
| 2024-11-06 | EcoR1 Capital, LLC 10% owner · See Note | Sold | $4.9m1.5m shares |
| 2024-10-25 | Davis Aaron I. +1 See remarks. | Sold | $4.3m633.0k shares |
| 2024-10-22 | Davis Aaron I. +1 See remarks | Sold | $1.7m250.0k shares |
| 2024-10-21 | Davis Aaron I. +1 See remarks | Sold | $4.4m625.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2024
| Manager | Shares | Change |
|---|---|---|
| TRV GP IV, LLC 64.97% of their portfolio | 16.9m $52.1m | Unchanged |
| TCG Crossover Management, LLC 3.24% of their portfolio | 10.7m $33.2m | New |
| EcoR1 Capital, LLC 1.31% of their portfolio | 10.6m $32.8m | Reduced -2.7m |
| Boxer Capital Management, LLC 2.73% of their portfolio | 10.4m $32.1m | First filing |
| Nextech Invest Ltd. 2.77% of their portfolio | 5.5m $17.1m | Unchanged |
| GILEAD SCIENCES, INC. 0.97% of their portfolio | 4.9m $15.0m | First filing |
| BlackRock, Inc. 0.00% of their portfolio | 4.4m $13.5m | Added +17.2k |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 0.07% of their portfolio | 4.0m $12.4m | Not comparable |
| VANGUARD GROUP INC 0.00% of their portfolio | 4.0m $12.3m | Added +339.9k |
| T. Rowe Price Investment Management, Inc. 0.01% of their portfolio | 3.3m $10.3m | Reduced -1.7m |
| Balyasny Asset Management L.P. 0.02% of their portfolio | 3.3m $10.1m | Added +592.0k |
| Nantahala Capital Management, LLC 0.61% of their portfolio | 2.8m $8.7m | New |
| Bain Capital Life Sciences Investors, LLC 0.99% of their portfolio | 2.7m $8.4m | Unchanged |
| Siren, L.L.C. 0.36% of their portfolio | 2.6m $8.0m | Unchanged |
| Blue Owl Capital Holdings LP 1.23% of their portfolio | 1.7m $5.4m | New |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 1.6m $5.0m | Reduced -1.1m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.4m $4.3m | Added +18.2k |
| STATE STREET CORP 0.00% of their portfolio | 1.2m $3.8m | Reduced -1.1m |
| Casdin Capital, LLC 0.25% of their portfolio | 1.2m $3.7m | Unchanged |
| ArrowMark Colorado Holdings LLC 0.03% of their portfolio | 708.4k $2.2m | Unchanged |
| BESSEMER GROUP INC 0.00% of their portfolio | 708.4k $2.2m | Unchanged |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 662.8k $2.0m | Added +302.1k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 655.2k $2.0m | New |
| SAMSARA BIOCAPITAL, LLC 0.27% of their portfolio | 630.0k $1.9m | Unchanged |
| ORBIMED ADVISORS LLC 0.04% of their portfolio | 550.0k $1.7m | New |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.01% of their portfolio | 517.4k $1.6m | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 513.4k $1.6m | Added +26.2k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 513.1k $1.6m | Added +33.8k |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 495.1k $1.5m | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 486.9k $1.5m | Reduced -56.6k |
| SUPERSTRING CAPITAL MANAGEMENT LP 1.29% of their portfolio | 475.0k $1.5m | Reduced -124.1k |
| UBS Group AG 0.00% of their portfolio | 414.5k $1.3m | Reduced -26.4k |
| Woodline Partners LP 0.01% of their portfolio | 394.4k $1.2m | New |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.02% of their portfolio | 347.3k $1.1m | First filing |
| MORGAN STANLEY 0.00% of their portfolio | 320.1k $989.0k | Reduced -21.9k |
| Walleye Capital LLC 0.01% of their portfolio | 287.1k $887.0k | Added +144.5k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 272.2k $841.2k | Added +96.9k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 249.6k $771.4k | New |
| CONGRESS ASSET MANAGEMENT CO 0.00% of their portfolio | 228.0k $704.5k | Added +18.9k |
| TRV GP VI, LLC 0.51% of their portfolio | 194.2k $600.0k | First filing |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 192.3k $594.1k | Reduced -12.6k |
| ALGERT GLOBAL LLC 0.01% of their portfolio | 162.3k $501.5k | New |
| Fisher Asset Management, LLC 0.00% of their portfolio | 154.9k $478.8k | Unchanged |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 138.2k $427.2k | Reduced -5.0k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 126.6k $391.0k | Added +110.1k |
| ExodusPoint Capital Management, LP 0.00% of their portfolio | 122.0k $377.0k | New |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 114.8k $354.8k | New |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 110.4k $341.3k | Added +12.2k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 103.0k $318.3k | Reduced -8.7k |
| PDT Partners, LLC 0.03% of their portfolio | 102.8k $317.7k | New |
| BARCLAYS PLC 0.00% of their portfolio | 99.8k $308.3k | Reduced -26.5k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 95.2k $294.3k | Added +44.5k |
| Swiss National Bank 0.00% of their portfolio | 94.9k $293.2k | Added +11.0k |
| GSA CAPITAL PARTNERS LLP 0.02% of their portfolio | 86.4k $267.0k | Added +41.2k |
| Verition Fund Management LLC 0.00% of their portfolio | 81.0k $250.4k | Added +49.0k |
| XTX Topco Ltd 0.02% of their portfolio | 77.9k $240.8k | Added +33.7k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 76.6k $236.5k | Added +1.2k |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 70.5k $217.7k | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 65.7k $203.1k | Added +1.9k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 64.9k $200.7k | Unchanged |
| Aristides Capital LLC 0.06% of their portfolio | 64.3k $198.7k | New |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 60.6k $187.3k | Reduced -2.7k |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 60.0k $438.0k | Unchanged |
| Ensign Peak Advisors, Inc 0.00% of their portfolio | 57.3k $177.1k | Added +28.7k |
| Nebula Research & Development LLC 0.02% of their portfolio | 51.9k $160.4k | Added +41.0k |
| Jain Global LLC 0.00% of their portfolio | 49.8k $153.9k | First filing |
| CITIGROUP INC 0.00% of their portfolio | 47.0k $145.2k | Added +8.3k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 45.0k $139.1k | Added +4.2k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 45.0k $139.0k | Reduced -23.2k |
| Janney Montgomery Scott LLC 0.00% of their portfolio | 40.0k $124.0k | Unchanged |
| Legal & General Group Plc 0.00% of their portfolio | 38.0k $117.3k | Unchanged |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 36.7k $113.3k | Added +7.1k |
| Graham Capital Management, L.P. 0.00% of their portfolio | 34.8k $107.5k | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 31.3k $96.8k | Reduced -74.4k |
| HRT FINANCIAL LP 0.00% of their portfolio | 31.1k $96.0k | New |
| Invesco Ltd. 0.00% of their portfolio | 29.5k $91.3k | Added +584 |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 27.9k $86.3k | Reduced -3.0k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 27.4k $84.7k | Reduced -2.9k |
| Simplicity Wealth,LLC 0.02% of their portfolio | 27.0k $83.3k | Unchanged |
| Catalina Capital Group, LLC 0.03% of their portfolio | 26.6k $82.2k | New |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 26.2k $81.0k | New |
| Clear Harbor Asset Management, LLC 0.01% of their portfolio | 25.5k $78.8k | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 25.3k $78.1k | Added +9.0k |
| VIRTUS ADVISERS, LLC 0.03% of their portfolio | 24.9k $77.1k | Added +14.0k |
| Corton Capital Inc. 0.04% of their portfolio | 24.4k $75.4k | New |
| Corebridge Financial, Inc. 0.00% of their portfolio | 23.7k $73.3k | Reduced -1.8k |
| China Universal Asset Management Co., Ltd. 0.01% of their portfolio | 22.8k $70.4k | Added +2.2k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 22.3k $68.9k | Added +7.6k |
| SG Americas Securities, LLC 0.00% of their portfolio | 22.0k $68.0k | Added +2.3k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 21.5k $66.4k | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 21.0k $65.0k | Added +4.8k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 19.6k $60.7k | Reduced -8.6k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 19.3k $59.6k | Added +69 |
| ProShare Advisors LLC 0.00% of their portfolio | 18.5k $57.2k | Added +3.2k |
| EXCHANGE TRADED CONCEPTS, LLC 0.00% of their portfolio | 17.4k $53.8k | Unchanged |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 15.1k $46.8k | Reduced -1.2k |
| Sequoia Financial Advisors, LLC 0.00% of their portfolio | 14.6k $45.2k | New |
| TEACHER RETIREMENT SYSTEM OF TEXAS 0.00% of their portfolio | 14.5k $45.0k | Added +3.8k |
| ARIZONA STATE RETIREMENT SYSTEM 0.00% of their portfolio | 14.0k $43.2k | Added +1.7k |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio | 13.5k $41.7k | Reduced -332 |