TANGO THERAPEUTICS INC TNGX
COM · Common Stock · CUSIP 87583X109
Company in Cambridge, United States
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersBoston, MA
- Founded2017
- Websitetangotx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($320.8k this quarter). Holder counts are more reliable. Shares outstanding: 168.6m as of 2026-08-04, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $30.87. Options: 7 managers hold calls ($11.2m notional), 3 hold puts ($6.6m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 87 |
| Q4 2022 | 83 |
| Q1 2023 | 93 |
| Q2 2023 | 90 |
| Q3 2023 | 101 |
| Q4 2023 | 122 |
| Q1 2024 | 127 |
| Q2 2024 | 121 |
| Q3 2024 | 122 |
| Q4 2024 | 139 |
| Q1 2025 | 123 |
| Q2 2025 | 116 |
| Q3 2025 | 141 |
| Q4 2025 | 170 |
| Q1 2026 | 194 |
| Q2 2026 | 248 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 54 | 51 |
| Q4 2024 | 74 | 55 |
| Q1 2025 | 57 | 68 |
| Q2 2025 | 62 | 59 |
| Q3 2025 | 85 | 45 |
| Q4 2025 | 124 | 49 |
| Q1 2026 | 116 | 88 |
| Q2 2026 | 174 | 77 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $1.6m | $172.8k | 0.11 |
| Q4 2025 | $840.8k | $265.8k | 0.32 |
| Q1 2026 | $2.1m | $1.9m | 0.88 |
| Q2 2026 | $11.2m | $6.6m | 0.59 |
Biggest buyers
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +5.5m |
| GOLDMAN SACHS GROUP INC | Added | +4.9m |
| BlackRock, Inc. | Added | +3.7m |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | Added | +3.2m |
| Seven Fleet Capital Management LP | Added | +2.7m |
| PERCEPTIVE ADVISORS LLC | Added | +2.6m |
| FMR LLC | Added | +2.4m |
| Paradigm Biocapital Advisors LP | Added | +2.3m |
| Commodore Capital LP | New | +2.2m |
| Jefferies Financial Group Inc. | New | +2.0m |
Biggest sellers
| Nextech Invest Ltd. | Sold out | -7.3m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Reduced | -7.2m |
| Woodline Partners LP | Reduced | -4.0m |
| Balyasny Asset Management L.P. | Reduced | -1.8m |
| Bellevue Group AG | Reduced | -1.7m |
| Holocene Advisors, LP | Reduced | -1.5m |
| TCG Crossover Management, LLC | Reduced | -1.4m |
| MORGAN STANLEY | Reduced | -966.7k |
| Vivo Capital, LLC | Reduced | -775.0k |
| Sofinnova Investments, Inc. | Sold out | -395.1k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $3.9m124.4k shares |
| Balyasny Asset Management L.P. | New | $3.1m100.0k shares |
| CITADEL ADVISORS LLC | Added | $3.0m95.7k shares |
| JANE STREET GROUP, LLC | New | $750.2k24.0k shares |
| STEMPOINT CAPITAL LP | New | $175.0k100.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $131.3k4.2k shares |
| GROUP ONE TRADING LLC | Reduced | $115.7k3.7k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $2.9m93.9k shares |
| CITADEL ADVISORS LLC | Added | $2.0m62.5k shares |
| JANE STREET GROUP, LLC | Added | $1.7m54.4k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
BCTG Holdings, LLC
13D · may seek influence
filed 2025-01-02
Stated purposeItem 4 is hereby amended by the addition of the following: The disclosure set forth above in Item 3 is hereby incorporated herein. Full filing |
10.0% |
| FARALLON PARTNERS L L C/CA 13G · passive investor filed 2026-02-06 | 10.0% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 13G · institution filed 2026-08-14 | 9.8% |
| RTW INVESTMENTS, LP 13G · institution new · filed 2026-05-15 | 9.3% |
| Farallon Capital Partners, L.P. 13G · passive investor -1.9 pts · filed 2026-05-11 | 7.8% |
| TCG Crossover GP II, LLC 13G · passive investor -1.1 pts · filed 2026-08-14 | 7.0% |
| FMR LLC 13G · institution +6.9 pts · filed 2026-05-06 | 6.9% |
| BlackRock, Inc. 13G · institution +1.3 pts · filed 2026-01-21 | 6.3% |
| GOLDMAN SACHS GROUP INC 13G · institution new · filed 2026-08-14 | 6.0% |
Fell to 5% or below in the last year: Woodline Partners LP (2.5%, 2026-08-14), Nextech Crossover I GP S.a r.l. (0.0%, 2026-08-14), Adage Capital Management, L.P. (3.4%, 2026-08-12), Invus Global Management, LLC (4.0%, 2026-05-04), VANGUARD GROUP INC (0.0%, 2026-03-27), EcoR1 Capital, LLC (0.0%, 2026-02-17), Third Rock Ventures IV, L.P. (4.7%, 2026-02-10)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 1 | $74.0k | 0 | — | — |
| Q1 2025 | 0 | — | 4 | $143.2k | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 0 | — | — |
| Q1 2026 | 0 | — | 3 | $2.0m | $1.2m |
| Q2 2026 | 0 | — | 1 | $2.7m | $2.7m |
| Q3 2026 | 0 | — | 2 | $2.3m | $2.3m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-09-22 | Newcomb Jessica Principal Accounting Officer | Sold plan | $198.6k8.2k shares |
| 2026-09-01 | Crystal Adam President, R&D | Sold plan | $604.0k27.0k shares |
| 2026-08-03 | Crystal Adam President, R&D | Sold plan | $735.5k27.0k shares |
| 2026-07-01 | Crystal Adam President, R&D | Sold plan | $798.9k27.0k shares |
| 2026-06-01 | Crystal Adam President, R&D | Sold plan | $617.6k27.0k shares |
| 2026-05-01 | Crystal Adam President, R&D | Sold plan | $573.0k27.0k shares |
| 2026-04-15 | Crystal Adam President, R&D | Sold plan | $961.5k38.5k shares |
| 2026-04-01 | Crystal Adam President, R&D | Sold plan | $572.4k27.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| RTW INVESTMENTS, LP 3.71% of their portfolio | 13.9m $434.5m | Added +600.0k |
| BlackRock, Inc. 0.01% of their portfolio | 12.4m $388.8m | Added +3.7m |
| FMR LLC 0.02% of their portfolio | 12.3m $385.5m | Added +2.4m |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 2.25% of their portfolio | 12.3m $383.8m | Added +3.2m |
| Boxer Capital Management, LLC 25.61% of their portfolio | 10.9m $340.0m | Unchanged |
| GOLDMAN SACHS GROUP INC 0.03% of their portfolio | 10.0m $312.0m | Added +4.9m |
| TCG Crossover Management, LLC 6.82% of their portfolio | 9.1m $283.9m | Reduced -1.4m |
| TRV GP IV, LLC 47.37% of their portfolio | 6.4m $120.2m | Unchanged |
| Paradigm Biocapital Advisors LP 3.72% of their portfolio | 6.4m $198.7m | Added +2.3m |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio | 6.3m $198.5m | Added +5.5m |
| Siren, L.L.C. 3.92% of their portfolio | 6.2m $193.2m | Added +522.3k |
| STATE STREET CORP 0.01% of their portfolio | 6.0m $186.9m | Added +1.3m |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 6.0m $186.2m | Added +795.9k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.25% of their portfolio | 5.6m $175.1m | Reduced -7.2m |
| Jupiter Topco LLC 0.06% of their portfolio | 5.1m $158.0m | First filing |
| Deep Track Capital, LP 1.93% of their portfolio | 4.2m $131.3m | Added +1.4m |
| DEERFIELD MANAGEMENT COMPANY, L.P. 1.37% of their portfolio | 4.2m $131.0m | Added +43.8k |
| Woodline Partners LP 0.39% of their portfolio | 4.0m $125.1m | Reduced -4.0m |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 3.7m $117.0m | Added +1.1m |
| PERCEPTIVE ADVISORS LLC 1.64% of their portfolio | 3.4m $105.6m | Added +2.6m |
| Seven Fleet Capital Management LP 15.79% of their portfolio | 3.2m $95.7m | Added +2.7m |
| Logos Global Management LP 3.84% of their portfolio | 2.9m $89.1m | Reduced -150.0k |
| Caligan Partners LP 3.77% of their portfolio | 2.5m $78.2m | Added +91.3k |
| Holocene Advisors, LP 0.17% of their portfolio | 2.4m $75.4m | Reduced -1.5m |
| Commodore Capital LP 4.19% of their portfolio | 2.2m $70.3m | New |
| Balyasny Asset Management L.P. 0.12% of their portfolio | 2.0m $63.0m | Reduced -1.8m |
| Jefferies Financial Group Inc. 0.58% of their portfolio | 2.0m $62.8m | New |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 1.9m $59.0m | Added +590.9k |
| Candriam S.C.A. 0.23% of their portfolio | 1.6m $50.9m | Added +361.3k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 1.6m $49.6m | Added +683.6k |
| Polar Capital Holdings Plc 0.13% of their portfolio | 1.5m $46.3m | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.4m $46.3m | Added +1.4m |
| Vivo Capital, LLC 3.94% of their portfolio | 1.4m $43.1m | Reduced -775.0k |
| DV EQUITIES, LLC 5.98% of their portfolio | 1.3m $41.2m | First filing |
| Cormorant Asset Management, LP 2.08% of their portfolio | 1.3m $40.6m | Reduced -125.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 1.2m $38.5m | Added +369.0k |
| STEMPOINT CAPITAL LP 6.62% of their portfolio | 1.2m $38.2m | Added +821.2k |
| FEDERATED HERMES, INC. 0.05% of their portfolio | 1.2m $38.0m | Added +1.2m |
| VOYA INVESTMENT MANAGEMENT LLC 0.03% of their portfolio | 1.1m $34.5m | Added +927.6k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 1.1m $33.5m | Added +233.4k |
| AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio | 1.0m $31.7m | New |
| Nantahala Capital Management, LLC 0.95% of their portfolio | 1.0m $31.3m | Reduced -249.1k |
| Integral Health Asset Management, LLC 1.28% of their portfolio | 1.0m $31.3m | Added +550.0k |
| VANGUARD FIDUCIARY TRUST CO 0.01% of their portfolio | 915.6k $28.6m | Added +252.6k |
| Nuveen, LLC 0.01% of their portfolio | 890.2k $27.8m | Added +529.4k |
| SAMLYN CAPITAL, LLC 0.40% of their portfolio | 766.5k $24.0m | New |
| RENAISSANCE TECHNOLOGIES LLC 0.03% of their portfolio | 748.3k $23.4m | New |
| Soleus Capital Management, L.P. 0.76% of their portfolio | 709.0k $22.2m | Added +259.0k |
| ArrowMark Colorado Holdings LLC 0.92% of their portfolio | 708.4k $22.1m | Unchanged |
| Bellevue Group AG 0.46% of their portfolio | 694.2k $21.7m | Reduced -1.7m |
| Alyeska Investment Group, L.P. 0.06% of their portfolio | 691.1k $21.6m | Added +673.9k |
| Assenagon Asset Management S.A. 0.01% of their portfolio | 690.3k $21.6m | New |
| Connor, Clark & Lunn Investment Management Ltd. 0.04% of their portfolio | 636.1k $19.9m | Added +280.8k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 600.8k $18.8m | Added +273.7k |
| Pictet Asset Management Holding SA 0.02% of their portfolio | 582.3k $18.3m | New |
| Fisher Asset Management, LLC 0.01% of their portfolio | 578.2k $18.1m | Added +415.8k |
| LORD, ABBETT & CO. LLC 0.05% of their portfolio | 532.1k $16.6m | New |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 514.3k $16.1m | New |
| MORGAN STANLEY 0.00% of their portfolio | 510.8k $16.0m | Reduced -966.7k |
| FIRST TRUST ADVISORS LP 0.01% of their portfolio | 509.3k $15.9m | New |
| BOOTHBAY FUND MANAGEMENT, LLC 0.29% of their portfolio | 500.5k $15.6m | Reduced -70.9k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 496.0k $15.5m | Added +70.4k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 488.3k $15.3m | Reduced -1.0k |
| Invesco Ltd. 0.00% of their portfolio | 462.7k $14.5m | Reduced -117.7k |
| Rock Springs Capital Management LP 0.70% of their portfolio | 456.6k $14.3m | Added +69.6k |
| BOONE CAPITAL MANAGEMENT LLC 3.33% of their portfolio | 455.6k $14.2m | New |
| Longaeva Partners L.P. 0.37% of their portfolio | 414.9k $13.0m | New |
| EVENTIDE ASSET MANAGEMENT, LLC 0.17% of their portfolio | 400.0k $12.5m | New |
| ACUTA CAPITAL PARTNERS, LLC 8.52% of their portfolio | 390.9k $12.2m | Reduced -50.9k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 390.9k $12.2m | Added +72.5k |
| UBS Group AG 0.00% of their portfolio | 383.7k $12.0m | Reduced -315.7k |
| CONGRESS ASSET MANAGEMENT CO 0.07% of their portfolio | 380.7k $11.9m | Added +39.4k |
| BESSEMER GROUP INC 0.02% of their portfolio | 354.2k $11.1m | Reduced -354.2k |
| Mass General Brigham, Inc 3.07% of their portfolio | 354.2k $11.1m | Unchanged |
| LMR Partners LLP 0.08% of their portfolio | 347.1k $10.9m | New |
| BAKER BROS. ADVISORS LP 0.05% of their portfolio | 333.3k $10.4m | New |
| PFM Health Sciences, LP 0.88% of their portfolio | 326.0k $10.2m | Reduced -80.2k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 306.3k $9.6m | Reduced -199.8k |
| Point72 Asset Management, L.P. 0.01% of their portfolio | 298.3k $9.3m | Reduced -235.6k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 297.1k $9.3m | Added +7.9k |
| Handelsbanken Fonder AB 0.03% of their portfolio | 287.9k $9.0m | New |
| Russell Investments Group, Ltd. 0.01% of their portfolio | 281.6k $8.8m | Added +268.8k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio | 278.5k $9.1m | Added +71.0k |
| ALGERT GLOBAL LLC 0.10% of their portfolio | 271.6k $8.5m | Added +125.9k |
| HighVista Strategies LLC 1.85% of their portfolio | 260.1k $8.1m | Added +155.9k |
| SPHERA FUNDS MANAGEMENT LTD. 1.14% of their portfolio | 254.2k $7.9m | Reduced -89.3k |
| T. Rowe Price Investment Management, Inc. 0.01% of their portfolio | 252.1k $7.9m | Reduced -187.9k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 241.8k $7.6m | Added +68.7k |
| KVP Capital Advisors, LP 5.28% of their portfolio | 230.3k $7.2m | Unchanged |
| TD Asset Management Inc 0.01% of their portfolio | 222.0k $6.9m | Added +119.4k |
| Sio Capital Management, LLC 1.12% of their portfolio | 208.5k $6.5m | New |
| Atle Fund Management AB 1.67% of their portfolio | 198.6k $6.2m | Added +168.6k |
| TRV GP VI, LLC 2.61% of their portfolio | 194.2k $6.1m | Unchanged |
| Walleye Capital LLC 0.03% of their portfolio | 192.3k $6.0m | New |
| Swiss National Bank 0.00% of their portfolio | 187.4k $5.9m | Added +99.6k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 181.2k $5.7m | Added +73.0k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 181.1k $5.7m | Added +1.6k |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 176.7k $5.5m | Added +123.9k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 175.1k $5.5m | Added +48.5k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 174.9k $5.5m | New |