SYNDAX PHARMACEUTICALS INC SNDX
COM · Common Stock · CUSIP 87164F105
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNew York, NY
- Websitesyndax.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($337.6k this quarter). Holder counts are more reliable. Shares outstanding: 86.9m as of 2025-10-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $21.01. Options: 13 managers hold calls ($30.0m notional), 11 hold puts ($14.4m).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 139 |
| Q4 2022 | 160 |
| Q1 2023 | 164 |
| Q2 2023 | 167 |
| Q3 2023 | 176 |
| Q4 2023 | 178 |
| Q1 2024 | 191 |
| Q2 2024 | 197 |
| Q3 2024 | 211 |
| Q4 2024 | 217 |
| Q1 2025 | 220 |
| Q2 2025 | 218 |
| Q3 2025 | 228 |
| Q4 2025 | 230 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 112 | 73 |
| Q2 2024 | 112 | 77 |
| Q3 2024 | 120 | 83 |
| Q4 2024 | 115 | 90 |
| Q1 2025 | 119 | 84 |
| Q2 2025 | 115 | 99 |
| Q3 2025 | 124 | 98 |
| Q4 2025 | 109 | 109 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $18.1m | $7.9m | 0.44 |
| Q2 2025 | $14.4m | $12.5m | 0.87 |
| Q3 2025 | $25.0m | $12.5m | 0.50 |
| Q4 2025 | $30.0m | $14.4m | 0.48 |
Biggest buyers
| Hood River Capital Management LLC | New | +2.3m |
| VANGUARD GROUP INC | Added | +1.1m |
| BANK OF AMERICA CORP /DE/ | Added | +1.0m |
| Ensign Peak Advisors, Inc | Added | +789.5k |
| STATE STREET CORP | Added | +743.0k |
| Point72 Asset Management, L.P. | Added | +627.0k |
| ExodusPoint Capital Management, LP | Added | +482.3k |
| TWO SIGMA INVESTMENTS, LP | Added | +434.3k |
| Brevan Howard Capital Management LP | Added | +390.6k |
| SPHERA FUNDS MANAGEMENT LTD. | Added | +374.8k |
Biggest sellers
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Sold out | -3.3m |
| Assenagon Asset Management S.A. | Reduced | -1.7m |
| MILLENNIUM MANAGEMENT LLC | Reduced | -994.5k |
| UBS Group AG | Reduced | -958.3k |
| Qube Research & Technologies Ltd | Reduced | -956.7k |
| BNP PARIBAS FINANCIAL MARKETS | Reduced | -585.6k |
| Kynam Capital Management, LP | Reduced | -469.0k |
| Catalio Capital Management, LP | Reduced | -417.9k |
| BlackRock, Inc. | Reduced | -386.2k |
| Zimmer Partners, LP | Sold out | -383.1k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $9.1m434.1k shares |
| Caption Management, LLC | Reduced | $8.9m424.5k shares |
| CITADEL ADVISORS LLC | Added | $2.9m137.2k shares |
| UBS Group AG | Unchanged | $1.5m72.3k shares |
| NOMURA HOLDINGS INC | New | $1.2m58.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $1.2m57.0k shares |
| GROUP ONE TRADING LLC | Reduced | $1.1m50.1k shares |
| MILLENNIUM MANAGEMENT LLC | New | $1.1m50.0k shares |
| TUDOR INVESTMENT CORP ET AL | New | $1.0m48.3k shares |
| JANE STREET GROUP, LLC | New | $979.1k46.6k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $5.5m262.5k shares |
| Caption Management, LLC | Reduced | $2.7m130.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $1.2m59.1k shares |
| Jefferies Financial Group Inc. | Unchanged | $1.1m50.1k shares |
| CITADEL ADVISORS LLC | Reduced | $989.6k47.1k shares |
| NOMURA HOLDINGS INC | New | $798.4k38.0k shares |
| JANE STREET GROUP, LLC | Reduced | $699.6k33.3k shares |
| CITIGROUP INC | New | $630.3k30.0k shares |
| Walleye Capital LLC | Reduced | $292.0k13.9k shares |
| Walleye Trading LLC | Added | $287.8k13.7k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Kynam Capital Management, LP 13G · institution filed 2025-02-14 | 10.0% |
| BlackRock, Inc. 13G · institution filed 2025-04-17 | 7.8% |
| GOLDMAN SACHS GROUP INC 13G · institution +1.3 pts · filed 2025-08-13 | 6.5% |
| STATE STREET CORP 13G · institution +1.1 pts · filed 2026-08-07 | 6.4% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.0% |
Fell to 5% or below in the last year: Point72 Asset Management, L.P. (2.3%, 2026-05-15), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 1 | $25.0k | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 3 | $453.7k | $117.6k |
| Q2 2025 | 4 | $241.9k | 0 | — | — |
| Q3 2025 | 0 | — | 3 | $3.5m | $3.5m |
| Q4 2025 | 0 | — | 0 | — | — |
None reported in Q4 2025.
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.00% of their portfolio | 8.2m $173.1m | Reduced -386.2k |
| Kynam Capital Management, LP 11.01% of their portfolio | 8.1m $169.2m | Reduced -469.0k |
| VANGUARD GROUP INC 0.00% of their portfolio | 6.2m $130.9m | Added +1.1m |
| GOLDMAN SACHS GROUP INC 0.02% of their portfolio | 5.7m $119.7m | Added +208.9k |
| Point72 Asset Management, L.P. 0.16% of their portfolio | 4.9m $102.6m | Added +627.0k |
| BANK OF AMERICA CORP /DE/ 0.01% of their portfolio | 4.7m $99.0m | Added +1.0m |
| STATE STREET CORP 0.00% of their portfolio | 4.6m $96.6m | Added +743.0k |
| Eversept Partners, LP 3.90% of their portfolio | 3.3m $69.6m | Reduced -152.9k |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 2.4m $50.9m | Added +31.1k |
| KINGDON CAPITAL MANAGEMENT, L.L.C. 7.56% of their portfolio | 2.4m $49.4m | Reduced -150.0k |
| Hood River Capital Management LLC 0.53% of their portfolio | 2.3m $48.7m | New |
| Soleus Capital Management, L.P. 2.00% of their portfolio | 2.2m $47.2m | Added +235.0k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 2.1m $43.9m | Reduced -399 |
| Elmind Capital, LP 11.50% of their portfolio | 1.9m $39.0m | First filing |
| Ensign Peak Advisors, Inc 0.06% of their portfolio | 1.6m $33.6m | Added +789.5k |
| Nuveen, LLC 0.01% of their portfolio | 1.5m $31.2m | Added +7.2k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.03% of their portfolio | 1.4m $28.9m | Added +139.6k |
| STEMPOINT CAPITAL LP 4.83% of their portfolio | 1.3m $28.1m | Reduced -26.8k |
| MPM BIOIMPACT LLC 3.22% of their portfolio | 1.3m $28.1m | Reduced -38.0k |
| Aisling Capital Management LP 5.78% of their portfolio | 1.3m $27.7m | Unchanged |
| Woodline Partners LP 0.10% of their portfolio | 1.3m $26.3m | Reduced -299.9k |
| EVENTIDE ASSET MANAGEMENT, LLC 0.41% of their portfolio | 1.2m $26.0m | Added +249.7k |
| D. E. Shaw & Co., Inc. 0.02% of their portfolio | 1.2m $25.6m | Added +142.0k |
| Catalio Capital Management, LP 4.44% of their portfolio | 1.2m $25.1m | Reduced -417.9k |
| TWO SIGMA INVESTMENTS, LP 0.04% of their portfolio | 1.1m $24.1m | Added +434.3k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 1.1m $23.0m | Added +41.8k |
| MORGAN STANLEY 0.00% of their portfolio | 1.1m $22.6m | Reduced -123.8k |
| ALGERT GLOBAL LLC 0.30% of their portfolio | 928.1k $19.5m | Reduced -2.7k |
| AQR CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 926.0k $19.5m | Added +367.9k |
| Candriam S.C.A. 0.10% of their portfolio | 925.3k $19.4m | Unchanged |
| Palo Alto Investors LP 2.32% of their portfolio | 794.5k $16.7m | Added +139.6k |
| SPHERA FUNDS MANAGEMENT LTD. 3.35% of their portfolio | 762.6k $16.0m | Added +374.8k |
| JANE STREET GROUP, LLC 0.02% of their portfolio | 748.9k $15.7m | Added +10.7k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 728.9k $15.3m | Reduced -47.8k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 727.4k $15.3m | Added +8.4k |
| Apis Capital Advisors, LLC 2.65% of their portfolio | 724.0k $15.2m | Added +86.0k |
| UBS Group AG 0.00% of their portfolio | 716.2k $15.0m | Reduced -958.3k |
| Qube Research & Technologies Ltd 0.02% of their portfolio | 688.1k $14.5m | Reduced -956.7k |
| Prosight Management, LP 2.89% of their portfolio | 665.0k $14.0m | Reduced -338.4k |
| SILVERARC CAPITAL MANAGEMENT, LLC 1.95% of their portfolio | 642.9k $13.5m | Added +179.2k |
| TWO SIGMA ADVISERS, LP 0.03% of their portfolio | 632.8k $13.3m | Added +249.7k |
| Parkman Healthcare Partners LLC 1.15% of their portfolio | 574.0k $12.1m | Reduced -272.9k |
| ExodusPoint Capital Management, LP 0.13% of their portfolio | 554.8k $11.7m | Added +482.3k |
| RENAISSANCE TECHNOLOGIES LLC 0.02% of their portfolio | 544.8k $11.4m | Reduced -315.7k |
| Brevan Howard Capital Management LP 0.21% of their portfolio | 515.1k $10.8m | Added +390.6k |
| Rhenman & Partners Asset Management AB 0.96% of their portfolio | 487.0k $10.2m | Reduced -87.0k |
| Knott David M Jr 4.04% of their portfolio | 415.0k $8.7m | Reduced -13.0k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 378.5k $8.0m | Reduced -129.2k |
| Aberdeen Group plc 0.01% of their portfolio | 372.8k $7.8m | Unchanged |
| Granahan Investment Management, LLC 0.33% of their portfolio | 366.8k $7.7m | Reduced -29.5k |
| BARCLAYS PLC 0.00% of their portfolio | 314.7k $6.6m | Reduced -33.4k |
| Pale Fire Capital SE 0.77% of their portfolio | 284.5k $6.0m | New |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 282.6k $5.9m | Added +187.1k |
| DAFNA Capital Management LLC 1.36% of their portfolio | 277.9k $5.8m | Reduced -222.8k |
| SECTOR GAMMA AS 1.21% of their portfolio | 252.1k $5.3m | Added +41.2k |
| PFM Health Sciences, LP 0.52% of their portfolio | 243.0k $5.1m | Reduced -13.5k |
| CAPITAL FUND MANAGEMENT S.A. 0.05% of their portfolio | 233.9k $4.9m | Reduced -107.3k |
| CANADA PENSION PLAN INVESTMENT BOARD 0.00% of their portfolio | 229.6k $4.8m | Unchanged |
| Pinnacle Financial Partners, Inc. 0.03% of their portfolio | 206.6k $4.3m | First filing |
| Integral Health Asset Management, LLC 0.21% of their portfolio | 200.0k $4.2m | New |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group 2.05% of their portfolio | 200.0k $4.2m | Unchanged |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 184.0k $3.9m | Reduced -362.3k |
| Hennion & Walsh Asset Management, Inc. 0.13% of their portfolio | 183.8k $3.9m | Added +129.1k |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.01% of their portfolio | 180.0k $3.8m | First filing |
| Hudson Bay Capital Management LP 0.02% of their portfolio | 165.0k $3.5m | Reduced -85.0k |
| Jump Financial, LLC 0.04% of their portfolio | 163.9k $3.4m | Added +31.2k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 161.9k $3.4m | Added +20.1k |
| Swiss National Bank 0.00% of their portfolio | 161.4k $3.4m | Added +2.9k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 160.8k $3.4m | Added +103.9k |
| Invesco Ltd. 0.00% of their portfolio | 160.5k $3.4m | Added +27.4k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 159.6k $3.4m | Added +116.2k |
| Y-Intercept (Hong Kong) Ltd 0.07% of their portfolio | 155.9k $3.3m | Added +55.1k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 142.4k $3.0m | Added +8.1k |
| Atom Investors LP 0.24% of their portfolio | 141.7k $3.0m | New |
| FMR LLC 0.00% of their portfolio | 140.6k $3.0m | Added +135.5k |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.00% of their portfolio | 137.6k $2.9m | New |
| Velan Capital Investment Management LP 1.59% of their portfolio | 130.0k $2.7m | Unchanged |
| SG Americas Securities, LLC 0.00% of their portfolio | 129.2k $2.7m | Added +83.8k |
| PANAGORA ASSET MANAGEMENT INC 0.01% of their portfolio | 125.1k $2.6m | Reduced -30.2k |
| Voss Capital, LP 0.14% of their portfolio | 125.0k $2.6m | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 118.8k $2.5m | Reduced -12.9k |
| Yelin Lapidot Holdings Management Ltd. 0.46% of their portfolio | 108.4k $2.3m | Unchanged |
| NEOS Investment Management LLC 0.01% of their portfolio | 101.6k $2.1m | Reduced -8.5k |
| Tema ETFs LLC 0.16% of their portfolio | 100.1k $2.1m | Reduced -10.0k |
| Ishara Investments LP 2.45% of their portfolio | 100.0k $2.1m | First filing |
| IEQ CAPITAL, LLC 0.01% of their portfolio | 99.9k $2.1m | Added +44.7k |
| Torray Investment Partners LLC 0.29% of their portfolio | 97.8k $2.1m | New |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 94.9k $2.0m | Reduced -31.8k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 94.8k $2.0m | Added +3.7k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 89.6k $1.9m | Added +10.1k |
| Trexquant Investment LP 0.02% of their portfolio | 87.5k $1.8m | New |
| Legal & General Group Plc 0.00% of their portfolio | 78.2k $1.6m | Reduced -6.3k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 78.2k $1.6m | Reduced -88 |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 75.9k $1.6m | Reduced -22.4k |
| DARK FOREST CAPITAL MANAGEMENT LP 0.07% of their portfolio | 72.7k $1.5m | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 66.6k $1.4m | Reduced -5.9k |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 65.3k $874.1k | Added +10.1k |
| SECTORAL ASSET MANAGEMENT INC 1.03% of their portfolio | 61.2k $1.3m | Reduced -18.2k |
| PROFUND ADVISORS LLC 0.04% of their portfolio | 60.0k $1.3m | Added +29.2k |
| Pavaki Capital Management LLC 0.88% of their portfolio | 60.0k $1.3m | First filing |