SYNDAX PHARMACEUTICALS INC SNDX
COM · Common Stock · CUSIP 87164F105
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNew York, NY
- Websitesyndax.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 69.6m as of 2023-10-27, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $21.61. Options: 11 managers hold calls ($20.0m notional), 8 hold puts ($14.9m).
Trends to Q4 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 139 |
| Q4 2022 | 160 |
| Q1 2023 | 164 |
| Q2 2023 | 167 |
| Q3 2023 | 176 |
| Q4 2023 | 178 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 95 | 51 |
| Q1 2023 | 106 | 57 |
| Q2 2023 | 104 | 63 |
| Q3 2023 | 95 | 70 |
| Q4 2023 | 111 | 77 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2023 | $2.0m | $3.5m | 1.77 |
| Q2 2023 | $2.2m | $4.7m | 2.10 |
| Q3 2023 | $66.1m | $67.5m | 1.02 |
| Q4 2023 | $20.0m | $14.9m | 0.74 |
Biggest buyers
| MORGAN STANLEY | Added | +2.8m |
| Kynam Capital Management, LP | Added | +2.1m |
| BVF INC/IL | New | +1.9m |
| Avoro Capital Advisors LLC | Added | +1.7m |
| T. Rowe Price Investment Management, Inc. | Added | +1.6m |
| Woodline Partners LP | Added | +1.5m |
| MARSHALL WACE, LLP | Added | +1.5m |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | New | +1.5m |
| STATE STREET CORP | Added | +1.4m |
| FRANKLIN RESOURCES INC | New | +1.4m |
Biggest sellers
| Hudson Bay Capital Management LP | Sold out | -2.5m |
| Paradigm Biocapital Advisors LP | Sold out | -2.4m |
| JENNISON ASSOCIATES LLC | Reduced | -2.3m |
| PFM Health Sciences, LP | Reduced | -2.1m |
| Commodore Capital LP | Sold out | -957.5k |
| Frazier Life Sciences Management, L.P. | Sold out | -600.0k |
| LORD, ABBETT & CO. LLC | Sold out | -425.9k |
| ACUTA CAPITAL PARTNERS, LLC | Sold out | -297.0k |
| Saturn V Capital Management LP | Reduced | -289.2k |
| RENAISSANCE TECHNOLOGIES LLC | Sold out | -218.3k |
Biggest calls
| Nantahala Capital Management, LLC | Added | $8.6m400.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $3.1m143.9k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $2.8m129.0k shares |
| JANE STREET GROUP, LLC | Reduced | $2.4m109.5k shares |
| Caption Management, LLC | Reduced | $862.2k39.9k shares |
| CITADEL ADVISORS LLC | Reduced | $834.1k38.6k shares |
| GROUP ONE TRADING LLC | Reduced | $548.9k25.4k shares |
| Belvedere Trading LLC | New | $432.2k20.0k shares |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | Reduced | $326.2k75.0k shares |
| Walleye Capital LLC | New | $88.6k4.1k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $3.2m148.6k shares |
| SIMPLEX TRADING, LLC | Added | $3.2m148.2k shares |
| BANK OF AMERICA CORP /DE/ | Added | $3.1m144.0k shares |
| CITADEL ADVISORS LLC | Reduced | $2.9m133.8k shares |
| GROUP ONE TRADING LLC | Reduced | $1.4m66.6k shares |
| Caption Management, LLC | Reduced | $862.2k39.9k shares |
| Walleye Capital LLC | New | $140.5k6.5k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Kynam Capital Management, LP 13G · institution filed 2025-02-14 | 10.0% |
| BlackRock, Inc. 13G · institution filed 2025-04-17 | 7.8% |
| GOLDMAN SACHS GROUP INC 13G · institution +1.3 pts · filed 2025-08-13 | 6.5% |
| STATE STREET CORP 13G · institution +1.1 pts · filed 2026-08-07 | 6.4% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.0% |
Fell to 5% or below in the last year: Point72 Asset Management, L.P. (2.3%, 2026-05-15), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q4 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2022 | 0 | — | 2 | $39.6k | — |
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 6 | $16.7m | — |
| Q4 2022 | 0 | — | 3 | $1.9m | — |
| Q1 2023 | 0 | — | 4 | $4.5m | — |
| Q2 2023 | 0 | — | 2 | $3.3m | $3.3m |
| Q3 2023 | 0 | — | 2 | $3.7m | $3.7m |
| Q4 2023 | 0 | — | 0 | — | — |
None reported in Q4 2023.
Holders, Q4 2023
| Manager | Shares | Change |
|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP 0.03% of their portfolio | 7.6m $163.9m | Reduced -57.2k |
| BlackRock Inc. 0.00% of their portfolio | 7.0m $151.6m | Added +1.1m |
| Kynam Capital Management, LP 13.84% of their portfolio | 5.7m $122.3m | Added +2.1m |
| STATE STREET CORP 0.01% of their portfolio | 5.0m $108.4m | Added +1.4m |
| VANGUARD GROUP INC 0.00% of their portfolio | 4.3m $93.7m | Added +718.1k |
| Avoro Capital Advisors LLC 1.26% of their portfolio | 4.2m $91.2m | Added +1.7m |
| Avidity Partners Management LP 3.26% of their portfolio | 4.0m $85.4m | Added +1.1m |
| Eversept Partners, LP 7.17% of their portfolio | 3.4m $73.1m | Added +787.0k |
| MORGAN STANLEY 0.00% of their portfolio | 3.3m $71.9m | Added +2.8m |
| Point72 Asset Management, L.P. 0.19% of their portfolio | 2.8m $61.3m | Added +740.3k |
| T. Rowe Price Investment Management, Inc. 0.04% of their portfolio | 2.7m $58.6m | Added +1.6m |
| MARSHALL WACE, LLP 0.09% of their portfolio | 2.1m $45.4m | Added +1.5m |
| BVF INC/IL 1.01% of their portfolio | 1.9m $40.5m | New |
| ORBIMED ADVISORS LLC 0.76% of their portfolio | 1.7m $37.8m | Added +465.0k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.6m $33.8m | Added +832.8k |
| Woodline Partners LP 0.36% of their portfolio | 1.5m $33.4m | Added +1.5m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.5m $33.2m | Added +174.1k |
| KINGDON CAPITAL MANAGEMENT, L.L.C. 3.08% of their portfolio | 1.5m $32.3m | New |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 1.4m $29.2m | New |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 1.3m $27.0m | Reduced -16.8k |
| Cormorant Asset Management, LP 1.22% of their portfolio | 1.2m $25.4m | New |
| STEMPOINT CAPITAL LP 6.80% of their portfolio | 1.1m $23.7m | First filing |
| Sofinnova Investments, Inc. 1.30% of their portfolio | 1.1m $23.2m | Added +134.0k |
| Aisling Capital Management LP 6.61% of their portfolio | 1.0m $22.2m | Unchanged |
| Candriam S.C.A. 0.15% of their portfolio | 1.0m $22.1m | Added +781.0k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 984.3k $21.3m | Added +724.4k |
| MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio | 942.6k $20.4m | Added +502.9k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.04% of their portfolio | 900.0k $19.4m | Reduced -100.0k |
| Foresite Capital Management IV, LLC 9.56% of their portfolio | 875.0k $18.9m | Unchanged |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.06% of their portfolio | 780.0k $16.9m | New |
| SPHERA FUNDS MANAGEMENT LTD. 3.10% of their portfolio | 773.0k $16.7m | Reduced -97 |
| DAFNA Capital Management LLC 3.85% of their portfolio | 742.6k $16.0m | Added +284.2k |
| Parkman Healthcare Partners LLC 2.26% of their portfolio | 738.6k $16.0m | Added +526.1k |
| Nantahala Capital Management, LLC 0.79% of their portfolio | 730.5k $15.8m | Added +490.5k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 678.1k $14.7m | Added +42.6k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 624.0k $13.5m | Added +450.6k |
| PFM Health Sciences, LP 0.77% of their portfolio | 595.5k $12.9m | Reduced -2.1m |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 577.0k $12.5m | Added +70.6k |
| TWO SIGMA INVESTMENTS, LP 0.03% of their portfolio | 535.9k $11.6m | Added +104.4k |
| ALGERT GLOBAL LLC 0.46% of their portfolio | 528.2k $11.4m | Added +71.9k |
| Saturn V Capital Management LP 4.29% of their portfolio | 518.8k $11.2m | Reduced -289.2k |
| Ensign Peak Advisors, Inc 0.02% of their portfolio | 514.9k $11.1m | Unchanged |
| Soleus Capital Management, L.P. 1.23% of their portfolio | 514.0k $11.1m | Added +394.5k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 506.0k $10.9m | Added +6.5k |
| Palo Alto Investors LP 0.92% of their portfolio | 472.6k $10.2m | Unchanged |
| Schonfeld Strategic Advisors LLC 0.08% of their portfolio | 471.5k $10.2m | Added +253.1k |
| Assenagon Asset Management S.A. 0.03% of their portfolio | 412.0k $8.9m | Added +21.4k |
| Rafferty Asset Management, LLC 0.04% of their portfolio | 403.4k $8.7m | Added +119.3k |
| ExodusPoint Capital Management, LP 0.09% of their portfolio | 353.3k $7.6m | Added +197.5k |
| Granahan Investment Management, LLC 0.23% of their portfolio | 320.9k $6.9m | New |
| UBS Group AG 0.00% of their portfolio | 290.8k $6.3m | Added +215.4k |
| Zimmer Partners, LP 0.22% of their portfolio | 275.1k $5.9m | New |
| BARCLAYS PLC 0.00% of their portfolio | 255.9k $5.5m | Reduced -166.1k |
| MACQUARIE GROUP LTD 0.01% of their portfolio | 244.1k $5.3m | Added +11.6k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 243.0k $5.3m | Reduced -192.5k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 230.9k $5.0m | Added +3.4k |
| PEREGRINE CAPITAL MANAGEMENT LLC 0.13% of their portfolio | 196.0k $4.2m | Reduced -23.9k |
| PANAGORA ASSET MANAGEMENT INC 0.02% of their portfolio | 174.1k $3.8m | Added +82.6k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 166.0k $3.6m | Added +117.1k |
| Balyasny Asset Management L.P. 0.01% of their portfolio | 165.0k $3.6m | Added +16.5k |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 162.9k $3.5m | Added +44.9k |
| CITIGROUP INC 0.00% of their portfolio | 162.4k $3.5m | Added +42.2k |
| State of New Jersey Common Pension Fund D 0.01% of their portfolio | 159.8k $3.5m | Added +26.8k |
| TWO SIGMA ADVISERS, LP 0.01% of their portfolio | 151.5k $3.3m | Added +84.4k |
| Casdin Capital, LLC 0.32% of their portfolio | 150.0k $3.2m | New |
| Trexquant Investment LP 0.07% of their portfolio | 143.5k $3.1m | New |
| Verition Fund Management LLC 0.03% of their portfolio | 143.3k $3.1m | Added +128.3k |
| Swiss National Bank 0.00% of their portfolio | 142.4k $3.1m | Added +21.4k |
| Walleye Capital LLC 0.04% of their portfolio | 127.9k $2.8m | New |
| Yelin Lapidot Holdings Management Ltd. 0.60% of their portfolio | 114.5k $2.5m | Reduced -114.5k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 109.3k $2.4m | Added +3.2k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 107.1k $2.3m | Reduced -43.1k |
| Crestline Management, L.P. 0.20% of their portfolio | 100.6k $2.2m | Reduced -33.8k |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.07% of their portfolio | 95.9k $2.1m | Not comparable |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 95.3k $2.1m | Reduced -3.7k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 93.1k $2.0m | Added +16.4k |
| SECTORAL ASSET MANAGEMENT INC 0.86% of their portfolio | 92.1k $2.0m | New |
| AXIOM INVESTORS LLC /DE 0.02% of their portfolio | 86.2k $1.9m | Added +75.4k |
| TWINBEECH CAPITAL LP 0.03% of their portfolio | 83.5k $1.8m | Reduced -104.7k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 78.8k $1.7m | Added +24.3k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 77.5k $1.7m | Unchanged |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 75.4k $1.6m | Added +12.2k |
| CREDIT SUISSE AG/ 0.00% of their portfolio | 72.8k $1.6m | Added +1.6k |
| TUDOR INVESTMENT CORP ET AL 0.02% of their portfolio | 69.0k $1.5m | Added +39.0k |
| Polar Asset Management Partners Inc. 0.04% of their portfolio | 67.1k $1.5m | New |
| PROFUND ADVISORS LLC 0.06% of their portfolio | 65.2k $1.4m | Added +17.1k |
| SIMPLEX TRADING, LLC 0.04% of their portfolio | 64.0k $1.4m | New |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 57.4k $1.2m | Reduced -149.0k |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 55.2k $1.2m | Added +12.1k |
| Legal & General Group Plc 0.00% of their portfolio | 55.1k $1.2m | Added +4.9k |
| Lighthouse Investment Partners, LLC 0.08% of their portfolio | 52.2k $1.1m | New |
| Squarepoint Ops LLC 0.00% of their portfolio | 52.0k $1.1m | Added +22.9k |
| JENNISON ASSOCIATES LLC 0.00% of their portfolio | 50.8k $1.1m | Reduced -2.3m |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 48.7k $1.1m | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 48.5k $1.0m | Reduced -1.4k |
| ALPS ADVISORS INC 0.01% of their portfolio | 48.1k $1.0m | Reduced -3.1k |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 46.9k $1.0m | Added +4.7k |
| Parallax Volatility Advisers, L.P. 0.02% of their portfolio | 42.0k $907.3k | Added +28.2k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 42.0k $906.9k | Reduced -106.6k |
| FMR LLC 0.00% of their portfolio | 40.7k $879.4k | Reduced -3.3k |