SURROZEN INC SRZN
COM NEW · Common Stock · CUSIP 86889P208
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSouth San Francisco, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 8.6m as of 2025-11-05, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $21.48.
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q4 2023 | 17 |
| Q1 2024 | 16 |
| Q2 2024 | 21 |
| Q3 2024 | 23 |
| Q4 2024 | 24 |
| Q1 2025 | 30 |
| Q2 2025 | 31 |
| Q3 2025 | 35 |
| Q4 2025 | 54 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 6 | 4 |
| Q2 2024 | 12 | 6 |
| Q3 2024 | 8 | 7 |
| Q4 2024 | 8 | 9 |
| Q1 2025 | 17 | 3 |
| Q2 2025 | 12 | 5 |
| Q3 2025 | 15 | 7 |
| Q4 2025 | 39 | 9 |
Biggest buyers
| MILLENNIUM MANAGEMENT LLC | Added | +611.5k |
| Boxer Capital Management, LLC | New | +416.1k |
| BRAIDWELL LP | Added | +330.0k |
| Woodline Partners LP | Added | +182.4k |
| SILVERARC CAPITAL MANAGEMENT, LLC | New | +157.3k |
| Balyasny Asset Management L.P. | Added | +119.8k |
| FRED ALGER MANAGEMENT, LLC | New | +99.6k |
| 5AM Venture Management, LLC | Added | +77.5k |
| Ikarian Capital, LLC | New | +65.8k |
| AMERIPRISE FINANCIAL INC | New | +65.7k |
Biggest sellers
| RA CAPITAL MANAGEMENT, L.P. | Sold out | -602.6k |
| SAMSARA BIOCAPITAL, LLC | Sold out | -241.4k |
| Stonepine Capital Management, LLC | Reduced | -136.5k |
| STEMPOINT CAPITAL LP | Reduced | -93.7k |
| Board of Trustees of The Leland Stanford Junior University | Sold out | -52.1k |
| Trustees of Columbia University in the City of New York | Sold out | -47.9k |
| WOLVERINE ASSET MANAGEMENT LLC | Sold out | -281 |
| BARCLAYS PLC | Sold out | -13 |
| SBI Securities Co., Ltd. | Sold out | -2 |
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
COLUMN GROUP III GP, LP
13D · may seek influence
-7.8 pts · filed 2026-10-22
Stated purposeThe information set forth in Item 4 of the Original Schedule 13D is incorporated herein by reference. Full filing |
21.5% |
| Boxer Capital Management, LLC 13G · institution +2.7 pts · filed 2026-10-07 | 11.6% |
Column Group IV GP, LP
13D · may seek influence
new · filed 2026-02-12
Stated purposeThe information set forth in Item 3 of this Statement is incorporated herein by reference. The Reporting Persons hold the securities of the Issuer for general investment purposes. The Reporting Persons may, from time to time, depending on prevailing market, economic and other conditions, acquire additional shares of Common Stock or other securities of the Issuer, dispose of any such securities, or engage in discussions with the Issuer concerning such acquisitions or dispositions or further investments in the Issuer. The Reporting Persons intend to review their investment in the Issuer on a continuing basis and, depending upon the price and availability of shares of Common Stock or other securities of the Issuer, subsequent developments affecting the Issuer, the Issuer's business and prospe… Full filing |
11.6% |
| TCG Crossover GP II, LLC 13G · passive investor -2.8 pts · filed 2026-07-24 | 9.9% |
| Venrock Healthcare Capital Partners III, L.P. 13G · passive investor no change · filed 2026-05-15 | 9.9% |
| AI Biotechnology LLC 13G · passive investor new · filed 2025-03-31 | 9.9% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor -0.7 pts · filed 2026-02-17 | 9.2% |
| INTEGRATED CORE STRATEGIES (US) LLC 13G · passive investor +1.9 pts · filed 2026-02-05 | 8.5% |
| 5AM Partners VII, LLC 13G · passive investor -1.7 pts · filed 2026-08-11 | 7.8% |
| Commodore Capital LP 13G · passive investor new · filed 2026-10-01 | 7.5% |
| Point72 Asset Management, L.P. 13G · passive investor new · filed 2026-04-23 | 5.4% |
| STEMPOINT CAPITAL LP 13G · institution +0.5 pts · filed 2026-08-14 | 5.0% |
Fell to 5% or below in the last year: BRAIDWELL LP (3.9%, 2026-08-14), Nantahala Capital Management, LLC (2.1%, 2026-05-15), Stonepine Capital Management, LLC (3.6%, 2026-02-13)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 3 | $3.0m | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 2 | $35.2k | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 1 | $4.7m | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-12-05 | Kutzkey Tim Director · By The Column Group III-A, LP | Bought | $320.1k16.4k shares |
| 2025-12-05 | COLUMN GROUP III-A, LP +5 10% owner · By The Column Group III-A, LP | Bought | $320.1k16.4k shares |
| 2025-12-05 | COLUMN GROUP III-A, LP +5 10% owner · By The Column Group III, LP | Bought | $283.4k14.5k shares |
| 2025-12-05 | Kutzkey Tim Director · By The Column Group III, LP | Bought | $283.4k14.5k shares |
| 2025-12-04 | Kutzkey Tim Director · By The Column Group III-A, LP | Bought | $48.4k2.8k shares |
| 2025-12-04 | COLUMN GROUP III-A, LP +5 10% owner · By The Column Group III-A, LP | Bought | $48.4k2.8k shares |
| 2025-12-04 | Kutzkey Tim Director · By The Column Group III, LP | Bought | $42.9k2.5k shares |
| 2025-12-04 | COLUMN GROUP III-A, LP +5 10% owner · By The Column Group III, LP | Bought | $42.9k2.5k shares |
| 2025-11-13 | COLUMN GROUP III-A, LP +5 10% owner · By The Column Group III-A, LP | Bought | $2.1m167.3k shares |
| 2025-11-13 | Kutzkey Tim Director · By The Column Group III-A, LP | Bought | $2.1m167.3k shares |
| 2025-11-13 | COLUMN GROUP III-A, LP +5 10% owner · By The Column Group III, LP | Bought | $1.9m148.2k shares |
| 2025-11-13 | Kutzkey Tim Director · By The Column Group III, LP | Bought | $1.9m148.2k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 721.3k $16.3m | Added +611.5k |
| Venrock Adviser, LLC 0.71% of their portfolio | 632.9k $14.3m | Unchanged |
| STEMPOINT CAPITAL LP 2.17% of their portfolio | 619.8k $12.7m | Reduced -93.7k |
| BRAIDWELL LP 0.34% of their portfolio | 470.0k $10.6m | Added +330.0k |
| Spruce Street Capital LP 3.23% of their portfolio | 432.0k $9.8m | First filing |
| Boxer Capital Management, LLC 2.06% of their portfolio | 416.1k $9.4m | New |
| 5AM Venture Management, LLC 2.75% of their portfolio | 387.5k $8.8m | Added +77.5k |
| Kalehua Capital Management LLC 1.87% of their portfolio | 385.2k $1.9m | First filing |
| VANGUARD GROUP INC 0.00% of their portfolio | 319.2k $7.2m | Added +52.8k |
| REGENTS OF THE UNIVERSITY OF CALIFORNIA 0.12% of their portfolio | 266.4k $6.0m | Unchanged |
| Vivo Capital, LLC 0.38% of their portfolio | 260.0k $5.9m | Unchanged |
| Woodline Partners LP 0.02% of their portfolio | 230.6k $5.2m | Added +182.4k |
| Nantahala Capital Management, LLC 0.31% of their portfolio | 229.5k $5.2m | Unchanged |
| Balyasny Asset Management L.P. 0.01% of their portfolio | 190.5k $4.3m | Added +119.8k |
| ACUTA CAPITAL PARTNERS, LLC 2.74% of their portfolio | 178.4k $4.0m | Unchanged |
| SILVERARC CAPITAL MANAGEMENT, LLC 0.51% of their portfolio | 157.3k $3.6m | New |
| Stonepine Capital Management, LLC 2.03% of their portfolio | 113.6k $2.6m | Reduced -136.5k |
| Empery Asset Management, LP 2.07% of their portfolio | 104.0k $2.3m | First filing |
| FRED ALGER MANAGEMENT, LLC 0.01% of their portfolio | 99.6k $2.3m | New |
| Eversept Partners, LP 0.12% of their portfolio | 95.3k $2.2m | Added +18.3k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.00% of their portfolio | 88.7k $2.0m | Unchanged |
| Euclidean Capital LLC 0.54% of their portfolio | 87.7k $2.0m | Unchanged |
| Schonfeld Strategic Advisors LLC 0.01% of their portfolio | 74.6k $1.7m | Added +5.6k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 67.0k $1.5m | Added +12.5k |
| Ikarian Capital, LLC 0.19% of their portfolio | 65.8k $1.5m | New |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 65.7k $1.5m | New |
| ArrowMark Colorado Holdings LLC 0.03% of their portfolio | 55.1k $1.2m | Unchanged |
| 683 Capital Management, LLC 0.08% of their portfolio | 42.0k $949.2k | New |
| Walleye Capital LLC 0.01% of their portfolio | 41.0k $927.5k | New |
| MORGAN STANLEY 0.00% of their portfolio | 37.0k $835.3k | Added +2.2k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 29.6k $669.1k | Added +29.6k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 27.6k $624.3k | New |
| BlackRock, Inc. 0.00% of their portfolio | 26.1k $590.3k | Added +12.4k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 25.8k $583.6k | New |
| STATE STREET CORP 0.00% of their portfolio | 24.3k $549.8k | Added +11.0k |
| LMR Partners LLP 0.01% of their portfolio | 23.6k $532.4k | New |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 22.6k $511.3k | Added +7.9k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 21.7k $491.0k | Unchanged |
| Brevan Howard Capital Management LP 0.01% of their portfolio | 18.9k $427.6k | New |
| BOOTHBAY FUND MANAGEMENT, LLC 0.01% of their portfolio | 18.3k $413.7k | New |
| Quadrature Capital Ltd 0.00% of their portfolio | 14.8k $334.5k | New |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 14.7k $333.1k | Added +865 |
| OMERS ADMINISTRATION Corp 0.00% of their portfolio | 13.7k $309.6k | New |
| NORTHERN TRUST CORP 0.00% of their portfolio | 13.5k $305.8k | New |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 13.5k $304.4k | New |
| MARSHALL WACE, LLP 0.00% of their portfolio | 10.9k $247.2k | New |
| Alyeska Investment Group, L.P. 0.00% of their portfolio | 10.2k $230.2k | Unchanged |
| Persistent Asset Partners Ltd 0.05% of their portfolio | 4.4k $98.5k | New |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 2.5k $57.0k | New |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 1.5k $34.0k | New |
| China Universal Asset Management Co., Ltd. 0.00% of their portfolio | 1.5k $33.9k | Added +500 |
| CITIGROUP INC 0.00% of their portfolio | 1.1k $24.0k | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 65 $1.0k | New |
| UBS Group AG 0.00% of their portfolio | 59 $1.3k | New |