STOKE THERAPEUTICS INC STOK
COM · Common Stock · CUSIP 86150R107 · ISIN US86150R1077
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersBedford, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($280.8k this quarter). Holder counts are more reliable. Shares outstanding: 39.4m as of 2022-10-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $9.23. Options: 3 managers hold calls ($182.8k notional), 2 hold puts ($40.6k).
Trends to Q4 2022
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 105 |
| Q4 2022 | 108 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $308.0k | $5.6m | 18.07 |
| Q4 2022 | $182.8k | $40.6k | 0.22 |
Biggest buyers
| BAKER BROS. ADVISORS LP | Added | +739.6k |
| Granahan Investment Management, LLC | Added | +291.2k |
| RTW INVESTMENTS, LP | Added | +219.2k |
| NORGES BANK | Added | +199.9k |
| BlackRock Inc. | Added | +123.4k |
| ACADIAN ASSET MANAGEMENT LLC | New | +77.2k |
| HRT FINANCIAL LP | Added | +49.0k |
| D. E. Shaw & Co., Inc. | Added | +42.7k |
| CITADEL ADVISORS LLC | Added | +37.7k |
| Trexquant Investment LP | Added | +37.7k |
Biggest sellers
| Avidity Partners Management LP | Sold out | -891.1k |
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -651.3k |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | Reduced | -468.7k |
| VANGUARD GROUP INC | Reduced | -445.9k |
| BANK OF MONTREAL /CAN/ | Reduced | -341.4k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -236.8k |
| Redmile Group, LLC | Reduced | -193.4k |
| MORGAN STANLEY | Reduced | -158.4k |
| FMR LLC | Reduced | -147.9k |
| ALGERT GLOBAL LLC | Reduced | -69.8k |
Biggest calls
| CITADEL ADVISORS LLC | New | $140.3k15.2k shares |
| GROUP ONE TRADING LLC | Added | $42.5k4.6k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CITADEL ADVISORS LLC | New | $40.6k4.4k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| RTW INVESTMENTS, LP 13G · institution -0.1 pts · filed 2026-05-15 | 9.9% |
| FMR LLC 13G · institution -1.3 pts · filed 2026-08-06 | 8.5% |
| BlackRock, Inc. 13G · institution +1.0 pts · filed 2025-10-17 | 6.8% |
| Redmile Group, LLC 13G · passive investor -1.3 pts · filed 2026-05-15 | 6.7% |
| Lynx1 Capital Management LP 13G · passive investor -1.6 pts · filed 2026-08-14 | 6.5% |
| MORGAN STANLEY 13G · institution filed 2025-02-03 | 6.5% |
| BAKER BROS. ADVISORS LP 13G · institution filed 2026-02-17 | 5.8% |
| BIOTECHNOLOGY VALUE FUND L P 13G · passive investor new · filed 2026-09-30 | 5.6% |
| WELLINGTON MANAGEMENT GROUP LLP 13G · institution new · filed 2026-05-15 | 5.2% |
Fell to 5% or below in the last year: TORONTO DOMINION BANK (4.9%, 2026-08-12), VANGUARD GROUP INC (0.0%, 2026-03-27), Cowen Financial Products LLC (0.0%, 2025-11-14)
Insider purchases and sales in Q4 2022
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2021 | 0 | — | 0 | — | — |
| Q2 2021 | 0 | — | 0 | — | — |
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 1 | $417.8k | — |
| Q1 2022 | 0 | — | 1 | $87.7k | — |
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
None reported in Q4 2022.
Holders, Q4 2022
| Manager | Shares | Change |
|---|---|---|
| Skorpios Trust 42.40% of their portfolio | 14.4m $133.3m | Unchanged |
| RTW INVESTMENTS, LP 0.73% of their portfolio | 3.9m $35.7m | Added +219.2k |
| FMR LLC 0.00% of their portfolio | 3.0m $28.0m | Reduced -147.9k |
| MORGAN STANLEY 0.00% of their portfolio | 2.5m $22.6m | Reduced -158.4k |
| BlackRock Inc. 0.00% of their portfolio | 1.8m $16.9m | Added +123.4k |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.6m $14.8m | Reduced -445.9k |
| BAKER BROS. ADVISORS LP 0.06% of their portfolio | 1.1m $10.2m | Added +739.6k |
| Cormorant Asset Management, LP 0.67% of their portfolio | 1.1m $10.0m | Unchanged |
| Octagon Capital Advisors LP 1.10% of their portfolio | 763.5k $7.0m | Unchanged |
| COWEN AND COMPANY, LLC 0.73% of their portfolio | 748.1k $6.9m | Reduced -21.1k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 747.8k $6.9m | Reduced -39.1k |
| Redmile Group, LLC 0.24% of their portfolio | 642.4k $5.9m | Reduced -193.4k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 612.1k $5.6m | Reduced -651.3k |
| Granahan Investment Management, LLC 0.16% of their portfolio | 550.2k $5.1m | Added +291.2k |
| M28 Capital Management LP 4.25% of their portfolio | 482.9k $4.5m | Reduced -39.7k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 474.2k $4.4m | Added +14.0k |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.02% of their portfolio | 428.2k $4.0m | Reduced -468.7k |
| BANK OF MONTREAL /CAN/ 0.00% of their portfolio | 427.9k $4.0m | Reduced -341.4k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 419.2k $3.9m | Reduced -236.8k |
| STATE STREET CORP 0.00% of their portfolio | 413.7k $3.8m | Added +2.3k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 395.1k $3.6m | Reduced -17.2k |
| NORGES BANK 0.00% of their portfolio | 394.3k $3.6m | Added +199.9k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 309.5k $2.9m | Added +37.7k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 292.0k $2.7m | Reduced -47.0k |
| Artal Group S.A. 0.13% of their portfolio | 250.0k $2.3m | Unchanged |
| NORTHERN TRUST CORP 0.00% of their portfolio | 198.5k $1.8m | Reduced -5.2k |
| SPHERA FUNDS MANAGEMENT LTD. 0.55% of their portfolio | 188.6k $1.7m | Added +31.4k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 164.9k $1.5m | Added +2.6k |
| HRT FINANCIAL LP 0.01% of their portfolio | 108.3k $999.0k | Added +49.0k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 104.6k $965.0k | Reduced -22.2k |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 91.6k $845.6k | Reduced -2.7k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 90.8k $837.9k | Added +10.6k |
| Trexquant Investment LP 0.02% of their portfolio | 87.5k $807.9k | Added +37.7k |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 77.2k $711.0k | New |
| Fort Point Capital Partners LLC 0.12% of their portfolio | 75.4k $696.2k | Reduced -60.6k |
| GSA CAPITAL PARTNERS LLP 0.08% of their portfolio | 71.6k $661.0k | Reduced -3.6k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 68.8k $635.3k | Added +42.7k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 67.9k $626.4k | Reduced -44.4k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 62.6k $578.0k | Reduced -37.8k |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 56.1k $518.0k | Added +15.9k |
| Cubist Systematic Strategies, LLC 0.00% of their portfolio | 49.0k $452.0k | Added +34.3k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 45.2k $410.0k | Reduced -33 |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 44.3k $409.3k | Added +29.1k |
| PDT Partners, LLC 0.06% of their portfolio | 40.5k $373.5k | Added +24.9k |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 40.4k $373.0k | Added +12.2k |
| Swiss National Bank 0.00% of their portfolio | 37.2k $343.4k | Unchanged |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 36.6k $337.8k | Added +11.0k |
| Tower Research Capital LLC (TRC) 0.01% of their portfolio | 34.5k $319.0k | Added +31.1k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 34.2k $316.0k | Added +475 |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 31.6k $291.3k | Added +14.5k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 30.4k $280.6k | Added +2.9k |
| Balyasny Asset Management L.P. 0.00% of their portfolio | 29.0k $268.0k | Added +17.6k |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 28.7k $264.9k | New |
| Ergoteles LLC 0.01% of their portfolio | 27.4k $253.0k | New |
| ALPS ADVISORS INC 0.00% of their portfolio | 26.7k $246.9k | Added +5.2k |
| TD Asset Management Inc 0.00% of their portfolio | 26.2k $241.7k | Unchanged |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 25.0k $230.9k | Added +19.2k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 23.9k $220.0k | Added +291 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 22.9k $211.5k | Added +569 |
| GILDER GAGNON HOWE & CO LLC 0.00% of their portfolio | 22.6k $208.6k | Reduced -35.3k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 21.8k $200.8k | Reduced -16.0k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 20.6k $190.4k | Added +3.3k |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 18.6k $171.5k | Reduced -1.2k |
| BARCLAYS PLC 0.00% of their portfolio | 18.4k $170.2k | First filing |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 18.3k $169.0k | Unchanged |
| VIRGINIA RETIREMENT SYSTEMS ET Al 0.00% of their portfolio | 17.1k $157.8k | Added +1.9k |
| VIRTUS ADVISERS, LLC 0.08% of their portfolio | 16.7k $154.3k | Added +6.7k |
| Jump Financial, LLC 0.01% of their portfolio | 15.6k $143.5k | Added +5.6k |
| Allspring Global Investments Holdings, LLC 0.00% of their portfolio | 15.3k $141.2k | New |
| Birchview Capital, LP 0.10% of their portfolio | 15.0k $138.0k | Unchanged |
| UBS Group AG 0.00% of their portfolio | 14.7k $136.0k | Added +11.0k |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 14.4k $133.2k | Added +3.4k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 14.4k $132.9k | Added +3 |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. 0.02% of their portfolio | 13.9k $128.6k | New |
| MetLife Investment Management, LLC 0.00% of their portfolio | 11.6k $107.3k | Unchanged |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 10.7k $98.0k | New |
| AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio | 10.6k $98.0k | Reduced -39 |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio | 10.5k $96.7k | Reduced -3.5k |
| ALGERT GLOBAL LLC 0.01% of their portfolio | 10.1k $93.2k | Reduced -69.8k |
| CREDIT SUISSE AG/ 0.00% of their portfolio | 9.9k $91.0k | Added +20 |
| Legal & General Group Plc 0.00% of their portfolio | 6.3k $58.1k | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 5.0k $46.0k | Added +4.7k |
| Quantbot Technologies LP 0.00% of their portfolio | 3.3k $30.4k | New |
| AMALGAMATED BANK 0.00% of their portfolio | 2.9k $26.0k | Unchanged |
| CANADA LIFE ASSURANCE Co 0.00% of their portfolio | 2.3k $21.0k | Added +476 |
| Point72 Middle East FZE 0.00% of their portfolio | 1.7k $15.9k | First filing |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 1.5k $13.9k | Unchanged |
| LAZARD ASSET MANAGEMENT LLC 0.00% of their portfolio | 1.5k $13.0k | New |
| Metropolitan Life Insurance Co/NY 0.00% of their portfolio | 1.4k $12.9k | Added +77 |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 1.4k $12.8k | Unchanged |
| CITIGROUP INC 0.00% of their portfolio | 1.0k $9.6k | Reduced -152 |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 900 $8.3k | New |
| SIGNATUREFD, LLC 0.00% of their portfolio | 568 $5.2k | Added +451 |
| Lindbrook Capital, LLC 0.00% of their portfolio | 558 $5.2k | Added +554 |
| US BANCORP \DE\ 0.00% of their portfolio | 491 $4.5k | Reduced -944 |
| China Universal Asset Management Co., Ltd. 0.00% of their portfolio | 401 $3.7k | Added +32 |
| QUADRANT CAPITAL GROUP LLC 0.00% of their portfolio | 366 $3.4k | New |
| Endurance Wealth Management, Inc. 0.00% of their portfolio | 300 $3.0k | Unchanged |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 192 $1.0k | Reduced -128 |
| Daiwa Securities Group Inc. 0.00% of their portfolio | 126 $1.0k | Unchanged |