Vault-13

STOKE THERAPEUTICS INC STOK

COM · Common Stock · CUSIP 86150R107 · ISIN US86150R1077

108 institutional holders +3 vs Q3 2022
40,254,66440.3m shares reported held*
102.1% of all shares outstanding*
$371.6mreported value*
13 new 43 added 33 reduced 12 sold out net sold ≈ $18.4m (-2.0m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($280.8k this quarter). Holder counts are more reliable. Shares outstanding: 39.4m as of 2022-10-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $9.23. Options: 3 managers hold calls ($182.8k notional), 2 hold puts ($40.6k).

Trends to Q4 2022

Institutional holders

Managers reporting a position, each quarter

050100150Q3 22: 105Q4 22: 108108Q3 22Q4 22
Numbers
QuarterHolders
Q3 2022105
Q4 2022108

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$2m$4m$6mQ3 22 calls: $308.0kQ3 22 puts: $5.6mQ3 22P/C 18.07Q4 22 calls: $182.8kQ4 22 puts: $40.6kQ4 22P/C 0.22
Numbers
QuarterCallsPutsP/C
Q3 2022$308.0k$5.6m18.07
Q4 2022$182.8k$40.6k0.22

Biggest buyers

BAKER BROS. ADVISORS LP Added +739,586+739.6k
Granahan Investment Management, LLC Added +291,205+291.2k
RTW INVESTMENTS, LP Added +219,158+219.2k
NORGES BANK Added +199,900+199.9k
BlackRock Inc. Added +123,444+123.4k
ACADIAN ASSET MANAGEMENT LLC New +77,194+77.2k
HRT FINANCIAL LP Added +48,963+49.0k
D. E. Shaw & Co., Inc. Added +42,700+42.7k
CITADEL ADVISORS LLC Added +37,725+37.7k
Trexquant Investment LP Added +37,673+37.7k

Biggest sellers

Avidity Partners Management LP Sold out -891,100-891.1k
WELLINGTON MANAGEMENT GROUP LLP Reduced -651,345-651.3k
HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND Reduced -468,700-468.7k
VANGUARD GROUP INC Reduced -445,859-445.9k
BANK OF MONTREAL /CAN/ Reduced -341,400-341.4k
MILLENNIUM MANAGEMENT LLC Reduced -236,770-236.8k
Redmile Group, LLC Reduced -193,400-193.4k
MORGAN STANLEY Reduced -158,356-158.4k
FMR LLC Reduced -147,854-147.9k
ALGERT GLOBAL LLC Reduced -69,848-69.8k

Biggest calls

CITADEL ADVISORS LLC New $140.3k15.2k shares
GROUP ONE TRADING LLC Added $42.5k4.6k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

CITADEL ADVISORS LLC New $40.6k4.4k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
RTW INVESTMENTS, LP 13G · institution -0.1 pts · filed 2026-05-15 9.9% -0.1 pts 5.9m≈ $194.4m 2026-05-15
FMR LLC 13G · institution -1.3 pts · filed 2026-08-06 8.5% -1.3 pts 5.3m≈ $173.8m 2026-08-06
BlackRock, Inc. 13G · institution +1.0 pts · filed 2025-10-17 6.8% +1.0 pts 3.7m≈ $122.1m 2025-10-17
Redmile Group, LLC 13G · passive investor -1.3 pts · filed 2026-05-15 6.7% -1.3 pts 4.2m≈ $136.3m 2026-05-15
Lynx1 Capital Management LP 13G · passive investor -1.6 pts · filed 2026-08-14 6.5% -1.6 pts 4.0m≈ $132.1m 2026-08-14
MORGAN STANLEY 13G · institution filed 2025-02-03 6.5% 3.4m≈ $112.1m 2025-02-03
BAKER BROS. ADVISORS LP 13G · institution filed 2026-02-17 5.8% 3.3m≈ $109.2m 2026-02-17
BIOTECHNOLOGY VALUE FUND L P 13G · passive investor new · filed 2026-09-30 5.6% new 3.6m≈ $118.1m 2026-09-30
WELLINGTON MANAGEMENT GROUP LLP 13G · institution new · filed 2026-05-15 5.2% new 3.1m≈ $101.3m 2026-05-15

Fell to 5% or below in the last year: TORONTO DOMINION BANK (4.9%, 2026-08-12), VANGUARD GROUP INC (0.0%, 2026-03-27), Cowen Financial Products LLC (0.0%, 2025-11-14)

Insider purchases and sales in Q4 2022

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
101Q1 21: 0 buyingQ1 21: 0 sellingQ2 21: 0 buyingQ2 21: 0 sellingQ2 21Q3 21: 0 buyingQ3 21: 0 sellingQ4 21: 0 buyingQ4 21: 1 sellingQ4 21Q1 22: 0 buyingQ1 22: 1 sellingQ2 22: 0 buyingQ2 22: 0 sellingQ2 22Q3 22: 0 buyingQ3 22: 0 sellingQ4 22: 0 buyingQ4 22: 0 sellingQ4 22
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q1 20210—0——
Q2 20210—0——
Q3 20210—0——
Q4 20210—1$417.8k—
Q1 20220—1$87.7k—
Q2 20220—0——
Q3 20220—0——
Q4 20220—0——

None reported in Q4 2022.

Holders, Q4 2022

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Skorpios Trust 42.40% of their portfolio LIMASSOL, G4 14,443,68114.4m $133.3m $133.3m 42.40% Unchanged
2 RTW INVESTMENTS, LP 0.73% of their portfolio NEW YORK, NY 3,870,9813.9m $35.7m $35.7m 0.73% Added +219.2k +219,158
3 FMR LLC 0.00% of their portfolio BOSTON, MA 3,034,6493.0m $28.0m $28.0m 0.00% Reduced -147.9k -147,854
4 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 2,453,6862.5m $22.6m $22.6m 0.00% Reduced -158.4k -158,356
5 BlackRock Inc. 0.00% of their portfolio New York, NY 1,830,6471.8m $16.9m $16.9m 0.00% Added +123.4k +123,444
6 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 1,602,0451.6m $14.8m $14.8m 0.00% Reduced -445.9k -445,859
7 BAKER BROS. ADVISORS LP 0.06% of their portfolio NEW YORK, NY 1,108,9131.1m $10.2m $10.2m 0.06% Added +739.6k +739,586
8 Cormorant Asset Management, LP 0.67% of their portfolio BOSTON, MA 1,087,8071.1m $10.0m $10.0m 0.67% Unchanged
9 Octagon Capital Advisors LP 1.10% of their portfolio NEW YORK, NY 763,456763.5k $7.0m $7.0m 1.10% Unchanged
10 COWEN AND COMPANY, LLC 0.73% of their portfolio NEW YORK, NY 748,077748.1k $6.9m $6.9m 0.73% Reduced -21.1k -21,092
11 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 747,786747.8k $6.9m $6.9m 0.00% Reduced -39.1k -39,099
12 Redmile Group, LLC 0.24% of their portfolio LARKSPUR, CA 642,430642.4k $5.9m $5.9m 0.24% Reduced -193.4k -193,400
13 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 612,054612.1k $5.6m $5.6m 0.00% Reduced -651.3k -651,345
14 Granahan Investment Management, LLC 0.16% of their portfolio WALTHAM, MA 550,219550.2k $5.1m $5.1m 0.16% Added +291.2k +291,205
15 M28 Capital Management LP 4.25% of their portfolio STAMFORD, CT 482,890482.9k $4.5m $4.5m 4.25% Reduced -39.7k -39,660
16 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 474,224474.2k $4.4m $4.4m 0.00% Added +14.0k +13,969
17 HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.02% of their portfolio TORONTO, A6 428,200428.2k $4.0m $4.0m 0.02% Reduced -468.7k -468,700
18 BANK OF MONTREAL /CAN/ 0.00% of their portfolio TORONTO, A6 427,888427.9k $4.0m $4.0m 0.00% Reduced -341.4k -341,400
19 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 419,179419.2k $3.9m $3.9m 0.00% Reduced -236.8k -236,770
20 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 413,749413.7k $3.8m $3.8m 0.00% Added +2.3k +2,259
21 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 395,107395.1k $3.6m $3.6m 0.00% Reduced -17.2k -17,236
22 NORGES BANK 0.00% of their portfolio OSLO, Q8 394,312394.3k $3.6m $3.6m 0.00% Added +199.9k +199,900
23 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 309,506309.5k $2.9m $2.9m 0.00% Added +37.7k +37,725
24 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 292,007292.0k $2.7m $2.7m 0.00% Reduced -47.0k -46,989
25 Artal Group S.A. 0.13% of their portfolio LUXEMBOURG, N4 250,000250.0k $2.3m $2.3m 0.13% Unchanged
26 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 198,516198.5k $1.8m $1.8m 0.00% Reduced -5.2k -5,199
27 SPHERA FUNDS MANAGEMENT LTD. 0.55% of their portfolio TEL AVIV, L3 188,640188.6k $1.7m $1.7m 0.55% Added +31.4k +31,440
28 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 164,862164.9k $1.5m $1.5m 0.00% Added +2.6k +2,617
29 HRT FINANCIAL LP 0.01% of their portfolio NEW YORK, NY 108,282108.3k $999.0k $999.0k 0.01% Added +49.0k +48,963
30 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 104,600104.6k $965.0k $965.0k 0.00% Reduced -22.2k -22,200
31 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 91,61591.6k $845.6k $845.6k 0.00% Reduced -2.7k -2,738
32 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 90,77590.8k $837.9k $837.9k 0.00% Added +10.6k +10,595
33 Trexquant Investment LP 0.02% of their portfolio STAMFORD, CT 87,52987.5k $807.9k $807.9k 0.02% Added +37.7k +37,673
34 ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio Boston, MA 77,19477.2k $711.0k $711.0k 0.00% New
35 Fort Point Capital Partners LLC 0.12% of their portfolio San Francisco, CA 75,42975.4k $696.2k $696.2k 0.12% Reduced -60.6k -60,610
36 GSA CAPITAL PARTNERS LLP 0.08% of their portfolio LONDON, X0 71,57271.6k $661.0k $661.0k 0.08% Reduced -3.6k -3,555
37 D. E. Shaw & Co., Inc. 0.00% of their portfolio New York, NY 68,83568.8k $635.3k $635.3k 0.00% Added +42.7k +42,700
38 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 67,86267.9k $626.4k $626.4k 0.00% Reduced -44.4k -44,404
39 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 62,58462.6k $578.0k $578.0k 0.00% Reduced -37.8k -37,781
40 Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio VANCOUVER, A1 56,12556.1k $518.0k $518.0k 0.00% Added +15.9k +15,887
41 Cubist Systematic Strategies, LLC 0.00% of their portfolio STAMFORD, CT 48,97649.0k $452.0k $452.0k 0.00% Added +34.3k +34,340
42 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 45,15245.2k $410.0k $410.0k 0.00% Reduced -33 -33
43 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 44,34544.3k $409.3k $409.3k 0.00% Added +29.1k +29,115
44 PDT Partners, LLC 0.06% of their portfolio New York, NY 40,46240.5k $373.5k $373.5k 0.06% Added +24.9k +24,851
45 LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio LOS ANGELES, CA 40,41340.4k $373.0k $373.0k 0.00% Added +12.2k +12,190
46 Swiss National Bank 0.00% of their portfolio ZURICH, V8 37,20037.2k $343.4k $343.4k 0.00% Unchanged
47 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 36,60036.6k $337.8k $337.8k 0.00% Added +11.0k +11,000
48 Tower Research Capital LLC (TRC) 0.01% of their portfolio NEW YORK, NY 34,49334.5k $319.0k $319.0k 0.01% Added +31.1k +31,094
49 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 34,19134.2k $316.0k $316.0k 0.00% Added +475 +475
50 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 31,56431.6k $291.3k $291.3k 0.00% Added +14.5k +14,452
51 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 30,40030.4k $280.6k $280.6k 0.00% Added +2.9k +2,900
52 Balyasny Asset Management L.P. 0.00% of their portfolio Chicago, IL 29,03829.0k $268.0k $268.0k 0.00% Added +17.6k +17,608
53 Point72 Asset Management, L.P. 0.00% of their portfolio STAMFORD, CT 28,70028.7k $264.9k $264.9k 0.00% New
54 Ergoteles LLC 0.01% of their portfolio NEW YORK, NY 27,40827.4k $253.0k $253.0k 0.01% New
55 ALPS ADVISORS INC 0.00% of their portfolio Denver, CO 26,74926.7k $246.9k $246.9k 0.00% Added +5.2k +5,234
56 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 26,18626.2k $241.7k $241.7k 0.00% Unchanged
57 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 25,01225.0k $230.9k $230.9k 0.00% Added +19.2k +19,161
58 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 23,85923.9k $220.0k $220.0k 0.00% Added +291 +291
59 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 22,91922.9k $211.5k $211.5k 0.00% Added +569 +569
60 GILDER GAGNON HOWE & CO LLC 0.00% of their portfolio New York, NY 22,60422.6k $208.6k $208.6k 0.00% Reduced -35.3k -35,260
61 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 21,75421.8k $200.8k $200.8k 0.00% Reduced -16.0k -15,990
62 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 20,63120.6k $190.4k $190.4k 0.00% Added +3.3k +3,304
63 VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio San Antonio, TX 18,58118.6k $171.5k $171.5k 0.00% Reduced -1.2k -1,217
64 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 18,44318.4k $170.2k $170.2k 0.00% First filing
65 TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio STAMFORD, CT 18,31318.3k $169.0k $169.0k 0.00% Unchanged
66 VIRGINIA RETIREMENT SYSTEMS ET Al 0.00% of their portfolio RICHMOND, VA 17,10017.1k $157.8k $157.8k 0.00% Added +1.9k +1,900
67 VIRTUS ADVISERS, LLC 0.08% of their portfolio HARTFORD, CT 16,71516.7k $154.3k $154.3k 0.08% Added +6.7k +6,745
68 Jump Financial, LLC 0.01% of their portfolio Chicago, IL 15,55215.6k $143.5k $143.5k 0.01% Added +5.6k +5,552
69 Allspring Global Investments Holdings, LLC 0.00% of their portfolio CHARLOTTE, NC 15,30015.3k $141.2k $141.2k 0.00% New
70 Birchview Capital, LP 0.10% of their portfolio BURLINGTON, VT 15,00015.0k $138.0k $138.0k 0.10% Unchanged
71 UBS Group AG 0.00% of their portfolio ZURICH, V8 14,73814.7k $136.0k $136.0k 0.00% Added +11.0k +11,046
72 Rafferty Asset Management, LLC 0.00% of their portfolio New York, NY 14,42914.4k $133.2k $133.2k 0.00% Added +3.4k +3,382
73 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 14,39814.4k $132.9k $132.9k 0.00% Added +3 +3
74 LANDSCAPE CAPITAL MANAGEMENT, L.L.C. 0.02% of their portfolio Englewood, NJ 13,93613.9k $128.6k $128.6k 0.02% New
75 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 11,62111.6k $107.3k $107.3k 0.00% Unchanged
76 SIMPLEX TRADING, LLC 0.00% of their portfolio CHICAGO, IL 10,65810.7k $98.0k $98.0k 0.00% New
77 AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio New York, NY 10,61710.6k $98.0k $98.0k 0.00% Reduced -39 -39
78 STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio TALLAHASSEE, FL 10,47310.5k $96.7k $96.7k 0.00% Reduced -3.5k -3,530
79 ALGERT GLOBAL LLC 0.01% of their portfolio SAN FRANCISCO, CA 10,10010.1k $93.2k $93.2k 0.01% Reduced -69.8k -69,848
80 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 9,8599.9k $91.0k $91.0k 0.00% Added +20 +20
81 Legal & General Group Plc 0.00% of their portfolio London, X0 6,2986.3k $58.1k $58.1k 0.00% Unchanged
82 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 5,0215.0k $46.0k $46.0k 0.00% Added +4.7k +4,667
83 Quantbot Technologies LP 0.00% of their portfolio NEW YORK, NY 3,2913.3k $30.4k $30.4k 0.00% New
84 AMALGAMATED BANK 0.00% of their portfolio NEW YORK, NY 2,8532.9k $26.0k $26.0k 0.00% Unchanged
85 CANADA LIFE ASSURANCE Co 0.00% of their portfolio WINNIPEG, A2 2,3092.3k $21.0k $21.0k 0.00% Added +476 +476
86 Point72 Middle East FZE 0.00% of their portfolio DUBAI, C0 1,7211.7k $15.9k $15.9k 0.00% First filing
87 Ameritas Investment Partners, Inc. 0.00% of their portfolio LINCOLN, NE 1,4971.5k $13.9k $13.9k 0.00% Unchanged
88 LAZARD ASSET MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 1,4971.5k $13.0k $13.0k 0.00% New
89 Metropolitan Life Insurance Co/NY 0.00% of their portfolio New York, NY 1,4021.4k $12.9k $12.9k 0.00% Added +77 +77
90 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 1,3821.4k $12.8k $12.8k 0.00% Unchanged
91 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 1,0421.0k $9.6k $9.6k 0.00% Reduced -152 -152
92 GROUP ONE TRADING LLC 0.00% of their portfolio CHICAGO, IL 900900 $8.3k $8.3k 0.00% New
93 SIGNATUREFD, LLC 0.00% of their portfolio ATLANTA, GA 568568 $5.2k $5.2k 0.00% Added +451 +451
94 Lindbrook Capital, LLC 0.00% of their portfolio CALABASAS, CA 558558 $5.2k $5.2k 0.00% Added +554 +554
95 US BANCORP \DE\ 0.00% of their portfolio MINNEAPOLIS, MN 491491 $4.5k $4.5k 0.00% Reduced -944 -944
96 China Universal Asset Management Co., Ltd. 0.00% of their portfolio SHANGHAI, F4 401401 $3.7k $3.7k 0.00% Added +32 +32
97 QUADRANT CAPITAL GROUP LLC 0.00% of their portfolio CINCINNATI, OH 366366 $3.4k $3.4k 0.00% New
98 Endurance Wealth Management, Inc. 0.00% of their portfolio Providence, RI 300300 $3.0k $3.0k 0.00% Unchanged
99 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 192192 $1.0k $1.0k 0.00% Reduced -128 -128
100 Daiwa Securities Group Inc. 0.00% of their portfolio CHIYODA-KU,TOKYO, M0 126126 $1.0k $1.0k 0.00% Unchanged