SPERO THERAPEUTICS INC SPRO
COM · Common Stock · CUSIP 84833T103
Company in Cambridge, United States
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersCambridge, MA
- Websitesperotherapeutics.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 53.0m as of 2023-11-06, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.21. Options: 2 managers hold calls ($0 notional), 2 hold puts ($72.6k).
Trends to Q3 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 70 |
| Q4 2022 | 61 |
| Q1 2023 | 49 |
| Q2 2023 | 57 |
| Q3 2023 | 55 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 24 | 40 |
| Q1 2023 | 18 | 20 |
| Q2 2023 | 21 | 17 |
| Q3 2023 | 17 | 21 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q4 2022 | $382.0k | $226.1k | 0.59 |
| Q1 2023 | $29.6k | $145.0k | 4.90 |
| Q2 2023 | $25.8k | $179.9k | 6.97 |
| Q3 2023 | $0 | $72.6k | — |
Biggest buyers
| Anson Funds Management LP | Added | +714.7k |
| Murchinson Ltd. | Added | +100.0k |
| ACADIAN ASSET MANAGEMENT LLC | Added | +98.5k |
| Squarepoint Ops LLC | Added | +51.4k |
| VANGUARD GROUP INC | Added | +31.1k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | Added | +25.0k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +21.9k |
| STATE STREET CORP | Added | +19.8k |
| HRT FINANCIAL LP | New | +18.6k |
| ERn Financial, LLC | New | +15.8k |
Biggest sellers
| Rock Springs Capital Management LP | Reduced | -612.2k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -254.2k |
| TWO SIGMA INVESTMENTS, LP | Reduced | -67.5k |
| GROUP ONE TRADING LLC | Reduced | -57.8k |
| AWM Investment Company, Inc. | Reduced | -50.0k |
| XTX Topco Ltd | Reduced | -48.0k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -46.3k |
| BlackRock Inc. | Reduced | -42.0k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -24.2k |
| ROYCE & ASSOCIATES LP | Sold out | -22.9k |
Biggest calls
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
| SIMPLEX TRADING, LLC | Reduced | $0500 shares |
Biggest puts
| GROUP ONE TRADING LLC | Reduced | $72.6k60.0k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| GSK plc 13D · may seek influence filed 2025-03-28 | 16.4% |
Insider purchases and sales in Q3 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2021 | 0 | — | 1 | $116.6k | — |
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 1 | $5.4k | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 0 | — | 4 | $45.9k | — |
| Q2 2023 | 0 | — | 0 | — | — |
| Q3 2023 | 0 | — | 5 | $69.3k | $7.7k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2023-09-13 | HAMED KAMAL Chief Medical Officer | Sold | $50.2k39.5k shares |
| 2023-08-29 | Shukla Sath CEO and President, director | Sold plan | $5.4k4.2k shares |
| 2023-08-28 | Mahadevia Ankit Director | Sold | $11.4k9.0k shares |
| 2023-08-28 | Shukla Sath CEO and President, director | Sold plan | $2.3k1.9k shares |
| 2023-08-28 | JOSEPH TAMARA L Chief Legal Officer | Sold | $2.3k1.9k shares |
| 2023-08-28 | Keutzer Timothy Chief Development Officer | Sold | $2.3k1.9k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q3 2023
| Manager | Shares | Change |
|---|---|---|
| Anson Funds Management LP 1.50% of their portfolio | 4.2m $5.0m | Added +714.7k |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.6m $1.9m | Added +31.1k |
| Atlas Venture Associates IX, LLC 13.93% of their portfolio | 1.4m $1.6m | Unchanged |
| Atlas Venture Life Science Advisors, LLC 0.19% of their portfolio | 1.0m $1.2m | Unchanged |
| Alphabet Inc. 0.07% of their portfolio | 890.0k $1.1m | Unchanged |
| Murchinson Ltd. 0.16% of their portfolio | 862.7k $1.0m | Added +100.0k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 547.2k $662.0k | Reduced -46.3k |
| BlackRock Inc. 0.00% of their portfolio | 481.8k $583.0k | Reduced -42.0k |
| NOVO HOLDINGS A/S 0.04% of their portfolio | 468.9k $567.4k | Unchanged |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 463.6k $561.0k | Reduced -4.3k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 412.7k $499.5k | Added +21.9k |
| AWM Investment Company, Inc. 0.06% of their portfolio | 333.4k $403.4k | Reduced -50.0k |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 272.0k $327.0k | Added +98.5k |
| OUP Management Co., LLC 0.68% of their portfolio | 249.1k $301.4k | Unchanged |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 134.8k $163.1k | Added +25.0k |
| STATE STREET CORP 0.00% of their portfolio | 130.5k $157.9k | Added +19.8k |
| Squarepoint Ops LLC 0.00% of their portfolio | 129.5k $156.7k | Added +51.4k |
| DAFNA Capital Management LLC 0.05% of their portfolio | 125.0k $151.2k | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 119.7k $144.8k | Reduced -254.2k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 88.9k $107.5k | Added +136 |
| XTX Topco Ltd 0.01% of their portfolio | 58.4k $70.6k | Reduced -48.0k |
| Rock Springs Capital Management LP 0.00% of their portfolio | 57.4k $69.4k | Reduced -612.2k |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 34.2k $41.4k | Reduced -57.8k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 28.6k $34.6k | Unchanged |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 28.2k $34.1k | Added +3.8k |
| UBS Group AG 0.00% of their portfolio | 27.1k $32.8k | Added +64 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 20.2k $24.4k | Reduced -24.2k |
| HRT FINANCIAL LP 0.00% of their portfolio | 18.6k $22.0k | New |
| MACKENZIE FINANCIAL CORP 0.00% of their portfolio | 17.2k $20.1k | Unchanged |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 17.0k $20.6k | Reduced -67.5k |
| ERn Financial, LLC 0.00% of their portfolio | 15.8k $19.1k | New |
| BOURGEON CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 15.1k $18.3k | Unchanged |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 11.8k $14.2k | Unchanged |
| Texas Yale Capital Corp. 0.00% of their portfolio | 10.0k $12.1k | Unchanged |
| MORGAN STANLEY 0.00% of their portfolio | 9.0k $10.9k | Reduced -542 |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 8.8k $10.6k | Reduced -4.5k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 6.4k $7.7k | Unchanged |
| WR Wealth Planners, LLC 0.00% of their portfolio | 2.6k $3.1k | Unchanged |
| Cullen/Frost Bankers, Inc. 0.00% of their portfolio | 2.0k $2.4k | Unchanged |
| Federation des caisses Desjardins du Quebec 0.00% of their portfolio | 730 $883 | Unchanged |
| Allworth Financial LP 0.00% of their portfolio | 600 $726 | Unchanged |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 572 $692 | Added +537 |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 515 $623 | Reduced -14 |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 458 $554 | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 300 $0 | New |
| PFS Partners, LLC 0.00% of their portfolio | 250 $303 | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 236 $286 | Unchanged |
| Beaird Harris Wealth Management, LLC 0.00% of their portfolio | 202 $245 | Unchanged |
| Heritage Wealth Advisors 0.00% of their portfolio | 187 $226 | Unchanged |
| US BANCORP \DE\ 0.00% of their portfolio | 151 $183 | Unchanged |
| NewEdge Advisors, LLC 0.00% of their portfolio | 100 $121 | Unchanged |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 97 $117 | Reduced -2.1k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 12 $15 | New |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 1 $1 | New |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 0 $0 | Unchanged |