Vault-13

SPERO THERAPEUTICS INC SPRO

COM · Common Stock · CUSIP 84833T103

Company in Cambridge, United States

55 institutional holders -2 vs Q2 2023
14,186,35114.2m shares reported held*
26.8% of all shares outstanding*
$17.2mreported value*
5 new 12 added 14 reduced 7 sold out net sold ≈ $213.9k (-176.8k shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 53.0m as of 2023-11-06, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.21. Options: 2 managers hold calls ($0 notional), 2 hold puts ($72.6k).

Trends to Q3 2023

Institutional holders

Managers reporting a position, each quarter

0255075Q3 22: 70Q4 22: 61Q1 23: 49Q2 23: 57Q3 23: 5555Q3 22Q4 22Q1 23Q2 23Q3 23
Numbers
QuarterHolders
Q3 202270
Q4 202261
Q1 202349
Q2 202357
Q3 202355

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
40040Q4 22: 24 bought or addedQ4 22: 40 cut or sold outQ4 22Q1 23: 18 bought or addedQ1 23: 20 cut or sold outQ1 23Q2 23: 21 bought or addedQ2 23: 17 cut or sold outQ2 23Q3 23: 17 bought or addedQ3 23: 21 cut or sold outQ3 23
Numbers
QuarterBought or addedCut or sold out
Q4 20222440
Q1 20231820
Q2 20232117
Q3 20231721

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$100k$200k$300k$400kQ4 22 calls: $382.0kQ4 22 puts: $226.1kQ4 22P/C 0.59Q1 23 calls: $29.6kQ1 23 puts: $145.0kQ1 23P/C 4.90Q2 23 calls: $25.8kQ2 23 puts: $179.9kQ2 23P/C 6.97Q3 23 calls: $0Q3 23 puts: $72.6kQ3 23P/C —
Numbers
QuarterCallsPutsP/C
Q4 2022$382.0k$226.1k0.59
Q1 2023$29.6k$145.0k4.90
Q2 2023$25.8k$179.9k6.97
Q3 2023$0$72.6k—

Biggest buyers

Anson Funds Management LP Added +714,710+714.7k
Murchinson Ltd. Added +100,000+100.0k
ACADIAN ASSET MANAGEMENT LLC Added +98,485+98.5k
Squarepoint Ops LLC Added +51,434+51.4k
VANGUARD GROUP INC Added +31,122+31.1k
BRIDGEWAY CAPITAL MANAGEMENT, LLC Added +25,000+25.0k
GEODE CAPITAL MANAGEMENT, LLC Added +21,902+21.9k
STATE STREET CORP Added +19,800+19.8k
HRT FINANCIAL LP New +18,627+18.6k
ERn Financial, LLC New +15,766+15.8k

Biggest sellers

Rock Springs Capital Management LP Reduced -612,160-612.2k
MILLENNIUM MANAGEMENT LLC Reduced -254,156-254.2k
TWO SIGMA INVESTMENTS, LP Reduced -67,512-67.5k
GROUP ONE TRADING LLC Reduced -57,780-57.8k
AWM Investment Company, Inc. Reduced -50,000-50.0k
XTX Topco Ltd Reduced -48,016-48.0k
RENAISSANCE TECHNOLOGIES LLC Reduced -46,266-46.3k
BlackRock Inc. Reduced -41,995-42.0k
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced -24,176-24.2k
ROYCE & ASSOCIATES LP Sold out -22,851-22.9k

Biggest calls

CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares
SIMPLEX TRADING, LLC Reduced $0500 shares

Biggest puts

GROUP ONE TRADING LLC Reduced $72.6k60.0k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
GSK plc 13D · may seek influence filed 2025-03-28 16.4% 9.2m≈ $20.3m 2025-03-28

Insider purchases and sales in Q3 2023

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
505Q4 21: 0 buyingQ4 21: 1 sellingQ1 22: 0 buyingQ1 22: 0 sellingQ1 22Q2 22: 0 buyingQ2 22: 0 sellingQ3 22: 0 buyingQ3 22: 1 sellingQ3 22Q4 22: 0 buyingQ4 22: 0 sellingQ1 23: 0 buyingQ1 23: 4 sellingQ1 23Q2 23: 0 buyingQ2 23: 0 sellingQ3 23: 0 buyingQ3 23: 5 sellingQ3 23
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q4 20210—1$116.6k—
Q1 20220—0——
Q2 20220—0——
Q3 20220—1$5.4k—
Q4 20220—0——
Q1 20230—4$45.9k—
Q2 20230—0——
Q3 20230—5$69.3k$7.7k
DateInsiderTradeSharesPrice ValueTheir holding
2023-09-13 HAMED KAMAL Chief Medical Officer Sold 39,496 $1.27 $50.2k39.5k shares -6%
2023-08-29 Shukla Sath CEO and President, director Sold plan 4,163 $1.30 $5.4k4.2k shares -1%
2023-08-28 Mahadevia Ankit Director Sold 9,040 $1.26 $11.4k9.0k shares -1%
2023-08-28 Shukla Sath CEO and President, director Sold plan 1,854 $1.26 $2.3k1.9k shares -<1%
2023-08-28 JOSEPH TAMARA L Chief Legal Officer Sold 1,854 $1.26 $2.3k1.9k shares -1%
2023-08-28 Keutzer Timothy Chief Development Officer Sold 1,854 $1.26 $2.3k1.9k shares -1%

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q3 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Anson Funds Management LP 1.50% of their portfolio DALLAS, TX 4,159,5724.2m $5.0m $5.0m 1.50% Added +714.7k +714,710
2 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 1,557,5961.6m $1.9m $1.9m 0.00% Added +31.1k +31,122
3 Atlas Venture Associates IX, LLC 13.93% of their portfolio Boston, MA 1,353,3031.4m $1.6m $1.6m 13.93% Unchanged
4 Atlas Venture Life Science Advisors, LLC 0.19% of their portfolio CAMBRIDGE, MA 1,013,4381.0m $1.2m $1.2m 0.19% Unchanged
5 Alphabet Inc. 0.07% of their portfolio Mountain View, CA 889,979890.0k $1.1m $1.1m 0.07% Unchanged
6 Murchinson Ltd. 0.16% of their portfolio TORONTO, A6 862,700862.7k $1.0m $1.0m 0.16% Added +100.0k +100,000
7 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 547,165547.2k $662.0k $662.0k 0.00% Reduced -46.3k -46,266
8 BlackRock Inc. 0.00% of their portfolio New York, NY 481,809481.8k $583.0k $583.0k 0.00% Reduced -42.0k -41,995
9 NOVO HOLDINGS A/S 0.04% of their portfolio HELLERUP, G7 468,902468.9k $567.4k $567.4k 0.04% Unchanged
10 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 463,641463.6k $561.0k $561.0k 0.00% Reduced -4.3k -4,319
11 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 412,707412.7k $499.5k $499.5k 0.00% Added +21.9k +21,902
12 AWM Investment Company, Inc. 0.06% of their portfolio NEW YORK, NY 333,400333.4k $403.4k $403.4k 0.06% Reduced -50.0k -50,000
13 ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio Boston, MA 272,024272.0k $327.0k $327.0k 0.00% Added +98.5k +98,485
14 OUP Management Co., LLC 0.68% of their portfolio Bala Cynwyd, PA 249,070249.1k $301.4k $301.4k 0.68% Unchanged
15 BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio HOUSTON, TX 134,800134.8k $163.1k $163.1k 0.00% Added +25.0k +25,000
16 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 130,511130.5k $157.9k $157.9k 0.00% Added +19.8k +19,800
17 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 129,497129.5k $156.7k $156.7k 0.00% Added +51.4k +51,434
18 DAFNA Capital Management LLC 0.05% of their portfolio LOS ANGELES, CA 125,000125.0k $151.2k $151.2k 0.05% Unchanged
19 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 119,694119.7k $144.8k $144.8k 0.00% Reduced -254.2k -254,156
20 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 88,88188.9k $107.5k $107.5k 0.00% Added +136 +136
21 XTX Topco Ltd 0.01% of their portfolio LONDON, X0 58,36858.4k $70.6k $70.6k 0.01% Reduced -48.0k -48,016
22 Rock Springs Capital Management LP 0.00% of their portfolio Baltimore, MD 57,37357.4k $69.4k $69.4k 0.00% Reduced -612.2k -612,160
23 GROUP ONE TRADING LLC 0.00% of their portfolio CHICAGO, IL 34,19034.2k $41.4k $41.4k 0.00% Reduced -57.8k -57,780
24 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 28,56528.6k $34.6k $34.6k 0.00% Unchanged
25 PRUDENTIAL FINANCIAL INC 0.00% of their portfolio NEWARK, NJ 28,20028.2k $34.1k $34.1k 0.00% Added +3.8k +3,800
26 UBS Group AG 0.00% of their portfolio ZURICH, V8 27,13527.1k $32.8k $32.8k 0.00% Added +64 +64
27 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 20,18320.2k $24.4k $24.4k 0.00% Reduced -24.2k -24,176
28 HRT FINANCIAL LP 0.00% of their portfolio NEW YORK, NY 18,62718.6k $22.0k $22.0k 0.00% New
29 MACKENZIE FINANCIAL CORP 0.00% of their portfolio TORONTO ONTARIO, A6 17,19817.2k $20.1k $20.1k 0.00% Unchanged
30 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 17,02317.0k $20.6k $20.6k 0.00% Reduced -67.5k -67,512
31 ERn Financial, LLC 0.00% of their portfolio MIDDLETON, WI 15,76615.8k $19.1k $19.1k 0.00% New
32 BOURGEON CAPITAL MANAGEMENT LLC 0.00% of their portfolio Darien, CT 15,10015.1k $18.3k $18.3k 0.00% Unchanged
33 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 11,75311.8k $14.2k $14.2k 0.00% Unchanged
34 Texas Yale Capital Corp. 0.00% of their portfolio ST. PETERSBURG, FL 10,00010.0k $12.1k $12.1k 0.00% Unchanged
35 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 8,9889.0k $10.9k $10.9k 0.00% Reduced -542 -542
36 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 8,7828.8k $10.6k $10.6k 0.00% Reduced -4.5k -4,455
37 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 6,4006.4k $7.7k $7.7k 0.00% Unchanged
38 WR Wealth Planners, LLC 0.00% of their portfolio COLUMBIA, MO 2,6002.6k $3.1k $3.1k 0.00% Unchanged
39 Cullen/Frost Bankers, Inc. 0.00% of their portfolio San Antonio, TX 2,0002.0k $2.4k $2.4k 0.00% Unchanged
40 Federation des caisses Desjardins du Quebec 0.00% of their portfolio LEVIS, A8 730730 $883 $883 0.00% Unchanged
41 Allworth Financial LP 0.00% of their portfolio FOLSOM, CA 600600 $726 $726 0.00% Unchanged
42 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 572572 $692 $692 0.00% Added +537 +537
43 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 515515 $623 $623 0.00% Reduced -14 -14
44 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 458458 $554 $554 0.00% Unchanged
45 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 300300 $0 $0 0.00% New
46 PFS Partners, LLC 0.00% of their portfolio MINE HILL, NJ 250250 $303 $303 0.00% Unchanged
47 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 236236 $286 $286 0.00% Unchanged
48 Beaird Harris Wealth Management, LLC 0.00% of their portfolio DALLAS, TX 202202 $245 $245 0.00% Unchanged
49 Heritage Wealth Advisors 0.00% of their portfolio RICHMOND, VA 187187 $226 $226 0.00% Unchanged
50 US BANCORP \DE\ 0.00% of their portfolio MINNEAPOLIS, MN 151151 $183 $183 0.00% Unchanged
51 NewEdge Advisors, LLC 0.00% of their portfolio NEW ORLEANS, LA 100100 $121 $121 0.00% Unchanged
52 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 9797 $117 $117 0.00% Reduced -2.1k -2,092
53 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 1212 $15 $15 0.00% New
54 Qube Research & Technologies Ltd 0.00% of their portfolio LONDON, X0 11 $1 $1 0.00% New
55 CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio BIRMINGHAM, AL 00 $0 $0 0.00% Unchanged