ARS PHARMACEUTICALS INC SPRY
COM · Common Stock · CUSIP 82835W108
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersSan Diego, CA
- Founded2016
- Websitesilverbacktx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($374.9k this quarter). Holder counts are more reliable. Shares outstanding: 98.8m as of 2025-08-11, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $17.45. Options: 10 managers hold calls ($11.1m notional), 6 hold puts ($4.1m).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 61 |
| Q4 2022 | 74 |
| Q1 2023 | 91 |
| Q2 2023 | 94 |
| Q3 2023 | 98 |
| Q4 2023 | 101 |
| Q1 2024 | 114 |
| Q2 2024 | 116 |
| Q3 2024 | 152 |
| Q4 2024 | 167 |
| Q1 2025 | 185 |
| Q2 2025 | 189 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 61 | 39 |
| Q4 2023 | 47 | 45 |
| Q1 2024 | 64 | 40 |
| Q2 2024 | 66 | 46 |
| Q3 2024 | 105 | 35 |
| Q4 2024 | 86 | 61 |
| Q1 2025 | 97 | 73 |
| Q2 2025 | 107 | 68 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $14.2m | $9.5m | 0.67 |
| Q4 2024 | $2.7m | $3.6m | 1.36 |
| Q1 2025 | $2.7m | $4.5m | 1.70 |
| Q2 2025 | $11.1m | $4.1m | 0.36 |
Biggest buyers
| ADAGE CAPITAL PARTNERS GP, L.L.C. | New | +1.7m |
| Southpoint Capital Advisors LP | New | +1.7m |
| CITADEL ADVISORS LLC | Added | +1.4m |
| WELLINGTON MANAGEMENT GROUP LLP | Added | +1.3m |
| GOLDMAN SACHS GROUP INC | Added | +746.4k |
| Octagon Capital Advisors LP | Added | +725.0k |
| NEXT CENTURY GROWTH INVESTORS LLC | New | +622.8k |
| FMR LLC | Added | +576.1k |
| Aberdeen Group plc | Added | +499.9k |
| BARCLAYS PLC | Added | +490.2k |
Biggest sellers
| LEVIN CAPITAL STRATEGIES, L.P. | Reduced | -875.5k |
| DEERFIELD MANAGEMENT COMPANY, L.P. | Reduced | -790.1k |
| Cormorant Asset Management, LP | Reduced | -500.0k |
| ROYCE & ASSOCIATES LP | Reduced | -386.5k |
| Nicholas Investment Partners, LP | Reduced | -356.6k |
| Woodline Partners LP | Reduced | -299.9k |
| Advisor Resource Council | Sold out | -249.2k |
| VANGUARD GROUP INC | Reduced | -225.6k |
| First Turn Management, LLC | Reduced | -213.1k |
| Nextech Invest Ltd. | Reduced | -195.0k |
Biggest calls
| DIADEMA PARTNERS LP | New | $4.9m280.7k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $2.2m124.7k shares |
| Caption Management, LLC | New | $1.8m100.5k shares |
| WOLVERINE TRADING, LLC | New | $886.3k48.7k shares |
| GROUP ONE TRADING LLC | Reduced | $443.2k25.4k shares |
| CITADEL ADVISORS LLC | Reduced | $315.8k18.1k shares |
| SIMPLEX TRADING, LLC | Reduced | $279.0k16.0k shares |
| Persistent Asset Partners Ltd | New | $248.0k646 shares |
| LEVIN CAPITAL STRATEGIES, L.P. | New | $130.9k7.5k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CITADEL ADVISORS LLC | Reduced | $1.7m98.7k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $1.0m59.1k shares |
| JANE STREET GROUP, LLC | Added | $739.9k42.4k shares |
| GROUP ONE TRADING LLC | Reduced | $445.0k25.5k shares |
| SIMPLEX TRADING, LLC | Reduced | $116.0k6.7k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
RA CAPITAL MANAGEMENT, L.P.
13D · may seek influence
filed 2025-10-01
Stated purposeItem 4 is hereby amended and supplemented as follows: On September 29, 2025, the Issuer and certain direct and indirect subsidiaries of the Issuer who may become a party thereto from time to time, as guarantors (the "Guarantors"), and ARS Pharmaceuticals Operations, Inc., a wholly owned subsidiary of the Issuer, as the borrower (the "Borrower" and, collectively with the Guarantors, the "Credit Parties"), entered into a credit agreement (the "Credit Agreement") with RA Capital Agency Services, LLC (as the "Administrative Agent" and as the "Collateral Agent"), and affiliates of OMERS Administration Corporation and RA Capital, as lenders, and such other lenders from time to time party thereto (the "Lenders"), providing for up to $250.0 million of term loans from the Lenders to the Borrower (… Full filing |
11.1% |
| Rubric Capital Management LP 13G · institution +1.8 pts · filed 2026-05-15 | 8.1% |
| Flynn James E 13D · may seek influence -1.0 pts · filed 2025-08-01 | 7.8% |
| BlackRock, Inc. 13G · institution +0.3 pts · filed 2026-07-27 | 5.3% |
Fell to 5% or below in the last year: MILLENNIUM MANAGEMENT LLC (2.5%, 2026-07-14)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 4 | $34.9m | 1 | $2.1m | $1.5m |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 1 | $13.3m | 2 | $2.8m | $2.8m |
| Q2 2024 | 0 | — | 2 | $4.6m | $4.6m |
| Q3 2024 | 0 | — | 7 | $21.5m | $8.9m |
| Q4 2024 | 0 | — | 7 | $19.0m | $12.0m |
| Q1 2025 | 0 | — | 2 | $1.9m | $1.9m |
| Q2 2025 | 0 | — | 5 | $4.7m | $855.0k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-06-27 | DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) +5 10% owner · Through Deerfield Private Design Fund III, L.P. | Sold | $6.8m370.1k shares |
| 2025-06-27 | DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) +5 10% owner · Through Deerfield Private Design Fund IV, L.P. | Sold | $6.8m370.1k shares |
| 2025-06-18 | Karas Eric Chief Commercial Officer | Sold plan | $240.0k15.0k shares |
| 2025-05-20 | SAUNDERS BRENT L Director | Sold | $1.7m120.0k shares |
| 2025-05-20 | Fitzpatrick Alexander A Chief Legal Officer | Sold | $1.5m103.0k shares |
| 2025-05-20 | Scott Kathleen D. Chief Financial Officer | Sold | $705.0k50.0k shares |
| 2025-04-07 | Shawver Laura Director | Sold plan | $615.0k50.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. 3.19% of their portfolio | 10.9m $189.5m | Unchanged |
| DEERFIELD MANAGEMENT COMPANY, L.P. 3.08% of their portfolio | 9.7m $169.7m | Reduced -790.1k |
| ORBIMED ADVISORS LLC 3.64% of their portfolio | 8.3m $144.6m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 4.4m $77.2m | Added +124.5k |
| SR One Capital Management, LP 15.18% of their portfolio | 4.0m $70.0m | Unchanged |
| ALLIANCEBERNSTEIN L.P. 0.02% of their portfolio | 3.8m $66.8m | Reduced -97.0k |
| VANGUARD GROUP INC 0.00% of their portfolio | 3.3m $56.9m | Reduced -225.6k |
| CITADEL ADVISORS LLC 0.03% of their portfolio | 2.2m $39.1m | Added +1.4m |
| STATE STREET CORP 0.00% of their portfolio | 2.2m $38.3m | Added +163.3k |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 1.8m $31.9m | Reduced -28.8k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.05% of their portfolio | 1.7m $30.2m | New |
| Southpoint Capital Advisors LP 0.75% of their portfolio | 1.7m $29.8m | New |
| FMR LLC 0.00% of their portfolio | 1.6m $27.3m | Added +576.1k |
| Aberdeen Group plc 0.04% of their portfolio | 1.5m $26.2m | Added +499.9k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 1.5m $25.6m | Added +746.4k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 1.4m $25.0m | Added +1.3m |
| Octagon Capital Advisors LP 5.17% of their portfolio | 1.4m $23.6m | Added +725.0k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.3m $23.4m | Added +81.9k |
| MPM BIOIMPACT LLC 3.94% of their portfolio | 1.3m $22.7m | Reduced -9.7k |
| Rubric Capital Management LP 0.36% of their portfolio | 1.3m $22.6m | Added +265.8k |
| Cormorant Asset Management, LP 1.43% of their portfolio | 1.1m $19.2m | Reduced -500.0k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 878.2k $15.3m | Added +71.1k |
| UBS Group AG 0.00% of their portfolio | 866.9k $15.1m | Added +275.8k |
| Nextech Invest Ltd. 2.45% of their portfolio | 741.7k $12.9m | Reduced -195.0k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 673.4k $11.8m | Reduced -33.4k |
| NEXT CENTURY GROWTH INVESTORS LLC 0.84% of their portfolio | 622.8k $10.9m | New |
| BARCLAYS PLC 0.00% of their portfolio | 622.2k $10.9m | Added +490.2k |
| Janney Montgomery Scott LLC 0.03% of their portfolio | 591.4k $10.3m | Added +142.8k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 485.0k $8.5m | Reduced -2.0k |
| ARDSLEY ADVISORY PARTNERS LP 1.35% of their portfolio | 475.0k $8.3m | Added +150.0k |
| Driehaus Capital Management LLC 0.06% of their portfolio | 464.0k $8.1m | New |
| PEREGRINE CAPITAL MANAGEMENT LLC 0.24% of their portfolio | 457.0k $8.0m | Reduced -44.8k |
| First Turn Management, LLC 1.48% of their portfolio | 456.0k $8.0m | Reduced -213.1k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 442.2k $7.7m | Added +25.5k |
| Lisanti Capital Growth, LLC 2.03% of their portfolio | 420.1k $7.3m | Added +226.2k |
| MORGAN STANLEY 0.00% of their portfolio | 383.6k $6.7m | Reduced -58.9k |
| WEXFORD CAPITAL LP 1.86% of their portfolio | 382.6k $6.7m | Reduced -26.0k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 345.1k $6.0m | Added +240.9k |
| FIRST TRUST ADVISORS LP 0.00% of their portfolio | 340.1k $5.9m | New |
| Balyasny Asset Management L.P. 0.01% of their portfolio | 329.1k $5.7m | Added +157.9k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 325.6k $5.7m | Added +45.8k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 325.4k $5.7m | Reduced -119.4k |
| NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio | 324.9k $5.7m | Added +7.5k |
| K2 PRINCIPAL FUND, L.P. 1.01% of their portfolio | 317.1k $5.5m | Reduced -168.2k |
| Woodline Partners LP 0.03% of their portfolio | 300.4k $5.2m | Reduced -299.9k |
| Allspring Global Investments Holdings, LLC 0.01% of their portfolio | 294.1k $5.1m | Reduced -74.4k |
| Alyeska Investment Group, L.P. 0.02% of their portfolio | 290.1k $5.1m | Unchanged |
| LEVIN CAPITAL STRATEGIES, L.P. 0.50% of their portfolio | 289.1k $5.0m | Reduced -875.5k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 257.0k $4.5m | Added +52.8k |
| ROYCE & ASSOCIATES LP 0.05% of their portfolio | 256.3k $4.5m | Reduced -386.5k |
| Nicholas Investment Partners, LP 0.40% of their portfolio | 255.1k $4.5m | Reduced -356.6k |
| Pictet Asset Management Holding SA 0.00% of their portfolio | 234.8k $4.3m | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 205.6k $3.6m | Added +187.0k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 180.5k $3.1m | Reduced -7.2k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 166.2k $2.9m | Added +34.7k |
| FAS Wealth Partners, Inc. 0.19% of their portfolio | 149.2k $2.6m | Added +9.6k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 145.1k $2.5m | Added +12.9k |
| Avidity Partners Management LP 0.49% of their portfolio | 140.0k $2.4m | New |
| Nuveen, LLC 0.00% of their portfolio | 139.1k $2.4m | Reduced -15.3k |
| Steward Partners Investment Advisory, LLC 0.02% of their portfolio | 128.2k $2.2m | Added +79.7k |
| Invesco Ltd. 0.00% of their portfolio | 117.5k $2.1m | Added +87.6k |
| HUSSMAN STRATEGIC ADVISORS, INC. 0.42% of their portfolio | 105.0k $1.8m | New |
| Legato Capital Management LLC 0.22% of their portfolio | 104.1k $1.8m | Added +7.5k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.00% of their portfolio | 101.7k $1.8m | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 93.3k $1.6m | Added +20.5k |
| Cambridge Investment Research Advisors, Inc. 0.00% of their portfolio | 87.2k $1.5m | Added +4 |
| Coastal Bridge Advisors, LLC 0.13% of their portfolio | 87.0k $1.5m | New |
| SEI INVESTMENTS CO 0.00% of their portfolio | 85.1k $1.5m | Reduced -10.0k |
| Swiss National Bank 0.00% of their portfolio | 84.3k $1.5m | Added +8.6k |
| VALLEY FORGE INVESTMENT CONSULTANTS INC ADV 0.47% of their portfolio | 83.2k $1.5m | Unchanged |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 81.3k $1.4m | Added +11.5k |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 80.8k $1.4m | Added +5.5k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.04% of their portfolio | 75.5k $1.3m | New |
| Epoch Investment Partners, Inc. 0.01% of their portfolio | 72.8k $1.3m | Reduced -46.2k |
| JANUS HENDERSON GROUP PLC 0.00% of their portfolio | 69.5k $1.2m | Added +47.9k |
| Knights of Columbus Asset Advisors LLC 0.07% of their portfolio | 68.1k $1.2m | Added +24.9k |
| SECTORAL ASSET MANAGEMENT INC 0.76% of their portfolio | 65.8k $1.1m | Reduced -34.4k |
| CastleKnight Management LP 0.08% of their portfolio | 65.3k $1.1m | Unchanged |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 61.1k $1.1m | Added +1.5k |
| Harbour Capital Advisors, LLC 0.20% of their portfolio | 58.0k $970.7k | Added +29.3k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 57.4k $1.0m | Added +23.7k |
| AssuredPartners Investment Advisors, LLC 0.24% of their portfolio | 57.0k $994.1k | Reduced -12.1k |
| Matisse Capital 0.47% of their portfolio | 56.7k $989.7k | Added +1.0k |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 55.4k $967.5k | New |
| Legal & General Group Plc 0.00% of their portfolio | 54.8k $956.7k | Added +19.5k |
| ALPS ADVISORS INC 0.01% of their portfolio | 53.0k $924.9k | New |
| Miura Global Management, LLC 0.94% of their portfolio | 50.0k $872.5k | Reduced -25.0k |
| Aquatic Capital Management LLC 0.02% of their portfolio | 48.7k $849.6k | New |
| GSA CAPITAL PARTNERS LLP 0.06% of their portfolio | 45.3k $790.0k | Added +17.8k |
| Quinn Opportunity Partners LLC 0.07% of their portfolio | 45.0k $785.2k | Reduced -66.6k |
| SCHULHOFF & CO INC 0.34% of their portfolio | 43.5k $759.1k | Added +3.0k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 41.2k $718.9k | Added +300 |
| DIKER MANAGEMENT LLC 0.67% of their portfolio | 41.0k $715.5k | Added +20.0k |
| SIT INVESTMENT ASSOCIATES INC 0.02% of their portfolio | 40.4k $704.0k | New |
| BAMCO INC /NY/ 0.00% of their portfolio | 40.0k $698.0k | New |
| MARSHALL WACE, LLP 0.00% of their portfolio | 39.9k $696.5k | Reduced -116.7k |
| Mariner, LLC 0.00% of their portfolio | 39.7k $693.0k | Added +1.7k |
| Creative Planning 0.00% of their portfolio | 37.6k $656.2k | Added +4.5k |
| CITIGROUP INC 0.00% of their portfolio | 37.6k $655.8k | Reduced -57.6k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 37.0k $645.9k | Reduced -2.1k |