SCHRODINGER INC SDGR
COM · Common Stock · CUSIP 80810D103 · ISIN US80810D1037
American life sciences company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNew York, NY
- Founded1990
- Websiteschrodinger.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($52.9m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $20.06. Options: 10 managers hold calls ($57.6m notional), 7 hold puts ($6.2m).
Trends to Q3 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 198 |
| Q4 2022 | 171 |
| Q1 2023 | 184 |
| Q2 2023 | 241 |
| Q3 2023 | 237 |
| Q4 2023 | 240 |
| Q1 2024 | 224 |
| Q2 2024 | 208 |
| Q3 2024 | 209 |
| Q4 2024 | 213 |
| Q1 2025 | 220 |
| Q2 2025 | 234 |
| Q3 2025 | 225 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2023 | 115 | 114 |
| Q1 2024 | 101 | 115 |
| Q2 2024 | 97 | 110 |
| Q3 2024 | 95 | 104 |
| Q4 2024 | 87 | 105 |
| Q1 2025 | 104 | 89 |
| Q2 2025 | 120 | 106 |
| Q3 2025 | 91 | 128 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q4 2024 | $10.3m | $6.9m | 0.68 |
| Q1 2025 | $15.3m | $5.0m | 0.33 |
| Q2 2025 | $55.5m | $6.0m | 0.11 |
| Q3 2025 | $57.6m | $6.2m | 0.11 |
Biggest buyers
| MILLENNIUM MANAGEMENT LLC | Added | +1.4m |
| LAZARD ASSET MANAGEMENT LLC | Added | +927.2k |
| Sumitomo Mitsui Trust Group, Inc. | Added | +904.6k |
| MORGAN STANLEY | Added | +585.1k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | Added | +577.9k |
| TUDOR INVESTMENT CORP ET AL | Added | +323.6k |
| Rubric Capital Management LP | Added | +268.8k |
| GOLDMAN SACHS GROUP INC | Added | +241.7k |
| JUPITER ASSET MANAGEMENT LTD | New | +234.6k |
| Man Group plc | Added | +116.5k |
Biggest sellers
| CADIAN CAPITAL MANAGEMENT, LP | Sold out | -3.0m |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | Reduced | -822.0k |
| BANK OF AMERICA CORP /DE/ | Reduced | -408.2k |
| UBS Group AG | Reduced | -386.2k |
| ROYAL BANK OF CANADA | Reduced | -364.1k |
| VANGUARD GROUP INC | Reduced | -277.6k |
| Parkman Healthcare Partners LLC | Reduced | -247.4k |
| FMR LLC | Reduced | -239.4k |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | Reduced | -219.6k |
| BlackRock, Inc. | Reduced | -216.0k |
Biggest calls
| PEAK6 LLC | Added | $43.8m2.2m shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $7.9m393.8k shares |
| SIMPLEX TRADING, LLC | Added | $1.3m62.6k shares |
| WOLVERINE TRADING, LLC | Added | $1.2m57.4k shares |
| JANE STREET GROUP, LLC | Added | $940.8k46.9k shares |
| CITADEL ADVISORS LLC | Reduced | $876.6k43.7k shares |
| IMC-Chicago, LLC | Reduced | $764.3k38.1k shares |
| Walleye Trading LLC | Reduced | $367.1k18.3k shares |
| GROUP ONE TRADING LLC | Reduced | $355.1k17.7k shares |
| BARCLAYS PLC | Unchanged | $124.4k6.2k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $2.9m146.2k shares |
| CITADEL ADVISORS LLC | Added | $2.2m107.7k shares |
| IMC-Chicago, LLC | Reduced | $427.3k21.3k shares |
| JANE STREET GROUP, LLC | Reduced | $292.9k14.6k shares |
| WOLVERINE TRADING, LLC | Reduced | $224.4k11.2k shares |
| GROUP ONE TRADING LLC | Added | $76.2k3.8k shares |
| SIMPLEX TRADING, LLC | Reduced | $66.0k3.3k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2025-07-18 | 12.7% |
| Rubric Capital Management LP 13G · institution +2.8 pts · filed 2026-05-15 | 9.3% |
| VANGUARD PORTFOLIO MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 6.0% |
Fell to 5% or below in the last year: Sumitomo Mitsui Trust Group, Inc. (4.9%, 2026-04-30), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD PORTFOLIO MANAGEMENT LLC)
Insider purchases and sales in Q3 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 5 | $189.7k | $102.4k |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 0 | — | 1 | $27.2k | $27.2k |
| Q1 2025 | 0 | — | 5 | $339.9k | $220.4k |
| Q2 2025 | 0 | — | 1 | $419.5k | $419.5k |
| Q3 2025 | 0 | — | 0 | — | — |
None reported in Q3 2025.
Holders, Q3 2025
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.00% of their portfolio | 9.6m $191.8m | Reduced -216.0k |
| GATES FOUNDATION TRUST 0.38% of their portfolio | 7.0m $140.1m | Unchanged |
| VANGUARD GROUP INC 0.00% of their portfolio | 6.3m $127.2m | Reduced -277.6k |
| Rubric Capital Management LP 1.42% of their portfolio | 5.3m $105.7m | Added +268.8k |
| Sumitomo Mitsui Trust Group, Inc. 0.05% of their portfolio | 4.6m $91.4m | Added +904.6k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio | 3.3m $66.3m | Reduced -111.6k |
| Amova Asset Management Americas, Inc. 0.51% of their portfolio | 2.6m $52.9m | Added +47.4k |
| LAZARD ASSET MANAGEMENT LLC 0.06% of their portfolio | 2.3m $47.1m | Added +927.2k |
| STATE STREET CORP 0.00% of their portfolio | 2.2m $44.2m | Added +19.3k |
| Stephens Investment Management Group LLC 0.57% of their portfolio | 2.2m $44.0m | Reduced -68.3k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.01% of their portfolio | 2.1m $41.6m | Added +577.9k |
| ARK Investment Management LLC 0.22% of their portfolio | 1.9m $37.6m | Reduced -86.6k |
| MORGAN STANLEY 0.00% of their portfolio | 1.7m $34.9m | Added +585.1k |
| MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio | 1.6m $31.1m | Added +1.4m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.3m $25.6m | Reduced -85.8k |
| AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio | 1.1m $21.8m | Reduced -1.1k |
| BAILLIE GIFFORD & CO 0.01% of their portfolio | 974.8k $19.6m | Reduced -10.9k |
| UBS Group AG 0.00% of their portfolio | 953.7k $19.1m | Reduced -386.2k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 851.4k $17.1m | Added +108.9k |
| TWO SIGMA INVESTMENTS, LP 0.02% of their portfolio | 791.1k $15.9m | Reduced -30.1k |
| TWO SIGMA ADVISERS, LP 0.03% of their portfolio | 741.1k $14.9m | Added +18.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 586.0k $11.8m | Reduced -30.0k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 562.1k $11.3m | Added +241.7k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 485.5k $9.7m | Reduced -36.1k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 428.8k $8.6m | Reduced -364.1k |
| Parkman Healthcare Partners LLC 0.75% of their portfolio | 340.2k $6.8m | Reduced -247.4k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 339.3k $6.8m | Reduced -16.6k |
| TUDOR INVESTMENT CORP ET AL 0.04% of their portfolio | 336.4k $6.7m | Added +323.6k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 286.4k $5.7m | Added +20.3k |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 0.03% of their portfolio | 284.0k $5.7m | Reduced -822.0k |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 271.1k $5.4m | Reduced -6.0k |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 244.8k $4.9m | Added +104.6k |
| JUPITER ASSET MANAGEMENT LTD 0.04% of their portfolio | 234.6k $4.7m | New |
| Public Sector Pension Investment Board 0.02% of their portfolio | 218.6k $4.4m | Added +28.2k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.01% of their portfolio | 206.3k $4.1m | Added +2.3k |
| Allspring Global Investments Holdings, LLC 0.01% of their portfolio | 199.4k $4.0m | Reduced -5.9k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 198.7k $4.0m | Reduced -408.2k |
| FMR LLC 0.00% of their portfolio | 197.8k $4.0m | Reduced -239.4k |
| Nuveen, LLC 0.00% of their portfolio | 183.5k $3.7m | Added +53.2k |
| Invesco Ltd. 0.00% of their portfolio | 180.5k $3.6m | Added +24.6k |
| TOCQUEVILLE ASSET MANAGEMENT L.P. 0.05% of their portfolio | 172.2k $3.5m | Reduced -219.6k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 165.9k $3.3m | Reduced -5.4k |
| FIRST TRUST ADVISORS LP 0.00% of their portfolio | 163.4k $3.3m | Added +102.4k |
| Man Group plc 0.01% of their portfolio | 163.2k $3.3m | Added +116.5k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 162.6k $3.3m | Added +79.1k |
| Legal & General Group Plc 0.00% of their portfolio | 156.7k $3.1m | Reduced -5.0k |
| CITIGROUP INC 0.00% of their portfolio | 155.2k $3.1m | Added +85.4k |
| Tejara Capital Ltd 1.43% of their portfolio | 129.7k $2.6m | Reduced -32.8k |
| Swiss National Bank 0.00% of their portfolio | 124.4k $2.5m | Added +2.4k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 110.5k $2.2m | Reduced -8.2k |
| FRED ALGER MANAGEMENT, LLC 0.01% of their portfolio | 103.1k $2.1m | Added +58.2k |
| BARCLAYS PLC 0.00% of their portfolio | 99.0k $2.0m | Reduced -42.8k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 97.2k $1.9m | Added +47.2k |
| Slow Capital, Inc. 0.22% of their portfolio | 93.9k $1.9m | Reduced -9.8k |
| Connor, Clark & Lunn Investment Management Ltd. 0.01% of their portfolio | 87.6k $1.8m | New |
| Campbell & CO Investment Adviser LLC 0.13% of their portfolio | 86.3k $1.7m | New |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 72.0k $1.4m | Unchanged |
| CANADA LIFE ASSURANCE Co 0.00% of their portfolio | 66.5k $1.3m | Added +3.0k |
| Verity Asset Management, Inc. 0.43% of their portfolio | 64.9k $1.3m | Added +19.7k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 64.3k $1.3m | Reduced -62.5k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 58.4k $1.2m | Added +3 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 58.1k $1.2m | Added +133 |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 56.3k $1.1m | Reduced -1.4k |
| PIER 88 INVESTMENT PARTNERS LLC 0.20% of their portfolio | 54.2k $1.1m | Added +40.9k |
| XTX Topco Ltd 0.06% of their portfolio | 53.6k $1.1m | Added +24.2k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 53.0k $1.1m | Added +3.1k |
| LPL Financial LLC 0.00% of their portfolio | 50.9k $1.0m | Added +63 |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 50.5k $986.8k | Added +171 |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 50.3k $1.0m | Added +20.2k |
| HRT FINANCIAL LP 0.00% of their portfolio | 46.4k $931.0k | New |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 45.9k $921.0k | Unchanged |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 45.3k $908.5k | Added +16.9k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 42.1k $843.7k | Added +5.0k |
| Kestra Advisory Services, LLC 0.00% of their portfolio | 41.5k $831.7k | New |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd 0.06% of their portfolio | 41.4k $830.0k | Added +15.8k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 41.1k $824.3k | Reduced -517 |
| Thrivent Financial for Lutherans 0.00% of their portfolio | 40.4k $811.0k | Reduced -632 |
| MARSHALL WACE, LLP 0.00% of their portfolio | 38.5k $772.0k | Reduced -25.3k |
| SG Americas Securities, LLC 0.00% of their portfolio | 38.1k $765.0k | Added +5.0k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 35.4k $710.5k | Added +18.0k |
| Prosight Management, LP 0.17% of their portfolio | 34.8k $698.7k | New |
| INTECH INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 33.9k $681.0k | Reduced -3.6k |
| ALGERT GLOBAL LLC 0.01% of their portfolio | 33.9k $679.8k | Reduced -85.5k |
| AlphaQuest LLC 0.04% of their portfolio | 33.1k $663.4k | Added +7.9k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 32.9k $660.6k | Unchanged |
| CAPITAL FUND MANAGEMENT S.A. 0.01% of their portfolio | 32.2k $645.6k | Reduced -41.7k |
| Illinois Municipal Retirement Fund 0.01% of their portfolio | 31.3k $627.5k | Added +7.1k |
| IMC-Chicago, LLC 0.01% of their portfolio | 31.0k $622.8k | New |
| SEI INVESTMENTS CO 0.00% of their portfolio | 30.9k $619.8k | Reduced -7.3k |
| TrueMark Investments, LLC 0.11% of their portfolio | 30.6k $612.8k | Reduced -2.5k |
| Brevan Howard Capital Management LP 0.01% of their portfolio | 29.4k $590.0k | Reduced -38.4k |
| JANUS HENDERSON GROUP PLC 0.00% of their portfolio | 28.3k $568.0k | Reduced -25.8k |
| Susquehanna Portfolio Strategies, LLC 0.01% of their portfolio | 28.3k $567.4k | Reduced -20.3k |
| State of Alaska, Department of Revenue 0.01% of their portfolio | 28.2k $565.0k | Reduced -5.0k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 26.7k $535.4k | Reduced -1.7k |
| Schonfeld Strategic Advisors LLC 0.00% of their portfolio | 26.4k $529.7k | Reduced -124.4k |
| Louisiana State Employees Retirement System 0.01% of their portfolio | 25.8k $517.5k | Reduced -300 |
| Creative Planning 0.00% of their portfolio | 25.6k $513.3k | Reduced -2.2k |
| State of Tennessee, Department of Treasury 0.00% of their portfolio | 25.4k $508.9k | Reduced -3.7k |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio | 24.5k $490.8k | Added +362 |