SAREPTA THERAPEUTICS INC SRPT
COM · Common Stock · CUSIP 803607100 · ISIN US8036071004
Biopharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersCambridge, MA
- Founded1980
- Websitesarepta.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($9.6m this quarter). Holder counts are more reliable. Shares outstanding: 105.6m as of 2026-05-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $21.70. Options: 16 managers hold calls ($101.7m notional), 20 hold puts ($104.7m).
Trends to Q1 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 376 |
| Q4 2022 | 414 |
| Q1 2023 | 427 |
| Q2 2023 | 406 |
| Q3 2023 | 396 |
| Q4 2023 | 397 |
| Q1 2024 | 416 |
| Q2 2024 | 486 |
| Q3 2024 | 460 |
| Q4 2024 | 467 |
| Q1 2025 | 433 |
| Q2 2025 | 365 |
| Q3 2025 | 320 |
| Q4 2025 | 349 |
| Q1 2026 | 346 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2024 | 291 | 175 |
| Q3 2024 | 225 | 237 |
| Q4 2024 | 212 | 220 |
| Q1 2025 | 211 | 249 |
| Q2 2025 | 222 | 217 |
| Q3 2025 | 173 | 208 |
| Q4 2025 | 198 | 132 |
| Q1 2026 | 150 | 177 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2025 | $133.9m | $80.0m | 0.60 |
| Q3 2025 | $140.5m | $115.1m | 0.82 |
| Q4 2025 | $116.8m | $135.4m | 1.16 |
| Q1 2026 | $101.7m | $104.7m | 1.03 |
Biggest buyers
| RA CAPITAL MANAGEMENT, L.P. | New | +3.9m |
| TWO SIGMA INVESTMENTS, LP | Added | +2.2m |
| FIRST TRUST ADVISORS LP | Added | +2.1m |
| CANADA PENSION PLAN INVESTMENT BOARD | Added | +896.0k |
| MORGAN STANLEY | Added | +684.4k |
| Legal & General Group Plc | Added | +602.3k |
| MARSHALL WACE, LLP | Added | +581.6k |
| HOTCHKIS & WILEY CAPITAL MANAGEMENT LLC | New | +560.1k |
| CITADEL ADVISORS LLC | Added | +533.4k |
| GOLDMAN SACHS GROUP INC | Added | +514.8k |
Biggest sellers
| TWO SIGMA ADVISERS, LP | Sold out | -2.1m |
| AQR CAPITAL MANAGEMENT LLC | Reduced | -1.4m |
| D. E. Shaw & Co., Inc. | Reduced | -1.1m |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | Reduced | -445.9k |
| TANG CAPITAL MANAGEMENT LLC | Sold out | -349.2k |
| HRT FINANCIAL LP | Sold out | -294.1k |
| NATIONAL BANK OF CANADA /FI/ | Reduced | -222.9k |
| Point72 Asset Management, L.P. | Sold out | -207.5k |
| Aquatic Capital Management LLC | Reduced | -194.6k |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Reduced | -180.7k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $35.7m1.6m shares |
| CITADEL ADVISORS LLC | Added | $28.4m1.3m shares |
| GROUP ONE TRADING LLC | Reduced | $13.6m626.7k shares |
| SIMPLEX TRADING, LLC | Reduced | $5.9m272.7k shares |
| Caption Management, LLC | Reduced | $3.6m167.5k shares |
| LMR Partners LLP | Reduced | $3.4m155.2k shares |
| Balyasny Asset Management L.P. | Reduced | $3.3m150.0k shares |
| IMC-Chicago, LLC | Added | $2.0m92.8k shares |
| CAPITAL FUND MANAGEMENT S.A. | Reduced | $1.4m65.0k shares |
| Walleye Capital LLC | Reduced | $1.2m55.8k shares |
Biggest puts
| LMR Partners LLP | Reduced | $31.0m1.4m shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $27.9m1.3m shares |
| GROUP ONE TRADING LLC | Reduced | $10.6m487.5k shares |
| SIMPLEX TRADING, LLC | Reduced | $7.4m339.7k shares |
| CITADEL ADVISORS LLC | Reduced | $7.1m324.6k shares |
| IMC-Chicago, LLC | Reduced | $6.1m281.3k shares |
| WHITEBOX ADVISORS LLC | Reduced | $4.7m214.6k shares |
| D. E. Shaw & Co., Inc. | Added | $2.8m126.8k shares |
| Balyasny Asset Management L.P. | Reduced | $1.6m75.0k shares |
| Walleye Capital LLC | Reduced | $1.1m52.0k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution +3.2 pts · filed 2026-07-30 | 15.8% |
| STATE STREET CORP 13G · institution +3.0 pts · filed 2026-08-07 | 8.4% |
| VANGUARD PORTFOLIO MANAGEMENT LLC 13G · institution +1.6 pts · filed 2026-07-31 | 8.1% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.1% |
| AQR CAPITAL MANAGEMENT LLC 13G · institution -2.7 pts · filed 2026-08-13 | 5.0% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD PORTFOLIO MANAGEMENT LLC), D. E. SHAW & CO, L.P. (1.9%, 2025-11-14)
Insider purchases and sales in Q1 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2024 | 0 | — | 3 | $8.7m | $8.7m |
| Q3 2024 | 1 | $5.0m | 1 | $822.1k | — |
| Q4 2024 | 0 | — | 2 | $1.5m | — |
| Q1 2025 | 0 | — | 1 | $248.2k | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 1 | $294.2k | — |
| Q1 2026 | 0 | — | 1 | $123.2k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-03-12 | Mayo Stephen Director | Sold | $123.2k7.2k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2026
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.01% of their portfolio | 14.8m $321.1m | Added +472.0k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.01% of their portfolio | 6.6m $144.5m | First filing |
| STATE STREET CORP 0.00% of their portfolio | 6.6m $143.9m | Added +13.9k |
| AQR CAPITAL MANAGEMENT LLC 0.06% of their portfolio | 6.4m $138.6m | Reduced -1.4m |
| TWO SIGMA INVESTMENTS, LP 0.08% of their portfolio | 4.6m $99.9m | Added +2.2m |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 4.6m $99.6m | First filing |
| FIRST TRUST ADVISORS LP 0.06% of their portfolio | 4.1m $90.0m | Added +2.1m |
| RA CAPITAL MANAGEMENT, L.P. 0.90% of their portfolio | 3.9m $84.9m | New |
| Erste Asset Management GmbH 0.57% of their portfolio | 3.0m $61.3m | Added +240.0k |
| MORGAN STANLEY 0.00% of their portfolio | 2.6m $56.5m | Added +684.4k |
| Aberdeen Group plc 0.08% of their portfolio | 2.3m $50.5m | Added +67.3k |
| UBS Group AG 0.01% of their portfolio | 2.2m $48.6m | Added +173.8k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 2.1m $46.7m | Added +451.3k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 2.0m $43.3m | Added +84.5k |
| FEDERATED HERMES, INC. 0.06% of their portfolio | 1.8m $38.9m | Added +472.7k |
| RENAISSANCE TECHNOLOGIES LLC 0.06% of their portfolio | 1.7m $36.2m | Added +505.5k |
| CANADA PENSION PLAN INVESTMENT BOARD 0.02% of their portfolio | 1.2m $27.0m | Added +896.0k |
| MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio | 1.2m $26.6m | Added +221.6k |
| CITIGROUP INC 0.02% of their portfolio | 1.1m $25.0m | Added +1.5k |
| T. Rowe Price Investment Management, Inc. 0.02% of their portfolio | 1.1m $24.7m | Reduced -128.6k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 1.1m $23.5m | Added +514.8k |
| Connor, Clark & Lunn Investment Management Ltd. 0.05% of their portfolio | 1.0m $22.2m | Reduced -62.8k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.03% of their portfolio | 897.5k $19.5m | Added +469.9k |
| Legal & General Group Plc 0.00% of their portfolio | 866.7k $18.9m | Added +602.3k |
| Voleon Capital Management LP 0.38% of their portfolio | 800.7k $17.4m | Reduced -79.3k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 791.1k $17.2m | Added +25.7k |
| 683 Capital Management, LLC 1.51% of their portfolio | 750.0k $16.3m | Reduced -60.0k |
| MARSHALL WACE, LLP 0.02% of their portfolio | 725.1k $15.8m | Added +581.6k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 724.3k $15.8m | Reduced -9.2k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 703.2k $14.4m | Reduced -40.8k |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 699.8k $15.2m | Reduced -28.0k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 687.6k $15.0m | Reduced -3.5k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 656.8k $14.3m | First filing |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 652.2k $14.2m | Added +533.4k |
| HOTCHKIS & WILEY CAPITAL MANAGEMENT LLC 0.04% of their portfolio | 560.1k $12.2m | New |
| SG Americas Securities, LLC 0.01% of their portfolio | 559.1k $12.2m | Added +367.7k |
| PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio | 509.6k $11.1m | Added +12.3k |
| Jump Financial, LLC 0.16% of their portfolio | 507.8k $11.1m | Added +338.9k |
| C WorldWide Group Holding A/S 0.23% of their portfolio | 490.3k $10.7m | Unchanged |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 475.0k $10.3m | Reduced -1.1m |
| CAPITAL FUND MANAGEMENT S.A. 0.09% of their portfolio | 459.3k $10.0m | Reduced -26.1k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.04% of their portfolio | 432.5k $9.4m | Reduced -445.9k |
| Invesco Ltd. 0.00% of their portfolio | 410.3k $8.9m | Added +13.3k |
| Balyasny Asset Management L.P. 0.02% of their portfolio | 392.0k $8.5m | Added +300.4k |
| Public Sector Pension Investment Board 0.03% of their portfolio | 374.9k $8.2m | Added +12.2k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.03% of their portfolio | 372.6k $8.1m | Reduced -180.7k |
| IEQ CAPITAL, LLC 0.04% of their portfolio | 370.5k $8.1m | Reduced -104.5k |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.01% of their portfolio | 365.3k $7.9m | Reduced -113.9k |
| Clear Street Group Inc. 0.04% of their portfolio | 361.4k $7.9m | Reduced -71.6k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 336.7k $7.3m | Reduced -121.4k |
| Trexquant Investment LP 0.05% of their portfolio | 323.9k $7.0m | Added +145.6k |
| Walleye Capital LLC 0.04% of their portfolio | 288.5k $6.3m | Added +15.8k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 277.0k $6.0m | Added +10.4k |
| ADAR1 Capital Management, LLC 0.34% of their portfolio | 262.1k $5.7m | Added +233.2k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 261.3k $5.7m | Added +43.8k |
| Hudson Bay Capital Management LP 0.03% of their portfolio | 260.0k $5.7m | Reduced -15.0k |
| HIGHBRIDGE CAPITAL MANAGEMENT LLC 0.32% of their portfolio | 250.0k $5.1m | Reduced -150.0k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 222.8k $4.8m | Added +15.9k |
| Mariner, LLC 0.01% of their portfolio | 219.7k $4.8m | Reduced -37.4k |
| WORLDQUANT MILLENNIUM ADVISORS LLC 0.02% of their portfolio | 214.6k $4.7m | Added +184.6k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 203.1k $4.4m | Added +13.0k |
| CWM, LLC 0.01% of their portfolio | 198.3k $4.3m | Reduced -42.2k |
| Swiss National Bank 0.00% of their portfolio | 196.0k $4.3m | Unchanged |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 187.7k $4.1m | New |
| Nuveen, LLC 0.00% of their portfolio | 186.8k $4.1m | Reduced -10.0k |
| Generali Investments CEE, investicni spolecnost, a.s. 0.19% of their portfolio | 163.3k $3.6m | Added +26.8k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 162.7k $3.5m | Reduced -32.6k |
| Boxer Capital Management, LLC 0.43% of their portfolio | 150.0k $3.3m | Unchanged |
| Cerity Partners LLC 0.00% of their portfolio | 149.8k $3.3m | Reduced -62.5k |
| Squarepoint Ops LLC 0.01% of their portfolio | 148.8k $3.2m | Added +97.9k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 136.6k $3.0m | Reduced -162.8k |
| BARCLAYS PLC 0.00% of their portfolio | 136.0k $3.0m | Reduced -97.2k |
| Bridgewater Associates, LP 0.01% of their portfolio | 134.3k $2.9m | Reduced -146.3k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 128.8k $2.8m | First filing |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 127.2k $2.8m | Reduced -40.5k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 120.7k $2.6m | Added +26.1k |
| Empowered Funds, LLC 0.02% of their portfolio | 113.9k $2.5m | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 103.3k $2.2m | Added +13.2k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 103.0k $2.1m | Reduced -132.0k |
| GROUP ONE TRADING LLC 0.07% of their portfolio | 99.9k $2.2m | Reduced -40.9k |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 99.1k $2.2m | Added +5.6k |
| AXQ CAPITAL, LP 0.28% of their portfolio | 98.2k $2.1m | Added +78.0k |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 97.1k $2.1m | Reduced -3.5k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 94.4k $2.1m | New |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 94.1k $2.0m | Reduced -340 |
| Quantinno Capital Management LP 0.00% of their portfolio | 91.2k $2.0m | Reduced -16.4k |
| GSA CAPITAL PARTNERS LLP 0.12% of their portfolio | 91.0k $2.0m | Added +20.6k |
| VANGUARD ASSET MANAGEMENT, Ltd 0.00% of their portfolio | 89.7k $2.0m | First filing |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 89.5k $1.8m | Reduced -17.3k |
| Y-Intercept (Hong Kong) Ltd 0.04% of their portfolio | 88.9k $1.9m | New |
| Jain Global LLC 0.02% of their portfolio | 87.4k $1.9m | New |
| ALPS ADVISORS INC 0.01% of their portfolio | 85.5k $1.9m | Reduced -568 |
| CANADA LIFE ASSURANCE Co 0.00% of their portfolio | 85.2k $1.9m | Reduced -4.0k |
| Creative Planning 0.00% of their portfolio | 84.2k $1.8m | Reduced -11.0k |
| HARBOR CAPITAL ADVISORS, INC. 0.14% of their portfolio | 80.1k $1.7m | New |
| Jefferies Financial Group Inc. 0.02% of their portfolio | 79.0k $1.7m | New |
| MERCER GLOBAL ADVISORS INC /ADV 0.00% of their portfolio | 78.2k $1.7m | Reduced -17.5k |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio | 77.8k $1.7m | Reduced -507 |
| PROFUND ADVISORS LLC 0.06% of their portfolio | 74.0k $1.6m | Reduced -2.2k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 73.1k $1.6m | Added +3.0k |