SAREPTA THERAPEUTICS INC SRPT
COM · Common Stock · CUSIP 803607100 · ISIN US8036071004
Biopharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersCambridge, MA
- Founded1980
- Websitesarepta.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($3.7m this quarter). Holder counts are more reliable. Shares outstanding: 98.3m as of 2025-05-02, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $64.11. Options: 28 managers hold calls ($102.4m notional), 25 hold puts ($81.3m).
Trends to Q1 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 376 |
| Q4 2022 | 414 |
| Q1 2023 | 427 |
| Q2 2023 | 406 |
| Q3 2023 | 396 |
| Q4 2023 | 397 |
| Q1 2024 | 416 |
| Q2 2024 | 486 |
| Q3 2024 | 460 |
| Q4 2024 | 467 |
| Q1 2025 | 433 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2023 | 204 | 205 |
| Q3 2023 | 201 | 180 |
| Q4 2023 | 181 | 206 |
| Q1 2024 | 215 | 178 |
| Q2 2024 | 291 | 175 |
| Q3 2024 | 225 | 237 |
| Q4 2024 | 212 | 220 |
| Q1 2025 | 211 | 249 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2024 | $728.7m | $324.9m | 0.45 |
| Q3 2024 | $285.3m | $239.6m | 0.84 |
| Q4 2024 | $211.4m | $184.1m | 0.87 |
| Q1 2025 | $102.4m | $81.3m | 0.79 |
Biggest buyers
| MORGAN STANLEY | Added | +980.5k |
| Deep Track Capital, LP | New | +899.7k |
| Assenagon Asset Management S.A. | Added | +580.1k |
| WELLINGTON MANAGEMENT GROUP LLP | Added | +577.8k |
| EcoR1 Capital, LLC | Added | +522.4k |
| TWO SIGMA INVESTMENTS, LP | Added | +475.8k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | New | +457.3k |
| Capital International Investors | Added | +363.6k |
| Erste Asset Management GmbH | Added | +352.8k |
| CITIGROUP INC | Added | +309.7k |
Biggest sellers
| Bank of New York Mellon Corp | Reduced | -1.4m |
| BlackRock, Inc. | Reduced | -1.3m |
| JANUS HENDERSON GROUP PLC | Reduced | -963.5k |
| ORBIMED ADVISORS LLC | Sold out | -963.4k |
| Thrivent Financial for Lutherans | Reduced | -616.9k |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | Reduced | -523.7k |
| CITADEL ADVISORS LLC | Reduced | -382.0k |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | Sold out | -379.1k |
| GOLDMAN SACHS GROUP INC | Reduced | -295.0k |
| FMR LLC | Reduced | -270.4k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $29.1m456.6k shares |
| GROUP ONE TRADING LLC | Added | $11.8m185.2k shares |
| JANE STREET GROUP, LLC | Added | $10.6m166.3k shares |
| CITADEL ADVISORS LLC | Reduced | $7.2m113.3k shares |
| NOMURA HOLDINGS INC | Added | $5.8m91.1k shares |
| GOLDMAN SACHS GROUP INC | Reduced | $3.6m57.1k shares |
| JPMORGAN CHASE & CO | Reduced | $3.5m55.0k shares |
| Squarepoint Ops LLC | Added | $3.5m54.7k shares |
| SIMPLEX TRADING, LLC | Reduced | $3.4m53.2k shares |
| Caption Management, LLC | Added | $3.3m51.0k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $10.7m167.4k shares |
| JANE STREET GROUP, LLC | Added | $10.5m164.6k shares |
| GROUP ONE TRADING LLC | Reduced | $9.3m145.7k shares |
| ROYAL BANK OF CANADA | New | $8.8m137.8k shares |
| CITADEL ADVISORS LLC | Reduced | $8.7m135.6k shares |
| PEAK6 LLC | Added | $6.5m102.4k shares |
| JPMORGAN CHASE & CO | Unchanged | $4.5m70.0k shares |
| GOLDMAN SACHS GROUP INC | Reduced | $3.6m57.1k shares |
| NOMURA HOLDINGS INC | New | $2.2m34.4k shares |
| Point72 Asset Management, L.P. | New | $1.9m30.0k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution +3.2 pts · filed 2026-07-30 | 15.8% |
| STATE STREET CORP 13G · institution +3.0 pts · filed 2026-08-07 | 8.4% |
| VANGUARD PORTFOLIO MANAGEMENT LLC 13G · institution +1.6 pts · filed 2026-07-31 | 8.1% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.1% |
| AQR CAPITAL MANAGEMENT LLC 13G · institution -2.7 pts · filed 2026-08-13 | 5.0% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD PORTFOLIO MANAGEMENT LLC), D. E. SHAW & CO, L.P. (1.9%, 2025-11-14)
Insider purchases and sales in Q1 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2023 | 0 | — | 0 | — | — |
| Q3 2023 | 1 | $7.4m | 1 | $1.6m | — |
| Q4 2023 | 2 | $5.9m | 0 | — | — |
| Q1 2024 | 0 | — | 6 | $3.0m | — |
| Q2 2024 | 0 | — | 3 | $8.7m | $8.7m |
| Q3 2024 | 1 | $5.0m | 1 | $822.1k | — |
| Q4 2024 | 0 | — | 2 | $1.5m | — |
| Q1 2025 | 0 | — | 1 | $248.2k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-03-12 | Nicaise Claude Director | Sold | $248.2k2.5k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2025
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.01% of their portfolio | 9.9m $632.3m | Reduced -1.3m |
| Capital International Investors 0.11% of their portfolio | 9.1m $578.3m | Added +363.6k |
| VANGUARD GROUP INC 0.01% of their portfolio | 9.0m $576.5m | Reduced -52.8k |
| STATE STREET CORP 0.01% of their portfolio | 4.1m $259.6m | Reduced -1.4k |
| JANUS HENDERSON GROUP PLC 0.13% of their portfolio | 3.4m $236.9m | Reduced -963.5k |
| Avoro Capital Advisors LLC 2.66% of their portfolio | 2.7m $170.7m | Added +119.3k |
| WELLINGTON MANAGEMENT GROUP LLP 0.03% of their portfolio | 2.6m $168.9m | Added +577.8k |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 0.81% of their portfolio | 2.3m $149.4m | Reduced -523.7k |
| JPMORGAN CHASE & CO 0.01% of their portfolio | 2.2m $143.2m | Added +223.8k |
| T. Rowe Price Investment Management, Inc. 0.08% of their portfolio | 2.0m $127.5m | Added +41.4k |
| MORGAN STANLEY 0.01% of their portfolio | 2.0m $125.9m | Added +980.5k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 1.8m $116.2m | Added +114.6k |
| DEUTSCHE BANK AG\ 0.04% of their portfolio | 1.7m $106.2m | Added +224 |
| UBS Group AG 0.02% of their portfolio | 1.4m $92.3m | Reduced -33.5k |
| GROUPAMA ASSET MANAGMENT 0.02% of their portfolio | 1.3m $1.2m | Unchanged |
| EcoR1 Capital, LLC 4.90% of their portfolio | 1.3m $82.5m | Added +522.4k |
| NORGES BANK 0.01% of their portfolio | 1.2m $76.1m | Added +153.5k |
| Erste Asset Management GmbH 0.81% of their portfolio | 1.1m $62.8m | Added +352.8k |
| Pictet Asset Management Holding SA 0.07% of their portfolio | 937.0k $60.7m | Reduced -109.0k |
| Casdin Capital, LLC 4.70% of their portfolio | 900.8k $57.5m | Reduced -172.7k |
| Deep Track Capital, LP 1.86% of their portfolio | 899.7k $57.4m | New |
| ALKEON CAPITAL MANAGEMENT LLC 0.32% of their portfolio | 853.8k $54.5m | Unchanged |
| Camber Capital Management LP 3.19% of their portfolio | 800.0k $51.1m | Reduced -200.0k |
| Bank of New York Mellon Corp 0.01% of their portfolio | 791.1k $50.5m | Reduced -1.4m |
| NORTHERN TRUST CORP 0.01% of their portfolio | 769.8k $49.1m | Reduced -33.7k |
| Assenagon Asset Management S.A. 0.08% of their portfolio | 712.6k $45.5m | Added +580.1k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 692.1k $44.2m | Added +82.5k |
| Aberdeen Group plc 0.08% of their portfolio | 650.3k $41.7m | Added +192.6k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 646.3k $41.2m | Added +22.5k |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 586.3k $37.4m | Added +275.5k |
| TWO SIGMA INVESTMENTS, LP 0.08% of their portfolio | 550.9k $35.2m | Added +475.8k |
| ROYAL BANK OF CANADA 0.01% of their portfolio | 543.4k $34.7m | Reduced -29.3k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio | 463.3k $29.6m | Added +164.0k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.11% of their portfolio | 457.3k $29.2m | New |
| Amundi 0.01% of their portfolio | 456.8k $26.8m | Added +3.1k |
| BARCLAYS PLC 0.01% of their portfolio | 445.7k $28.4m | Reduced -44.4k |
| FMR LLC 0.00% of their portfolio | 422.5k $27.0m | Reduced -270.4k |
| FIRST TRUST ADVISORS LP 0.02% of their portfolio | 394.2k $25.2m | Added +82.4k |
| CITIGROUP INC 0.02% of their portfolio | 383.8k $24.5m | Added +309.7k |
| RAYMOND JAMES FINANCIAL INC 0.01% of their portfolio | 362.9k $23.2m | Reduced -33.9k |
| Nuveen, LLC 0.01% of their portfolio | 352.7k $22.5m | First filing |
| Fiera Capital Corp 0.08% of their portfolio | 345.8k $22.1m | Reduced -4.6k |
| AMERIPRISE FINANCIAL INC 0.01% of their portfolio | 336.8k $21.5m | Added +25.8k |
| Sofinnova Investments, Inc. 1.58% of their portfolio | 327.6k $20.9m | Reduced -101.2k |
| FEDERATED HERMES, INC. 0.04% of their portfolio | 292.1k $18.6m | Reduced -88.3k |
| TWO SIGMA ADVISERS, LP 0.04% of their portfolio | 276.3k $17.6m | New |
| RHUMBLINE ADVISERS 0.02% of their portfolio | 265.2k $16.9m | Reduced -2.7k |
| TWINBEECH CAPITAL LP 0.31% of their portfolio | 265.0k $16.9m | New |
| Squarepoint Ops LLC 0.04% of their portfolio | 252.5k $16.1m | Added +222.1k |
| C WorldWide Group Holding A/S 0.20% of their portfolio | 250.3k $16.0m | Added +60.0k |
| Connor, Clark & Lunn Investment Management Ltd. 0.07% of their portfolio | 244.8k $15.6m | Added +97.5k |
| PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio | 244.8k $15.6m | Reduced -37.3k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 238.2k $15.2m | Reduced -3.4k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 235.8k $15.0m | Reduced -382.0k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 234.9k $15.0m | Reduced -1.2k |
| BRAIDWELL LP 0.53% of their portfolio | 234.5k $15.0m | Reduced -130.4k |
| MIZUHO MARKETS AMERICAS LLC 0.31% of their portfolio | 227.3k $14.5m | Reduced -178.5k |
| EVENTIDE ASSET MANAGEMENT, LLC 0.27% of their portfolio | 214.4k $13.7m | Reduced -58.6k |
| Palo Alto Investors LP 2.56% of their portfolio | 210.3k $13.4m | Unchanged |
| Legal & General Group Plc 0.00% of their portfolio | 208.3k $13.3m | Added +56.9k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 206.9k $13.2m | Added +193.9k |
| Invesco Ltd. 0.00% of their portfolio | 205.2k $13.1m | Reduced -60.1k |
| Hudson Bay Capital Management LP 0.08% of their portfolio | 200.2k $12.8m | Added +135.2k |
| CAPITAL FUND MANAGEMENT S.A. 0.16% of their portfolio | 200.1k $12.8m | Added +26.4k |
| Vestal Point Capital, LP 0.91% of their portfolio | 200.0k $12.8m | Reduced -50.0k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio | 197.6k $12.6m | Added +4.0k |
| Trexquant Investment LP 0.14% of their portfolio | 188.0k $12.0m | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 182.1k $11.6m | Reduced -295.0k |
| Brandywine Global Investment Management, LLC 0.08% of their portfolio | 174.6k $11.1m | Reduced -11.4k |
| Ikarian Capital, LLC 3.52% of their portfolio | 169.1k $10.8m | Added +135.0k |
| Swiss National Bank 0.01% of their portfolio | 166.5k $10.6m | Reduced -2.3k |
| 683 Capital Management, LLC 1.07% of their portfolio | 165.0k $10.5m | Added +63.0k |
| Rock Springs Capital Management LP 0.58% of their portfolio | 159.3k $10.2m | Reduced -148.2k |
| SPHERA FUNDS MANAGEMENT LTD. 2.49% of their portfolio | 157.9k $10.1m | Added +59.0k |
| Finepoint Capital LP 1.70% of their portfolio | 157.6k $10.1m | Reduced -4.4k |
| JANE STREET GROUP, LLC 0.02% of their portfolio | 155.1k $9.9m | Added +103.7k |
| VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 154.4k $9.9m | Added +66.0k |
| BANK OF MONTREAL /CAN/ 0.01% of their portfolio | 150.1k $9.6m | Reduced -6.3k |
| Bellevue Group AG 0.21% of their portfolio | 149.1k $9.5m | Reduced -22.2k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 148.8k $9.5m | Added +33.4k |
| ExodusPoint Capital Management, LP 0.12% of their portfolio | 145.9k $9.3m | New |
| Clearbridge Investments, LLC 0.01% of their portfolio | 145.2k $9.3m | Reduced -91.8k |
| TD Asset Management Inc 0.01% of their portfolio | 142.4k $9.1m | Unchanged |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 133.1k $8.5m | Reduced -46.8k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.01% of their portfolio | 129.6k $8.3m | Reduced -3.8k |
| Capital Group Private Client Services, Inc. 0.08% of their portfolio | 127.1k $8.1m | Added +7.9k |
| ADAR1 Capital Management, LLC 1.51% of their portfolio | 122.9k $7.8m | Added +82.9k |
| Retirement Systems of Alabama 0.03% of their portfolio | 116.3k $7.4m | Added +114 |
| California Public Employees Retirement System 0.00% of their portfolio | 107.7k $6.9m | Reduced -35.5k |
| Corebridge Financial, Inc. 0.04% of their portfolio | 106.5k $6.8m | Reduced -2.6k |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 103.7k $6.6m | Reduced -76.9k |
| Rafferty Asset Management, LLC 0.03% of their portfolio | 99.1k $6.3m | Reduced -10.1k |
| Aquatic Capital Management LLC 0.15% of their portfolio | 92.3k $5.9m | New |
| Russell Investments Group, Ltd. 0.01% of their portfolio | 88.4k $5.6m | Added +16.7k |
| VAN ECK ASSOCIATES CORP 0.01% of their portfolio | 85.9k $5.5m | Added +1.1k |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.01% of their portfolio | 84.2k $5.4m | Unchanged |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio | 82.0k $5.2m | Added +1.3k |
| PINNACLE ASSOCIATES LTD 0.08% of their portfolio | 80.9k $5.2m | Reduced -3.2k |
| AXA S.A. 0.02% of their portfolio | 79.4k $5.1m | Added +20.5k |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio | 79.4k $5.1m | Added +2.5k |