SAREPTA THERAPEUTICS INC SRPT
COM · Common Stock · CUSIP 803607100 · ISIN US8036071004
Biopharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersCambridge, MA
- Founded1980
- Websitesarepta.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($7.9m this quarter). Holder counts are more reliable. Shares outstanding: 95.5m as of 2024-11-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $121.50. Options: 27 managers hold calls ($211.4m notional), 23 hold puts ($184.1m).
Trends to Q4 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 376 |
| Q4 2022 | 414 |
| Q1 2023 | 427 |
| Q2 2023 | 406 |
| Q3 2023 | 396 |
| Q4 2023 | 397 |
| Q1 2024 | 416 |
| Q2 2024 | 486 |
| Q3 2024 | 460 |
| Q4 2024 | 467 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2023 | 219 | 183 |
| Q2 2023 | 204 | 205 |
| Q3 2023 | 201 | 180 |
| Q4 2023 | 181 | 206 |
| Q1 2024 | 215 | 178 |
| Q2 2024 | 291 | 175 |
| Q3 2024 | 225 | 237 |
| Q4 2024 | 212 | 220 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2024 | $656.0m | $204.9m | 0.31 |
| Q2 2024 | $728.7m | $324.9m | 0.45 |
| Q3 2024 | $285.3m | $239.6m | 0.84 |
| Q4 2024 | $211.4m | $184.1m | 0.87 |
Biggest buyers
| Capital International Investors | Added | +2.4m |
| UBS Group AG | Added | +1.1m |
| EcoR1 Capital, LLC | New | +770.0k |
| Sofinnova Investments, Inc. | New | +428.8k |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | Added | +285.1k |
| Vestal Point Capital, LP | New | +250.0k |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | Added | +241.0k |
| Camber Capital Management LP | Added | +225.0k |
| ALKEON CAPITAL MANAGEMENT LLC | Added | +220.0k |
| DEUTSCHE BANK AG\ | Added | +200.2k |
Biggest sellers
| JPMORGAN CHASE & CO | Reduced | -2.4m |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Sold out | -753.8k |
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -657.8k |
| Boxer Capital, LLC | Sold out | -650.0k |
| FMR LLC | Reduced | -542.9k |
| Man Group plc | Sold out | -311.3k |
| CITADEL ADVISORS LLC | Reduced | -308.4k |
| RENAISSANCE TECHNOLOGIES LLC | Sold out | -230.5k |
| Assenagon Asset Management S.A. | Reduced | -217.6k |
| Invesco Ltd. | Reduced | -216.9k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $56.9m467.9k shares |
| Twin Tree Management, LP | Reduced | $31.8m261.9k shares |
| GROUP ONE TRADING LLC | Added | $16.6m136.3k shares |
| CITADEL ADVISORS LLC | Reduced | $15.5m127.8k shares |
| JPMORGAN CHASE & CO | Reduced | $11.9m97.5k shares |
| JANE STREET GROUP, LLC | Added | $11.0m90.3k shares |
| Ikarian Capital, LLC | New | $9.8m81.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $9.3m76.7k shares |
| PEAK6 LLC | First filing | $8.4m68.8k shares |
| GOLDMAN SACHS GROUP INC | Added | $7.0m57.7k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $46.4m381.2k shares |
| GROUP ONE TRADING LLC | Added | $24.7m203.2k shares |
| CITADEL ADVISORS LLC | Reduced | $18.3m150.4k shares |
| JANE STREET GROUP, LLC | Reduced | $16.6m136.9k shares |
| GOLDMAN SACHS GROUP INC | Added | $13.0m107.1k shares |
| HSBC HOLDINGS PLC | New | $12.1m100.0k shares |
| Caption Management, LLC | Added | $10.3m85.0k shares |
| JPMORGAN CHASE & CO | Reduced | $8.5m70.0k shares |
| Twin Tree Management, LP | Reduced | $7.9m64.9k shares |
| SIMPLEX TRADING, LLC | Reduced | $4.7m39.0k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution +3.2 pts · filed 2026-07-30 | 15.8% |
| STATE STREET CORP 13G · institution +3.0 pts · filed 2026-08-07 | 8.4% |
| VANGUARD PORTFOLIO MANAGEMENT LLC 13G · institution +1.6 pts · filed 2026-07-31 | 8.1% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.1% |
| AQR CAPITAL MANAGEMENT LLC 13G · institution -2.7 pts · filed 2026-08-13 | 5.0% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD PORTFOLIO MANAGEMENT LLC), D. E. SHAW & CO, L.P. (1.9%, 2025-11-14)
Insider purchases and sales in Q4 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 0 | — | — |
| Q3 2023 | 1 | $7.4m | 1 | $1.6m | — |
| Q4 2023 | 2 | $5.9m | 0 | — | — |
| Q1 2024 | 0 | — | 6 | $3.0m | — |
| Q2 2024 | 0 | — | 3 | $8.7m | $8.7m |
| Q3 2024 | 1 | $5.0m | 1 | $822.1k | — |
| Q4 2024 | 0 | — | 2 | $1.5m | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-12-12 | Wigzell Hans Lennart Rudolf Director | Sold | $1.3m10.5k shares |
| 2024-12-05 | Boor Kathryn Jean Director | Sold | $205.4k1.6k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2024
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.03% of their portfolio | 11.2m $1.4bn | Added +168.7k |
| VANGUARD GROUP INC 0.02% of their portfolio | 9.1m $1.1bn | Added +117.9k |
| Capital International Investors 0.20% of their portfolio | 8.7m $1.1bn | Added +2.4m |
| JANUS HENDERSON GROUP PLC 0.27% of their portfolio | 4.3m $526.2m | Reduced -30.2k |
| STATE STREET CORP 0.02% of their portfolio | 4.1m $494.9m | Reduced -200.9k |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 1.84% of their portfolio | 2.9m $348.4m | Added +285.1k |
| Avoro Capital Advisors LLC 4.40% of their portfolio | 2.6m $310.7m | Unchanged |
| Bank of New York Mellon Corp 0.05% of their portfolio | 2.1m $260.9m | Added +26.6k |
| WELLINGTON MANAGEMENT GROUP LLP 0.05% of their portfolio | 2.1m $251.5m | Reduced -657.8k |
| JPMORGAN CHASE & CO 0.02% of their portfolio | 2.0m $245.7m | Reduced -2.4m |
| T. Rowe Price Investment Management, Inc. 0.15% of their portfolio | 2.0m $237.9m | Added +10.3k |
| GEODE CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 1.7m $207.5m | Added +10.0k |
| DEUTSCHE BANK AG\ 0.08% of their portfolio | 1.7m $202.2m | Added +200.2k |
| UBS Group AG 0.04% of their portfolio | 1.5m $180.0m | Added +1.1m |
| GROUPAMA ASSET MANAGMENT 0.03% of their portfolio | 1.3m $1.4m | Unchanged |
| Casdin Capital, LLC 8.73% of their portfolio | 1.1m $130.5m | Unchanged |
| Pictet Asset Management Holding SA 0.14% of their portfolio | 1.0m $127.2m | Reduced -5.0k |
| NORGES BANK 0.02% of their portfolio | 1.0m $126.3m | Added +32.5k |
| Camber Capital Management LP 4.76% of their portfolio | 1.0m $121.6m | Added +225.0k |
| MORGAN STANLEY 0.01% of their portfolio | 991.7k $120.6m | Added +38.6k |
| ORBIMED ADVISORS LLC 2.43% of their portfolio | 963.4k $117.1m | Added +8.9k |
| ALKEON CAPITAL MANAGEMENT LLC 0.60% of their portfolio | 853.8k $103.8m | Added +220.0k |
| NORTHERN TRUST CORP 0.01% of their portfolio | 803.5k $97.7m | Added +147.9k |
| EcoR1 Capital, LLC 3.74% of their portfolio | 770.0k $93.6m | New |
| Erste Asset Management GmbH 0.93% of their portfolio | 708.2k $76.0m | Added +72.2k |
| FMR LLC 0.01% of their portfolio | 692.9k $84.2m | Reduced -542.9k |
| Thrivent Financial for Lutherans 0.15% of their portfolio | 639.3k $77.7m | Added +14.4k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 623.7k $75.8m | Added +12.0k |
| CITADEL ADVISORS LLC 0.07% of their portfolio | 617.8k $75.1m | Reduced -308.4k |
| BANK OF AMERICA CORP /DE/ 0.01% of their portfolio | 609.6k $74.1m | Reduced -173.4k |
| ROYAL BANK OF CANADA 0.02% of their portfolio | 572.7k $69.6m | Reduced -13.3k |
| Nuveen Asset Management, LLC 0.02% of their portfolio | 524.6k $63.8m | Added +50.4k |
| BARCLAYS PLC 0.03% of their portfolio | 490.0k $59.6m | Added +30.1k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 477.1k $58.0m | Added +176.0k |
| Aberdeen Group plc 0.10% of their portfolio | 457.7k $55.3m | Added +26.6k |
| Amundi 0.02% of their portfolio | 453.7k $57.3m | Added +95.8k |
| Sofinnova Investments, Inc. 3.82% of their portfolio | 428.8k $52.1m | New |
| MIZUHO MARKETS AMERICAS LLC 0.95% of their portfolio | 405.7k $49.3m | Added +6.7k |
| RAYMOND JAMES FINANCIAL INC 0.02% of their portfolio | 396.8k $48.2m | First filing |
| FEDERATED HERMES, INC. 0.10% of their portfolio | 380.4k $46.3m | Reduced -128.4k |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC 1.54% of their portfolio | 379.1k $46.1m | Added +241.0k |
| BRAIDWELL LP 1.32% of their portfolio | 364.9k $44.4m | Reduced -5.5k |
| Fiera Capital Corp 0.13% of their portfolio | 350.3k $42.6m | Reduced -9.7k |
| FIRST TRUST ADVISORS LP 0.03% of their portfolio | 311.8k $37.9m | Reduced -153.1k |
| AMERIPRISE FINANCIAL INC 0.01% of their portfolio | 311.0k $37.8m | Reduced -6.3k |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 310.8k $37.8m | Added +30.6k |
| Rock Springs Capital Management LP 1.42% of their portfolio | 307.5k $37.4m | Unchanged |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio | 299.3k $36.4m | Added +31.1k |
| PRINCIPAL FINANCIAL GROUP INC 0.02% of their portfolio | 282.1k $34.3m | Added +15.0k |
| EVENTIDE ASSET MANAGEMENT, LLC 0.60% of their portfolio | 273.0k $33.2m | Unchanged |
| FRED ALGER MANAGEMENT, LLC 0.16% of their portfolio | 269.1k $32.7m | Reduced -17.8k |
| RHUMBLINE ADVISERS 0.03% of their portfolio | 267.9k $32.6m | Reduced -2.9k |
| Invesco Ltd. 0.01% of their portfolio | 265.3k $32.3m | Reduced -216.9k |
| Vestal Point Capital, LP 1.80% of their portfolio | 250.0k $30.4m | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 241.7k $29.4m | Added +5.1k |
| Clearbridge Investments, LLC 0.02% of their portfolio | 237.1k $28.8m | Added +1 |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 236.1k $28.7m | Added +949 |
| SOROS FUND MANAGEMENT LLC 0.49% of their portfolio | 230.9k $28.1m | Added +24.3k |
| Palo Alto Investors LP 3.96% of their portfolio | 210.3k $25.6m | Unchanged |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.02% of their portfolio | 193.7k $23.5m | Added +118.9k |
| C WorldWide Group Holding A/S 0.28% of their portfolio | 190.3k $23.1m | Added +50.0k |
| Brandywine Global Investment Management, LLC 0.16% of their portfolio | 186.0k $22.6m | New |
| HSBC HOLDINGS PLC 0.01% of their portfolio | 180.6k $21.9m | Added +21.9k |
| ALLIANCEBERNSTEIN L.P. 0.01% of their portfolio | 179.9k $21.9m | Reduced -39.1k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.04% of their portfolio | 175.0k $21.3m | Reduced -100.0k |
| CAPITAL FUND MANAGEMENT S.A. 0.21% of their portfolio | 173.7k $21.1m | Reduced -30.4k |
| Ensign Peak Advisors, Inc 0.04% of their portfolio | 173.5k $21.1m | Reduced -51.8k |
| Bellevue Group AG 0.40% of their portfolio | 171.3k $20.8m | Reduced -173.0k |
| Swiss National Bank 0.01% of their portfolio | 168.8k $20.5m | Added +2.7k |
| Balyasny Asset Management L.P. 0.05% of their portfolio | 166.0k $20.2m | Reduced -158.4k |
| Finepoint Capital LP 2.27% of their portfolio | 161.9k $19.7m | Added +28.4k |
| BANK OF MONTREAL /CAN/ 0.01% of their portfolio | 156.4k $19.0m | Reduced -29.2k |
| Legal & General Group Plc 0.00% of their portfolio | 151.4k $18.4m | Added +8.5k |
| Connor, Clark & Lunn Investment Management Ltd. 0.08% of their portfolio | 147.2k $17.9m | Added +69.0k |
| California Public Employees Retirement System 0.01% of their portfolio | 143.1k $17.4m | Reduced -7.4k |
| TD Asset Management Inc 0.02% of their portfolio | 142.4k $17.3m | Unchanged |
| Swedbank AB 0.02% of their portfolio | 137.4k $16.7m | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.02% of their portfolio | 133.4k $16.2m | Reduced -3.0k |
| Assenagon Asset Management S.A. 0.03% of their portfolio | 132.5k $16.1m | Reduced -217.6k |
| Altium Capital Management LLC 4.81% of their portfolio | 127.0k $15.4m | Reduced -43.0k |
| Cutter Capital Management, LP 6.19% of their portfolio | 124.3k $15.1m | Added +40.5k |
| Capital Group Private Client Services, Inc. 0.13% of their portfolio | 119.2k $14.5m | Added +58.3k |
| Retirement Systems of Alabama 0.05% of their portfolio | 116.1k $14.1m | Added +299 |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 115.5k $14.0m | Added +4.1k |
| Rafferty Asset Management, LLC 0.05% of their portfolio | 109.2k $13.3m | Reduced -28.8k |
| Corebridge Financial, Inc. 0.07% of their portfolio | 109.1k $13.3m | Reduced -4.7k |
| 683 Capital Management, LLC 1.22% of their portfolio | 102.0k $12.4m | Added +14.8k |
| PFM Health Sciences, LP 0.93% of their portfolio | 100.2k $12.2m | Added +12.0k |
| BRAUN STACEY ASSOCIATES INC 0.45% of their portfolio | 100.0k $12.2m | Reduced -3.0k |
| SPHERA FUNDS MANAGEMENT LTD. 2.22% of their portfolio | 98.9k $12.0m | Reduced -26.9k |
| VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio | 88.8k $10.8m | Added +22.5k |
| VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 88.4k $10.7m | Reduced -136.7k |
| J. Goldman & Co LP 0.38% of their portfolio | 87.9k $10.7m | Reduced -11.4k |
| Allspring Global Investments Holdings, LLC 0.02% of their portfolio | 85.4k $10.6m | Added +84.9k |
| VAN ECK ASSOCIATES CORP 0.01% of their portfolio | 84.8k $10.3m | Added +16.7k |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.02% of their portfolio | 84.2k $10.2m | Reduced -60 |
| PINNACLE ASSOCIATES LTD 0.14% of their portfolio | 84.0k $10.2m | Reduced -7.9k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio | 80.7k $9.8m | Reduced -259 |
| MUFG Securities EMEA plc 0.18% of their portfolio | 79.0k $9.6m | New |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM 0.02% of their portfolio | 76.8k $9.3m | Reduced -1.3k |