SANA BIOTECHNOLOGY INC SANA
COM · Common Stock · CUSIP 799566104 · ISIN US7995661045
Biotechnology company
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($405.6k this quarter). Holder counts are more reliable. Shares outstanding: 299.4m as of 2026-08-03, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $3.49. Options: 6 managers hold calls ($2.6m notional), 5 hold puts ($1.0m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 125 |
| Q4 2022 | 121 |
| Q1 2023 | 121 |
| Q2 2023 | 124 |
| Q3 2023 | 137 |
| Q4 2023 | 133 |
| Q1 2024 | 155 |
| Q2 2024 | 149 |
| Q3 2024 | 156 |
| Q4 2024 | 165 |
| Q1 2025 | 162 |
| Q2 2025 | 156 |
| Q3 2025 | 178 |
| Q4 2025 | 203 |
| Q1 2026 | 203 |
| Q2 2026 | 212 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 71 | 69 |
| Q4 2024 | 88 | 65 |
| Q1 2025 | 83 | 71 |
| Q2 2025 | 74 | 78 |
| Q3 2025 | 108 | 58 |
| Q4 2025 | 110 | 68 |
| Q1 2026 | 91 | 81 |
| Q2 2026 | 98 | 87 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $1.5m | $1.7m | 1.14 |
| Q4 2025 | $3.5m | $1.1m | 0.32 |
| Q1 2026 | $2.2m | $577.2k | 0.27 |
| Q2 2026 | $2.6m | $1.0m | 0.40 |
Biggest buyers
| RA CAPITAL MANAGEMENT, L.P. | New | +18.8m |
| BANK OF AMERICA CORP /DE/ | Added | +2.8m |
| BlackRock, Inc. | Added | +2.4m |
| MARSHALL WACE, LLP | Added | +2.3m |
| TORONTO DOMINION BANK | New | +2.0m |
| JACOBS LEVY EQUITY MANAGEMENT, INC | New | +1.9m |
| VANGUARD CAPITAL MANAGEMENT LLC | Added | +940.7k |
| STATE STREET CORP | Added | +665.0k |
| Point72 Asset Management, L.P. | New | +595.1k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +496.0k |
Biggest sellers
| BAILLIE GIFFORD & CO | Sold out | -6.6m |
| Integral Health Asset Management, LLC | Reduced | -1.2m |
| Balyasny Asset Management L.P. | Sold out | -1.0m |
| MILLENNIUM MANAGEMENT LLC | Reduced | -937.5k |
| GOLDMAN SACHS GROUP INC | Reduced | -813.2k |
| TWO SIGMA INVESTMENTS, LP | Reduced | -559.7k |
| CITADEL ADVISORS LLC | Reduced | -407.9k |
| MORGAN STANLEY | Reduced | -320.2k |
| UBS Group AG | Reduced | -293.8k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -220.1k |
Biggest calls
| SIMPLEX TRADING, LLC | Reduced | $772.3k221.3k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $694.5k199.0k shares |
| PEAK6 LLC | New | $523.5k150.0k shares |
| CITADEL ADVISORS LLC | Reduced | $380.4k109.0k shares |
| JANE STREET GROUP, LLC | Added | $125.3k35.9k shares |
| GROUP ONE TRADING LLC | Reduced | $100.9k28.9k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $517.2k148.2k shares |
| CITADEL ADVISORS LLC | Reduced | $250.2k71.7k shares |
| GROUP ONE TRADING LLC | Reduced | $137.2k39.3k shares |
| SIMPLEX TRADING, LLC | Added | $84.1k24.1k shares |
| JANE STREET GROUP, LLC | New | $39.8k11.4k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| ARCH Venture Fund IX, L.P. 13G · exempt (held before listing) -1.9 pts · filed 2026-08-14 | 15.4% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor new · filed 2026-05-21 | 6.3% |
| BlackRock, Inc. 13G · institution +0.2 pts · filed 2026-01-21 | 5.1% |
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
None reported since 1 Apr 2026.
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.01% of their portfolio | 37.4m $130.6m | Reduced -769 |
| Flagship Pioneering, LLC 5.67% of their portfolio | 25.0m $87.3m | Unchanged |
| RA CAPITAL MANAGEMENT, L.P. 0.57% of their portfolio | 18.8m $65.4m | New |
| BlackRock, Inc. 0.00% of their portfolio | 16.7m $58.2m | Added +2.4m |
| STATE STREET CORP 0.00% of their portfolio | 11.2m $39.1m | Added +665.0k |
| CANADA PENSION PLAN INVESTMENT BOARD 0.02% of their portfolio | 10.2m $35.7m | Reduced -3.5k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 8.4m $29.2m | Added +940.7k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 5.7m $20.1m | Added +2.8m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 4.7m $16.3m | Added +496.0k |
| Marex Group Ltd 0.10% of their portfolio | 4.0m $13.9m | Reduced -10.0k |
| MARSHALL WACE, LLP 0.01% of their portfolio | 2.9m $10.2m | Added +2.3m |
| Alphabet Inc. 0.01% of their portfolio | 2.8m $9.8m | Unchanged |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 2.4m $8.3m | Reduced -813.2k |
| Integral Health Asset Management, LLC 0.29% of their portfolio | 2.0m $7.0m | Reduced -1.2m |
| TORONTO DOMINION BANK 0.01% of their portfolio | 2.0m $6.9m | New |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 1.9m $6.6m | Added +174.2k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.02% of their portfolio | 1.9m $6.5m | New |
| NORTHERN TRUST CORP 0.00% of their portfolio | 1.6m $5.6m | Added +125.2k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 1.4m $4.8m | Added +13.0k |
| Woodline Partners LP 0.01% of their portfolio | 1.3m $4.6m | Unchanged |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 1.2m $4.3m | Added +173.8k |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 1.2m $4.3m | Reduced -220.1k |
| MORGAN STANLEY 0.00% of their portfolio | 1.1m $4.0m | Reduced -320.2k |
| UBS Group AG 0.00% of their portfolio | 1.1m $3.7m | Reduced -293.8k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 963.1k $3.4m | Reduced -161.1k |
| Omega Fund Management, LLC 1.59% of their portfolio | 843.8k $2.9m | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 777.3k $2.7m | Reduced -8.5k |
| Crestline Management, L.P. 4.93% of their portfolio | 755.7k $2.6m | Unchanged |
| ArrowMark Colorado Holdings LLC 0.10% of their portfolio | 685.1k $2.4m | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 653.5k $2.3m | Reduced -937.5k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 645.1k $2.3m | Added +53.2k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 638.8k $2.2m | Reduced -559.7k |
| Corient Private Wealth LP 0.00% of their portfolio | 628.1k $2.2m | Reduced -14.0k |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 595.1k $2.1m | New |
| Invesco Ltd. 0.00% of their portfolio | 504.3k $1.8m | Reduced -64.9k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 477.5k $1.7m | Added +34.9k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 384.1k $1.3m | Reduced -37.5k |
| Nuveen, LLC 0.00% of their portfolio | 369.7k $1.3m | Added +42.8k |
| Swiss National Bank 0.00% of their portfolio | 348.1k $1.2m | Added +5.5k |
| BAKER BROS. ADVISORS LP 0.01% of their portfolio | 310.5k $1.1m | Unchanged |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 294.8k $1.0m | Added +3.6k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 284.5k $992.8k | Added +52.8k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 282.9k $988.0k | Added +75.4k |
| CITIGROUP INC 0.00% of their portfolio | 272.5k $951.1k | Added +212.1k |
| XTX Topco Ltd 0.01% of their portfolio | 226.6k $790.8k | Added +116.3k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 223.4k $779.7k | Added +24.7k |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 196.7k $686.6k | Reduced -156.9k |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 193.3k $674.6k | Added +118.5k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 186.9k $538.4k | Unchanged |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 181.7k $634.3k | Added +18.2k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 174.8k $610.0k | Added +163.7k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 173.5k $605.7k | Added +97.9k |
| Clearstead Advisors, LLC 0.01% of their portfolio | 170.7k $595.9k | Reduced -166.0k |
| ALGERT GLOBAL LLC 0.01% of their portfolio | 168.6k $588.3k | Reduced -52.3k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 161.2k $562.5k | Reduced -407.9k |
| OPTIMIZE FINANCIAL INC. 0.18% of their portfolio | 140.2k $489.4k | Reduced -488 |
| Sound Capital Solutions LLC 0.11% of their portfolio | 140.2k $489.4k | First filing |
| Legal & General Group Plc 0.00% of their portfolio | 136.2k $475.3k | Added +9.8k |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 128.8k $449.5k | Reduced -58.9k |
| Virtus Investment Advisers, LLC 0.10% of their portfolio | 122.1k $426.1k | Added +69.0k |
| GROUP ONE TRADING LLC 0.01% of their portfolio | 120.3k $420.0k | Added +8.4k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 120.3k $419.8k | New |
| Banque Cantonale Vaudoise 0.02% of their portfolio | 114.0k $398.0k | Added +23.3k |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 112.0k $391.9k | Added +39.8k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 110.0k $383.8k | Added +43.4k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.00% of their portfolio | 109.6k $382.5k | New |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 107.4k $374.0k | Reduced -36.1k |
| VIRGINIA RETIREMENT SYSTEMS ET Al 0.00% of their portfolio | 102.8k $358.9k | Added +11.0k |
| VANGUARD ASSET MANAGEMENT, Ltd 0.00% of their portfolio | 101.7k $354.8k | Unchanged |
| PROFUND ADVISORS LLC 0.01% of their portfolio | 99.5k $347.3k | Reduced -57.6k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 95.2k $332.4k | Reduced -86.3k |
| SG Americas Securities, LLC 0.00% of their portfolio | 95.0k $332.0k | Reduced -35.0k |
| GILDER GAGNON HOWE & CO LLC 0.00% of their portfolio | 90.0k $314.0k | Reduced -5.8k |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 87.9k $306.7k | Reduced -45.3k |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio | 82.4k $287.6k | Unchanged |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 82.1k $286.4k | Added +2.5k |
| SCS Capital Management LLC 0.00% of their portfolio | 81.2k $283.6k | Unchanged |
| VARCOV Co. 0.11% of their portfolio | 79.9k $278.8k | New |
| Quadrature Capital Ltd 0.00% of their portfolio | 77.1k $268.9k | Added +63.1k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 72.2k $252.1k | Reduced -27.0k |
| DRW Securities, LLC 0.01% of their portfolio | 66.2k $231.2k | Added +53.9k |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 61.8k $238.0k | Reduced -209 |
| Creative Planning 0.00% of their portfolio | 60.6k $211.7k | Reduced -1.1k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 60.3k $210.5k | Unchanged |
| Quinn Opportunity Partners LLC 0.01% of their portfolio | 60.1k $209.7k | Unchanged |
| Palumbo Wealth Management LLC 0.04% of their portfolio | 59.8k $208.6k | Added +1.3k |
| Arax Advisory Partners 0.00% of their portfolio | 59.6k $207.9k | Added +37.4k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 59.5k $207.5k | Added +2.3k |
| Jupiter Topco LLC 0.00% of their portfolio | 58.2k $202.2k | First filing |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 57.9k $202.1k | Added +13.7k |
| State of New Jersey Common Pension Fund D 0.00% of their portfolio | 56.1k $195.7k | Reduced -3.1k |
| Brevan Howard Capital Management LP 0.00% of their portfolio | 52.5k $183.4k | Reduced -265 |
| BFSG, LLC 0.02% of their portfolio | 51.0k $178.0k | Unchanged |
| BARCLAYS PLC 0.00% of their portfolio | 49.4k $172.3k | Added +17.8k |
| ARIZONA STATE RETIREMENT SYSTEM 0.00% of their portfolio | 47.9k $167.0k | Added +307 |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 47.2k $164.6k | Added +5.2k |
| Cambridge Investment Research Advisors, Inc. 0.00% of their portfolio | 45.2k $158.0k | Added +25.6k |
| COLDSTREAM CAPITAL MANAGEMENT INC 0.00% of their portfolio | 45.0k $157.1k | Reduced -1 |
| China Universal Asset Management Co., Ltd. 0.01% of their portfolio | 44.3k $154.6k | Reduced -3.0k |
| Focus Partners Wealth 0.00% of their portfolio | 41.6k $145.0k | Reduced -2.1k |