SANA BIOTECHNOLOGY INC SANA
COM · Common Stock · CUSIP 799566104 · ISIN US7995661045
Biotechnology company
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($102.5k this quarter). Holder counts are more reliable. Shares outstanding: 266.4m as of 2025-10-29, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $3.56. Options: 6 managers hold calls ($1.5m notional), 6 hold puts ($1.7m).
Trends to Q3 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 125 |
| Q4 2022 | 121 |
| Q1 2023 | 121 |
| Q2 2023 | 124 |
| Q3 2023 | 137 |
| Q4 2023 | 133 |
| Q1 2024 | 155 |
| Q2 2024 | 149 |
| Q3 2024 | 156 |
| Q4 2024 | 165 |
| Q1 2025 | 162 |
| Q2 2025 | 156 |
| Q3 2025 | 178 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2023 | 71 | 58 |
| Q1 2024 | 84 | 55 |
| Q2 2024 | 77 | 63 |
| Q3 2024 | 71 | 69 |
| Q4 2024 | 88 | 65 |
| Q1 2025 | 83 | 71 |
| Q2 2025 | 74 | 78 |
| Q3 2025 | 108 | 58 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q4 2024 | $3.5m | $1.6m | 0.45 |
| Q1 2025 | $1.1m | $712.5k | 0.67 |
| Q2 2025 | $1.7m | $952.1k | 0.55 |
| Q3 2025 | $1.5m | $1.7m | 1.14 |
Biggest buyers
| STATE STREET CORP | Added | +3.8m |
| FMR LLC | Added | +3.6m |
| CITADEL ADVISORS LLC | Added | +3.6m |
| JPMORGAN CHASE & CO | Added | +3.5m |
| RENAISSANCE TECHNOLOGIES LLC | Added | +1.8m |
| VANGUARD GROUP INC | Added | +1.5m |
| BAILLIE GIFFORD & CO | Added | +1.4m |
| MILLENNIUM MANAGEMENT LLC | Added | +822.4k |
| GREAT POINT PARTNERS LLC | New | +700.0k |
| Woodline Partners LP | Added | +597.0k |
Biggest sellers
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -2.4m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Sold out | -702.0k |
| MORGAN STANLEY | Reduced | -603.3k |
| Crestline Management, L.P. | Reduced | -600.0k |
| ROYAL BANK OF CANADA | Reduced | -357.2k |
| Corient Private Wealth LP | Reduced | -319.0k |
| TD Asset Management Inc | Sold out | -309.0k |
| Skandinaviska Enskilda Banken AB (publ) | Sold out | -289.3k |
| Brevan Howard Capital Management LP | Sold out | -260.7k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | Reduced | -242.9k |
Biggest calls
| GROUP ONE TRADING LLC | Added | $674.5k190.0k shares |
| CITADEL ADVISORS LLC | Reduced | $362.1k102.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $140.9k39.7k shares |
| WOLVERINE TRADING, LLC | Reduced | $112.2k31.7k shares |
| SIMPLEX TRADING, LLC | Reduced | $102.0k28.9k shares |
| JANE STREET GROUP, LLC | Reduced | $65.7k18.5k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $466.8k131.5k shares |
| BANK OF AMERICA CORP /DE/ | Unchanged | $401.1k113.0k shares |
| CITADEL ADVISORS LLC | Added | $349.7k98.5k shares |
| SIMPLEX TRADING, LLC | Added | $214.0k60.4k shares |
| GROUP ONE TRADING LLC | Added | $193.1k54.4k shares |
| WOLVERINE TRADING, LLC | New | $35.8k10.1k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| ARCH Venture Fund IX, L.P. 13G · exempt (held before listing) -1.9 pts · filed 2026-08-14 | 15.4% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor new · filed 2026-05-21 | 6.3% |
| BlackRock, Inc. 13G · institution +0.2 pts · filed 2026-01-21 | 5.1% |
Insider purchases and sales in Q3 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2023 | 0 | — | 1 | $300.0k | $300.0k |
| Q1 2024 | 1 | $10.0m | 1 | $236.2k | — |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 1 | $1.2m | $1.2m |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
None reported in Q3 2025.
Holders, Q3 2025
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.01% of their portfolio | 37.4m $132.9m | Added +3.6m |
| Flagship Pioneering, LLC 30.33% of their portfolio | 25.0m $88.8m | Unchanged |
| BAILLIE GIFFORD & CO 0.03% of their portfolio | 11.4m $40.6m | Added +1.4m |
| BlackRock, Inc. 0.00% of their portfolio | 11.2m $39.9m | Added +367.2k |
| CANADA PENSION PLAN INVESTMENT BOARD 0.03% of their portfolio | 10.2m $36.1m | Unchanged |
| VANGUARD GROUP INC 0.00% of their portfolio | 9.1m $32.4m | Added +1.5m |
| STATE STREET CORP 0.00% of their portfolio | 6.7m $23.7m | Added +3.8m |
| CITADEL ADVISORS LLC 0.02% of their portfolio | 6.6m $23.3m | Added +3.6m |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 4.3m $15.2m | Added +3.5m |
| Marex Group Ltd 0.17% of their portfolio | 3.8m $13.6m | Added +5.0k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 3.4m $12.2m | Added +143.7k |
| Alphabet Inc. 0.41% of their portfolio | 2.8m $10.0m | Unchanged |
| BAKER BROS. ADVISORS LP 0.05% of their portfolio | 2.0m $7.2m | Unchanged |
| Integral Health Asset Management, LLC 0.52% of their portfolio | 2.0m $7.1m | Added +500.0k |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 2.0m $7.1m | Added +1.8m |
| Crestline Management, L.P. 11.13% of their portfolio | 1.8m $6.5m | Reduced -600.0k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 1.6m $5.8m | Added +822.4k |
| UBS Group AG 0.00% of their portfolio | 1.4m $5.1m | Added +298.6k |
| Woodline Partners LP 0.02% of their portfolio | 1.4m $4.9m | Added +597.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 1.3m $4.7m | Added +164.2k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 1.3m $4.5m | Added +186.4k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 1.2m $4.2m | Reduced -174.6k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 917.6k $3.3m | Added +32.8k |
| MORGAN STANLEY 0.00% of their portfolio | 876.5k $3.1m | Reduced -603.3k |
| Omega Fund Management, LLC 1.35% of their portfolio | 843.8k $3.0m | Unchanged |
| Corient Private Wealth LP 0.00% of their portfolio | 817.0k $2.9m | Reduced -319.0k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 778.1k $2.8m | Reduced -216.7k |
| GREAT POINT PARTNERS LLC 1.04% of their portfolio | 700.0k $2.5m | New |
| ArrowMark Colorado Holdings LLC 0.05% of their portfolio | 685.1k $2.4m | Unchanged |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 682.1k $2.4m | Added +378.9k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 610.1k $2.2m | Reduced -1.7k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 586.0k $2.1m | Reduced -357.2k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 543.3k $1.9m | Added +11.2k |
| BARCLAYS PLC 0.00% of their portfolio | 525.9k $1.9m | Added +31.4k |
| Clearline Capital LP 0.16% of their portfolio | 524.5k $1.9m | Added +114.0k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 513.5k $1.8m | Added +261.8k |
| Invesco Ltd. 0.00% of their portfolio | 452.8k $1.6m | Added +179.8k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 405.7k $1.4m | Added +10.7k |
| Nuveen, LLC 0.00% of their portfolio | 304.0k $1.1m | Unchanged |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 268.0k $951.3k | New |
| Swiss National Bank 0.00% of their portfolio | 262.3k $931.2k | New |
| LMR Partners LLP 0.01% of their portfolio | 242.6k $861.1k | New |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 239.9k $851.6k | Added +226 |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 230.6k $818.7k | Added +87.8k |
| Squarepoint Ops LLC 0.00% of their portfolio | 222.3k $789.2k | Added +131.3k |
| Clarius Group, LLC 0.04% of their portfolio | 212.5k $754.4k | Unchanged |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 198.2k $703.5k | New |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 196.7k $698.4k | Unchanged |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 195.7k $694.7k | Reduced -7.6k |
| Susquehanna Portfolio Strategies, LLC 0.01% of their portfolio | 167.5k $594.6k | Reduced -3.3k |
| Arax Advisory Partners 0.01% of their portfolio | 165.1k $606.1k | New |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 165.1k $586.0k | Added +859 |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 146.1k $519.0k | Reduced -2.4m |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 140.6k $499.3k | New |
| Legal & General Group Plc 0.00% of their portfolio | 129.3k $458.9k | Added +82.5k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 128.7k $456.8k | Added +119.1k |
| Quinn Opportunity Partners LLC 0.03% of their portfolio | 120.1k $426.4k | Unchanged |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 112.3k $1.2m | Unchanged |
| Palumbo Wealth Management LLC 0.13% of their portfolio | 111.3k $395.1k | Added +30.2k |
| XTX Topco Ltd 0.02% of their portfolio | 106.8k $379.1k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 106.4k $377.6k | Added +21.8k |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.00% of their portfolio | 104.4k $370.0k | Unchanged |
| SG Americas Securities, LLC 0.00% of their portfolio | 100.3k $356.0k | Added +17.6k |
| Ovata Capital Management Ltd 0.07% of their portfolio | 100.0k $355.0k | New |
| NewEdge Advisors, LLC 0.00% of their portfolio | 97.6k $346.6k | Added +63.0k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 93.1k $330.4k | Unchanged |
| GILDER GAGNON HOWE & CO LLC 0.00% of their portfolio | 91.5k $325.0k | New |
| CWM, LLC 0.00% of their portfolio | 85.1k $302.0k | Reduced -1.6k |
| CITIGROUP INC 0.00% of their portfolio | 84.7k $300.7k | Reduced -76.8k |
| SCS Capital Management LLC 0.00% of their portfolio | 81.3k $288.7k | Reduced -132 |
| MetLife Investment Management, LLC 0.00% of their portfolio | 79.0k $280.5k | Reduced -2.5k |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 78.2k $269.1k | Added +52.5k |
| Walleye Capital LLC 0.00% of their portfolio | 77.1k $273.6k | New |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 72.7k $257.9k | Reduced -35.8k |
| SIMPLEX TRADING, LLC 0.01% of their portfolio | 72.4k $257.0k | Added +49.7k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 67.3k $239.0k | Added +51.9k |
| Hilton Capital Management, LLC 0.02% of their portfolio | 67.1k $238.3k | New |
| Quadrature Capital Ltd 0.00% of their portfolio | 61.2k $217.4k | New |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.00% of their portfolio | 60.5k $214.7k | New |
| JANUS HENDERSON GROUP PLC 0.00% of their portfolio | 58.2k $206.3k | New |
| PROFUND ADVISORS LLC 0.01% of their portfolio | 57.7k $204.9k | New |
| Creative Planning 0.00% of their portfolio | 54.2k $192.3k | Added +2.7k |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 52.9k $217.8k | Added +2.0k |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio | 49.4k $175.5k | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 47.5k $168.7k | Reduced -242.9k |
| China Universal Asset Management Co., Ltd. 0.01% of their portfolio | 45.3k $161.0k | Added +45 |
| Virtus Investment Advisers, LLC 0.05% of their portfolio | 44.8k $159.0k | Added +7.8k |
| Graham Capital Management, L.P. 0.01% of their portfolio | 44.6k $158.2k | New |
| Cerity Partners LLC 0.00% of their portfolio | 42.1k $149.6k | Reduced -342 |
| Virtu Financial LLC 0.01% of their portfolio | 41.2k $146.0k | Added +18.6k |
| ARIZONA STATE RETIREMENT SYSTEM 0.00% of their portfolio | 40.0k $141.9k | New |
| Pallas Capital Advisors LLC 0.01% of their portfolio | 39.6k $140.7k | Added +63 |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 38.6k $137.1k | Unchanged |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 36.7k $130.4k | Added +10.2k |
| Employees Retirement System of Texas 0.00% of their portfolio | 34.7k $123.0k | Added +5.2k |
| TWO SIGMA SECURITIES, LLC 0.02% of their portfolio | 33.3k $118.2k | New |
| TEACHER RETIREMENT SYSTEM OF TEXAS 0.00% of their portfolio | 32.3k $114.8k | New |
| Jain Global LLC 0.00% of their portfolio | 32.2k $114.4k | Reduced -16.9k |
| ProShare Advisors LLC 0.00% of their portfolio | 32.0k $113.7k | Reduced -3.8k |
| Focus Partners Wealth 0.00% of their portfolio | 30.7k $109.0k | Added +388 |