SANA BIOTECHNOLOGY INC SANA
COM · Common Stock · CUSIP 799566104 · ISIN US7995661045
Biotechnology company
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($149.6k this quarter). Holder counts are more reliable. Shares outstanding: 237.8m as of 2025-08-04, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $2.74. Options: 7 managers hold calls ($1.7m notional), 7 hold puts ($952.1k).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 125 |
| Q4 2022 | 121 |
| Q1 2023 | 121 |
| Q2 2023 | 124 |
| Q3 2023 | 137 |
| Q4 2023 | 133 |
| Q1 2024 | 155 |
| Q2 2024 | 149 |
| Q3 2024 | 156 |
| Q4 2024 | 165 |
| Q1 2025 | 162 |
| Q2 2025 | 156 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 64 | 49 |
| Q4 2023 | 71 | 58 |
| Q1 2024 | 84 | 55 |
| Q2 2024 | 77 | 63 |
| Q3 2024 | 71 | 69 |
| Q4 2024 | 88 | 65 |
| Q1 2025 | 83 | 71 |
| Q2 2025 | 74 | 78 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $9.8m | $6.4m | 0.66 |
| Q4 2024 | $3.5m | $1.6m | 0.45 |
| Q1 2025 | $1.1m | $712.5k | 0.67 |
| Q2 2025 | $1.7m | $952.1k | 0.55 |
Biggest buyers
| Marex Group Ltd | Added | +3.8m |
| ROYAL BANK OF CANADA | Added | +940.5k |
| Corient Private Wealth LP | Added | +824.5k |
| AQR CAPITAL MANAGEMENT LLC | Added | +783.2k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | New | +702.0k |
| MORGAN STANLEY | Added | +654.1k |
| MILLENNIUM MANAGEMENT LLC | Added | +560.4k |
| TWO SIGMA INVESTMENTS, LP | Added | +504.3k |
| UBS Group AG | Added | +416.6k |
| BANK OF AMERICA CORP /DE/ | Added | +356.0k |
Biggest sellers
| Capital World Investors | Sold out | -5.4m |
| STATE STREET CORP | Reduced | -2.6m |
| BlackRock, Inc. | Reduced | -600.8k |
| Integral Health Asset Management, LLC | Reduced | -500.0k |
| CITADEL ADVISORS LLC | Reduced | -447.6k |
| DIMENSIONAL FUND ADVISORS LP | Reduced | -399.5k |
| Crestline Management, L.P. | Reduced | -370.0k |
| Balyasny Asset Management L.P. | Sold out | -354.2k |
| JANE STREET GROUP, LLC | Reduced | -309.3k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | Sold out | -284.9k |
Biggest calls
| CITADEL ADVISORS LLC | Added | $499.3k182.9k shares |
| GROUP ONE TRADING LLC | Added | $485.7k177.9k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $457.8k167.7k shares |
| SIMPLEX TRADING, LLC | Reduced | $129.0k47.6k shares |
| WOLVERINE TRADING, LLC | Added | $96.7k34.4k shares |
| JANE STREET GROUP, LLC | Added | $73.4k26.9k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $356.0k130.4k shares |
| BANK OF AMERICA CORP /DE/ | Unchanged | $308.5k113.0k shares |
| CITADEL ADVISORS LLC | Reduced | $139.5k51.1k shares |
| SIMPLEX TRADING, LLC | Reduced | $73.0k27.1k shares |
| GROUP ONE TRADING LLC | Reduced | $45.6k16.7k shares |
| NATIONAL BANK OF CANADA /FI/ | Unchanged | $29.5k108 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| ARCH Venture Fund IX, L.P. 13G · exempt (held before listing) -1.9 pts · filed 2026-08-14 | 15.4% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor new · filed 2026-05-21 | 6.3% |
| BlackRock, Inc. 13G · institution +0.2 pts · filed 2026-01-21 | 5.1% |
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 0 | — | 1 | $300.0k | $300.0k |
| Q1 2024 | 1 | $10.0m | 1 | $236.2k | — |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 1 | $1.2m | $1.2m |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
None reported in Q2 2025.
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.01% of their portfolio | 33.8m $92.4m | Added +79.8k |
| Flagship Pioneering, LLC 25.42% of their portfolio | 25.0m $68.3m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 10.9m $29.6m | Reduced -600.8k |
| CANADA PENSION PLAN INVESTMENT BOARD 0.02% of their portfolio | 10.2m $27.8m | Unchanged |
| BAILLIE GIFFORD & CO 0.02% of their portfolio | 10.1m $27.5m | Reduced -126.7k |
| VANGUARD GROUP INC 0.00% of their portfolio | 7.6m $20.8m | Reduced -253.9k |
| Marex Group Ltd 0.20% of their portfolio | 3.8m $10.4m | Added +3.8m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 3.3m $9.0m | Added +4.5k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 3.0m $8.1m | Reduced -447.6k |
| STATE STREET CORP 0.00% of their portfolio | 2.9m $7.8m | Reduced -2.6m |
| Alphabet Inc. 0.36% of their portfolio | 2.8m $7.7m | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 2.6m $7.0m | Reduced -96.3k |
| Crestline Management, L.P. 10.56% of their portfolio | 2.4m $6.6m | Reduced -370.0k |
| BAKER BROS. ADVISORS LP 0.05% of their portfolio | 2.0m $5.5m | Unchanged |
| Integral Health Asset Management, LLC 0.38% of their portfolio | 1.5m $4.1m | Reduced -500.0k |
| MORGAN STANLEY 0.00% of their portfolio | 1.5m $4.0m | Added +654.1k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 1.4m $3.7m | Added +783.2k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 1.2m $3.2m | Reduced -145.0k |
| UBS Group AG 0.00% of their portfolio | 1.1m $3.1m | Added +416.6k |
| Corient Private Wealth LP 0.00% of their portfolio | 1.1m $3.1m | Added +824.5k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 1.1m $3.0m | Added +19.9k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 994.8k $2.7m | Reduced -399.5k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 943.2k $2.6m | Added +940.5k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 884.8k $2.4m | Added +356.0k |
| Omega Fund Management, LLC 1.49% of their portfolio | 843.8k $2.3m | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 797.6k $2.2m | Added +560.4k |
| Woodline Partners LP 0.01% of their portfolio | 781.2k $2.1m | Added +566 |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 760.4k $2.1m | Reduced -44.7k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.00% of their portfolio | 702.0k $1.9m | New |
| ArrowMark Colorado Holdings LLC 0.03% of their portfolio | 685.1k $1.9m | Unchanged |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 611.8k $1.7m | Added +504.3k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 532.1k $1.5m | Reduced -134.3k |
| BARCLAYS PLC 0.00% of their portfolio | 494.4k $1.3m | Reduced -7.0k |
| Clearline Capital LP 0.10% of their portfolio | 410.5k $1.1m | Unchanged |
| Bank of New York Mellon Corp 0.00% of their portfolio | 395.0k $1.1m | Added +50.9k |
| TD Asset Management Inc 0.00% of their portfolio | 309.0k $843.7k | Unchanged |
| Nuveen, LLC 0.00% of their portfolio | 304.0k $830.0k | Reduced -46.5k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 303.2k $827.8k | Reduced -250.2k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 290.4k $792.8k | Added +316 |
| Skandinaviska Enskilda Banken AB (publ) 0.00% of their portfolio | 289.3k $786.8k | Unchanged |
| Invesco Ltd. 0.00% of their portfolio | 273.0k $745.2k | Added +107.3k |
| Brevan Howard Capital Management LP 0.01% of their portfolio | 260.7k $711.8k | Added +120.0k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 251.7k $687.3k | Reduced -65.6k |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 239.6k $654.2k | Added +134.8k |
| Clarius Group, LLC 0.03% of their portfolio | 212.5k $580.1k | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 203.7k $556.1k | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 203.3k $554.9k | Added +21.1k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 196.7k $537.1k | Added +32.5k |
| Susquehanna Portfolio Strategies, LLC 0.01% of their portfolio | 170.8k $466.3k | New |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 164.3k $448.4k | Reduced -108.4k |
| CITIGROUP INC 0.00% of their portfolio | 161.6k $441.1k | Reduced -153.0k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 142.9k $390.0k | Reduced -309.3k |
| Quinn Opportunity Partners LLC 0.03% of their portfolio | 120.1k $327.9k | Unchanged |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 112.3k $1.2m | Unchanged |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 111.3k $303.9k | New |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 108.4k $296.0k | Reduced -31.7k |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.00% of their portfolio | 104.4k $285.0k | Unchanged |
| GSA CAPITAL PARTNERS LLP 0.02% of their portfolio | 102.5k $280.0k | New |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 93.1k $254.1k | Added +43.2k |
| Squarepoint Ops LLC 0.00% of their portfolio | 91.0k $248.4k | Added +19.8k |
| CWM, LLC 0.00% of their portfolio | 86.8k $237.0k | Added +48.3k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 84.6k $230.9k | Added +20.6k |
| SG Americas Securities, LLC 0.00% of their portfolio | 82.7k $226.0k | Reduced -33.8k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 81.5k $222.5k | Added +639 |
| SCS Capital Management LLC 0.00% of their portfolio | 81.5k $222.4k | Unchanged |
| Palumbo Wealth Management LLC 0.07% of their portfolio | 81.1k $221.4k | New |
| ExodusPoint Capital Management, LP 0.00% of their portfolio | 71.4k $195.0k | New |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 64.6k $176.3k | New |
| AXQ CAPITAL, LP 0.05% of their portfolio | 57.0k $155.6k | New |
| Creative Planning 0.00% of their portfolio | 51.5k $140.5k | Reduced -13.3k |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 50.8k $162.2k | Added +20.6k |
| Bristlecone Advisors, LLC 0.01% of their portfolio | 50.0k $136.5k | Unchanged |
| Jain Global LLC 0.00% of their portfolio | 49.2k $134.2k | Reduced -3.5k |
| Legal & General Group Plc 0.00% of their portfolio | 46.8k $127.8k | Reduced -114.1k |
| China Universal Asset Management Co., Ltd. 0.01% of their portfolio | 45.3k $123.7k | Added +518 |
| Summit X, LLC 0.02% of their portfolio | 42.7k $116.5k | Added +6.7k |
| Cerity Partners LLC 0.00% of their portfolio | 42.5k $116.0k | Reduced -3.7k |
| Erste Asset Management GmbH 0.00% of their portfolio | 40.0k $112.4k | Unchanged |
| Pallas Capital Advisors LLC 0.00% of their portfolio | 39.6k $108.0k | Added +22.0k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 38.6k $105.4k | Unchanged |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 37.5k $102.4k | Reduced -37.5k |
| Virtus Investment Advisers, LLC 0.03% of their portfolio | 37.0k $101.1k | Reduced -43.4k |
| Vident Advisory, LLC 0.00% of their portfolio | 36.9k $100.6k | Reduced -22.8k |
| ProShare Advisors LLC 0.00% of their portfolio | 35.8k $97.7k | Reduced -2.9k |
| NewEdge Advisors, LLC 0.00% of their portfolio | 34.6k $94.5k | Added +34.3k |
| Focus Partners Wealth 0.00% of their portfolio | 30.3k $82.8k | Added +5.0k |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 29.6k $80.9k | Reduced -8.6k |
| Employees Retirement System of Texas 0.00% of their portfolio | 29.5k $80.0k | Unchanged |
| Viewpoint Capital Management LLC 0.04% of their portfolio | 28.0k $76.6k | Added +4.5k |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio | 26.7k $72.8k | Unchanged |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 26.6k $72.6k | Unchanged |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 25.7k $74.8k | Reduced -15.6k |
| Merit Financial Group, LLC 0.00% of their portfolio | 24.1k $65.9k | New |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 23.3k $63.5k | New |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 22.7k $61.0k | Added +7.2k |
| Virtu Financial LLC 0.00% of their portfolio | 22.6k $62.0k | New |
| Catalyst Funds Management Pty Ltd 0.02% of their portfolio | 22.6k $61.7k | New |
| SMITH, MOORE & CO. 0.01% of their portfolio | 22.5k $61.4k | Unchanged |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 20.8k $56.8k | Reduced -31.2k |
| Vanguard Personalized Indexing Management, LLC 0.00% of their portfolio | 19.7k $53.7k | Added +1.5k |