Vault-13

SAB BIOTHERAPEUTICS INC SABS

COM NEW · Common Stock · CUSIP 78397T202

34 institutional holders +8 vs Q2 2025
28,024,02528.0m shares reported held*
$56.3mreported value*
12 new 10 added 2 reduced 4 sold out net bought ≈ $52.4m (+26.1m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $2.01.

Trends to Q3 2025

Institutional holders

Managers reporting a position, each quarter

02040Q4 23: 3Q1 24: 25Q2 24: 23Q3 24: 26Q4 24: 26Q1 25: 27Q2 25: 26Q3 25: 3434Q4 23Q2 24Q4 24Q2 25Q3 25
Numbers
QuarterHolders
Q4 20233
Q1 202425
Q2 202423
Q3 202426
Q4 202426
Q1 202527
Q2 202526
Q3 202534

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
40040Q1 24: 23 bought or addedQ1 24: 3 cut or sold outQ1 24Q2 24: 7 bought or addedQ2 24: 8 cut or sold outQ3 24: 7 bought or addedQ3 24: 6 cut or sold outQ3 24Q4 24: 9 bought or addedQ4 24: 11 cut or sold outQ1 25: 10 bought or addedQ1 25: 10 cut or sold outQ1 25Q2 25: 9 bought or addedQ2 25: 8 cut or sold outQ3 25: 22 bought or addedQ3 25: 6 cut or sold outQ3 25
Numbers
QuarterBought or addedCut or sold out
Q1 2024233
Q2 202478
Q3 202476
Q4 2024911
Q1 20251010
Q2 202598
Q3 2025226

Biggest buyers

Vivo Capital, LLC New +11,420,000+11.4m
RA CAPITAL MANAGEMENT, L.P. New +4,401,500+4.4m
Commodore Capital LP New +4,401,500+4.4m
Woodline Partners LP New +2,850,881+2.9m
Sessa Capital IM, L.P. Added +1,740,000+1.7m
SPHERA FUNDS MANAGEMENT LTD. New +566,395+566.4k
HB Wealth Management, LLC New +307,500+307.5k
AWM Investment Company, Inc. New +200,000+200.0k
VANGUARD GROUP INC Added +83,382+83.4k
RENAISSANCE TECHNOLOGIES LLC Added +69,810+69.8k

Biggest sellers

CITADEL ADVISORS LLC Sold out -17,095-17.1k
Creative Planning Sold out -11,852-11.9k
Sachetta, LLC Sold out -4,100-4.1k
BlackRock, Inc. Reduced -667-667
OSAIC HOLDINGS, INC. Reduced -113-113
RAYMOND JAMES FINANCIAL INC Sold out -45-45

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Vivo Opportunity Fund Holdings, L.P. 13G · passive investor no change · filed 2026-08-14 10.0% no change 22.6m≈ $88.3m 2026-08-14
Commodore Capital LP 13G · passive investor no change · filed 2026-08-14 9.9% no change 8.9m≈ $34.9m 2026-08-14
RA CAPITAL MANAGEMENT, L.P. 13D · may seek influence no change · filed 2026-08-10 9.9% no change 9.6m≈ $37.5m 2026-08-10
BALYASNY ASSET MANAGEMENT L.P. 13G · institution -0.5 pts · filed 2026-08-14 9.4% -0.5 pts 7.2m≈ $28.2m 2026-08-14
BIOTECHNOLOGY VALUE FUND L P 13G · passive investor -0.9 pts · filed 2026-02-17 9.1% -0.9 pts 4.8m≈ $18.6m 2026-02-17
Caligan Partners LP 13G · institution -1.6 pts · filed 2026-08-14 8.8% -1.6 pts 8.0m≈ $31.1m 2026-08-14
Adage Capital Management, L.P. 13G · institution new · filed 2026-08-12 8.4% new 6.4m≈ $25.0m 2026-08-12
PERCEPTIVE ADVISORS LLC 13G · passive investor -1.1 pts · filed 2026-08-14 7.3% -1.1 pts 6.6m≈ $25.8m 2026-08-14
Woodline Partners LP 13G · institution -3.1 pts · filed 2026-08-14 6.8% -3.1 pts 5.5m≈ $21.3m 2026-08-14
MILLENNIUM MANAGEMENT LLC 13G · passive investor new · filed 2026-05-01 5.1% new 3.4m≈ $13.4m 2026-05-01

Fell to 5% or below in the last year: RTW INVESTMENTS, LP (3.2%, 2026-02-17)

Insider purchases and sales in Q3 2025

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
404Q4 23: 3 buyingQ4 23: 0 sellingQ1 24: 0 buyingQ1 24: 0 sellingQ1 24Q2 24: 0 buyingQ2 24: 0 sellingQ3 24: 0 buyingQ3 24: 0 sellingQ3 24Q4 24: 0 buyingQ4 24: 0 sellingQ1 25: 0 buyingQ1 25: 0 sellingQ1 25Q2 25: 0 buyingQ2 25: 0 sellingQ3 25: 0 buyingQ3 25: 0 sellingQ3 25
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q4 20233$15.8k0——
Q1 20240—0——
Q2 20240—0——
Q3 20240—0——
Q4 20240—0——
Q1 20250—0——
Q2 20250—0——
Q3 20250—0——

None reported in Q3 2025.

Holders, Q3 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Vivo Capital, LLC 1.85% of their portfolio Palo Alto, CA 11,420,00011.4m $23.0m $23.0m 1.85% New
2 RA CAPITAL MANAGEMENT, L.P. 0.11% of their portfolio BOSTON, MA 4,401,5004.4m $8.8m $8.8m 0.11% New
3 Commodore Capital LP 0.43% of their portfolio NEW YORK, NY 4,401,5004.4m $8.8m $8.8m 0.43% New
4 Woodline Partners LP 0.03% of their portfolio San Francisco, CA 2,850,8812.9m $5.7m $5.7m 0.03% New
5 Sessa Capital IM, L.P. 0.11% of their portfolio NEW YORK, NY 2,198,4572.2m $4.4m $4.4m 0.11% Added +1.7m +1,740,000
6 BVF INC/IL 0.08% of their portfolio San Francisco, CA 932,697932.7k $1.9m $1.9m 0.08% Added +14.9k +14,871
7 SPHERA FUNDS MANAGEMENT LTD. 0.27% of their portfolio TEL AVIV, L3 566,395566.4k $1.1m $1.1m 0.27% New
8 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 365,753365.8k $735.2k $735.2k 0.00% Added +83.4k +83,382
9 HB Wealth Management, LLC 0.00% of their portfolio Atlanta, GA 307,500307.5k $618.1k $618.1k 0.00% New
10 AWM Investment Company, Inc. 0.04% of their portfolio NEW YORK, NY 200,000200.0k $402.0k $402.0k 0.04% New
11 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 85,71885.7k $172.3k $172.3k 0.00% Added +946 +946
12 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 80,84080.8k $162.5k $162.5k 0.00% Added +69.8k +69,810
13 Pathstone Holdings, LLC 0.00% of their portfolio ENGLEWOOD, NJ 50,65050.6k $101.8k $101.8k 0.00% Unchanged
14 Virtu Financial LLC 0.00% of their portfolio New York, NY 19,98220.0k $40.0k $40.0k 0.00% New
15 NorthCoast Asset Management LLC 0.00% of their portfolio STAMFORD, CT 19,20119.2k $38.6k $38.6k 0.00% Unchanged
16 First PREMIER Bank 0.01% of their portfolio SIOUX FALLS, SD 18,98619.0k $38.0k $38.0k 0.01% Unchanged
17 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 15,78115.8k $31.7k $31.7k 0.00% New
18 ADAR1 Capital Management, LLC 0.00% of their portfolio AUSTIN, TX 15,00015.0k $30.1k $30.1k 0.00% New
19 UBS Group AG 0.00% of their portfolio ZURICH, V8 13,22113.2k $26.6k $26.6k 0.00% Added +2.6k +2,563
20 Kestra Advisory Services, LLC 0.00% of their portfolio AUSTIN, TX 11,93011.9k $24.0k $24.0k 0.00% Unchanged
21 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 11,38711.4k $22.9k $22.9k 0.00% Unchanged
22 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 11,22111.2k $22.6k $22.6k 0.00% New
23 CAXTON CORP 0.10% of their portfolio Princeton, NJ 10,93510.9k $22.0k $22.0k 0.10% Not comparable
24 BlackRock, Inc. 0.00% of their portfolio New York, NY 6,3396.3k $12.7k $12.7k 0.00% Reduced -667 -667
25 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 4,8244.8k $10.0k $10.0k 0.00% Reduced -113 -113
26 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 1,5601.6k $3.1k $3.1k 0.00% Added +834 +834
27 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 832832 $1.7k $1.7k 0.00% New
28 MAI Capital Management 0.00% of their portfolio INDEPENDENCE, OH 217217 $437 $437 0.00% Unchanged
29 GS Investments, Inc. 0.00% of their portfolio Eagan, MN 200200 $402 $402 0.00% Unchanged
30 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 174174 $350 $350 0.00% Added +87 +87
31 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 168168 $338 $338 0.00% Unchanged
32 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 7474 $149 $149 0.00% Added +1 +1
33 SBI Securities Co., Ltd. 0.00% of their portfolio TOKYO, M0 5252 $105 $105 0.00% Added +2 +2
34 HARBOUR INVESTMENTS, INC. 0.00% of their portfolio MADISON, WI 5050 $101 $101 0.00% Unchanged