REZOLUTE INC RZLT
COM NEW · Common Stock · CUSIP 76200L309
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersRedwood City, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($19 this quarter). Holder counts are more reliable. Shares outstanding: 95.7m as of 2026-02-09, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $2.36. Options: 16 managers hold calls ($4.6m notional), 5 hold puts ($1.8m).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 34 |
| Q4 2022 | 35 |
| Q1 2023 | 33 |
| Q2 2023 | 30 |
| Q3 2023 | 31 |
| Q4 2023 | 33 |
| Q1 2024 | 34 |
| Q2 2024 | 53 |
| Q3 2024 | 60 |
| Q4 2024 | 72 |
| Q1 2025 | 78 |
| Q2 2025 | 93 |
| Q3 2025 | 116 |
| Q4 2025 | 122 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 17 | 13 |
| Q2 2024 | 42 | 11 |
| Q3 2024 | 37 | 21 |
| Q4 2024 | 42 | 28 |
| Q1 2025 | 49 | 29 |
| Q2 2025 | 76 | 41 |
| Q3 2025 | 74 | 39 |
| Q4 2025 | 83 | 57 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $1.2m | $58.8k | 0.05 |
| Q2 2025 | $3.3m | $89.6k | 0.03 |
| Q3 2025 | $10.4m | $705.8k | 0.07 |
| Q4 2025 | $4.6m | $1.8m | 0.40 |
Biggest buyers
| RA CAPITAL MANAGEMENT, L.P. | New | +9.2m |
| Opaleye Management Inc. | Added | +5.4m |
| BANK OF AMERICA CORP /DE/ | Added | +3.0m |
| Balyasny Asset Management L.P. | Added | +2.7m |
| FEDERATED HERMES, INC. | Added | +2.5m |
| STATE STREET CORP | Added | +1.9m |
| BlackRock, Inc. | Added | +1.8m |
| Vestal Point Capital, LP | New | +1.7m |
| BARCLAYS PLC | Added | +1.6m |
| MILLENNIUM MANAGEMENT LLC | Added | +1.5m |
Biggest sellers
| FMR LLC | Reduced | -10.5m |
| Siren, L.L.C. | Sold out | -4.9m |
| MANGROVE PARTNERS IM, LLC | Sold out | -2.9m |
| MARSHALL WACE, LLP | Sold out | -2.7m |
| Vivo Capital, LLC | Sold out | -2.1m |
| Rosalind Advisors, Inc. | Sold out | -1.8m |
| GREAT POINT PARTNERS LLC | Reduced | -1.5m |
| Point72 Asset Management, L.P. | Sold out | -1.2m |
| STEMPOINT CAPITAL LP | Sold out | -917.6k |
| ADAR1 Capital Management, LLC | Reduced | -777.3k |
Biggest calls
| Centiva Capital, LP | Added | $961.0k407.2k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $837.6k354.9k shares |
| Caption Management, LLC | Reduced | $810.4k343.4k shares |
| SIMPLEX TRADING, LLC | Added | $435.2k184.4k shares |
| GROUP ONE TRADING LLC | Added | $371.9k157.6k shares |
| LMR Partners LLP | New | $330.4k140.0k shares |
| CITADEL ADVISORS LLC | Added | $300.0k127.1k shares |
| Shay Capital LLC | New | $141.6k60.0k shares |
| NOMURA HOLDINGS INC | New | $117.5k49.8k shares |
| SIG BROKERAGE, LP | New | $73.2k31.0k shares |
Biggest puts
| TUDOR INVESTMENT CORP ET AL | New | $1.4m610.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $140.2k59.4k shares |
| GROUP ONE TRADING LLC | Added | $114.5k48.5k shares |
| CITADEL ADVISORS LLC | Added | $102.0k43.2k shares |
| SIMPLEX TRADING, LLC | Added | $48.6k20.6k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor new · filed 2025-12-18 | 9.9% |
| Opaleye Management Inc. 13G · passive investor +1.3 pts · filed 2026-05-11 | 6.6% |
| Dellora Investments LP 13G · passive investor new · filed 2026-08-12 | 5.9% |
| JENNISON ASSOCIATES LLC 13G · institution new · filed 2026-10-28 | 5.5% |
| BlackRock, Inc. 13G · institution new · filed 2025-10-17 | 5.4% |
Fell to 5% or below in the last year: BALYASNY ASSET MANAGEMENT L.P. (4.8%, 2026-08-14), BANK OF AMERICA CORP /DE/ (1.2%, 2026-08-12), VANGUARD GROUP INC (0.0%, 2026-03-26), Invus Global Management, LLC (0.0%, 2026-02-13), FMR LLC (2.5%, 2026-01-08)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 4 | $318.9k | 0 | — | — |
| Q2 2024 | 4 | $5.2m | 0 | — | — |
| Q3 2024 | 1 | $20.0k | 0 | — | — |
| Q4 2024 | 1 | $84.3k | 0 | — | — |
| Q1 2025 | 3 | $159.5k | 0 | — | — |
| Q2 2025 | 4 | $4.0m | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 5 | $207.4k | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-12-16 | ROBERTS BRIAN KENNETH Chief Medical Officer | Bought | $47.6k28.0k shares |
| 2025-12-16 | Hogenhuis Wladimir Director | Bought | $9.5k5.7k shares |
| 2025-12-15 | Evans Daron CFO | Bought | $70.8k40.0k shares |
| 2025-12-15 | Elam Nevan C CEO, director | Bought | $50.9k32.0k shares |
| 2025-12-15 | Karnawat Sunil Ratilal Chief Commercial Officer | Bought | $19.6k12.1k shares |
| 2025-12-15 | Evans Daron CFO · Held by minor child #3 | Bought | $4.5k2.5k shares |
| 2025-12-15 | Evans Daron CFO | Bought | $4.5k2.5k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| FEDERATED HERMES, INC. 0.07% of their portfolio | 16.5m $39.0m | Added +2.5m |
| RA CAPITAL MANAGEMENT, L.P. 0.22% of their portfolio | 9.2m $21.7m | New |
| BlackRock, Inc. 0.00% of their portfolio | 6.8m $16.0m | Added +1.8m |
| Opaleye Management Inc. 1.96% of their portfolio | 6.3m $14.8m | Added +5.4m |
| VANGUARD GROUP INC 0.00% of their portfolio | 4.8m $11.3m | Added +378.4k |
| Balyasny Asset Management L.P. 0.02% of their portfolio | 4.5m $10.6m | Added +2.7m |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 4.3m $10.2m | Added +3.0m |
| STATE STREET CORP 0.00% of their portfolio | 4.0m $9.4m | Added +1.9m |
| UBS Group AG 0.00% of their portfolio | 2.8m $6.6m | Added +120.3k |
| Affinity Asset Advisors, LLC 0.40% of their portfolio | 2.4m $5.5m | Added +251.1k |
| FMR LLC 0.00% of their portfolio | 2.3m $5.4m | Reduced -10.5m |
| Integral Health Asset Management, LLC 0.24% of their portfolio | 2.0m $4.7m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 2.0m $4.6m | Added +107.3k |
| BARCLAYS PLC 0.00% of their portfolio | 1.9m $4.5m | Added +1.6m |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 1.7m $4.0m | Added +1.5m |
| Vestal Point Capital, LP 0.15% of their portfolio | 1.7m $4.0m | New |
| MORGAN STANLEY 0.00% of their portfolio | 1.5m $3.6m | Added +1.2m |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 1.4m $3.3m | Added +1.3m |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 1.3m $3.1m | Added +763.3k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 1.1m $2.6m | Added +842.3k |
| GREAT POINT PARTNERS LLC 0.73% of their portfolio | 951.8k $2.2m | Reduced -1.5m |
| 22NW, LP 0.82% of their portfolio | 820.7k $1.9m | Unchanged |
| Velan Capital Investment Management LP 1.03% of their portfolio | 750.0k $1.8m | Unchanged |
| NORTHERN TRUST CORP 0.00% of their portfolio | 737.3k $1.7m | Reduced -35.1k |
| KENNEDY CAPITAL MANAGEMENT LLC 0.03% of their portfolio | 697.9k $1.6m | Added +668.7k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 671.7k $1.6m | Added +480.4k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 665.2k $1.6m | Added +13.0k |
| SUPERSTRING CAPITAL MANAGEMENT LP 0.65% of their portfolio | 513.8k $1.2m | New |
| XTX Topco Ltd 0.03% of their portfolio | 481.9k $1.1m | Added +457.6k |
| HRT FINANCIAL LP 0.00% of their portfolio | 374.1k $882.0k | New |
| Woodline Partners LP 0.00% of their portfolio | 368.2k $868.9k | Reduced -570.7k |
| Knott David M Jr 0.37% of their portfolio | 340.0k $802.4k | Added +65.0k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 296.8k $700.5k | New |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 271.1k $639.7k | New |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 249.4k $588.6k | New |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 248.7k $586.9k | Added +21.1k |
| Caitong International Asset Management Co., Ltd 0.12% of their portfolio | 209.2k $493.7k | New |
| PFM Health Sciences, LP 0.05% of their portfolio | 206.3k $486.8k | Reduced -246.5k |
| Virtu Financial LLC 0.01% of their portfolio | 150.6k $355.0k | New |
| Graham Capital Management, L.P. 0.01% of their portfolio | 150.0k $353.9k | New |
| Virtus Investment Advisers, LLC 0.09% of their portfolio | 147.8k $348.8k | New |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 141.9k $334.8k | Added +43.4k |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 139.4k $329.0k | Added +86.5k |
| Pavaki Capital Management LLC 0.20% of their portfolio | 120.0k $283.2k | First filing |
| Nuveen, LLC 0.00% of their portfolio | 97.7k $230.5k | Reduced -210.7k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 96.0k $226.5k | Reduced -9.2k |
| Engineers Gate Manager LP 0.00% of their portfolio | 93.5k $220.7k | New |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 91.5k $215.8k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 89.6k $211.6k | Added +40.5k |
| Rangeley Capital, LLC 0.16% of their portfolio | 78.2k $184.6k | New |
| Scientech Research LLC 0.12% of their portfolio | 77.8k $183.7k | New |
| State of Alaska, Department of Revenue 0.00% of their portfolio | 77.0k $181.0k | New |
| ALPS ADVISORS INC 0.00% of their portfolio | 76.1k $179.7k | Added +33.2k |
| Persistent Asset Partners Ltd 0.08% of their portfolio | 72.6k $171.4k | New |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 69.4k $163.7k | Reduced -16.4k |
| AlphaCentric Advisors LLC 0.16% of their portfolio | 67.1k $158.3k | First filing |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 66.6k $157.3k | Added +3.3k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 63.7k $150.4k | Added +2.9k |
| SG Americas Securities, LLC 0.00% of their portfolio | 63.6k $150.0k | New |
| Decheng Capital LLC 0.02% of their portfolio | 59.9k $141.4k | Unchanged |
| PROFUND ADVISORS LLC 0.00% of their portfolio | 51.8k $122.3k | Added +39.5k |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. 0.01% of their portfolio | 46.4k $109.5k | New |
| Invesco Ltd. 0.00% of their portfolio | 45.4k $107.2k | Reduced -314.5k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 45.2k $106.6k | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 45.1k $107.0k | Added +3.6k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 45.1k $105.0k | Added +6.4k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 43.9k $103.5k | Unchanged |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 43.8k $103.4k | Added +17.6k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 42.2k $99.7k | Unchanged |
| ADAR1 Capital Management, LLC 0.01% of their portfolio | 38.7k $91.3k | Reduced -777.3k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 37.9k $89.4k | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 36.9k $87.2k | Reduced -29.5k |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 35.3k $83.0k | New |
| Pale Fire Capital SE 0.01% of their portfolio | 33.5k $79.1k | Reduced -8.4k |
| CITIGROUP INC 0.00% of their portfolio | 32.8k $77.3k | Added +29.4k |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 27.7k $65.3k | Added +26.5k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 25.8k $61.0k | Reduced -582 |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 25.5k $59.0k | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 24.6k $58.1k | Unchanged |
| PANAGORA ASSET MANAGEMENT INC 0.00% of their portfolio | 22.7k $53.5k | Reduced -143.4k |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 21.8k $51.4k | Unchanged |
| WINTON GROUP Ltd 0.00% of their portfolio | 18.5k $43.7k | New |
| FOX RUN MANAGEMENT, L.L.C. 0.01% of their portfolio | 17.5k $41.3k | New |
| Ikarian Capital, LLC 0.01% of their portfolio | 16.5k $38.9k | New |
| Jump Financial, LLC 0.00% of their portfolio | 15.3k $36.0k | New |
| Jefferies Financial Group Inc. 0.00% of their portfolio | 15.0k $35.4k | New |
| PFG Investments, LLC 0.00% of their portfolio | 15.0k $35.4k | New |
| ProShare Advisors LLC 0.00% of their portfolio | 14.8k $34.8k | Added +1.5k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 14.6k $34.5k | Added +3.8k |
| MML INVESTORS SERVICES, LLC 0.00% of their portfolio | 14.6k $34.5k | Added +714 |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 12.8k $30.2k | Unchanged |
| Fifth Third Wealth Advisors LLC 0.00% of their portfolio | 12.1k $28.6k | New |
| HB Wealth Management, LLC 0.00% of their portfolio | 11.1k $26.1k | New |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 10.6k $25.0k | New |
| ExodusPoint Capital Management, LP 0.00% of their portfolio | 10.5k $24.8k | New |
| NIA IMPACT ADVISORS, LLC 0.01% of their portfolio | 10.4k $24.4k | Reduced -1.1k |
| Auxano Advisors, LLC 0.00% of their portfolio | 10.0k $23.6k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 9.2k $21.7k | Added +6.7k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 8.3k $19.5k | Reduced -60.9k |
| Legal & General Group Plc 0.00% of their portfolio | 8.1k $19.2k | Reduced -101 |