REPLIGEN CORP RGEN
COM · Common Stock · CUSIP 759916109 · ISIN US7599161095
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersWaltham, MA
- Founded1981
- Websiterepligen.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($13.2m this quarter). Holder counts are more reliable. Shares outstanding: 56.3m as of 2025-10-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $163.87. Options: 12 managers hold calls ($33.6m notional), 6 hold puts ($66.7m).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 434 |
| Q4 2022 | 443 |
| Q1 2023 | 448 |
| Q2 2023 | 448 |
| Q3 2023 | 440 |
| Q4 2023 | 467 |
| Q1 2024 | 487 |
| Q2 2024 | 455 |
| Q3 2024 | 445 |
| Q4 2024 | 432 |
| Q1 2025 | 443 |
| Q2 2025 | 449 |
| Q3 2025 | 454 |
| Q4 2025 | 475 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 230 | 204 |
| Q2 2024 | 220 | 257 |
| Q3 2024 | 226 | 238 |
| Q4 2024 | 179 | 226 |
| Q1 2025 | 226 | 174 |
| Q2 2025 | 199 | 243 |
| Q3 2025 | 237 | 216 |
| Q4 2025 | 225 | 206 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $11.0m | $68.6m | 6.23 |
| Q2 2025 | $10.2m | $84.6m | 8.33 |
| Q3 2025 | $45.8m | $90.6m | 1.98 |
| Q4 2025 | $33.6m | $66.7m | 1.98 |
Biggest buyers
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | New | +1.2m |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +1.1m |
| RTW INVESTMENTS, LP | New | +1.1m |
| FRANKLIN RESOURCES INC | Added | +677.1k |
| FRED ALGER MANAGEMENT, LLC | Added | +553.1k |
| CONGRESS ASSET MANAGEMENT CO | Added | +527.7k |
| BlackRock, Inc. | Added | +479.5k |
| Invesco Ltd. | Added | +383.4k |
| MARSHALL WACE, LLP | Added | +335.3k |
| Walleye Capital LLC | Added | +231.4k |
Biggest sellers
| Balyasny Asset Management L.P. | Reduced | -652.2k |
| Point72 Asset Management, L.P. | Reduced | -434.4k |
| Holocene Advisors, LP | Reduced | -416.1k |
| PointState Capital LP | Sold out | -409.5k |
| GROUPAMA ASSET MANAGMENT | Sold out | -400.0k |
| BROWN CAPITAL MANAGEMENT LLC | Reduced | -394.9k |
| Champlain Investment Partners, LLC | Reduced | -335.3k |
| Vestal Point Capital, LP | Reduced | -317.0k |
| JPMORGAN CHASE & CO | Reduced | -298.0k |
| CITADEL ADVISORS LLC | Reduced | -290.5k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $11.9m72.8k shares |
| BARCLAYS PLC | New | $9.8m60.0k shares |
| CITADEL ADVISORS LLC | Reduced | $4.7m28.5k shares |
| D. E. Shaw & Co., Inc. | Added | $4.3m26.3k shares |
| MILLENNIUM MANAGEMENT LLC | Reduced | $1.7m10.1k shares |
| Walleye Trading LLC | Added | $491.6k3.0k shares |
| JANE STREET GROUP, LLC | Reduced | $278.6k1.7k shares |
| TUDOR INVESTMENT CORP ET AL | Reduced | $213.0k1.3k shares |
| SIMPLEX TRADING, LLC | Reduced | $147.5k900 shares |
| GROUP ONE TRADING LLC | Reduced | $32.8k200 shares |
Biggest puts
| JANE STREET GROUP, LLC | Reduced | $52.7m321.4k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $6.9m42.3k shares |
| IMC-Chicago, LLC | Added | $4.5m27.2k shares |
| CITADEL ADVISORS LLC | Reduced | $1.9m11.4k shares |
| Walleye Trading LLC | Added | $557.1k3.4k shares |
| SIMPLEX TRADING, LLC | Added | $213.0k1.3k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +7.9 pts · filed 2026-10-07 | 13.0% |
| BlackRock, Inc. 13G · institution filed 2025-04-24 | 9.3% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-07-31 | 5.0% |
Fell to 5% or below in the last year: PRICE T ROWE ASSOCIATES INC /MD/ (3.1%, 2026-08-14), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC), Roy T. Eddleman Living Trust (4.8%, 2026-02-13)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 0 | — | 4 | $5.0m | $3.3m |
| Q2 2024 | 3 | $600.5k | 1 | $3.4m | $3.4m |
| Q3 2024 | 0 | — | 2 | $5.1m | $3.2m |
| Q4 2024 | 0 | — | 1 | $3.4m | — |
| Q1 2025 | 1 | $37.7k | 1 | $4.1m | $4.1m |
| Q2 2025 | 0 | — | 1 | $3.3m | $3.3m |
| Q3 2025 | 1 | $201.8k | 1 | $3.5m | — |
| Q4 2025 | 0 | — | 4 | $8.6m | $5.1m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-12-17 | DAWES KAREN A Director | Sold | $44.3k275 shares |
| 2025-11-25 | Loeillot Olivier Chief Executive Officer, director | Sold plan | $1.2m7.0k shares |
| 2025-11-18 | Bylund James Chief Operating Officer | Sold | $331.3k2.2k shares |
| 2025-11-13 | Hunt Anthony Director | Sold | $3.1m20.0k shares |
| 2025-11-12 | Hunt Anthony Director | Sold plan | $3.9m25.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.02% of their portfolio | 6.6m $1.1bn | Added +479.5k |
| VANGUARD GROUP INC 0.01% of their portfolio | 5.0m $818.3m | Reduced -50.2k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.08% of their portfolio | 4.6m $753.6m | Added +1.1m |
| FMR LLC 0.02% of their portfolio | 2.9m $469.9m | Added +176.6k |
| UNITED CAPITAL FINANCIAL ADVISORS, LLC 2.74% of their portfolio | 2.8m $454.0m | Added +14.9k |
| STATE STREET CORP 0.01% of their portfolio | 1.7m $281.7m | Reduced -82.4k |
| CITADEL ADVISORS LLC 0.16% of their portfolio | 1.4m $228.5m | Reduced -290.5k |
| Bank of New York Mellon Corp 0.04% of their portfolio | 1.3m $220.3m | Added +28.9k |
| Invesco Ltd. 0.02% of their portfolio | 1.3m $205.9m | Added +383.4k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.06% of their portfolio | 1.2m $199.2m | New |
| FRANKLIN RESOURCES INC 0.04% of their portfolio | 1.1m $180.5m | Added +677.1k |
| RTW INVESTMENTS, LP 1.75% of their portfolio | 1.1m $174.3m | New |
| Conestoga Capital Advisors, LLC 2.92% of their portfolio | 1.1m $173.4m | Added +101.1k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 1.0m $168.8m | Reduced -2.6k |
| Point72 Asset Management, L.P. 0.26% of their portfolio | 1.0m $164.9m | Reduced -434.4k |
| Champlain Investment Partners, LLC 1.67% of their portfolio | 1.0m $164.5m | Reduced -335.3k |
| ALLIANCEBERNSTEIN L.P. 0.05% of their portfolio | 994.9k $163.0m | Reduced -109.3k |
| Holocene Advisors, LP 0.33% of their portfolio | 961.0k $157.5m | Reduced -416.1k |
| FRED ALGER MANAGEMENT, LLC 0.59% of their portfolio | 911.5k $149.4m | Added +553.1k |
| DIMENSIONAL FUND ADVISORS LP 0.03% of their portfolio | 804.4k $131.8m | Added +4.9k |
| CONGRESS ASSET MANAGEMENT CO 0.86% of their portfolio | 746.3k $122.3m | Added +527.7k |
| T. Rowe Price Investment Management, Inc. 0.04% of their portfolio | 689.5k $113.0m | Added +117.4k |
| Stephens Investment Management Group LLC 1.40% of their portfolio | 657.1k $107.7m | Added +58.8k |
| MILLENNIUM MANAGEMENT LLC 0.08% of their portfolio | 650.5k $106.6m | Reduced -166.5k |
| MORGAN STANLEY 0.01% of their portfolio | 571.0k $93.6m | Added +86.0k |
| GENEVA CAPITAL MANAGEMENT LLC 1.73% of their portfolio | 563.0k $92.2m | Reduced -33.8k |
| BAMCO INC /NY/ 0.24% of their portfolio | 544.8k $89.3m | Added +163.1k |
| VOYA INVESTMENT MANAGEMENT LLC 0.08% of their portfolio | 521.2k $85.4m | Added +218.5k |
| MARSHALL WACE, LLP 0.08% of their portfolio | 516.3k $84.6m | Added +335.3k |
| DF DENT & CO INC 1.17% of their portfolio | 495.6k $81.2m | Reduced -39.2k |
| AMERIPRISE FINANCIAL INC 0.02% of their portfolio | 494.2k $81.0m | Reduced -15.4k |
| NORGES BANK 0.01% of their portfolio | 462.1k $75.7m | Not comparable |
| NORTHERN TRUST CORP 0.01% of their portfolio | 446.1k $73.1m | Reduced -18.0k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.06% of their portfolio | 443.9k $72.7m | Reduced -16.7k |
| TimesSquare Capital Management, LLC 1.08% of their portfolio | 435.7k $71.4m | Added +73.6k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 430.7k $70.6m | Added +8.6k |
| Walleye Capital LLC 0.39% of their portfolio | 417.1k $68.3m | Added +231.4k |
| Impax Asset Management Group plc 0.42% of their portfolio | 413.4k $67.7m | Reduced -289.9k |
| Thrivent Financial for Lutherans 0.12% of their portfolio | 411.7k $67.5m | Reduced -47.1k |
| Artemis Investment Management LLP 0.81% of their portfolio | 410.4k $67.2m | Added +63.6k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 397.2k $65.1m | Added +7.8k |
| UBS Group AG 0.01% of their portfolio | 348.4k $57.1m | Reduced -108.5k |
| AMERICAN CAPITAL MANAGEMENT INC 2.42% of their portfolio | 335.1k $54.9m | Reduced -1.7k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.06% of their portfolio | 323.8k $53.1m | Added +40.4k |
| Iron Triangle Partners LP 6.00% of their portfolio | 320.5k $52.5m | Added +50.5k |
| PERCEPTIVE ADVISORS LLC 0.95% of their portfolio | 315.5k $51.7m | Added +45.1k |
| RIVERBRIDGE PARTNERS LLC 0.96% of their portfolio | 313.4k $51.3m | Reduced -30.1k |
| Allspring Global Investments Holdings, LLC 0.08% of their portfolio | 311.2k $51.1m | Added +7.4k |
| Blue Whale Capital LLP 2.59% of their portfolio | 308.5k $50.5m | Added +65.4k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 295.3k $48.4m | Added +174.8k |
| FIRST TRUST ADVISORS LP 0.03% of their portfolio | 282.8k $46.3m | Added +16.5k |
| BROWN CAPITAL MANAGEMENT LLC 3.68% of their portfolio | 274.0k $44.9m | Reduced -394.9k |
| AMERICAN CENTURY COMPANIES INC 0.02% of their portfolio | 250.3k $41.0m | Reduced -2.5k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 248.9k $40.8m | Reduced -298.0k |
| 12 West Capital Management LP 4.71% of their portfolio | 241.2k $39.5m | Unchanged |
| PALISADE CAPITAL MANAGEMENT, LP 1.13% of their portfolio | 232.2k $38.0m | Reduced -29.6k |
| Baird Financial Group, Inc. 0.05% of their portfolio | 205.6k $33.7m | Reduced -11.6k |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.05% of their portfolio | 204.9k $33.6m | First filing |
| NZS Capital, LLC 1.00% of their portfolio | 198.8k $32.6m | Added +2.0k |
| PRINCIPAL FINANCIAL GROUP INC 0.02% of their portfolio | 198.2k $32.5m | Added +80.8k |
| Artisan Partners Limited Partnership 0.05% of their portfolio | 193.7k $31.7m | Reduced -19.0k |
| Nuveen, LLC 0.01% of their portfolio | 192.7k $31.6m | Added +55.4k |
| PRIMECAP MANAGEMENT CO/CA/ 0.02% of their portfolio | 186.7k $30.6m | Reduced -200 |
| SEI INVESTMENTS CO 0.03% of their portfolio | 182.0k $29.8m | Reduced -33.0k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.04% of their portfolio | 171.0k $28.0m | Reduced -76.5k |
| RAYMOND JAMES FINANCIAL INC 0.01% of their portfolio | 168.9k $27.9m | Added +18.7k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio | 164.4k $26.9m | Reduced -213 |
| Ranger Investment Management, L.P. 1.83% of their portfolio | 162.4k $26.6m | Reduced -515 |
| BARCLAYS PLC 0.01% of their portfolio | 159.2k $26.1m | Reduced -97.7k |
| MOORE CAPITAL MANAGEMENT, LP 0.50% of their portfolio | 150.0k $24.6m | Added +5.0k |
| LOOMIS SAYLES & CO L P 0.03% of their portfolio | 149.8k $24.5m | Reduced -18.3k |
| COMERICA BANK 0.10% of their portfolio | 149.1k $24.4m | Added +36.0k |
| SEGALL BRYANT & HAMILL, LLC 0.33% of their portfolio | 147.0k $24.1m | Added +7.6k |
| ROYCE & ASSOCIATES LP 0.24% of their portfolio | 147.0k $24.1m | Reduced -1.7k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 143.3k $23.5m | Reduced -96.5k |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO 0.08% of their portfolio | 134.6k $22.1m | Unchanged |
| RHUMBLINE ADVISERS 0.02% of their portfolio | 134.1k $22.0m | Reduced -5.5k |
| Daiwa Securities Group Inc. 0.07% of their portfolio | 130.3k $21.3m | Added +79.0k |
| JENNISON ASSOCIATES LLC 0.01% of their portfolio | 123.6k $20.3m | New |
| Curi Capital, LLC 0.34% of their portfolio | 117.9k $19.3m | Reduced -4.4k |
| Balyasny Asset Management L.P. 0.04% of their portfolio | 115.1k $18.9m | Reduced -652.2k |
| AGF MANAGEMENT LTD 0.08% of their portfolio | 111.6k $18.3m | New |
| VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio | 109.1k $17.9m | Added +42.3k |
| Swiss National Bank 0.01% of their portfolio | 105.4k $17.3m | Added +2.0k |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.13% of their portfolio | 101.9k $16.7m | Reduced -19.5k |
| Ensign Peak Advisors, Inc 0.03% of their portfolio | 101.2k $16.6m | Reduced -14.6k |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 101.1k $16.6m | Reduced -3.1k |
| LORD, ABBETT & CO. LLC 0.05% of their portfolio | 90.2k $14.8m | New |
| OSAIC HOLDINGS, INC. 0.02% of their portfolio | 90.0k $14.7m | Added +53.8k |
| NORTH STAR ASSET MANAGEMENT INC 0.56% of their portfolio | 84.9k $13.9m | Reduced -536 |
| KORNITZER CAPITAL MANAGEMENT INC /KS 0.29% of their portfolio | 83.8k $13.7m | Added +5.5k |
| CITIGROUP INC 0.01% of their portfolio | 83.8k $13.7m | Added +32.2k |
| Vestal Point Capital, LP 0.50% of their portfolio | 83.0k $13.6m | Reduced -317.0k |
| BRAIDWELL LP 0.43% of their portfolio | 81.8k $13.4m | Reduced -113.9k |
| Legal & General Group Plc 0.00% of their portfolio | 78.8k $12.9m | Reduced -5.0k |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 74.0k $12.1m | Reduced -155.7k |
| Granahan Investment Management, LLC 0.51% of their portfolio | 72.0k $11.8m | Added +2.1k |
| California Public Employees Retirement System 0.01% of their portfolio | 70.1k $11.5m | Reduced -137 |
| WCM INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio | 63.6k $10.6m | Reduced -4.4k |
| Retirement Systems of Alabama 0.03% of their portfolio | 63.5k $10.4m | Reduced -433 |