REPLIGEN CORP RGEN
COM · Common Stock · CUSIP 759916109 · ISIN US7599161095
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersWaltham, MA
- Founded1981
- Websiterepligen.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($15.3m this quarter). Holder counts are more reliable. Shares outstanding: 56.3m as of 2025-08-04, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $123.60. Options: 9 managers hold calls ($10.2m notional), 12 hold puts ($84.6m).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 434 |
| Q4 2022 | 443 |
| Q1 2023 | 448 |
| Q2 2023 | 448 |
| Q3 2023 | 440 |
| Q4 2023 | 467 |
| Q1 2024 | 487 |
| Q2 2024 | 455 |
| Q3 2024 | 445 |
| Q4 2024 | 432 |
| Q1 2025 | 443 |
| Q2 2025 | 449 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 213 | 217 |
| Q4 2023 | 209 | 203 |
| Q1 2024 | 230 | 204 |
| Q2 2024 | 220 | 257 |
| Q3 2024 | 226 | 238 |
| Q4 2024 | 179 | 226 |
| Q1 2025 | 226 | 174 |
| Q2 2025 | 199 | 243 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $55.0m | $40.9m | 0.74 |
| Q4 2024 | $40.1m | $75.5m | 1.88 |
| Q1 2025 | $11.0m | $68.6m | 6.23 |
| Q2 2025 | $10.2m | $84.6m | 8.33 |
Biggest buyers
| FMR LLC | Added | +880.9k |
| Point72 Asset Management, L.P. | Added | +796.7k |
| MILLENNIUM MANAGEMENT LLC | Added | +681.3k |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | Added | +401.0k |
| GENEVA CAPITAL MANAGEMENT LLC | Added | +344.0k |
| ROYAL BANK OF CANADA | Added | +300.5k |
| T. Rowe Price Investment Management, Inc. | Added | +298.7k |
| Blue Whale Capital LLP | New | +287.7k |
| ExodusPoint Capital Management, LP | Added | +281.7k |
| JPMORGAN CHASE & CO | Added | +244.0k |
Biggest sellers
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -962.1k |
| MACQUARIE GROUP LTD | Reduced | -819.8k |
| BlackRock, Inc. | Reduced | -737.3k |
| Invesco Ltd. | Reduced | -295.4k |
| CITADEL ADVISORS LLC | Reduced | -266.7k |
| PARNASSUS INVESTMENTS, LLC | Sold out | -254.6k |
| AMERIPRISE FINANCIAL INC | Reduced | -204.7k |
| Artisan Partners Limited Partnership | Reduced | -183.1k |
| Thrivent Financial for Lutherans | Reduced | -176.1k |
| Allspring Global Investments Holdings, LLC | Reduced | -154.2k |
Biggest calls
| CITADEL ADVISORS LLC | Added | $3.3m26.7k shares |
| BARCLAYS PLC | New | $2.5m20.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $2.4m18.9k shares |
| JANE STREET GROUP, LLC | Reduced | $820.9k6.6k shares |
| WOLVERINE TRADING, LLC | New | $729.0k5.9k shares |
| GROUP ONE TRADING LLC | Added | $223.9k1.8k shares |
| SIMPLEX TRADING, LLC | Reduced | $149.0k1.2k shares |
| Walleye Capital LLC | Reduced | $74.6k600 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| JANE STREET GROUP, LLC | Added | $42.5m341.9k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $14.4m115.9k shares |
| BARCLAYS PLC | Added | $10.0m80.0k shares |
| Caption Management, LLC | Unchanged | $6.2m50.0k shares |
| CITADEL ADVISORS LLC | Added | $5.8m46.4k shares |
| D. E. Shaw & Co., Inc. | Unchanged | $2.5m20.0k shares |
| Parallax Volatility Advisers, L.P. | Unchanged | $1.9m15.0k shares |
| Verition Fund Management LLC | Reduced | $1.1m8.5k shares |
| Walleye Trading LLC | Unchanged | $211.4k1.7k shares |
| SIMPLEX TRADING, LLC | Reduced | $49.0k400 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +7.9 pts · filed 2026-10-07 | 13.0% |
| BlackRock, Inc. 13G · institution filed 2025-04-24 | 9.3% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-07-31 | 5.0% |
Fell to 5% or below in the last year: PRICE T ROWE ASSOCIATES INC /MD/ (3.1%, 2026-08-14), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC), Roy T. Eddleman Living Trust (4.8%, 2026-02-13)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 1 | $145.7k | — |
| Q4 2023 | 0 | — | 1 | $557.3k | — |
| Q1 2024 | 0 | — | 4 | $5.0m | $3.3m |
| Q2 2024 | 3 | $600.5k | 1 | $3.4m | $3.4m |
| Q3 2024 | 0 | — | 2 | $5.1m | $3.2m |
| Q4 2024 | 0 | — | 1 | $3.4m | — |
| Q1 2025 | 1 | $37.7k | 1 | $4.1m | $4.1m |
| Q2 2025 | 0 | — | 1 | $3.3m | $3.3m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-05-15 | Hunt Anthony Director | Sold plan | $3.3m26.4k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ 0.09% of their portfolio | 6.6m $821.4m | Reduced -962.1k |
| BlackRock, Inc. 0.01% of their portfolio | 6.1m $756.0m | Reduced -737.3k |
| VANGUARD GROUP INC 0.01% of their portfolio | 5.1m $631.5m | Reduced -2.7k |
| Point72 Asset Management, L.P. 0.56% of their portfolio | 1.9m $238.0m | Added +796.7k |
| STATE STREET CORP 0.01% of their portfolio | 1.6m $201.8m | Reduced -66.3k |
| FMR LLC 0.01% of their portfolio | 1.6m $200.7m | Added +880.9k |
| Champlain Investment Partners, LLC 1.22% of their portfolio | 1.4m $174.3m | Reduced -62.9k |
| Invesco Ltd. 0.03% of their portfolio | 1.4m $171.5m | Reduced -295.4k |
| Bank of New York Mellon Corp 0.03% of their portfolio | 1.3m $164.8m | Reduced -24.7k |
| SANDS CAPITAL MANAGEMENT, LLC 0.45% of their portfolio | 1.3m $155.6m | Reduced -43.1k |
| CITADEL ADVISORS LLC 0.11% of their portfolio | 1.1m $132.2m | Reduced -266.7k |
| BROWN CAPITAL MANAGEMENT LLC 3.64% of their portfolio | 1.0m $125.0m | Added +141.2k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 980.7k $122.0m | Reduced -10.8k |
| Conestoga Capital Advisors, LLC 1.80% of their portfolio | 976.9k $121.5m | Reduced -3.3k |
| Holocene Advisors, LP 0.29% of their portfolio | 936.8k $116.5m | Reduced -23.2k |
| ALLIANCEBERNSTEIN L.P. 0.04% of their portfolio | 906.4k $112.7m | Reduced -117.8k |
| DIMENSIONAL FUND ADVISORS LP 0.02% of their portfolio | 768.0k $95.5m | Added +54.4k |
| Impax Asset Management Group plc 0.54% of their portfolio | 761.0k $93.8m | Reduced -43.5k |
| MILLENNIUM MANAGEMENT LLC 0.08% of their portfolio | 701.2k $87.2m | Added +681.3k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.10% of their portfolio | 606.0k $75.4m | Reduced -19.4k |
| DF DENT & CO INC 0.93% of their portfolio | 586.5k $72.9m | Added +11.8k |
| T. Rowe Price Investment Management, Inc. 0.04% of their portfolio | 559.6k $69.6m | Added +298.7k |
| MORGAN STANLEY 0.00% of their portfolio | 529.1k $65.8m | Reduced -55.2k |
| Stephens Investment Management Group LLC 0.86% of their portfolio | 522.8k $65.0m | Reduced -16.7k |
| ExodusPoint Capital Management, LP 0.74% of their portfolio | 491.8k $61.2m | Added +281.7k |
| GENEVA CAPITAL MANAGEMENT LLC 1.02% of their portfolio | 487.5k $60.6m | Added +344.0k |
| AMERIPRISE FINANCIAL INC 0.01% of their portfolio | 480.3k $59.7m | Reduced -204.7k |
| NORTHERN TRUST CORP 0.01% of their portfolio | 469.8k $58.4m | Reduced -28.6k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 436.5k $54.3m | Added +244.0k |
| Thrivent Financial for Lutherans 0.12% of their portfolio | 430.1k $53.5m | Reduced -176.1k |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS 0.03% of their portfolio | 413.4k $5.7m | Added +401.0k |
| Alyeska Investment Group, L.P. 0.18% of their portfolio | 413.3k $51.4m | Reduced -46.9k |
| ROYAL BANK OF CANADA 0.01% of their portfolio | 413.2k $51.4m | Added +300.5k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 406.3k $50.5m | Added +10.1k |
| GROUPAMA ASSET MANAGMENT 0.01% of their portfolio | 400.0k $396.6k | Unchanged |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 399.0k $49.6m | Added +3.0k |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 382.3k $47.6m | Added +13.1k |
| RIVERBRIDGE PARTNERS LLC 0.74% of their portfolio | 368.1k $45.8m | Reduced -54.0k |
| RAYMOND JAMES FINANCIAL INC 0.02% of their portfolio | 356.0k $44.3m | Reduced -4.7k |
| AMERICAN CAPITAL MANAGEMENT INC 1.70% of their portfolio | 329.3k $41.0m | Reduced -51.7k |
| Allspring Global Investments Holdings, LLC 0.07% of their portfolio | 319.3k $40.4m | Reduced -154.2k |
| TWO SIGMA INVESTMENTS, LP 0.07% of their portfolio | 313.1k $38.9m | Added +87.8k |
| FRED ALGER MANAGEMENT, LLC 0.17% of their portfolio | 299.6k $37.3m | Reduced -137.5k |
| UBS Group AG 0.01% of their portfolio | 295.2k $36.7m | Added +54.1k |
| Blue Whale Capital LLP 2.34% of their portfolio | 287.7k $35.8m | New |
| BAMCO INC /NY/ 0.09% of their portfolio | 274.4k $34.1m | Added +69.5k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.08% of their portfolio | 273.3k $34.0m | Reduced -41.8k |
| Baird Financial Group, Inc. 0.06% of their portfolio | 272.2k $33.9m | Reduced -28.9k |
| PALISADE CAPITAL MANAGEMENT, LP 0.93% of their portfolio | 265.2k $33.0m | Reduced -8.3k |
| FIRST TRUST ADVISORS LP 0.03% of their portfolio | 261.6k $32.5m | Added +9.5k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio | 258.6k $32.2m | Added +6.1k |
| Artemis Investment Management LLP 0.41% of their portfolio | 254.9k $31.7m | Reduced -68.4k |
| AMERICAN CENTURY COMPANIES INC 0.02% of their portfolio | 251.9k $31.3m | Reduced -2.3k |
| BESSEMER GROUP INC 0.05% of their portfolio | 250.5k $31.2m | Reduced -2.5k |
| NORGES BANK 0.00% of their portfolio | 249.2k $31.0m | Added +64.0k |
| 12 West Capital Management LP 3.17% of their portfolio | 241.2k $30.0m | Unchanged |
| TimesSquare Capital Management, LLC 0.43% of their portfolio | 240.2k $29.9m | Added +4.2k |
| SEI INVESTMENTS CO 0.03% of their portfolio | 228.5k $28.4m | Reduced -22.2k |
| Artisan Partners Limited Partnership 0.04% of their portfolio | 220.5k $27.4m | Reduced -183.1k |
| JANE STREET GROUP, LLC 0.04% of their portfolio | 209.1k $26.0m | Added +54.4k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.02% of their portfolio | 206.4k $25.7m | New |
| Ranger Investment Management, L.P. 1.46% of their portfolio | 167.9k $20.9m | Reduced -54.8k |
| PERCEPTIVE ADVISORS LLC 0.77% of their portfolio | 166.0k $20.6m | Added +36.2k |
| Balyasny Asset Management L.P. 0.04% of their portfolio | 156.4k $19.5m | Added +106.3k |
| CONGRESS ASSET MANAGEMENT CO 0.13% of their portfolio | 152.4k $19.0m | Added +23.2k |
| Ensign Peak Advisors, Inc 0.03% of their portfolio | 149.0k $18.5m | Reduced -8.6k |
| SEGALL BRYANT & HAMILL, LLC 0.26% of their portfolio | 148.6k $18.5m | Added +3.2k |
| NZS Capital, LLC 0.61% of their portfolio | 145.3k $18.1m | Added +13.4k |
| BRAIDWELL LP 0.61% of their portfolio | 144.6k $18.0m | Added +62.9k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 143.5k $17.8m | New |
| RHUMBLINE ADVISERS 0.02% of their portfolio | 142.1k $17.7m | Reduced -4.0k |
| PRIMECAP MANAGEMENT CO/CA/ 0.01% of their portfolio | 138.3k $17.2m | Added +107.4k |
| Granahan Investment Management, LLC 0.68% of their portfolio | 135.0k $16.8m | Added +33.8k |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO 0.06% of their portfolio | 134.7k $16.8m | Unchanged |
| Nuveen, LLC 0.00% of their portfolio | 133.8k $16.6m | Reduced -145.5k |
| PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio | 118.6k $14.8m | Reduced -68.1k |
| HAWK RIDGE CAPITAL MANAGEMENT LP 0.60% of their portfolio | 115.4k $14.4m | New |
| Curi Capital, LLC 0.27% of their portfolio | 112.4k $14.0m | Added +1.2k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 111.5k $13.9m | Reduced -30.4k |
| VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 109.9k $13.7m | Reduced -97.4k |
| WCM INVESTMENT MANAGEMENT, LLC 0.03% of their portfolio | 109.9k $13.6m | Added +6.9k |
| Avidity Partners Management LP 2.66% of their portfolio | 106.5k $13.2m | New |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 105.9k $13.2m | Reduced -379 |
| LOOMIS SAYLES & CO L P 0.02% of their portfolio | 104.8k $13.0m | New |
| Swiss National Bank 0.01% of their portfolio | 101.9k $12.7m | Reduced -1.3k |
| COMERICA BANK 0.05% of their portfolio | 99.5k $12.4m | Reduced -260 |
| TWINBEECH CAPITAL LP 0.27% of their portfolio | 94.4k $11.7m | New |
| Walleye Capital LLC 0.11% of their portfolio | 91.6k $11.4m | Added +11.1k |
| MACQUARIE GROUP LTD 0.01% of their portfolio | 90.2k $11.2m | Reduced -819.8k |
| ROYCE & ASSOCIATES LP 0.11% of their portfolio | 89.5k $11.1m | New |
| NORTH STAR ASSET MANAGEMENT INC 0.46% of their portfolio | 87.6k $10.9m | Reduced -2.2k |
| CITIGROUP INC 0.01% of their portfolio | 87.1k $10.8m | Added +29.8k |
| Legal & General Group Plc 0.00% of their portfolio | 86.2k $10.7m | Added +1.1k |
| ZEVENBERGEN CAPITAL INVESTMENTS LLC 0.21% of their portfolio | 86.0k $10.7m | Reduced -1.6k |
| MARSHALL WACE, LLP 0.01% of their portfolio | 84.2k $10.5m | Reduced -573 |
| VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio | 81.7k $10.2m | Added +71.8k |
| TD Asset Management Inc 0.01% of their portfolio | 79.2k $9.9m | Added +28.1k |
| EVENTIDE ASSET MANAGEMENT, LLC 0.17% of their portfolio | 77.7k $9.7m | Reduced -41.3k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio | 74.0k $9.2m | Added +10.9k |
| Squarepoint Ops LLC 0.02% of their portfolio | 73.8k $9.2m | Added +24.5k |