REPLIGEN CORP RGEN
COM · Common Stock · CUSIP 759916109 · ISIN US7599161095
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersWaltham, MA
- Founded1981
- Websiterepligen.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($10.5m this quarter). Holder counts are more reliable. Shares outstanding: 56.0m as of 2024-11-12, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $143.93. Options: 11 managers hold calls ($40.1m notional), 17 hold puts ($75.5m).
Trends to Q4 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 434 |
| Q4 2022 | 443 |
| Q1 2023 | 448 |
| Q2 2023 | 448 |
| Q3 2023 | 440 |
| Q4 2023 | 467 |
| Q1 2024 | 487 |
| Q2 2024 | 455 |
| Q3 2024 | 445 |
| Q4 2024 | 432 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2023 | 207 | 201 |
| Q2 2023 | 218 | 219 |
| Q3 2023 | 213 | 217 |
| Q4 2023 | 209 | 203 |
| Q1 2024 | 230 | 204 |
| Q2 2024 | 220 | 257 |
| Q3 2024 | 226 | 238 |
| Q4 2024 | 179 | 226 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2024 | $212.4m | $46.9m | 0.22 |
| Q2 2024 | $66.9m | $18.1m | 0.27 |
| Q3 2024 | $55.0m | $40.9m | 0.74 |
| Q4 2024 | $40.1m | $75.5m | 1.88 |
Biggest buyers
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +743.8k |
| CITADEL ADVISORS LLC | Added | +663.6k |
| Point72 Asset Management, L.P. | Added | +594.2k |
| GROUPAMA ASSET MANAGMENT | New | +400.0k |
| Alyeska Investment Group, L.P. | New | +371.2k |
| Holocene Advisors, LP | New | +311.1k |
| Allspring Global Investments Holdings, LLC | Added | +203.0k |
| ALLIANCEBERNSTEIN L.P. | Added | +191.4k |
| MARSHALL WACE, LLP | Added | +175.0k |
| UBS Group AG | Added | +135.8k |
Biggest sellers
| Harding Loevner LP | Reduced | -576.1k |
| JPMORGAN CHASE & CO | Reduced | -566.0k |
| FEDERATED HERMES, INC. | Reduced | -316.6k |
| BlackRock, Inc. | Reduced | -250.3k |
| BROWN CAPITAL MANAGEMENT LLC | Reduced | -164.6k |
| BANK OF AMERICA CORP /DE/ | Reduced | -158.4k |
| Invesco Ltd. | Reduced | -152.8k |
| VOYA INVESTMENT MANAGEMENT LLC | Reduced | -139.2k |
| GOLDMAN SACHS GROUP INC | Reduced | -121.4k |
| BRAIDWELL LP | Reduced | -113.0k |
Biggest calls
| JANE STREET GROUP, LLC | Reduced | $9.5m66.0k shares |
| CITADEL ADVISORS LLC | Reduced | $8.1m56.0k shares |
| NOMURA HOLDINGS INC | New | $7.8m54.4k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $5.5m38.4k shares |
| Walleye Capital LLC | Reduced | $3.2m21.9k shares |
| IMC-Chicago, LLC | Reduced | $2.8m19.5k shares |
| SIMPLEX TRADING, LLC | Added | $1.4m9.6k shares |
| GROUP ONE TRADING LLC | Reduced | $878.0k6.1k shares |
| Walleye Trading LLC | Added | $489.4k3.4k shares |
| SUMMIT SECURITIES GROUP LLC | Unchanged | $489.4k3.4k shares |
Biggest puts
| JANE STREET GROUP, LLC | Added | $17.8m123.8k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $16.5m114.9k shares |
| Caption Management, LLC | Added | $7.2m50.0k shares |
| D. E. Shaw & Co., Inc. | Added | $6.5m45.0k shares |
| IMC-Chicago, LLC | Added | $4.3m29.8k shares |
| MILLENNIUM MANAGEMENT LLC | Added | $3.9m26.9k shares |
| SIMPLEX TRADING, LLC | Added | $3.8m26.7k shares |
| CITADEL ADVISORS LLC | Added | $3.7m26.0k shares |
| BARCLAYS PLC | New | $2.9m20.0k shares |
| Parallax Volatility Advisers, L.P. | New | $2.2m15.0k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +7.9 pts · filed 2026-10-07 | 13.0% |
| BlackRock, Inc. 13G · institution filed 2025-04-24 | 9.3% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-07-31 | 5.0% |
Fell to 5% or below in the last year: PRICE T ROWE ASSOCIATES INC /MD/ (3.1%, 2026-08-14), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC), Roy T. Eddleman Living Trust (4.8%, 2026-02-13)
Insider purchases and sales in Q4 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2023 | 0 | — | 1 | $1.1m | — |
| Q2 2023 | 1 | $238.3k | 0 | — | — |
| Q3 2023 | 0 | — | 1 | $145.7k | — |
| Q4 2023 | 0 | — | 1 | $557.3k | — |
| Q1 2024 | 0 | — | 4 | $5.0m | $3.3m |
| Q2 2024 | 3 | $600.5k | 1 | $3.4m | $3.4m |
| Q3 2024 | 0 | — | 2 | $5.1m | $3.2m |
| Q4 2024 | 0 | — | 1 | $3.4m | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-11-21 | Hunt Anthony Director | Sold | $3.4m24.2k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2024
| Manager | Shares | Change |
|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ 0.12% of their portfolio | 7.1m $1.0bn | Added +743.8k |
| BlackRock, Inc. 0.02% of their portfolio | 6.9m $987.0m | Reduced -250.3k |
| VANGUARD GROUP INC 0.01% of their portfolio | 5.1m $734.3m | Added +56.7k |
| STATE STREET CORP 0.01% of their portfolio | 1.7m $243.4m | Added +67.5k |
| Champlain Investment Partners, LLC 1.41% of their portfolio | 1.5m $222.2m | Added +122.6k |
| SANDS CAPITAL MANAGEMENT, LLC 0.58% of their portfolio | 1.4m $196.4m | Reduced -54.8k |
| Bank of New York Mellon Corp 0.04% of their portfolio | 1.4m $194.5m | Reduced -12.7k |
| CITADEL ADVISORS LLC 0.16% of their portfolio | 1.2m $169.8m | Added +663.6k |
| MACQUARIE GROUP LTD 0.19% of their portfolio | 1.1m $158.3m | Reduced -104.5k |
| Impax Asset Management Group plc 0.68% of their portfolio | 1.1m $150.3m | Reduced -6.2k |
| ALLIANCEBERNSTEIN L.P. 0.05% of their portfolio | 1.0m $145.5m | Added +191.4k |
| BROWN CAPITAL MANAGEMENT LLC 3.19% of their portfolio | 954.9k $137.5m | Reduced -164.6k |
| Conestoga Capital Advisors, LLC 1.81% of their portfolio | 947.6k $136.4m | Added +6.9k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 944.1k $135.9m | Added +1.7k |
| AMERIPRISE FINANCIAL INC 0.03% of their portfolio | 929.1k $133.7m | Reduced -25.2k |
| Point72 Asset Management, L.P. 0.36% of their portfolio | 918.6k $132.2m | Added +594.2k |
| Invesco Ltd. 0.02% of their portfolio | 905.1k $130.3m | Reduced -152.8k |
| FMR LLC 0.01% of their portfolio | 754.4k $108.6m | Reduced -48.9k |
| Thrivent Financial for Lutherans 0.17% of their portfolio | 605.1k $87.1m | Reduced -33.5k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.11% of their portfolio | 581.4k $83.7m | Added +14.4k |
| DIMENSIONAL FUND ADVISORS LP 0.02% of their portfolio | 580.5k $83.6m | Added +126.9k |
| DF DENT & CO INC 1.03% of their portfolio | 563.3k $81.1m | Reduced -27.0k |
| Stephens Investment Management Group LLC 1.03% of their portfolio | 536.8k $77.3m | Added +37.1k |
| MORGAN STANLEY 0.01% of their portfolio | 525.1k $75.6m | Reduced -71.4k |
| NORTHERN TRUST CORP 0.01% of their portfolio | 493.7k $71.1m | Added +102.0k |
| Allspring Global Investments Holdings, LLC 0.10% of their portfolio | 457.1k $65.4m | Added +203.0k |
| RIVERBRIDGE PARTNERS LLC 0.89% of their portfolio | 455.1k $65.5m | Reduced -45.9k |
| Artisan Partners Limited Partnership 0.09% of their portfolio | 413.7k $59.6m | Reduced -23.5k |
| MARSHALL WACE, LLP 0.07% of their portfolio | 412.2k $59.3m | Added +175.0k |
| GROUPAMA ASSET MANAGMENT 0.01% of their portfolio | 400.0k $410.4k | New |
| AMERICAN CAPITAL MANAGEMENT INC 2.06% of their portfolio | 383.5k $55.2m | Added +4.5k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 377.9k $54.4m | Added +14.5k |
| Alyeska Investment Group, L.P. 0.20% of their portfolio | 371.2k $53.4m | New |
| PARNASSUS INVESTMENTS, LLC 0.12% of their portfolio | 366.2k $52.7m | Reduced -15.2k |
| RAYMOND JAMES FINANCIAL INC 0.02% of their portfolio | 364.7k $52.5m | First filing |
| FRED ALGER MANAGEMENT, LLC 0.25% of their portfolio | 359.5k $51.7m | Reduced -39.0k |
| TWO SIGMA INVESTMENTS, LP 0.12% of their portfolio | 359.0k $51.7m | Reduced -77.1k |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 358.2k $51.6m | Added +25.8k |
| Baird Financial Group, Inc. 0.10% of their portfolio | 354.2k $51.0m | Reduced -28.4k |
| VOYA INVESTMENT MANAGEMENT LLC 0.05% of their portfolio | 346.2k $49.8m | Reduced -139.2k |
| Harding Loevner LP 0.33% of their portfolio | 340.1k $49.0m | Reduced -576.1k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.12% of their portfolio | 328.5k $47.3m | Added +47.3k |
| Holocene Advisors, LP 0.15% of their portfolio | 311.1k $44.8m | New |
| Nuveen Asset Management, LLC 0.01% of their portfolio | 291.5k $42.0m | Reduced -43.6k |
| FIRST TRUST ADVISORS LP 0.04% of their portfolio | 285.6k $41.1m | Reduced -15.0k |
| BRAIDWELL LP 1.21% of their portfolio | 283.8k $40.9m | Reduced -113.0k |
| AMERICAN CENTURY COMPANIES INC 0.02% of their portfolio | 281.7k $40.5m | Reduced -5.7k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 277.9k $40.0m | Reduced -158.4k |
| TimesSquare Capital Management, LLC 0.55% of their portfolio | 261.0k $37.6m | Reduced -14.6k |
| PALISADE CAPITAL MANAGEMENT, LP 1.00% of their portfolio | 260.1k $37.4m | Added +14.7k |
| BESSEMER GROUP INC 0.06% of their portfolio | 248.7k $35.8m | Reduced -6.5k |
| 12 West Capital Management LP 3.72% of their portfolio | 246.9k $35.5m | Reduced -6.0k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio | 235.3k $33.9m | Added +26.7k |
| Ranger Investment Management, L.P. 2.05% of their portfolio | 226.1k $32.5m | Reduced -4.3k |
| SEI INVESTMENTS CO 0.04% of their portfolio | 219.6k $31.6m | Added +24.7k |
| ExodusPoint Capital Management, LP 0.32% of their portfolio | 213.7k $30.8m | Added +117.8k |
| UBS Group AG 0.01% of their portfolio | 188.8k $27.2m | Added +135.8k |
| NORGES BANK 0.00% of their portfolio | 167.0k $24.0m | Added +26.5k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 161.0k $23.2m | Reduced -566.0k |
| BAMCO INC /NY/ 0.06% of their portfolio | 160.2k $23.1m | Reduced -6.8k |
| T. Rowe Price Investment Management, Inc. 0.01% of their portfolio | 159.1k $22.9m | Added +131.3k |
| Artemis Investment Management LLP 0.32% of their portfolio | 153.8k $22.1m | Added +23.9k |
| RHUMBLINE ADVISERS 0.02% of their portfolio | 146.1k $21.0m | Added +2.7k |
| Ensign Peak Advisors, Inc 0.04% of their portfolio | 138.1k $19.9m | Reduced -1.1k |
| GENEVA CAPITAL MANAGEMENT LLC 0.34% of their portfolio | 135.6k $19.5m | Reduced -3.1k |
| TWO SIGMA ADVISERS, LP 0.04% of their portfolio | 134.8k $19.4m | Added +8.5k |
| NZS Capital, LLC 0.82% of their portfolio | 133.7k $19.2m | Added +5.9k |
| SEGALL BRYANT & HAMILL, LLC 0.26% of their portfolio | 132.1k $19.0m | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 121.6k $17.5m | Reduced -121.4k |
| PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio | 119.9k $17.3m | Reduced -1.1k |
| EVENTIDE ASSET MANAGEMENT, LLC 0.31% of their portfolio | 119.0k $17.1m | Unchanged |
| CONGRESS ASSET MANAGEMENT CO 0.11% of their portfolio | 116.6k $16.8m | Added +12.9k |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO 0.07% of their portfolio | 116.2k $16.7m | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 114.9k $16.5m | Reduced -1.0k |
| ZEVENBERGEN CAPITAL INVESTMENTS LLC 0.33% of their portfolio | 112.7k $16.2m | Reduced -16.2k |
| Curi Capital, LLC 0.37% of their portfolio | 111.8k $16.1m | Reduced -1.4k |
| Granahan Investment Management, LLC 0.65% of their portfolio | 107.4k $15.5m | Added +19.2k |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 106.4k $15.3m | Reduced -5.8k |
| W1M Asset Management Ltd 1.29% of their portfolio | 105.5k $15.2m | Added +4.6k |
| Swiss National Bank 0.01% of their portfolio | 104.7k $15.1m | Added +900 |
| WCM INVESTMENT MANAGEMENT, LLC 0.03% of their portfolio | 97.1k $14.0m | Reduced -2.1k |
| Man Group plc 0.04% of their portfolio | 95.6k $13.8m | Added +41.8k |
| NORTH STAR ASSET MANAGEMENT INC 0.57% of their portfolio | 90.1k $13.0m | Reduced -2.0k |
| BARCLAYS PLC 0.01% of their portfolio | 87.8k $12.6m | Added +61.4k |
| Amundi 0.00% of their portfolio | 85.9k $13.3m | Added +8.8k |
| COMERICA BANK 0.05% of their portfolio | 84.4k $12.1m | Reduced -631 |
| CITIGROUP INC 0.01% of their portfolio | 84.1k $12.1m | Reduced -9.3k |
| First Light Asset Management, LLC 1.14% of their portfolio | 82.5k $11.9m | Reduced -83.4k |
| Legal & General Group Plc 0.00% of their portfolio | 81.9k $11.8m | Reduced -191 |
| California Public Employees Retirement System 0.01% of their portfolio | 69.3k $10.0m | Reduced -4.7k |
| Pier Capital, LLC 1.34% of their portfolio | 65.1k $9.4m | Added +766 |
| AWM Investment Company, Inc. 1.14% of their portfolio | 65.0k $9.4m | Reduced -5.0k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio | 64.2k $9.2m | Reduced -2.5k |
| Retirement Systems of Alabama 0.03% of their portfolio | 63.3k $9.1m | Added +60 |
| Alberta Investment Management Corp 0.06% of their portfolio | 63.2k $9.1m | Unchanged |
| OSTERWEIS CAPITAL MANAGEMENT INC 0.41% of their portfolio | 61.7k $8.9m | Added +8.2k |
| Cinctive Capital Management LP 0.48% of their portfolio | 61.4k $8.8m | Added +53.9k |
| Corebridge Financial, Inc. 0.05% of their portfolio | 59.1k $8.5m | Reduced -2.7k |
| Russell Investments Group, Ltd. 0.01% of their portfolio | 58.2k $8.4m | Added +669 |
| Eversept Partners, LP 0.80% of their portfolio | 54.1k $7.8m | Reduced -109.5k |