RELAY THERAPEUTICS INC RLAY
COM · Common Stock · CUSIP 75943R102
Company in Cambridge, United States
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersCambridge, MA
- Founded2016
- Websiterelaytx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($181.6k this quarter). Holder counts are more reliable. Shares outstanding: 172.4m as of 2025-08-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $3.46. Options: 2 managers hold calls ($1.0k notional), 3 hold puts ($127.7k).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 162 |
| Q4 2022 | 165 |
| Q1 2023 | 158 |
| Q2 2023 | 162 |
| Q3 2023 | 173 |
| Q4 2023 | 178 |
| Q1 2024 | 190 |
| Q2 2024 | 180 |
| Q3 2024 | 196 |
| Q4 2024 | 201 |
| Q1 2025 | 209 |
| Q2 2025 | 209 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 90 | 59 |
| Q4 2023 | 81 | 82 |
| Q1 2024 | 101 | 69 |
| Q2 2024 | 95 | 78 |
| Q3 2024 | 113 | 74 |
| Q4 2024 | 116 | 73 |
| Q1 2025 | 107 | 81 |
| Q2 2025 | 106 | 90 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $758.1k | $342.6k | 0.45 |
| Q4 2024 | $606.4k | $112.4k | 0.19 |
| Q1 2025 | $482.6k | $128.9k | 0.27 |
| Q2 2025 | $1.0k | $127.7k | 127.67 |
Biggest buyers
| Commodore Capital LP | New | +13.3m |
| Point72 Asset Management, L.P. | Added | +2.6m |
| Casdin Capital, LLC | Added | +2.3m |
| ROYAL BANK OF CANADA | Added | +864.0k |
| Bellevue Group AG | Added | +853.6k |
| BANK OF AMERICA CORP /DE/ | Added | +765.7k |
| AQR CAPITAL MANAGEMENT LLC | Added | +718.5k |
| Eversept Partners, LP | New | +533.4k |
| TWO SIGMA ADVISERS, LP | Added | +388.6k |
| Private Capital Advisors, Inc. | Added | +341.7k |
Biggest sellers
| NORGES BANK | Reduced | -3.8m |
| VANGUARD GROUP INC | Reduced | -2.7m |
| EVENTIDE ASSET MANAGEMENT, LLC | Sold out | -2.7m |
| Finepoint Capital LP | Sold out | -2.1m |
| MILLENNIUM MANAGEMENT LLC | Reduced | -1.1m |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -767.9k |
| EcoR1 Capital, LLC | Sold out | -641.4k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -601.9k |
| Candriam S.C.A. | Sold out | -580.1k |
| JPMORGAN CHASE & CO | Reduced | -571.4k |
Biggest calls
| SIMPLEX TRADING, LLC | Reduced | $1.0k500 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CITADEL ADVISORS LLC | Added | $124.9k36.1k shares |
| GROUP ONE TRADING LLC | New | $2.8k800 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +0.6 pts · filed 2026-08-07 | 10.0% |
| Casdin Capital, LLC 13G · passive investor no change · filed 2026-02-17 | 7.5% |
| PERCEPTIVE ADVISORS LLC 13G · passive investor +1.1 pts · filed 2026-08-10 | 6.4% |
| BlackRock, Inc. 13G · institution -2.7 pts · filed 2025-04-17 | 6.1% |
| Commodore Capital LP 13G · passive investor -4.4 pts · filed 2026-08-14 | 5.5% |
Fell to 5% or below in the last year: Point72 Asset Management, L.P. (0.0%, 2026-05-15), VANGUARD GROUP INC (0.0%, 2026-03-27)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 4 | $96.7k | — |
| Q4 2023 | 0 | — | 4 | $66.5k | — |
| Q1 2024 | 0 | — | 4 | $95.3k | — |
| Q2 2024 | 0 | — | 4 | $653.4k | $599.1k |
| Q3 2024 | 0 | — | 5 | $1.3m | $1.3m |
| Q4 2024 | 0 | — | 5 | $617.0k | $576.4k |
| Q1 2025 | 0 | — | 5 | $3.9m | $2.3m |
| Q2 2025 | 0 | — | 5 | $378.4k | $20.0k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-04-30 | Bergstrom Donald A President, R&D | Sold | $82.4k27.5k shares |
| 2025-04-30 | Adams Brian Chief Legal Officer | Sold | $38.8k12.9k shares |
| 2025-04-30 | Catinazzo Thomas Chief Financial Officer | Sold plan | $38.8k12.9k shares |
| 2025-04-30 | Rahmer Peter Officer | Sold | $32.2k10.7k shares |
| 2025-04-29 | Catinazzo Thomas Chief Financial Officer | Sold plan | $11.5k3.6k shares |
| 2025-04-28 | Bergstrom Donald A President, R&D | Sold | $13.0k4.1k shares |
| 2025-04-28 | Catinazzo Thomas Chief Financial Officer | Sold plan | $8.5k2.7k shares |
| 2025-04-28 | Adams Brian Chief Legal Officer | Sold | $5.2k1.6k shares |
| 2025-04-28 | Rahmer Peter Officer | Sold | $4.3k1.4k shares |
| 2025-04-23 | Patel Sanjiv President and CEO, director | Sold | $182.4k61.4k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| SB INVESTMENT ADVISERS (UK) LTD 0.77% of their portfolio | 27.9m $96.6m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 14.0m $48.3m | Reduced -524.3k |
| Point72 Asset Management, L.P. 0.11% of their portfolio | 13.4m $46.5m | Added +2.6m |
| Commodore Capital LP 3.26% of their portfolio | 13.3m $46.2m | New |
| Casdin Capital, LLC 3.59% of their portfolio | 11.4m $39.4m | Added +2.3m |
| VANGUARD GROUP INC 0.00% of their portfolio | 9.4m $32.5m | Reduced -2.7m |
| Bellevue Group AG 0.63% of their portfolio | 8.2m $28.5m | Added +853.6k |
| TANG CAPITAL MANAGEMENT LLC 1.41% of their portfolio | 8.1m $27.9m | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 5.2m $18.0m | Added +43.6k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 4.3m $15.0m | Reduced -571.4k |
| Nextech Invest Ltd. 2.52% of their portfolio | 3.8m $13.3m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 3.2m $11.2m | Added +159.5k |
| Kynam Capital Management, LP 1.08% of their portfolio | 2.9m $10.0m | Reduced -176.3k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 2.9m $10.0m | Reduced -601.9k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 2.8m $9.7m | Reduced -9.6k |
| MPM BIOIMPACT LLC 1.37% of their portfolio | 2.3m $7.9m | Reduced -13.2k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 1.9m $6.7m | Reduced -142.8k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 1.9m $6.5m | Reduced -1.1m |
| Alphabet Inc. 0.25% of their portfolio | 1.6m $5.4m | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 1.5m $5.2m | Reduced -767.9k |
| MORGAN STANLEY 0.00% of their portfolio | 1.4m $4.9m | Reduced -170.8k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.3m $4.6m | Added +765.7k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 1.2m $4.0m | Added +19.2k |
| BAKER BROS. ADVISORS LP 0.04% of their portfolio | 1.2m $4.0m | Unchanged |
| TWO SIGMA ADVISERS, LP 0.01% of their portfolio | 1.1m $3.9m | Added +388.6k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 1.1m $3.8m | Added +41.4k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 1.1m $3.7m | Added +718.5k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 1.0m $3.5m | Added +179.5k |
| Woodline Partners LP 0.02% of their portfolio | 1.0m $3.5m | Reduced -500.4k |
| ALGERT GLOBAL LLC 0.07% of their portfolio | 1.0m $3.5m | Added +70.8k |
| Foresite Capital Management IV, LLC 2.79% of their portfolio | 1.0m $3.5m | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 876.1k $3.0m | Added +864.0k |
| NORGES BANK 0.00% of their portfolio | 835.9k $2.9m | Reduced -3.8m |
| ACADIAN ASSET MANAGEMENT LLC 0.01% of their portfolio | 794.6k $2.7m | Added +112.6k |
| Ikarian Capital, LLC 0.85% of their portfolio | 743.3k $2.6m | Unchanged |
| Tetragon Partners GP Ltd 0.44% of their portfolio | 699.0k $2.4m | Added +80.0k |
| BESSEMER GROUP INC 0.00% of their portfolio | 584.5k $2.0m | Unchanged |
| BARCLAYS PLC 0.00% of their portfolio | 556.5k $1.9m | Added +87.4k |
| ArrowMark Colorado Holdings LLC 0.03% of their portfolio | 541.1k $1.9m | Unchanged |
| Eversept Partners, LP 0.19% of their portfolio | 533.4k $1.8m | New |
| Rhenman & Partners Asset Management AB 0.20% of their portfolio | 460.0k $1.6m | Unchanged |
| Private Capital Advisors, Inc. 0.19% of their portfolio | 441.7k $1.5m | Added +341.7k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 410.9k $1.4m | Added +38.5k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 408.9k $1.4m | Added +107.4k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 394.1k $1.4m | Added +223.0k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 358.4k $1.2m | Added +28.5k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 358.2k $1.2m | Reduced -35.1k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 349.4k $1.2m | Added +40.7k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 306.1k $1.1m | Added +49.3k |
| Man Group plc 0.00% of their portfolio | 298.5k $1.0m | Added +92.8k |
| HarbourVest Partners LLC 1.12% of their portfolio | 296.4k $1.0m | Unchanged |
| Verition Fund Management LLC 0.01% of their portfolio | 290.6k $1.0m | Added +151.4k |
| Nuveen, LLC 0.00% of their portfolio | 288.4k $998.0k | Reduced -31.9k |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.03% of their portfolio | 279.2k $966.1k | Reduced -77.0k |
| Invesco Ltd. 0.00% of their portfolio | 273.4k $945.9k | Added +88.6k |
| XTX Topco Ltd 0.03% of their portfolio | 241.2k $834.7k | Added +161.3k |
| Susquehanna Portfolio Strategies, LLC 0.02% of their portfolio | 238.8k $826.3k | New |
| Swiss National Bank 0.00% of their portfolio | 227.0k $785.4k | Unchanged |
| BOOTHBAY FUND MANAGEMENT, LLC 0.02% of their portfolio | 223.0k $771.5k | Reduced -3.8k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 221.9k $767.6k | Added +47.7k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 212.1k $734.0k | Added +6.5k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 190.5k $659.1k | Added +6.0k |
| CW Advisors, LLC 0.01% of their portfolio | 186.1k $643.8k | Unchanged |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 182.0k $629.6k | Reduced -23.1k |
| Raiffeisen Bank International AG 0.01% of their portfolio | 180.0k $586.8k | Unchanged |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 179.3k $620.5k | Added +123.0k |
| UBS Group AG 0.00% of their portfolio | 173.1k $598.9k | Reduced -102.5k |
| ExodusPoint Capital Management, LP 0.01% of their portfolio | 170.2k $589.0k | New |
| Thrivent Financial for Lutherans 0.00% of their portfolio | 166.7k $576.0k | Unchanged |
| FMR LLC 0.00% of their portfolio | 158.2k $547.3k | Added +115.2k |
| CONGRESS ASSET MANAGEMENT CO 0.00% of their portfolio | 156.7k $542.2k | Added +498 |
| HighVista Strategies LLC 0.19% of their portfolio | 149.7k $518.0k | New |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 145.3k $502.6k | Reduced -23.0k |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.01% of their portfolio | 127.0k $439.5k | Reduced -255.9k |
| CITIGROUP INC 0.00% of their portfolio | 123.4k $426.9k | Reduced -136.9k |
| Legal & General Group Plc 0.00% of their portfolio | 112.3k $388.6k | Reduced -16.9k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 109.8k $379.9k | Added +39.0k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 106.3k $367.8k | Unchanged |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 104.3k $351.8k | Reduced -12.2k |
| Brooklyn Investment Group 0.05% of their portfolio | 101.1k $349.7k | Added +95.0k |
| TD Asset Management Inc 0.00% of their portfolio | 99.1k $342.7k | Reduced -57.4k |
| NEOS Investment Management LLC 0.00% of their portfolio | 97.2k $336.1k | Added +8.0k |
| Tema ETFs LLC 0.09% of their portfolio | 97.2k $336.1k | Added +8.0k |
| ICONIQ Capital, LLC 0.01% of their portfolio | 94.7k $327.7k | Unchanged |
| ALPS ADVISORS INC 0.00% of their portfolio | 92.5k $320.1k | New |
| Squarepoint Ops LLC 0.00% of their portfolio | 87.6k $302.9k | Reduced -27.1k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 85.0k $294.0k | Added +9.5k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 82.4k $283.5k | Reduced -1.7k |
| GSA CAPITAL PARTNERS LLP 0.02% of their portfolio | 80.6k $279.0k | Added +28.1k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 75.1k $259.9k | Added +9.8k |
| Creative Planning 0.00% of their portfolio | 72.6k $251.3k | Added +49.5k |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 71.2k $246.4k | Reduced -25.1k |
| OP Asset Management Ltd 0.00% of their portfolio | 70.5k $244.1k | New |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 68.6k $237.4k | Added +3.3k |
| Intellectus Partners, LLC 0.05% of their portfolio | 61.4k $212.5k | Unchanged |
| Allspring Global Investments Holdings, LLC 0.00% of their portfolio | 60.3k $212.4k | Reduced -3.3k |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 60.0k $531.0k | Reduced -8.9k |
| Sanctuary Advisors, LLC 0.00% of their portfolio | 58.7k $202.9k | New |
| CWM, LLC 0.00% of their portfolio | 57.0k $197.0k | Added +36.7k |
| BANK OF MONTREAL /CAN/ 0.00% of their portfolio | 55.2k $190.9k | Added +23.4k |