RELAY THERAPEUTICS INC RLAY
COM · Common Stock · CUSIP 75943R102
Company in Cambridge, United States
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersCambridge, MA
- Founded2016
- Websiterelaytx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.5m this quarter). Holder counts are more reliable. Shares outstanding: 167.4m as of 2024-11-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $4.12. Options: 5 managers hold calls ($606.4k notional), 4 hold puts ($112.4k).
Trends to Q4 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 162 |
| Q4 2022 | 165 |
| Q1 2023 | 158 |
| Q2 2023 | 162 |
| Q3 2023 | 173 |
| Q4 2023 | 178 |
| Q1 2024 | 190 |
| Q2 2024 | 180 |
| Q3 2024 | 196 |
| Q4 2024 | 201 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2023 | 75 | 79 |
| Q2 2023 | 91 | 62 |
| Q3 2023 | 90 | 59 |
| Q4 2023 | 81 | 82 |
| Q1 2024 | 101 | 69 |
| Q2 2024 | 95 | 78 |
| Q3 2024 | 113 | 74 |
| Q4 2024 | 116 | 73 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2024 | $60.9k | $98.1k | 1.61 |
| Q2 2024 | $12.1k | $117.4k | 9.71 |
| Q3 2024 | $758.1k | $342.6k | 0.45 |
| Q4 2024 | $606.4k | $112.4k | 0.19 |
Biggest buyers
| TANG CAPITAL MANAGEMENT LLC | Added | +4.5m |
| BlackRock, Inc. | Added | +2.9m |
| MILLENNIUM MANAGEMENT LLC | Added | +1.5m |
| DIMENSIONAL FUND ADVISORS LP | Added | +1.2m |
| Kynam Capital Management, LP | New | +1.0m |
| STATE STREET CORP | Added | +979.5k |
| RENAISSANCE TECHNOLOGIES LLC | Added | +878.1k |
| GOLDMAN SACHS GROUP INC | Added | +730.5k |
| Balyasny Asset Management L.P. | New | +692.3k |
| Candriam S.C.A. | Added | +636.5k |
Biggest sellers
| JPMORGAN CHASE & CO | Reduced | -6.1m |
| BRAIDWELL LP | Sold out | -3.5m |
| CITADEL ADVISORS LLC | Reduced | -2.2m |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -2.0m |
| EcoR1 Capital, LLC | Reduced | -1.9m |
| Boxer Capital, LLC | Sold out | -1.8m |
| First Light Asset Management, LLC | Sold out | -1.5m |
| MARSHALL WACE, LLP | Reduced | -1.4m |
| FRANKLIN RESOURCES INC | Reduced | -1.3m |
| First Turn Management, LLC | Sold out | -1.2m |
Biggest calls
| DIADEMA PARTNERS LP | First filing | $412.0k100.0k shares |
| GROUP ONE TRADING LLC | Added | $170.2k41.3k shares |
| Persistent Asset Partners Ltd | First filing | $24.2k303 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
| SIMPLEX TRADING, LLC | Reduced | $0200 shares |
Biggest puts
| CITADEL ADVISORS LLC | Reduced | $64.3k15.6k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $46.1k11.2k shares |
| SIMPLEX TRADING, LLC | Reduced | $2.0k600 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +0.6 pts · filed 2026-08-07 | 10.0% |
| Casdin Capital, LLC 13G · passive investor no change · filed 2026-02-17 | 7.5% |
| PERCEPTIVE ADVISORS LLC 13G · passive investor +1.1 pts · filed 2026-08-10 | 6.4% |
| BlackRock, Inc. 13G · institution -2.7 pts · filed 2025-04-17 | 6.1% |
| Commodore Capital LP 13G · passive investor -4.4 pts · filed 2026-08-14 | 5.5% |
Fell to 5% or below in the last year: Point72 Asset Management, L.P. (0.0%, 2026-05-15), VANGUARD GROUP INC (0.0%, 2026-03-27)
Insider purchases and sales in Q4 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2023 | 0 | — | 5 | $2.9m | — |
| Q2 2023 | 0 | — | 4 | $108.7k | — |
| Q3 2023 | 0 | — | 4 | $96.7k | — |
| Q4 2023 | 0 | — | 4 | $66.5k | — |
| Q1 2024 | 0 | — | 4 | $95.3k | — |
| Q2 2024 | 0 | — | 4 | $653.4k | $599.1k |
| Q3 2024 | 0 | — | 5 | $1.3m | $1.3m |
| Q4 2024 | 0 | — | 5 | $617.0k | $576.4k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-12-27 | Catinazzo Thomas Chief Financial Officer | Sold plan | $21.5k4.9k shares |
| 2024-12-27 | Bergstrom Donald A President, R&D | Sold | $2.9k657 shares |
| 2024-12-27 | Rahmer Peter Officer | Sold | $1.8k400 shares |
| 2024-12-27 | Adams Brian Chief Legal Officer | Sold | $1.3k299 shares |
| 2024-12-16 | Patel Sanjiv President and CEO, director · By The Patel Family Irrevocable Trust of 2019 | Sold plan | $500.0k100.0k shares |
| 2024-10-29 | Catinazzo Thomas Chief Financial Officer | Sold plan | $13.7k2.3k shares |
| 2024-10-28 | Catinazzo Thomas Chief Financial Officer | Sold plan | $41.2k6.8k shares |
| 2024-10-28 | Bergstrom Donald A President, R&D | Sold | $16.3k2.7k shares |
| 2024-10-28 | Adams Brian Chief Legal Officer | Sold | $9.9k1.6k shares |
| 2024-10-28 | Rahmer Peter Officer | Sold | $9.8k1.6k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2024
| Manager | Shares | Change |
|---|---|---|
| SB INVESTMENT ADVISERS (UK) LTD 1.01% of their portfolio | 27.9m $115.0m | Unchanged |
| VANGUARD GROUP INC 0.00% of their portfolio | 15.0m $61.9m | Added +566.6k |
| BlackRock, Inc. 0.00% of their portfolio | 14.7m $60.5m | Added +2.9m |
| Casdin Capital, LLC 2.47% of their portfolio | 8.9m $36.9m | Reduced -302.5k |
| TANG CAPITAL MANAGEMENT LLC 2.20% of their portfolio | 8.1m $33.2m | Added +4.5m |
| Bellevue Group AG 0.59% of their portfolio | 7.4m $30.4m | Added +108 |
| NORGES BANK 0.00% of their portfolio | 5.8m $23.8m | Reduced -135.6k |
| STATE STREET CORP 0.00% of their portfolio | 5.3m $21.8m | Added +979.5k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 5.0m $20.5m | Reduced -6.1m |
| Nextech Invest Ltd. 2.57% of their portfolio | 3.8m $15.8m | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 3.3m $13.7m | Reduced -2.0m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 3.0m $12.5m | Added +297.9k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 3.0m $12.2m | Added +1.2m |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 2.7m $11.1m | Added +730.5k |
| EVENTIDE ASSET MANAGEMENT, LLC 0.20% of their portfolio | 2.7m $11.1m | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 2.6m $10.6m | Added +1.5m |
| MPM BIOIMPACT LLC 1.33% of their portfolio | 2.3m $9.3m | Added +235.8k |
| Finepoint Capital LP 1.03% of their portfolio | 2.2m $9.0m | Added +549.5k |
| Candriam S.C.A. 0.04% of their portfolio | 1.7m $7.1m | Added +636.5k |
| Point72 Asset Management, L.P. 0.02% of their portfolio | 1.6m $6.6m | Added +243.4k |
| Alphabet Inc. 0.38% of their portfolio | 1.6m $6.5m | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 1.5m $6.4m | Added +878.1k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.01% of their portfolio | 1.4m $5.8m | Reduced -250.0k |
| MORGAN STANLEY 0.00% of their portfolio | 1.3m $5.4m | Added +338.7k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 1.2m $4.8m | Added +231.7k |
| BAKER BROS. ADVISORS LP 0.05% of their portfolio | 1.2m $4.8m | Unchanged |
| Exome Asset Management LLC 3.36% of their portfolio | 1.1m $4.5m | Added +254.2k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 1.0m $4.2m | Reduced -25.0k |
| Foresite Capital Management IV, LLC 3.79% of their portfolio | 1.0m $4.1m | Unchanged |
| Kynam Capital Management, LP 0.27% of their portfolio | 1.0m $4.1m | New |
| ALGERT GLOBAL LLC 0.10% of their portfolio | 994.9k $4.1m | Added +481.6k |
| Trexquant Investment LP 0.05% of their portfolio | 978.1k $4.0m | Added +566.3k |
| Walleye Capital LLC 0.04% of their portfolio | 927.1k $3.8m | Reduced -892.8k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 816.1k $3.4m | Reduced -199.5k |
| Ikarian Capital, LLC 0.82% of their portfolio | 693.3k $2.9m | Reduced -42 |
| Balyasny Asset Management L.P. 0.01% of their portfolio | 692.3k $2.9m | New |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 686.9k $2.8m | Reduced -2.2m |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 653.4k $2.7m | Added +378.3k |
| EcoR1 Capital, LLC 0.11% of their portfolio | 641.4k $2.6m | Reduced -1.9m |
| TWO SIGMA ADVISERS, LP 0.01% of their portfolio | 638.9k $2.6m | Added +24.7k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.01% of their portfolio | 623.3k $2.6m | Reduced -607.0k |
| BESSEMER GROUP INC 0.00% of their portfolio | 584.5k $2.4m | Reduced -170 |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 549.6k $2.3m | Added +173.0k |
| ArrowMark Colorado Holdings LLC 0.03% of their portfolio | 541.1k $2.2m | Unchanged |
| Boxer Capital Management, LLC 0.19% of their portfolio | 536.1k $2.2m | First filing |
| DIADEMA PARTNERS LP 2.35% of their portfolio | 505.8k $2.1m | First filing |
| Parkman Healthcare Partners LLC 0.27% of their portfolio | 500.5k $2.1m | New |
| Rhenman & Partners Asset Management AB 0.19% of their portfolio | 460.0k $1.9m | Unchanged |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 457.3k $1.9m | Reduced -794.0k |
| Schonfeld Strategic Advisors LLC 0.01% of their portfolio | 354.5k $1.5m | New |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.02% of their portfolio | 346.3k $1.4m | First filing |
| UBS Group AG 0.00% of their portfolio | 343.2k $1.4m | Added +151.5k |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.03% of their portfolio | 330.7k $1.4m | Added +218.7k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 328.9k $1.4m | Added +50.2k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 326.1k $1.3m | Added +302.7k |
| Cubist Systematic Strategies, LLC 0.02% of their portfolio | 317.2k $1.3m | Reduced -42.1k |
| BARCLAYS PLC 0.00% of their portfolio | 313.2k $1.3m | Added +61.4k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 305.4k $1.3m | Added +29.0k |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.10% of their portfolio | 297.2k $1.2m | Added +187.3k |
| HarbourVest Partners LLC 0.60% of their portfolio | 296.4k $1.2m | Unchanged |
| BIT Capital GmbH 0.10% of their portfolio | 284.5k $1.2m | New |
| Woodline Partners LP 0.01% of their portfolio | 276.9k $1.1m | Unchanged |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 272.2k $1.1m | Added +51.5k |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 249.6k $1.0m | Added +69.5k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 239.7k $987.4k | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 232.6k $958.2k | Added +9.3k |
| Swiss National Bank 0.00% of their portfolio | 219.6k $904.8k | Unchanged |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 218.9k $901.8k | Added +3.3k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.03% of their portfolio | 214.4k $883.3k | Added +5.7k |
| CITIGROUP INC 0.00% of their portfolio | 205.7k $847.4k | Added +118.3k |
| HighTower Advisors, LLC 0.00% of their portfolio | 199.7k $822.9k | Added +44.8k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 189.0k $778.9k | First filing |
| Fernwood Investment Management, LLC 0.27% of their portfolio | 185.8k $765.3k | Unchanged |
| Raiffeisen Bank International AG 0.01% of their portfolio | 180.0k $752.4k | First filing |
| Man Group plc 0.00% of their portfolio | 173.6k $715.3k | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 171.4k $706.3k | Added +13.5k |
| Thrivent Financial for Lutherans 0.00% of their portfolio | 166.7k $687.0k | Added +6.2k |
| Squarepoint Ops LLC 0.00% of their portfolio | 162.6k $669.9k | Added +137.0k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 161.8k $666.7k | Added +128.9k |
| CONGRESS ASSET MANAGEMENT CO 0.00% of their portfolio | 157.5k $648.8k | Added +11.1k |
| TD Asset Management Inc 0.00% of their portfolio | 156.5k $644.6k | Reduced -30.2k |
| Persistent Asset Partners Ltd 0.56% of their portfolio | 145.8k $651.9k | First filing |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 138.3k $569.7k | Unchanged |
| Jump Financial, LLC 0.01% of their portfolio | 138.2k $569.5k | Added +36.3k |
| GSA CAPITAL PARTNERS LLP 0.04% of their portfolio | 129.9k $535.0k | Added +114.5k |
| Legal & General Group Plc 0.00% of their portfolio | 124.9k $514.5k | Added +1.6k |
| Invesco Ltd. 0.00% of their portfolio | 119.4k $492.0k | Added +5.3k |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 111.8k $458.3k | Added +77.3k |
| PDT Partners, LLC 0.04% of their portfolio | 108.6k $447.4k | Reduced -18.7k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 106.3k $437.9k | Added +23.8k |
| FMR LLC 0.00% of their portfolio | 96.7k $398.3k | Added +6.9k |
| ICONIQ Capital, LLC 0.01% of their portfolio | 94.7k $390.2k | Unchanged |
| Verition Fund Management LLC 0.00% of their portfolio | 90.5k $372.8k | Added +14.3k |
| FIRST TRUST ADVISORS LP 0.00% of their portfolio | 89.9k $370.6k | New |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 87.9k $362.0k | New |
| Nebula Research & Development LLC 0.04% of their portfolio | 86.6k $357.0k | Added +47.1k |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 86.4k $355.8k | Added +5.7k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 82.5k $339.7k | Added +30.3k |
| MARTINGALE ASSET MANAGEMENT L P 0.01% of their portfolio | 80.4k $331.1k | Added +2.7k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 79.8k $328.8k | Added +68.6k |