PYXIS ONCOLOGY INC PYXS
COMMON STOCK · Common Stock · CUSIP 747324101
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersBoston, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 62.3m as of 2025-10-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.15. Options: 4 managers hold calls ($583.5k notional), 3 hold puts ($86.0k).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 38 |
| Q4 2022 | 32 |
| Q1 2023 | 48 |
| Q2 2023 | 49 |
| Q3 2023 | 55 |
| Q4 2023 | 52 |
| Q1 2024 | 72 |
| Q2 2024 | 81 |
| Q3 2024 | 93 |
| Q4 2024 | 100 |
| Q1 2025 | 90 |
| Q2 2025 | 75 |
| Q3 2025 | 73 |
| Q4 2025 | 79 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 52 | 14 |
| Q2 2024 | 43 | 37 |
| Q3 2024 | 50 | 26 |
| Q4 2024 | 48 | 38 |
| Q1 2025 | 34 | 43 |
| Q2 2025 | 36 | 53 |
| Q3 2025 | 25 | 46 |
| Q4 2025 | 43 | 33 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $40.6k | $35.9k | 0.88 |
| Q2 2025 | $15.6k | $2.0k | 0.13 |
| Q3 2025 | $350.5k | $0 | 0.00 |
| Q4 2025 | $583.5k | $86.0k | 0.15 |
Biggest buyers
| Laurion Capital Management LP | Added | +1.2m |
| Atle Fund Management AB | New | +617.2k |
| JANE STREET GROUP, LLC | Added | +482.3k |
| MARSHALL WACE, LLP | New | +389.8k |
| 683 Capital Management, LLC | Added | +366.9k |
| ExodusPoint Capital Management, LP | New | +317.8k |
| XTX Topco Ltd | Added | +271.3k |
| Point72 Asset Management, L.P. | New | +188.1k |
| Graham Capital Management, L.P. | New | +183.9k |
| VANGUARD GROUP INC | Added | +171.8k |
Biggest sellers
| TANG CAPITAL MANAGEMENT LLC | Sold out | -2.5m |
| PERCEPTIVE ADVISORS LLC | Sold out | -1.2m |
| STEMPOINT CAPITAL LP | Sold out | -689.5k |
| Driehaus Capital Management LLC | Sold out | -418.6k |
| SCHULHOFF & CO INC | Sold out | -275.0k |
| PIER 88 INVESTMENT PARTNERS LLC | Sold out | -151.7k |
| DIADEMA PARTNERS LP | Sold out | -150.0k |
| Walleye Capital LLC | Sold out | -119.6k |
| CITADEL ADVISORS LLC | Reduced | -93.8k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -72.2k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $207.3k180.3k shares |
| GROUP ONE TRADING LLC | Added | $193.4k168.2k shares |
| SIMPLEX TRADING, LLC | Added | $95.9k83.4k shares |
| CITADEL ADVISORS LLC | New | $86.8k75.5k shares |
Biggest puts
| CITADEL ADVISORS LLC | New | $68.0k59.1k shares |
| GROUP ONE TRADING LLC | New | $10.9k9.5k shares |
| SIMPLEX TRADING, LLC | New | $7.1k6.2k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| GordonMD Global Investments LP 13G · passive investor -1.1 pts · filed 2026-10-09 | 16.4% |
Sullivan Lara
13D · may seek influence
+0.9 pts · filed 2025-04-02
Stated purposeItem 4 of the Schedule 13D is hereby amended and supplemented as follows: The response to Item 3 of this Amendment No. 5 is incorporated by reference herein. Full filing |
11.2% |
| BIOTECHNOLOGY VALUE FUND L P 13G · passive investor new · filed 2026-07-10 | 10.0% |
| Laurion Capital Management LP 13G · institution filed 2026-02-09 | 7.7% |
| Coastlands Capital LP 13G · institution new · filed 2026-10-05 | 5.4% |
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 0 | — | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 1 | $174.4k | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 1 | $15.9k | $15.9k |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 0 | — | — |
None reported in Q4 2025.
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| Pfizer Inc 3.42% of their portfolio | 7.0m $8.1m | Unchanged |
| Laurion Capital Management LP 0.38% of their portfolio | 4.8m $5.5m | Added +1.2m |
| GordonMD Global Investments LP 3.40% of their portfolio | 4.1m $4.7m | First filing |
| VANGUARD GROUP INC 0.00% of their portfolio | 2.3m $2.7m | Added +171.8k |
| Palo Alto Investors LP 0.17% of their portfolio | 1.0m $1.2m | Unchanged |
| 683 Capital Management, LLC 0.09% of their portfolio | 891.9k $1.0m | Added +366.9k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 786.0k $903.9k | Added +482.3k |
| BlackRock, Inc. 0.00% of their portfolio | 784.1k $901.7k | Added +100.4k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 743.1k $854.6k | Reduced -72.2k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 728.4k $837.6k | Added +152.0k |
| Atle Fund Management AB 0.23% of their portfolio | 617.2k $709.8k | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 587.9k $676.0k | Reduced -28.1k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 577.2k $664.2k | Added +32.7k |
| Longaeva Partners L.P. 0.07% of their portfolio | 503.2k $578.7k | Unchanged |
| UBS Group AG 0.00% of their portfolio | 392.8k $451.7k | Added +19.0k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 389.8k $448.2k | New |
| Decheng Capital LLC 0.05% of their portfolio | 326.8k $375.8k | Unchanged |
| ExodusPoint Capital Management, LP 0.00% of their portfolio | 317.8k $365.4k | New |
| XTX Topco Ltd 0.01% of their portfolio | 289.0k $332.4k | Added +271.3k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 243.6k $280.1k | Reduced -93.8k |
| STATE STREET CORP 0.00% of their portfolio | 241.6k $277.9k | Added +39.6k |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 188.1k $216.4k | New |
| Graham Capital Management, L.P. 0.01% of their portfolio | 183.9k $211.5k | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 165.0k $189.8k | Unchanged |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 145.8k $167.7k | Added +115.0k |
| NewEdge Wealth, LLC 0.00% of their portfolio | 116.0k $133.4k | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 108.4k $124.7k | Reduced -29.1k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 105.5k $121.4k | Added +59.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 101.9k $117.2k | Added +1.2k |
| Quadrature Capital Ltd 0.00% of their portfolio | 100.5k $115.6k | New |
| MORGAN STANLEY 0.00% of their portfolio | 89.2k $102.6k | Reduced -17.4k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 86.1k $99.1k | Reduced -39.3k |
| TORONTO DOMINION BANK 0.00% of their portfolio | 75.0k $86.2k | New |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 72.7k $83.6k | Reduced -4.0k |
| OMERS ADMINISTRATION Corp 0.00% of their portfolio | 67.0k $77.0k | New |
| Cable Car Capital, LP 0.00% of their portfolio | 61.6k $70.8k | Unchanged |
| BARCLAYS PLC 0.00% of their portfolio | 60.4k $69.4k | Added +57.4k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 55.6k $64.0k | Reduced -22.4k |
| J. Derek Lewis & Associates Inc. 0.01% of their portfolio | 53.0k $61.0k | First filing |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 50.1k $57.6k | Added +13.6k |
| UNIVERSITY OF CHICAGO 0.03% of their portfolio | 48.7k $56.0k | Unchanged |
| Velan Capital Investment Management LP 0.03% of their portfolio | 40.0k $46.0k | Reduced -15.0k |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 39.8k $45.7k | Reduced -21.4k |
| HRT FINANCIAL LP 0.00% of their portfolio | 39.6k $45.0k | Added +24.3k |
| LPL Financial LLC 0.00% of their portfolio | 35.1k $40.4k | Added +21.1k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 31.9k $36.7k | New |
| Lighthouse Investment Partners, LLC 0.00% of their portfolio | 28.9k $33.2k | New |
| Avanza Fonder AB 0.00% of their portfolio | 27.3k $31.4k | New |
| Cetera Investment Advisers 0.00% of their portfolio | 27.3k $31.3k | Reduced -500 |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 24.3k $27.9k | Added +22.6k |
| Engineers Gate Manager LP 0.00% of their portfolio | 22.8k $26.2k | New |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 22.6k $26.0k | Reduced -29.9k |
| FOX RUN MANAGEMENT, L.L.C. 0.00% of their portfolio | 22.6k $26.0k | New |
| Maia Wealth LLC 0.01% of their portfolio | 22.0k $29.6k | New |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 17.2k $19.8k | Added +2.0k |
| Jefferies Financial Group Inc. 0.00% of their portfolio | 16.0k $18.4k | New |
| FMR LLC 0.00% of their portfolio | 12.9k $14.8k | Reduced -2.6k |
| PACES FERRY WEALTH ADVISORS, LLC 0.01% of their portfolio | 11.4k $13.2k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 10.8k $12.4k | Reduced -2.2k |
| NewEdge Advisors, LLC 0.00% of their portfolio | 10.2k $11.8k | Added +10.0k |
| China Universal Asset Management Co., Ltd. 0.00% of their portfolio | 10.1k $11.7k | Reduced -725 |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 9.8k $11.3k | Added +2.4k |
| Balyasny Asset Management L.P. 0.00% of their portfolio | 8.2k $9.5k | New |
| Winthrop Capital Management, LLC 0.00% of their portfolio | 6.0k $7.0k | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 5.5k $6.3k | Reduced -3.5k |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 3.0k $3.5k | Added +628 |
| CITIGROUP INC 0.00% of their portfolio | 2.9k $3.3k | Added +1.6k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 2.3k $2.6k | Added +2.0k |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 1.9k $2.2k | New |
| GF FUND MANAGEMENT CO. LTD. 0.00% of their portfolio | 1.3k $1.5k | Reduced -57 |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 961 $1.1k | Unchanged |
| Physician Wealth Advisors, Inc. 0.00% of their portfolio | 943 $1.1k | Unchanged |
| JONES FINANCIAL COMPANIES LLLP 0.00% of their portfolio | 500 $575 | Unchanged |
| Cornerstone Financial Management LLC 0.00% of their portfolio | 172 $198 | First filing |
| US BANCORP \DE\ 0.00% of their portfolio | 94 $108 | New |
| CWM, LLC 0.00% of their portfolio | 70 $0 | Reduced -344 |
| Arax Advisory Partners 0.00% of their portfolio | 14 $16 | Unchanged |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 0.00% of their portfolio | 12 $14 | Unchanged |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 1 $1 | Reduced -1 |