Vault-13

PYXIS ONCOLOGY INC PYXS

COMMON STOCK · Common Stock · CUSIP 747324101

79 institutional holders +6 vs Q3 2025
30,196,01530.2m shares reported held*
48.5% of all shares outstanding*
$34.7mreported value*
19 new 24 added 19 reduced 14 sold out net sold ≈ $876.4k (-762.1k shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 62.3m as of 2025-10-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.15. Options: 4 managers hold calls ($583.5k notional), 3 hold puts ($86.0k).

Trends to Q4 2025

Institutional holders

Managers reporting a position, each quarter

050100Q3 22: 38Q4 22: 32Q1 23: 48Q2 23: 49Q3 23: 55Q4 23: 52Q1 24: 72Q2 24: 81Q3 24: 93Q4 24: 100Q1 25: 90Q2 25: 75Q3 25: 73Q4 25: 7979Q3 22Q2 23Q1 24Q4 24Q4 25
Numbers
QuarterHolders
Q3 202238
Q4 202232
Q1 202348
Q2 202349
Q3 202355
Q4 202352
Q1 202472
Q2 202481
Q3 202493
Q4 2024100
Q1 202590
Q2 202575
Q3 202573
Q4 202579

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q1 24: 52 bought or addedQ1 24: 14 cut or sold outQ2 24: 43 bought or addedQ2 24: 37 cut or sold outQ2 24Q3 24: 50 bought or addedQ3 24: 26 cut or sold outQ4 24: 48 bought or addedQ4 24: 38 cut or sold outQ4 24Q1 25: 34 bought or addedQ1 25: 43 cut or sold outQ2 25: 36 bought or addedQ2 25: 53 cut or sold outQ2 25Q3 25: 25 bought or addedQ3 25: 46 cut or sold outQ4 25: 43 bought or addedQ4 25: 33 cut or sold outQ4 25
Numbers
QuarterBought or addedCut or sold out
Q1 20245214
Q2 20244337
Q3 20245026
Q4 20244838
Q1 20253443
Q2 20253653
Q3 20252546
Q4 20254333

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$200k$400k$600kQ1 25 calls: $40.6kQ1 25 puts: $35.9kQ1 25P/C 0.88Q2 25 calls: $15.6kQ2 25 puts: $2.0kQ2 25P/C 0.13Q3 25 calls: $350.5kQ3 25 puts: $0Q3 25P/C 0.00Q4 25 calls: $583.5kQ4 25 puts: $86.0kQ4 25P/C 0.15
Numbers
QuarterCallsPutsP/C
Q1 2025$40.6k$35.9k0.88
Q2 2025$15.6k$2.0k0.13
Q3 2025$350.5k$00.00
Q4 2025$583.5k$86.0k0.15

Biggest buyers

Laurion Capital Management LP Added +1,170,505+1.2m
Atle Fund Management AB New +617,245+617.2k
JANE STREET GROUP, LLC Added +482,310+482.3k
MARSHALL WACE, LLP New +389,764+389.8k
683 Capital Management, LLC Added +366,910+366.9k
ExodusPoint Capital Management, LP New +317,769+317.8k
XTX Topco Ltd Added +271,334+271.3k
Point72 Asset Management, L.P. New +188,136+188.1k
Graham Capital Management, L.P. New +183,942+183.9k
VANGUARD GROUP INC Added +171,806+171.8k

Biggest sellers

TANG CAPITAL MANAGEMENT LLC Sold out -2,500,000-2.5m
PERCEPTIVE ADVISORS LLC Sold out -1,178,307-1.2m
STEMPOINT CAPITAL LP Sold out -689,538-689.5k
Driehaus Capital Management LLC Sold out -418,632-418.6k
SCHULHOFF & CO INC Sold out -275,000-275.0k
PIER 88 INVESTMENT PARTNERS LLC Sold out -151,730-151.7k
DIADEMA PARTNERS LP Sold out -150,000-150.0k
Walleye Capital LLC Sold out -119,561-119.6k
CITADEL ADVISORS LLC Reduced -93,770-93.8k
MILLENNIUM MANAGEMENT LLC Reduced -72,224-72.2k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $207.3k180.3k shares
GROUP ONE TRADING LLC Added $193.4k168.2k shares
SIMPLEX TRADING, LLC Added $95.9k83.4k shares
CITADEL ADVISORS LLC New $86.8k75.5k shares

Biggest puts

CITADEL ADVISORS LLC New $68.0k59.1k shares
GROUP ONE TRADING LLC New $10.9k9.5k shares
SIMPLEX TRADING, LLC New $7.1k6.2k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
GordonMD Global Investments LP 13G · passive investor -1.1 pts · filed 2026-10-09 16.4% -1.1 pts 20.4m≈ $45.3m 2026-10-09
Sullivan Lara 13D · may seek influence +0.9 pts · filed 2025-04-02
Stated purposeItem 4 of the Schedule 13D is hereby amended and supplemented as follows: The response to Item 3 of this Amendment No. 5 is incorporated by reference herein. Full filing
11.2% +0.9 pts 7.5m≈ $22.7m 2025-04-02
BIOTECHNOLOGY VALUE FUND L P 13G · passive investor new · filed 2026-07-10 10.0% new 8.3m≈ $25.1m 2026-07-10
Laurion Capital Management LP 13G · institution filed 2026-02-09 7.7% 4.8m≈ $14.4m 2026-02-09
Coastlands Capital LP 13G · institution new · filed 2026-10-05 5.4% new 6.4m≈ $15.0m 2026-10-05

Insider purchases and sales in Q4 2025

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
101Q1 24: 0 buyingQ1 24: 0 sellingQ2 24: 0 buyingQ2 24: 0 sellingQ2 24Q3 24: 0 buyingQ3 24: 0 sellingQ4 24: 1 buyingQ4 24: 0 sellingQ4 24Q1 25: 0 buyingQ1 25: 0 sellingQ2 25: 0 buyingQ2 25: 1 sellingQ2 25Q3 25: 0 buyingQ3 25: 0 sellingQ4 25: 0 buyingQ4 25: 0 sellingQ4 25
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q1 20240—0——
Q2 20240—0——
Q3 20240—0——
Q4 20241$174.4k0——
Q1 20250—0——
Q2 20250—1$15.9k$15.9k
Q3 20250—0——
Q4 20250—0——

None reported in Q4 2025.

Holders, Q4 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Pfizer Inc 3.42% of their portfolio New York, NY 7,032,7707.0m $8.1m $8.1m 3.42% Unchanged
2 Laurion Capital Management LP 0.38% of their portfolio NEW YORK, NY 4,796,4794.8m $5.5m $5.5m 0.38% Added +1.2m +1,170,505
3 GordonMD Global Investments LP 3.40% of their portfolio Beverely Hills, CA 4,121,8704.1m $4.7m $4.7m 3.40% First filing
4 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 2,335,7682.3m $2.7m $2.7m 0.00% Added +171.8k +171,806
5 Palo Alto Investors LP 0.17% of their portfolio PALO ALTO, CA 1,037,4211.0m $1.2m $1.2m 0.17% Unchanged
6 683 Capital Management, LLC 0.09% of their portfolio NEW YORK, NY 891,910891.9k $1.0m $1.0m 0.09% Added +366.9k +366,910
7 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 786,010786.0k $903.9k $903.9k 0.00% Added +482.3k +482,310
8 BlackRock, Inc. 0.00% of their portfolio New York, NY 784,077784.1k $901.7k $901.7k 0.00% Added +100.4k +100,375
9 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 743,107743.1k $854.6k $854.6k 0.00% Reduced -72.2k -72,224
10 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 728,380728.4k $837.6k $837.6k 0.00% Added +152.0k +152,044
11 Atle Fund Management AB 0.23% of their portfolio STOCKHOLM, V7 617,245617.2k $709.8k $709.8k 0.23% New
12 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 587,851587.9k $676.0k $676.0k 0.00% Reduced -28.1k -28,071
13 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 577,211577.2k $664.2k $664.2k 0.00% Added +32.7k +32,703
14 Longaeva Partners L.P. 0.07% of their portfolio Chicago, IL 503,214503.2k $578.7k $578.7k 0.07% Unchanged
15 UBS Group AG 0.00% of their portfolio ZURICH, V8 392,766392.8k $451.7k $451.7k 0.00% Added +19.0k +19,039
16 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 389,764389.8k $448.2k $448.2k 0.00% New
17 Decheng Capital LLC 0.05% of their portfolio MENLO PARK, CA 326,810326.8k $375.8k $375.8k 0.05% Unchanged
18 ExodusPoint Capital Management, LP 0.00% of their portfolio NEW YORK, NY 317,769317.8k $365.4k $365.4k 0.00% New
19 XTX Topco Ltd 0.01% of their portfolio LONDON, X0 289,033289.0k $332.4k $332.4k 0.01% Added +271.3k +271,334
20 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 243,589243.6k $280.1k $280.1k 0.00% Reduced -93.8k -93,770
21 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 241,637241.6k $277.9k $277.9k 0.00% Added +39.6k +39,582
22 Point72 Asset Management, L.P. 0.00% of their portfolio STAMFORD, CT 188,136188.1k $216.4k $216.4k 0.00% New
23 Graham Capital Management, L.P. 0.01% of their portfolio ROWAYTON, CT 183,942183.9k $211.5k $211.5k 0.01% New
24 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 165,044165.0k $189.8k $189.8k 0.00% Unchanged
25 Qube Research & Technologies Ltd 0.00% of their portfolio LONDON, X0 145,813145.8k $167.7k $167.7k 0.00% Added +115.0k +115,005
26 NewEdge Wealth, LLC 0.00% of their portfolio STAMFORD, CT 116,006116.0k $133.4k $133.4k 0.00% Unchanged
27 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 108,414108.4k $124.7k $124.7k 0.00% Reduced -29.1k -29,117
28 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 105,528105.5k $121.4k $121.4k 0.00% Added +59.0k +59,027
29 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 101,948101.9k $117.2k $117.2k 0.00% Added +1.2k +1,175
30 Quadrature Capital Ltd 0.00% of their portfolio LONDON, X0 100,536100.5k $115.6k $115.6k 0.00% New
31 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 89,22289.2k $102.6k $102.6k 0.00% Reduced -17.4k -17,385
32 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 86,14586.1k $99.1k $99.1k 0.00% Reduced -39.3k -39,309
33 TORONTO DOMINION BANK 0.00% of their portfolio TORONTO, ONTARIO, A6 75,00075.0k $86.2k $86.2k 0.00% New
34 BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio HOUSTON, TX 72,70072.7k $83.6k $83.6k 0.00% Reduced -4.0k -4,000
35 OMERS ADMINISTRATION Corp 0.00% of their portfolio TORONTO, A6 67,00067.0k $77.0k $77.0k 0.00% New
36 Cable Car Capital, LP 0.00% of their portfolio SAN FRANCISCO, CA 61,60661.6k $70.8k $70.8k 0.00% Unchanged
37 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 60,38560.4k $69.4k $69.4k 0.00% Added +57.4k +57,424
38 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 55,55155.6k $64.0k $64.0k 0.00% Reduced -22.4k -22,429
39 J. Derek Lewis & Associates Inc. 0.01% of their portfolio NEWPORT BEACH, CA 53,00053.0k $61.0k $61.0k 0.01% First filing
40 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 50,06650.1k $57.6k $57.6k 0.00% Added +13.6k +13,550
41 UNIVERSITY OF CHICAGO 0.03% of their portfolio CHICAGO, IL 48,73148.7k $56.0k $56.0k 0.03% Unchanged
42 Velan Capital Investment Management LP 0.03% of their portfolio ALPHARETTA, GA 40,00040.0k $46.0k $46.0k 0.03% Reduced -15.0k -15,000
43 COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio WALTHAM, MA 39,75539.8k $45.7k $45.7k 0.00% Reduced -21.4k -21,400
44 HRT FINANCIAL LP 0.00% of their portfolio NEW YORK, NY 39,64939.6k $45.0k $45.0k 0.00% Added +24.3k +24,251
45 LPL Financial LLC 0.00% of their portfolio FORT MILL, SC 35,10235.1k $40.4k $40.4k 0.00% Added +21.1k +21,100
46 AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio KANSAS CITY, MO 31,93631.9k $36.7k $36.7k 0.00% New
47 Lighthouse Investment Partners, LLC 0.00% of their portfolio Palm Beach Gardens, FL 28,86028.9k $33.2k $33.2k 0.00% New
48 Avanza Fonder AB 0.00% of their portfolio STOCKHOLM, V7 27,34527.3k $31.4k $31.4k 0.00% New
49 Cetera Investment Advisers 0.00% of their portfolio SCHAUMBURG, IL 27,26027.3k $31.3k $31.3k 0.00% Reduced -500 -500
50 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 24,27924.3k $27.9k $27.9k 0.00% Added +22.6k +22,562
51 Engineers Gate Manager LP 0.00% of their portfolio NEW YORK, NY 22,81622.8k $26.2k $26.2k 0.00% New
52 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 22,62422.6k $26.0k $26.0k 0.00% Reduced -29.9k -29,900
53 FOX RUN MANAGEMENT, L.L.C. 0.00% of their portfolio GREENWICH, CT 22,56622.6k $26.0k $26.0k 0.00% New
54 Maia Wealth LLC 0.01% of their portfolio DENVER, CO 21,95922.0k $29.6k $29.6k 0.01% New
55 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 17,22417.2k $19.8k $19.8k 0.00% Added +2.0k +2,003
56 Jefferies Financial Group Inc. 0.00% of their portfolio NEW YORK, NY 16,00016.0k $18.4k $18.4k 0.00% New
57 FMR LLC 0.00% of their portfolio BOSTON, MA 12,85812.9k $14.8k $14.8k 0.00% Reduced -2.6k -2,597
58 PACES FERRY WEALTH ADVISORS, LLC 0.01% of their portfolio ATLANTA, GA 11,44011.4k $13.2k $13.2k 0.01% New
59 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 10,81010.8k $12.4k $12.4k 0.00% Reduced -2.2k -2,172
60 NewEdge Advisors, LLC 0.00% of their portfolio NEW ORLEANS, LA 10,25010.2k $11.8k $11.8k 0.00% Added +10.0k +10,000
61 China Universal Asset Management Co., Ltd. 0.00% of their portfolio SHANGHAI, F4 10,14610.1k $11.7k $11.7k 0.00% Reduced -725 -725
62 SIMPLEX TRADING, LLC 0.00% of their portfolio CHICAGO, IL 9,7909.8k $11.3k $11.3k 0.00% Added +2.4k +2,357
63 Balyasny Asset Management L.P. 0.00% of their portfolio Chicago, IL 8,2278.2k $9.5k $9.5k 0.00% New
64 Winthrop Capital Management, LLC 0.00% of their portfolio Carmel, IN 6,0006.0k $7.0k $7.0k 0.00% Unchanged
65 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 5,5145.5k $6.3k $6.3k 0.00% Reduced -3.5k -3,512
66 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 3,0263.0k $3.5k $3.5k 0.00% Added +628 +628
67 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 2,9022.9k $3.3k $3.3k 0.00% Added +1.6k +1,621
68 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 2,2852.3k $2.6k $2.6k 0.00% Added +2.0k +2,000
69 FEDERATED HERMES, INC. 0.00% of their portfolio PITTSBURGH, PA 1,8941.9k $2.2k $2.2k 0.00% New
70 GF FUND MANAGEMENT CO. LTD. 0.00% of their portfolio GUANGZHOU, F4 1,2771.3k $1.5k $1.5k 0.00% Reduced -57 -57
71 NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio ST. LOUIS, MO 961961 $1.1k $1.1k 0.00% Unchanged
72 Physician Wealth Advisors, Inc. 0.00% of their portfolio MIDVALE, UT 943943 $1.1k $1.1k 0.00% Unchanged
73 JONES FINANCIAL COMPANIES LLLP 0.00% of their portfolio DES PERES, MO 500500 $575 $575 0.00% Unchanged
74 Cornerstone Financial Management LLC 0.00% of their portfolio BURLINGTON, MA 172172 $198 $198 0.00% First filing
75 US BANCORP \DE\ 0.00% of their portfolio MINNEAPOLIS, MN 9494 $108 $108 0.00% New
76 CWM, LLC 0.00% of their portfolio OMAHA, NE 7070 $0 $0 0.00% Reduced -344 -344
77 Arax Advisory Partners 0.00% of their portfolio NEW YORK, NY 1414 $16 $16 0.00% Unchanged
78 NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 0.00% of their portfolio MILWAUKEE, WI 1212 $14 $14 0.00% Unchanged
79 SBI Securities Co., Ltd. 0.00% of their portfolio TOKYO, M0 11 $1 $1 0.00% Reduced -1 -1