PYXIS ONCOLOGY INC PYXS
COMMON STOCK · Common Stock · CUSIP 747324101
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersBoston, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 58.9m as of 2024-08-13, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $3.31. Options: 6 managers hold calls ($1.7m notional), 3 hold puts ($17.6k).
Trends to Q2 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 38 |
| Q4 2022 | 32 |
| Q1 2023 | 48 |
| Q2 2023 | 49 |
| Q3 2023 | 55 |
| Q4 2023 | 52 |
| Q1 2024 | 72 |
| Q2 2024 | 81 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 13 | 15 |
| Q1 2023 | 32 | 15 |
| Q2 2023 | 35 | 23 |
| Q3 2023 | 29 | 20 |
| Q4 2023 | 17 | 23 |
| Q1 2024 | 52 | 14 |
| Q2 2024 | 43 | 37 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2023 | $47.4k | $0 | 0.00 |
| Q4 2023 | $24.0k | $2.0k | 0.08 |
| Q1 2024 | $543.1k | $203.2k | 0.37 |
| Q2 2024 | $1.7m | $17.6k | 0.01 |
Biggest buyers
| BlackRock Inc. | Added | +2.5m |
| Blue Owl Capital Holdings LP | New | +1.0m |
| MILLENNIUM MANAGEMENT LLC | Added | +753.9k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +687.6k |
| VANGUARD GROUP INC | Added | +659.0k |
| STATE STREET CORP | Added | +633.6k |
| Bank of New York Mellon Corp | Added | +149.5k |
| Nuveen Asset Management, LLC | New | +149.0k |
| Alpine Global Management, LLC | New | +115.5k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | Added | +115.2k |
Biggest sellers
| STEMPOINT CAPITAL LP | Reduced | -591.5k |
| Monashee Investment Management LLC | Sold out | -442.5k |
| GOLDMAN SACHS GROUP INC | Reduced | -219.4k |
| JANE STREET GROUP, LLC | Reduced | -140.0k |
| HRT FINANCIAL LP | Sold out | -139.1k |
| MARSHALL WACE, LLP | Reduced | -123.6k |
| Man Group plc | Reduced | -94.2k |
| Qube Research & Technologies Ltd | Reduced | -85.0k |
| CORNERCAP INVESTMENT COUNSEL INC | Sold out | -74.9k |
| Squarepoint Ops LLC | Sold out | -68.4k |
Biggest calls
| Ikarian Capital, LLC | New | $1.2m3.6k shares |
| BOOTHBAY FUND MANAGEMENT, LLC | New | $328.0k99.1k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $74.1k22.4k shares |
| SIMPLEX TRADING, LLC | Reduced | $43.0k13.1k shares |
| CITADEL ADVISORS LLC | Reduced | $29.8k9.0k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CITADEL ADVISORS LLC | Reduced | $16.6k5.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $1.0k600 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| GordonMD Global Investments LP 13G · passive investor -1.1 pts · filed 2026-10-09 | 16.4% |
Sullivan Lara
13D · may seek influence
+0.9 pts · filed 2025-04-02
Stated purposeItem 4 of the Schedule 13D is hereby amended and supplemented as follows: The response to Item 3 of this Amendment No. 5 is incorporated by reference herein. Full filing |
11.2% |
| BIOTECHNOLOGY VALUE FUND L P 13G · passive investor new · filed 2026-07-10 | 10.0% |
| Laurion Capital Management LP 13G · institution filed 2026-02-09 | 7.7% |
| Coastlands Capital LP 13G · institution new · filed 2026-10-05 | 5.4% |
Insider purchases and sales in Q2 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 0 | — | — |
| Q3 2023 | 2 | $73.5k | 1 | $81.4k | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 0 | — | — |
| Q2 2024 | 0 | — | 0 | — | — |
None reported in Q2 2024.
Holders, Q2 2024
| Manager | Shares | Change |
|---|---|---|
| Deep Track Capital, LP 0.41% of their portfolio | 4.2m $13.8m | Unchanged |
| Laurion Capital Management LP 0.42% of their portfolio | 3.9m $12.8m | Unchanged |
| BlackRock Inc. 0.00% of their portfolio | 2.8m $9.2m | Added +2.5m |
| Balyasny Asset Management L.P. 0.02% of their portfolio | 2.6m $8.5m | Reduced -31.4k |
| VANGUARD GROUP INC 0.00% of their portfolio | 2.1m $6.8m | Added +659.0k |
| Ikarian Capital, LLC 1.72% of their portfolio | 1.7m $5.5m | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 1.3m $4.4m | Added +753.9k |
| STEMPOINT CAPITAL LP 1.17% of their portfolio | 1.2m $4.0m | Reduced -591.5k |
| Blue Owl Capital Holdings LP 0.96% of their portfolio | 1.0m $3.5m | New |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.0m $3.4m | Added +687.6k |
| STATE STREET CORP 0.00% of their portfolio | 742.9k $2.5m | Added +633.6k |
| Aberdeen Group plc 0.00% of their portfolio | 708.3k $2.3m | Unchanged |
| BOOTHBAY FUND MANAGEMENT, LLC 0.05% of their portfolio | 492.5k $1.6m | Unchanged |
| SUPERSTRING CAPITAL MANAGEMENT LP 2.02% of their portfolio | 484.4k $1.6m | Reduced -9.3k |
| HHLR ADVISORS, LTD. 0.03% of their portfolio | 382.6k $1.3m | Unchanged |
| Decheng Capital LLC 0.33% of their portfolio | 326.8k $1.1m | Unchanged |
| Bank of New York Mellon Corp 0.00% of their portfolio | 311.6k $1.0m | Added +149.5k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 246.5k $815.9k | Added +15.0k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 238.4k $789.1k | Added +73.4k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 149.0k $493.3k | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 129.8k $429.5k | Added +115.2k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 128.4k $425.0k | Added +67.2k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 117.2k $388.1k | Reduced -219.4k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 115.7k $382.9k | Added +46.2k |
| Alpine Global Management, LLC 0.07% of their portfolio | 115.5k $382.4k | New |
| ExodusPoint Capital Management, LP 0.00% of their portfolio | 114.4k $379.0k | Added +24.9k |
| PIER 88 INVESTMENT PARTNERS LLC 0.08% of their portfolio | 113.7k $376.3k | Added +62.3k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 96.9k $320.9k | Reduced -51.1k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 95.7k $316.8k | New |
| MORGAN STANLEY 0.00% of their portfolio | 82.6k $273.4k | Reduced -48.0k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 81.9k $271.2k | Reduced -19.9k |
| Yu Fan 0.30% of their portfolio | 69.3k $229.4k | Unchanged |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 68.0k $225.1k | Reduced -85.0k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 65.3k $216.1k | New |
| Cable Car Capital, LP 0.22% of their portfolio | 61.6k $203.9k | Unchanged |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 58.3k $192.8k | Added +20.9k |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.00% of their portfolio | 57.0k $188.8k | Reduced -25.4k |
| Man Group plc 0.00% of their portfolio | 53.0k $175.3k | Reduced -94.2k |
| UNIVERSITY OF CHICAGO 0.12% of their portfolio | 48.7k $161.3k | Unchanged |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 44.8k $148.2k | Added +15.1k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 42.6k $141.1k | Added +41.6k |
| SCHULHOFF & CO INC 0.06% of their portfolio | 42.0k $139.0k | Added +20.0k |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 40.8k $134.0k | New |
| XTX Topco Ltd 0.01% of their portfolio | 36.3k $120.1k | Reduced -29.6k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 35.2k $116.5k | Reduced -140.0k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 31.2k $103.3k | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 30.2k $100.0k | Added +4.6k |
| Cetera Investment Advisers 0.00% of their portfolio | 28.1k $93.0k | Reduced -1.2k |
| Corebridge Financial, Inc. 0.00% of their portfolio | 26.3k $87.2k | First filing |
| Invesco Ltd. 0.00% of their portfolio | 22.1k $73.2k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 22.0k $73.0k | Added +21.2k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 19.7k $65.3k | New |
| UBS Group AG 0.00% of their portfolio | 17.7k $58.5k | Reduced -10.6k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 17.2k $56.9k | New |
| BARCLAYS PLC 0.00% of their portfolio | 17.1k $56.6k | New |
| Marathon Trading Investment Management LLC 0.01% of their portfolio | 16.4k $54.2k | Reduced -40.6k |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 16.2k $54.0k | Reduced -14.0k |
| LAZARD ASSET MANAGEMENT LLC 0.00% of their portfolio | 16.2k $53.0k | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 15.7k $0 | New |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 14.1k $46.7k | Reduced -1.5k |
| Jump Financial, LLC 0.00% of their portfolio | 13.9k $46.0k | Reduced -26.6k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 13.5k $44.6k | New |
| MetLife Investment Management, LLC 0.00% of their portfolio | 13.3k $44.1k | New |
| FULLCIRCLE WEALTH LLC 0.02% of their portfolio | 12.0k $45.2k | First filing |
| CITIGROUP INC 0.00% of their portfolio | 11.0k $36.3k | Reduced -33.7k |
| BLAIR WILLIAM & CO/IL 0.00% of their portfolio | 10.0k $33.1k | Reduced -100 |
| MARSHALL WACE, LLP 0.00% of their portfolio | 10.0k $33.1k | Reduced -123.6k |
| ADAR1 Capital Management, LLC 0.01% of their portfolio | 10.0k $33.1k | Unchanged |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 4.8k $15.8k | New |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 4.4k $14.5k | Added +1.2k |
| Legal & General Group Plc 0.00% of their portfolio | 4.2k $13.9k | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 3.5k $11.7k | New |
| AMALGAMATED BANK 0.00% of their portfolio | 1.7k $6.0k | New |
| Redwood Wealth Management Group, LLC 0.00% of their portfolio | 1.4k $4.6k | New |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC 0.00% of their portfolio | 1.1k $3.5k | New |
| HARBOUR INVESTMENTS, INC. 0.00% of their portfolio | 581 $1.9k | Unchanged |
| JONES FINANCIAL COMPANIES LLLP 0.00% of their portfolio | 500 $1.7k | New |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 0.00% of their portfolio | 250 $828 | New |
| NewEdge Advisors, LLC 0.00% of their portfolio | 250 $828 | Unchanged |
| Coston, McIsaac & Partners 0.00% of their portfolio | 30 $0 | Unchanged |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 0 $0 | Unchanged |