PUMA BIOTECHNOLOGY INC PBYI
COM · Common Stock · CUSIP 74587V107 · ISIN US74587V1070
Pharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersLos Angeles, CA
- Websitepumabiotechnology.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($159.9k this quarter). Holder counts are more reliable. Shares outstanding: 50.4m as of 2025-08-04, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $3.43. Options: 5 managers hold calls ($329.7k notional), 3 hold puts ($4.1k).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 83 |
| Q4 2022 | 89 |
| Q1 2023 | 79 |
| Q2 2023 | 69 |
| Q3 2023 | 70 |
| Q4 2023 | 83 |
| Q1 2024 | 94 |
| Q2 2024 | 100 |
| Q3 2024 | 101 |
| Q4 2024 | 113 |
| Q1 2025 | 117 |
| Q2 2025 | 122 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 26 | 28 |
| Q4 2023 | 47 | 21 |
| Q1 2024 | 56 | 35 |
| Q2 2024 | 57 | 46 |
| Q3 2024 | 50 | 39 |
| Q4 2024 | 62 | 36 |
| Q1 2025 | 66 | 44 |
| Q2 2025 | 62 | 48 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $165.8k | $56.6k | 0.34 |
| Q4 2024 | $136.9k | $16.4k | 0.12 |
| Q1 2025 | $177.6k | $10.1k | 0.06 |
| Q2 2025 | $329.7k | $4.1k | 0.01 |
Biggest buyers
| JANUS HENDERSON GROUP PLC | New | +745.5k |
| CITADEL ADVISORS LLC | New | +507.8k |
| LSV ASSET MANAGEMENT | Added | +482.3k |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | Added | +329.7k |
| DIMENSIONAL FUND ADVISORS LP | Added | +261.4k |
| RITHOLTZ WEALTH MANAGEMENT | New | +197.0k |
| AMERICAN CENTURY COMPANIES INC | Added | +192.6k |
| ACORN CAPITAL ADVISORS, LLC | Added | +191.2k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | Added | +121.7k |
| EVERGREEN CAPITAL MANAGEMENT LLC | New | +96.0k |
Biggest sellers
| MILLENNIUM MANAGEMENT LLC | Reduced | -1.1m |
| MARSHALL WACE, LLP | Reduced | -143.0k |
| GSA CAPITAL PARTNERS LLP | Sold out | -99.4k |
| GOLDMAN SACHS GROUP INC | Reduced | -92.2k |
| BNP PARIBAS FINANCIAL MARKETS | Reduced | -71.6k |
| FRANKLIN RESOURCES INC | Reduced | -60.5k |
| Integrated Quantitative Investments LLC | Sold out | -59.7k |
| Man Group plc | Sold out | -37.5k |
| Eversept Partners, LP | Reduced | -35.1k |
| Virtu Financial LLC | Sold out | -31.5k |
Biggest calls
| CITADEL ADVISORS LLC | Added | $160.2k46.7k shares |
| GROUP ONE TRADING LLC | Reduced | $73.7k21.5k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $73.7k21.5k shares |
| SIMPLEX TRADING, LLC | Added | $22.0k6.5k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| GROUP ONE TRADING LLC | Unchanged | $4.1k1.2k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
| SIMPLEX TRADING, LLC | Reduced | $0200 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
AUERBACH ALAN H
13D · may seek influence
filed 2026-10-06
Stated purposeThe information set forth or incorporated in Item 3 above is incorporated herein by reference. From time to time, Mr. Auerbach may acquire beneficial ownership of additional shares of Common Stock or other securities of the Issuer by purchase, as compensation from the Issuer, or otherwise, including, but not limited to, awards of restricted Common Shares, options to purchase Common Shares, and restricted stock units for Common Shares, or dispose of some or all of the shares of Common Stock beneficially owned by Mr. Auerbach in the open market or in privately negotiated transactions (which may be with the Issuer or with third parties) on such terms and at such times as Mr. Auerbach may deem advisable. Mr. Auerbach is the President, Chief Executive Officer and a director of the Issuer. In … Full filing |
16.0% |
| ACORN BIOVENTURES, L.P. 13G · passive investor +1.3 pts · filed 2025-02-14 | 8.0% |
| BlackRock, Inc. 13G · institution filed 2025-04-17 | 5.6% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 5 | $338.4k | $338.4k |
| Q4 2023 | 0 | — | 2 | $71.8k | $1.1k |
| Q1 2024 | 0 | — | 5 | $386.7k | $386.7k |
| Q2 2024 | 0 | — | 5 | $234.0k | $234.0k |
| Q3 2024 | 0 | — | 5 | $314.1k | $232.6k |
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 4 | $195.7k | $195.7k |
| Q2 2025 | 0 | — | 6 | $311.6k | $311.6k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-06-13 | Senderowicz Adrian Director | Sold plan | $91.8k27.0k shares |
| 2025-06-13 | MOYES JAY M Director | Sold plan | $74.8k22.0k shares |
| 2025-06-13 | Cesano Alessandra Director | Sold plan | $41.3k12.2k shares |
| 2025-06-13 | Dorval Allison Director | Sold plan | $39.5k11.6k shares |
| 2025-06-13 | WILSON TROY EDWARD Director | Sold plan | $36.7k10.8k shares |
| 2025-06-13 | Stuglik Brian M Director | Sold plan | $27.5k8.1k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| ACORN CAPITAL ADVISORS, LLC 9.27% of their portfolio | 4.1m $14.2m | Added +191.2k |
| BlackRock, Inc. 0.00% of their portfolio | 3.8m $13.2m | Reduced -11.7k |
| VANGUARD GROUP INC 0.00% of their portfolio | 3.7m $12.7m | Added +37.2k |
| ACADIAN ASSET MANAGEMENT LLC 0.01% of their portfolio | 2.0m $6.9m | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 1.9m $6.4m | Added +45.5k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 1.3m $4.6m | Added +192.6k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 1.2m $3.9m | Added +261.4k |
| KENNEDY CAPITAL MANAGEMENT LLC 0.08% of their portfolio | 987.0k $3.4m | Added +75.9k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 971.7k $3.3m | Added +16.2k |
| Connor, Clark & Lunn Investment Management Ltd. 0.01% of their portfolio | 900.3k $3.1m | Added +68.6k |
| JANUS HENDERSON GROUP PLC 0.00% of their portfolio | 745.5k $2.6m | New |
| STATE STREET CORP 0.00% of their portfolio | 734.6k $2.5m | Added +84.8k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 640.8k $2.2m | Added +69.1k |
| LSV ASSET MANAGEMENT 0.00% of their portfolio | 535.7k $1.8m | Added +482.3k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 507.8k $1.7m | New |
| GLOBEFLEX CAPITAL L P 0.13% of their portfolio | 452.6k $1.6m | Unchanged |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.00% of their portfolio | 451.6k $1.5m | Added +93.0k |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 445.5k $1.5m | Added +38.6k |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC 0.01% of their portfolio | 437.7k $1.5m | Added +329.7k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 347.2k $1.2m | Reduced -445 |
| Bank of New York Mellon Corp 0.00% of their portfolio | 344.1k $1.2m | Added +3.2k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 334.6k $1.1m | Reduced -1.1m |
| MORGAN STANLEY 0.00% of their portfolio | 322.5k $1.1m | Added +59.9k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 302.0k $1.0m | Reduced -15.4k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 281.2k $964.7k | Reduced -26.9k |
| UBS Group AG 0.00% of their portfolio | 274.1k $940.2k | Reduced -5.6k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 245.7k $842.8k | Reduced -1.1k |
| Eversept Partners, LP 0.08% of their portfolio | 240.7k $825.6k | Reduced -35.1k |
| MACKENZIE FINANCIAL CORP 0.00% of their portfolio | 207.6k $712.0k | Added +49.9k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 202.8k $695.6k | Added +121.7k |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 202.3k $694.0k | Added +1.4k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 202.0k $693.0k | Reduced -92.2k |
| TANG CAPITAL MANAGEMENT LLC 0.03% of their portfolio | 200.0k $686.0k | Unchanged |
| RITHOLTZ WEALTH MANAGEMENT 0.01% of their portfolio | 197.0k $675.7k | New |
| Prospera Financial Services Inc 0.01% of their portfolio | 191.2k $655.9k | Added +7.0k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 190.6k $653.8k | Reduced -2.2k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 153.3k $524.0k | Added +67.3k |
| STRS OHIO 0.00% of their portfolio | 147.3k $505.2k | Added +5.4k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 141.8k $486.3k | Added +91.3k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 137.1k $470.2k | Reduced -15.9k |
| FMR LLC 0.00% of their portfolio | 132.4k $454.0k | Added +5.2k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 127.4k $437.1k | Added +9.2k |
| BARCLAYS PLC 0.00% of their portfolio | 108.7k $372.7k | Added +25.4k |
| XTX Topco Ltd 0.01% of their portfolio | 104.4k $358.2k | Reduced -20.9k |
| EVERGREEN CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 96.0k $329.3k | New |
| Hillsdale Investment Management Inc. 0.01% of their portfolio | 84.8k $290.9k | New |
| Nuveen, LLC 0.00% of their portfolio | 79.1k $271.3k | Unchanged |
| PANAGORA ASSET MANAGEMENT INC 0.00% of their portfolio | 76.7k $263.0k | New |
| MARSHALL WACE, LLP 0.00% of their portfolio | 73.4k $251.8k | Reduced -143.0k |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio | 71.7k $246.0k | New |
| Kapitalo Investimentos Ltda 0.05% of their portfolio | 70.3k $241.0k | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 67.2k $230.6k | Reduced -25.8k |
| MACQUARIE GROUP LTD 0.00% of their portfolio | 61.3k $210.0k | Unchanged |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 60.6k $207.9k | Added +22.3k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 57.7k $198.0k | Reduced -15.1k |
| Metis Global Partners, LLC 0.00% of their portfolio | 55.8k $191.4k | Added +13.0k |
| VIRTUS ADVISERS, LLC 0.12% of their portfolio | 55.4k $190.1k | Unchanged |
| LPL Financial LLC 0.00% of their portfolio | 53.3k $182.8k | Added +10.0k |
| Invesco Ltd. 0.00% of their portfolio | 50.0k $171.4k | Added +12.4k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 39.4k $135.3k | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.00% of their portfolio | 39.3k $134.8k | Unchanged |
| Empowered Funds, LLC 0.00% of their portfolio | 38.3k $131.3k | New |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 33.4k $114.6k | Reduced -4.3k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 30.7k $105.4k | Unchanged |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 28.0k $96.1k | Added +4.6k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 27.2k $93.2k | Added +37 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 23.8k $81.5k | Reduced -1.1k |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 20.8k $71.4k | Reduced -9.7k |
| C2C Wealth Management, LLC 0.06% of their portfolio | 20.6k $70.7k | Added +5.5k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 20.2k $69.4k | Reduced -28.1k |
| Kathmere Capital Management, LLC 0.01% of their portfolio | 20.2k $69.3k | New |
| PFG Investments, LLC 0.00% of their portfolio | 20.0k $68.6k | Unchanged |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 19.8k $66.6k | Reduced -758 |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 19.6k $68.0k | Unchanged |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 17.9k $61.5k | Added +450 |
| Squarepoint Ops LLC 0.00% of their portfolio | 17.8k $61.0k | New |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 17.7k $60.7k | Reduced -60.5k |
| ROYCE & ASSOCIATES LP 0.00% of their portfolio | 17.3k $59.3k | Reduced -1.4k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 15.6k $53.4k | Reduced -930 |
| Ethic Inc. 0.00% of their portfolio | 15.2k $50.5k | New |
| D'Orazio & Associates, Inc. 0.01% of their portfolio | 15.0k $51.5k | New |
| CITIGROUP INC 0.00% of their portfolio | 14.3k $49.1k | Reduced -15.1k |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 14.3k $49.1k | New |
| CAUSEWAY CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 14.1k $48.3k | Unchanged |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 13.8k $47.3k | New |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 13.0k $44.5k | Reduced -11.8k |
| Williams & Novak, LLC 0.04% of their portfolio | 12.5k $42.9k | Reduced -2.2k |
| Cerity Partners LLC 0.00% of their portfolio | 10.5k $36.1k | New |
| CWM, LLC 0.00% of their portfolio | 9.5k $32.0k | Added +6.5k |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 8.5k $29.0k | Added +5.4k |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 8.3k $28.5k | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 5.8k $19.8k | Reduced -71.6k |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 4.1k $13.9k | Unchanged |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 3.6k $12.3k | Unchanged |
| Legal & General Group Plc 0.00% of their portfolio | 3.6k $12.2k | Reduced -348 |
| Ball & Co Wealth Management Inc. 0.01% of their portfolio | 3.5k $12.0k | Unchanged |
| Private Wealth Asset Management, LLC 0.00% of their portfolio | 3.5k $12.0k | Added +1.5k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 3.0k $10.3k | Unchanged |
| Headlands Technologies LLC 0.00% of their portfolio | 1.5k $5.3k | Added +321 |
| Global Retirement Partners, LLC 0.00% of their portfolio | 1.5k $5.1k | First filing |