PROTAGONIST THERAPEUTICS INC PTGX
COM · Common Stock · CUSIP 74366E102 · ISIN US74366E1029
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNewark, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($13.5m this quarter). Holder counts are more reliable. Shares outstanding: 64.3m as of 2026-04-30, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $105.36. Options: 11 managers hold calls ($36.4m notional), 7 hold puts ($11.1m).
Trends to Q1 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 132 |
| Q4 2022 | 138 |
| Q1 2023 | 138 |
| Q2 2023 | 168 |
| Q3 2023 | 145 |
| Q4 2023 | 157 |
| Q1 2024 | 186 |
| Q2 2024 | 189 |
| Q3 2024 | 241 |
| Q4 2024 | 243 |
| Q1 2025 | 277 |
| Q2 2025 | 276 |
| Q3 2025 | 276 |
| Q4 2025 | 318 |
| Q1 2026 | 322 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2024 | 90 | 94 |
| Q3 2024 | 153 | 86 |
| Q4 2024 | 130 | 116 |
| Q1 2025 | 150 | 125 |
| Q2 2025 | 169 | 125 |
| Q3 2025 | 123 | 145 |
| Q4 2025 | 161 | 141 |
| Q1 2026 | 159 | 153 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2025 | $18.4m | $20.8m | 1.13 |
| Q3 2025 | $12.2m | $3.4m | 0.28 |
| Q4 2025 | $85.2m | $4.6m | 0.05 |
| Q1 2026 | $36.4m | $11.1m | 0.31 |
Biggest buyers
| UBS Group AG | Added | +2.4m |
| Hood River Capital Management LLC | New | +829.3k |
| JENNISON ASSOCIATES LLC | Added | +740.8k |
| Invesco Ltd. | Added | +596.8k |
| WELLINGTON MANAGEMENT GROUP LLP | Added | +428.2k |
| Rubric Capital Management LP | New | +428.0k |
| BANK OF AMERICA CORP /DE/ | Added | +427.9k |
| CITADEL ADVISORS LLC | Added | +425.2k |
| Alyeska Investment Group, L.P. | Added | +393.7k |
| Vestal Point Capital, LP | New | +326.2k |
Biggest sellers
| Commodore Capital LP | Sold out | -450.0k |
| MARSHALL WACE, LLP | Reduced | -396.9k |
| Driehaus Capital Management LLC | Reduced | -378.2k |
| Skandinaviska Enskilda Banken AB (publ) | Sold out | -205.6k |
| MPM BIOIMPACT LLC | Sold out | -199.5k |
| AIHC Capital Management Ltd | Sold out | -189.8k |
| GOLDMAN SACHS GROUP INC | Reduced | -182.2k |
| BARCLAYS PLC | Reduced | -173.2k |
| Qube Research & Technologies Ltd | Sold out | -153.9k |
| PERCEPTIVE ADVISORS LLC | Reduced | -119.5k |
Biggest calls
| Caption Management, LLC | Reduced | $13.2m124.8k shares |
| CITADEL ADVISORS LLC | Reduced | $5.1m48.8k shares |
| JANE STREET GROUP, LLC | Reduced | $4.5m42.5k shares |
| SIMPLEX TRADING, LLC | New | $3.7m35.2k shares |
| Walleye Capital LLC | Added | $3.2m30.8k shares |
| GROUP ONE TRADING LLC | Reduced | $2.0m18.8k shares |
| 683 Capital Management, LLC | Reduced | $1.6m15.1k shares |
| Walleye Trading LLC | Reduced | $1.5m14.7k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $737.8k7.0k shares |
| TUDOR INVESTMENT CORP ET AL | Added | $653.5k6.2k shares |
Biggest puts
| GROUP ONE TRADING LLC | New | $4.0m38.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $3.9m37.0k shares |
| Caption Management, LLC | New | $1.2m11.8k shares |
| Walleye Capital LLC | Added | $748.3k7.1k shares |
| Walleye Trading LLC | Reduced | $453.2k4.3k shares |
| TUDOR INVESTMENT CORP ET AL | Added | $400.5k3.8k shares |
| CITADEL ADVISORS LLC | Reduced | $390.0k3.7k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution +1.4 pts · filed 2026-10-27 | 15.2% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 13G · institution filed 2026-08-13 | 10.0% |
| Farallon Capital Partners, L.P. 13G · passive investor no change · filed 2026-02-06 | 10.0% |
| RTW INVESTMENTS, LP 13G · institution filed 2026-02-17 | 8.1% |
| VANGUARD PORTFOLIO MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 5.5% |
| STATE STREET CORP 13G · institution +0.3 pts · filed 2026-08-07 | 5.2% |
| WELLINGTON MANAGEMENT GROUP LLP 13G · institution new · filed 2026-02-10 | 5.1% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.1% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD PORTFOLIO MANAGEMENT LLC), BIOTECHNOLOGY VALUE FUND L P (4.1%, 2025-11-14), Deep Track Capital, LP (2.8%, 2025-11-14)
Insider purchases and sales in Q1 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2024 | 0 | — | 3 | $2.3m | $2.2m |
| Q3 2024 | 0 | — | 2 | $1.3m | $680.0k |
| Q4 2024 | 0 | — | 3 | $11.8m | — |
| Q1 2025 | 0 | — | 4 | $3.6m | $217.0k |
| Q2 2025 | 0 | — | 2 | $1.2m | — |
| Q3 2025 | 0 | — | 2 | $3.9m | $494.0k |
| Q4 2025 | 0 | — | 2 | $1.2m | $979.5k |
| Q1 2026 | 0 | — | 6 | $29.5m | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-03-26 | Ali Asif Chief Financial Officer | Sold | $2.6m24.8k shares |
| 2026-03-26 | SELICK HAROLD E Director | Sold | $2.5m24.0k shares |
| 2026-03-26 | MOLINA ARTURO MD Chief Medical Officer | Sold | $1.6m15.0k shares |
| 2026-03-25 | PATEL DINESH V PH D President and CEO, director | Sold | $5.5m54.6k shares |
| 2026-03-24 | PATEL DINESH V PH D President and CEO, director | Sold | $6.0k59 shares |
| 2026-02-17 | Williams Lewis T Director | Sold | $1.5m18.0k shares |
| 2026-02-06 | Waddill William D. Director | Sold | $1.7m20.0k shares |
| 2026-01-27 | Ali Asif Chief Financial Officer | Sold | $3.8m46.2k shares |
| 2026-01-27 | MOLINA ARTURO MD Chief Medical Officer | Sold | $410.0k5.0k shares |
| 2026-01-27 | PATEL DINESH V PH D President and CEO, director | Sold | $338.4k4.1k shares |
| 2026-01-26 | PATEL DINESH V PH D President and CEO, director | Sold | $2.1m24.9k shares |
| 2026-01-26 | MOLINA ARTURO MD Chief Medical Officer | Sold | $411.4k5.0k shares |
| 2026-01-23 | PATEL DINESH V PH D President and CEO, director | Sold | $1.6m19.3k shares |
| 2026-01-23 | MOLINA ARTURO MD Chief Medical Officer | Sold | $1.1m13.2k shares |
| 2026-01-20 | PATEL DINESH V PH D President and CEO, director | Sold | $2.8m34.4k shares |
| 2026-01-20 | MOLINA ARTURO MD Chief Medical Officer | Sold | $784.7k9.5k shares |
| 2026-01-20 | Ali Asif Chief Financial Officer | Sold | $708.3k8.6k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2026
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.02% of their portfolio | 9.8m $1.0bn | Added +63.4k |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 3.97% of their portfolio | 6.3m $669.2m | Added +204.9k |
| UBS Group AG 0.10% of their portfolio | 5.2m $545.7m | Added +2.4m |
| RTW INVESTMENTS, LP 5.31% of their portfolio | 5.1m $533.2m | Unchanged |
| WELLINGTON MANAGEMENT GROUP LLP 0.07% of their portfolio | 3.6m $379.4m | Added +428.2k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.02% of their portfolio | 3.5m $366.9m | First filing |
| STATE STREET CORP 0.01% of their portfolio | 3.1m $328.5m | Reduced -83.0k |
| JANUS HENDERSON GROUP PLC 0.15% of their portfolio | 2.9m $304.9m | Added +241.5k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 2.8m $295.7m | First filing |
| JOHNSON & JOHNSON 39.57% of their portfolio | 2.4m $258.1m | Unchanged |
| Invesco Ltd. 0.02% of their portfolio | 2.2m $228.2m | Added +596.8k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 1.7m $176.0m | Added +216.4k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio | 1.7m $175.5m | Added +264.8k |
| CITADEL ADVISORS LLC 0.12% of their portfolio | 1.6m $163.6m | Added +425.2k |
| Woodline Partners LP 0.56% of their portfolio | 1.4m $149.1m | Added +5.4k |
| BANK OF AMERICA CORP /DE/ 0.01% of their portfolio | 1.3m $136.5m | Added +427.9k |
| PERCEPTIVE ADVISORS LLC 2.56% of their portfolio | 1.2m $129.7m | Reduced -119.5k |
| JENNISON ASSOCIATES LLC 0.08% of their portfolio | 1.1m $113.0m | Added +740.8k |
| MORGAN STANLEY 0.01% of their portfolio | 1.0m $107.3m | Added +139.2k |
| ADAR1 Capital Management, LLC 6.30% of their portfolio | 994.1k $104.8m | Reduced -55.0k |
| Hood River Capital Management LLC 0.88% of their portfolio | 829.3k $87.4m | New |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 778.9k $82.1m | Reduced -182.2k |
| Driehaus Capital Management LLC 0.56% of their portfolio | 720.9k $76.0m | Reduced -378.2k |
| FMR LLC 0.00% of their portfolio | 662.0k $69.8m | Added +122.1k |
| MARSHALL WACE, LLP 0.07% of their portfolio | 628.1k $66.2m | Reduced -396.9k |
| Clearbridge Investments, LLC 0.06% of their portfolio | 621.8k $65.5m | Added +132.0k |
| Alyeska Investment Group, L.P. 0.18% of their portfolio | 593.2k $62.5m | Added +393.7k |
| NORTHERN TRUST CORP 0.01% of their portfolio | 588.0k $62.0m | Added +12.8k |
| Pictet Asset Management Holding SA 0.06% of their portfolio | 581.1k $61.2m | Added +51.5k |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. 5.11% of their portfolio | 571.8k $60.3m | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 553.0k $58.3m | Reduced -3.8k |
| AMERICAN CENTURY COMPANIES INC 0.03% of their portfolio | 537.3k $56.6m | Added +1.9k |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 508.1k $53.5m | Added +93.7k |
| VOYA INVESTMENT MANAGEMENT LLC 0.05% of their portfolio | 454.4k $47.9m | Added +88.2k |
| Rubric Capital Management LP 0.55% of their portfolio | 428.0k $45.1m | New |
| VANGUARD FIDUCIARY TRUST CO 0.01% of their portfolio | 412.7k $43.5m | First filing |
| PRINCIPAL FINANCIAL GROUP INC 0.02% of their portfolio | 367.8k $38.8m | Added +19.9k |
| 683 Capital Management, LLC 3.47% of their portfolio | 355.0k $37.4m | Reduced -25.7k |
| Bank of New York Mellon Corp 0.01% of their portfolio | 341.5k $36.0m | Reduced -8.9k |
| Vestal Point Capital, LP 0.96% of their portfolio | 326.2k $34.4m | New |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.04% of their portfolio | 306.0k $32.3m | Reduced -24.8k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.05% of their portfolio | 282.4k $29.8m | Added +49.6k |
| SEB Asset Management AB 0.10% of their portfolio | 232.4k $24.5m | First filing |
| NEXTBio Capital Management LP 11.24% of their portfolio | 229.6k $24.2m | Unchanged |
| SEGALL BRYANT & HAMILL, LLC 0.32% of their portfolio | 212.7k $22.4m | Added +83.7k |
| Public Sector Pension Investment Board 0.07% of their portfolio | 210.3k $22.2m | Added +6.9k |
| Holocene Advisors, LP 0.05% of their portfolio | 209.9k $22.1m | Reduced -103 |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 194.5k $20.5m | Added +96.8k |
| TD Asset Management Inc 0.02% of their portfolio | 183.7k $19.4m | Added +25.0k |
| Eagle Health Investments LP 3.97% of their portfolio | 179.3k $18.9m | Added +122.0k |
| RAYMOND JAMES FINANCIAL INC 0.01% of their portfolio | 177.4k $17.8m | Reduced -4.1k |
| Fisher Asset Management, LLC 0.01% of their portfolio | 174.0k $18.3m | Added +108.9k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 173.0k $17.3m | Added +17.7k |
| Affinity Asset Advisors, LLC 1.06% of their portfolio | 172.1k $18.1m | Unchanged |
| Boxer Capital Management, LLC 2.35% of their portfolio | 170.0k $17.9m | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.02% of their portfolio | 167.6k $17.7m | Added +155.8k |
| LORD, ABBETT & CO. LLC 0.06% of their portfolio | 163.5k $17.2m | New |
| NAN FUNG TRINITY (HK) LTD 1.86% of their portfolio | 160.7k $16.9m | Reduced -20.0k |
| Duquesne Family Office LLC 0.57% of their portfolio | 159.7k $16.8m | Unchanged |
| CITIGROUP INC 0.01% of their portfolio | 158.7k $16.7m | Added +63.8k |
| RHUMBLINE ADVISERS 0.01% of their portfolio | 157.4k $16.6m | Added +2.5k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 145.7k $15.4m | Reduced -23.8k |
| STEMPOINT CAPITAL LP 1.48% of their portfolio | 145.2k $15.3m | Added +85.7k |
| NEUBERGER BERMAN GROUP LLC 0.01% of their portfolio | 141.4k $14.9m | Added +43.0k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 137.9k $14.5m | Added +61.4k |
| KENNEDY CAPITAL MANAGEMENT LLC 0.31% of their portfolio | 137.1k $14.5m | Reduced -84.3k |
| Legal & General Group Plc 0.00% of their portfolio | 135.4k $14.3m | Reduced -13.8k |
| Nuveen, LLC 0.00% of their portfolio | 127.9k $13.5m | Added +2.1k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio | 127.8k $13.5m | Added +14.5k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 125.5k $13.2m | Added +20.0k |
| PANAGORA ASSET MANAGEMENT INC 0.05% of their portfolio | 116.6k $12.3m | Reduced -8.8k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 107.4k $11.3m | Added +2.9k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.02% of their portfolio | 105.5k $11.1m | Reduced -8.5k |
| Balyasny Asset Management L.P. 0.02% of their portfolio | 101.3k $10.7m | New |
| Opaleye Management Inc. 1.39% of their portfolio | 100.0k $10.5m | Reduced -5.0k |
| Swiss National Bank 0.01% of their portfolio | 98.9k $10.4m | Added +700 |
| PRUDENTIAL FINANCIAL INC 0.01% of their portfolio | 95.2k $10.0m | Reduced -15.1k |
| FIRST TRUST ADVISORS LP 0.01% of their portfolio | 87.9k $9.3m | Added +41.4k |
| AXIOM INVESTORS LLC /DE 0.10% of their portfolio | 85.5k $9.0m | Reduced -4.0k |
| VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio | 83.5k $8.8m | Added +3.0k |
| SEI INVESTMENTS CO 0.01% of their portfolio | 83.2k $8.8m | Added +45.9k |
| ALGERT GLOBAL LLC 0.12% of their portfolio | 78.5k $8.3m | Added +73.4k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 73.8k $6.4m | Added +568 |
| GREAT LAKES ADVISORS, LLC 0.06% of their portfolio | 71.0k $7.5m | Reduced -2.9k |
| Knott David M Jr 3.95% of their portfolio | 63.0k $6.6m | Reduced -10.0k |
| Atika Capital Management LLC 1.03% of their portfolio | 62.1k $6.5m | Reduced -23.9k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio | 58.7k $6.2m | Added +10.6k |
| BESSEMER GROUP INC 0.01% of their portfolio | 54.2k $5.7m | Added +16 |
| Moody Aldrich Partners LLC 1.02% of their portfolio | 53.9k $5.7m | Reduced -26.7k |
| KVP Capital Advisors, LP 4.17% of their portfolio | 53.0k $5.6m | Unchanged |
| NORDEA INVESTMENT MANAGEMENT AB 0.00% of their portfolio | 51.8k $5.3m | New |
| EFG International AG 0.11% of their portfolio | 50.1k $5.3m | Reduced -22.5k |
| Integral Health Asset Management, LLC 0.28% of their portfolio | 50.0k $5.3m | New |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 0.00% of their portfolio | 49.0k $5.2m | Added +126 |
| Creative Planning 0.00% of their portfolio | 48.0k $5.1m | Added +6.7k |
| SILVERCREST ASSET MANAGEMENT GROUP LLC 0.04% of their portfolio | 47.9k $5.1m | Reduced -5.3k |
| CANADA LIFE ASSURANCE Co 0.01% of their portfolio | 47.4k $5.0m | Reduced -2.2k |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio | 47.4k $5.0m | Reduced -1.9k |
| Rafferty Asset Management, LLC 0.02% of their portfolio | 46.8k $4.9m | Reduced -16.9k |
| ASSETMARK, INC 0.01% of their portfolio | 46.4k $4.9m | Added +46.2k |