PROTAGONIST THERAPEUTICS INC PTGX
COM · Common Stock · CUSIP 74366E102 · ISIN US74366E1029
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNewark, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($11.2m this quarter). Holder counts are more reliable. Shares outstanding: 62.5m as of 2025-10-29, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $86.99. Options: 16 managers hold calls ($85.2m notional), 5 hold puts ($4.6m).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 132 |
| Q4 2022 | 138 |
| Q1 2023 | 138 |
| Q2 2023 | 168 |
| Q3 2023 | 145 |
| Q4 2023 | 157 |
| Q1 2024 | 186 |
| Q2 2024 | 189 |
| Q3 2024 | 241 |
| Q4 2024 | 243 |
| Q1 2025 | 277 |
| Q2 2025 | 276 |
| Q3 2025 | 276 |
| Q4 2025 | 318 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 110 | 76 |
| Q2 2024 | 90 | 94 |
| Q3 2024 | 153 | 86 |
| Q4 2024 | 130 | 116 |
| Q1 2025 | 150 | 125 |
| Q2 2025 | 169 | 125 |
| Q3 2025 | 123 | 145 |
| Q4 2025 | 161 | 141 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $51.1m | $31.9m | 0.63 |
| Q2 2025 | $18.4m | $20.8m | 1.13 |
| Q3 2025 | $12.2m | $3.4m | 0.28 |
| Q4 2025 | $85.2m | $4.6m | 0.05 |
Biggest buyers
| JANUS HENDERSON GROUP PLC | Added | +1.5m |
| WELLINGTON MANAGEMENT GROUP LLP | Added | +1.3m |
| VANGUARD GROUP INC | Added | +1.2m |
| CITADEL ADVISORS LLC | Added | +888.8k |
| UBS Group AG | Added | +874.0k |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | New | +571.8k |
| Invesco Ltd. | Added | +564.1k |
| Clearbridge Investments, LLC | New | +489.8k |
| JENNISON ASSOCIATES LLC | New | +331.2k |
| PERCEPTIVE ADVISORS LLC | Added | +320.3k |
Biggest sellers
| BVF INC/IL | Sold out | -2.6m |
| Deep Track Capital, LP | Sold out | -1.7m |
| Jefferies Financial Group Inc. | Reduced | -816.5k |
| Lynx1 Capital Management LP | Sold out | -700.0k |
| RTW INVESTMENTS, LP | Reduced | -697.2k |
| Commodore Capital LP | Reduced | -575.0k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Reduced | -485.4k |
| MANGROVE PARTNERS IM, LLC | Sold out | -478.4k |
| Focus Partners Wealth | Sold out | -449.0k |
| TORONTO DOMINION BANK | Sold out | -445.4k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $30.4m348.6k shares |
| Caption Management, LLC | Added | $15.3m174.8k shares |
| CITADEL ADVISORS LLC | Added | $7.8m88.8k shares |
| JANE STREET GROUP, LLC | Added | $6.1m69.6k shares |
| 683 Capital Management, LLC | New | $4.4m50.3k shares |
| Taconic Capital Advisors LP | Not comparable | $4.4m50.0k shares |
| J. Goldman & Co LP | New | $3.6m40.7k shares |
| Verition Fund Management LLC | New | $3.1m36.0k shares |
| Walleye Capital LLC | New | $2.1m23.6k shares |
| GROUP ONE TRADING LLC | Added | $2.0m23.2k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $2.8m31.9k shares |
| CITADEL ADVISORS LLC | Added | $559.0k6.4k shares |
| Walleye Capital LLC | New | $559.0k6.4k shares |
| Walleye Trading LLC | New | $419.2k4.8k shares |
| TUDOR INVESTMENT CORP ET AL | New | $244.6k2.8k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution +1.4 pts · filed 2026-10-27 | 15.2% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 13G · institution filed 2026-08-13 | 10.0% |
| Farallon Capital Partners, L.P. 13G · passive investor no change · filed 2026-02-06 | 10.0% |
| RTW INVESTMENTS, LP 13G · institution filed 2026-02-17 | 8.1% |
| VANGUARD PORTFOLIO MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 5.5% |
| STATE STREET CORP 13G · institution +0.3 pts · filed 2026-08-07 | 5.2% |
| WELLINGTON MANAGEMENT GROUP LLP 13G · institution new · filed 2026-02-10 | 5.1% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.1% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD PORTFOLIO MANAGEMENT LLC), BIOTECHNOLOGY VALUE FUND L P (4.1%, 2025-11-14), Deep Track Capital, LP (2.8%, 2025-11-14)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 0 | — | 4 | $2.2m | $1.5m |
| Q2 2024 | 0 | — | 3 | $2.3m | $2.2m |
| Q3 2024 | 0 | — | 2 | $1.3m | $680.0k |
| Q4 2024 | 0 | — | 3 | $11.8m | — |
| Q1 2025 | 0 | — | 4 | $3.6m | $217.0k |
| Q2 2025 | 0 | — | 2 | $1.2m | — |
| Q3 2025 | 0 | — | 2 | $3.9m | $494.0k |
| Q4 2025 | 0 | — | 2 | $1.2m | $979.5k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-11-17 | MOLINA ARTURO MD Chief Medical Officer | Sold | $229.9k2.7k shares |
| 2025-10-10 | Waddill William D. Director | Sold plan | $979.5k12.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.01% of their portfolio | 9.7m $848.6m | Added +311.8k |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 2.79% of their portfolio | 6.1m $536.6m | Reduced -52.0k |
| VANGUARD GROUP INC 0.01% of their portfolio | 5.4m $472.8m | Added +1.2m |
| RTW INVESTMENTS, LP 4.43% of their portfolio | 5.1m $441.9m | Reduced -697.2k |
| STATE STREET CORP 0.01% of their portfolio | 3.2m $279.5m | Added +33.9k |
| WELLINGTON MANAGEMENT GROUP LLP 0.05% of their portfolio | 3.2m $277.0m | Added +1.3m |
| UBS Group AG 0.05% of their portfolio | 2.8m $241.9m | Added +874.0k |
| JANUS HENDERSON GROUP PLC 0.10% of their portfolio | 2.6m $231.4m | Added +1.5m |
| JOHNSON & JOHNSON 38.54% of their portfolio | 2.4m $213.9m | Unchanged |
| Invesco Ltd. 0.01% of their portfolio | 1.6m $136.9m | Added +564.1k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 1.5m $126.9m | Added +36.3k |
| Woodline Partners LP 0.48% of their portfolio | 1.4m $123.0m | Reduced -29.5k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio | 1.4m $122.3m | Added +180.3k |
| PERCEPTIVE ADVISORS LLC 2.16% of their portfolio | 1.4m $117.9m | Added +320.3k |
| CITADEL ADVISORS LLC 0.07% of their portfolio | 1.1m $98.4m | Added +888.8k |
| Driehaus Capital Management LLC 0.65% of their portfolio | 1.1m $96.0m | Reduced -40.7k |
| ADAR1 Capital Management, LLC 6.85% of their portfolio | 1.0m $91.6m | Added +60.0k |
| MARSHALL WACE, LLP 0.09% of their portfolio | 1.0m $89.5m | Reduced -60.6k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 961.1k $83.9m | Added +179.4k |
| MORGAN STANLEY 0.00% of their portfolio | 879.0k $76.8m | Added +110.7k |
| BANK OF AMERICA CORP /DE/ 0.01% of their portfolio | 867.6k $75.8m | Added +37.7k |
| NORTHERN TRUST CORP 0.01% of their portfolio | 575.1k $50.2m | Reduced -28.1k |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. 4.43% of their portfolio | 571.8k $49.9m | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 556.8k $48.6m | Added +3.9k |
| FMR LLC 0.00% of their portfolio | 539.9k $47.2m | Added +19.2k |
| AMERICAN CENTURY COMPANIES INC 0.02% of their portfolio | 535.4k $46.8m | Reduced -64.6k |
| Pictet Asset Management Holding SA 0.04% of their portfolio | 529.6k $46.3m | Reduced -292.6k |
| Clearbridge Investments, LLC 0.03% of their portfolio | 489.8k $42.8m | New |
| Commodore Capital LP 2.62% of their portfolio | 450.0k $39.3m | Reduced -575.0k |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 414.4k $36.2m | Reduced -24.1k |
| 683 Capital Management, LLC 2.76% of their portfolio | 380.7k $33.2m | Reduced -26.8k |
| VOYA INVESTMENT MANAGEMENT LLC 0.03% of their portfolio | 366.2k $32.0m | Added +60.7k |
| Bank of New York Mellon Corp 0.01% of their portfolio | 350.4k $30.6m | Reduced -12.9k |
| PRINCIPAL FINANCIAL GROUP INC 0.02% of their portfolio | 347.9k $30.4m | Added +21.8k |
| JENNISON ASSOCIATES LLC 0.02% of their portfolio | 331.2k $28.9m | New |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.03% of their portfolio | 330.8k $28.9m | Reduced -121.0k |
| Deeter Investments LLP 0.62% of their portfolio | 300.0k $2.9m | First filing |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.03% of their portfolio | 232.8k $20.3m | Reduced -485.4k |
| NEXTBio Capital Management LP 11.76% of their portfolio | 229.6k $20.1m | First filing |
| KENNEDY CAPITAL MANAGEMENT LLC 0.41% of their portfolio | 221.4k $19.3m | Added +13.0k |
| Holocene Advisors, LP 0.04% of their portfolio | 210.0k $18.3m | New |
| Skandinaviska Enskilda Banken AB (publ) 0.07% of their portfolio | 205.6k $18.0m | Added +126.8k |
| Public Sector Pension Investment Board 0.06% of their portfolio | 203.4k $17.8m | Reduced -24.7k |
| Alyeska Investment Group, L.P. 0.05% of their portfolio | 199.5k $17.4m | New |
| MPM BIOIMPACT LLC 1.99% of their portfolio | 199.5k $17.4m | New |
| AIHC Capital Management Ltd 15.54% of their portfolio | 189.8k $16.6m | First filing |
| BARCLAYS PLC 0.01% of their portfolio | 187.6k $16.4m | Added +16.2k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 181.5k $15.8m | Reduced -112.8k |
| NAN FUNG TRINITY (HK) LTD 1.25% of their portfolio | 180.7k $15.8m | Added +35.8k |
| Affinity Asset Advisors, LLC 1.08% of their portfolio | 172.1k $15.0m | Reduced -48.5k |
| Boxer Capital Management, LLC 3.25% of their portfolio | 170.0k $14.8m | Added +60.0k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 169.5k $14.8m | Added +16.3k |
| Duquesne Family Office LLC 0.33% of their portfolio | 159.7k $13.9m | Unchanged |
| TD Asset Management Inc 0.01% of their portfolio | 158.7k $13.9m | Added +8.3k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 155.3k $13.6m | Reduced -349.5k |
| RHUMBLINE ADVISERS 0.01% of their portfolio | 154.9k $13.5m | Reduced -9.0k |
| Qube Research & Technologies Ltd 0.02% of their portfolio | 153.9k $13.4m | New |
| Legal & General Group Plc 0.00% of their portfolio | 149.2k $13.0m | Reduced -6.7k |
| SEGALL BRYANT & HAMILL, LLC 0.15% of their portfolio | 129.1k $11.3m | Added +5.9k |
| Nuveen, LLC 0.00% of their portfolio | 125.9k $11.0m | Reduced -2.5k |
| PANAGORA ASSET MANAGEMENT INC 0.04% of their portfolio | 125.4k $11.0m | Reduced -23.3k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.02% of their portfolio | 114.0k $10.0m | Added +23.7k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio | 113.3k $9.9m | Reduced -21.8k |
| PRUDENTIAL FINANCIAL INC 0.01% of their portfolio | 110.4k $9.6m | Reduced -16.0k |
| Hudson Bay Capital Management LP 0.05% of their portfolio | 109.6k $9.6m | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 105.5k $9.2m | Reduced -11.8k |
| Opaleye Management Inc. 1.21% of their portfolio | 105.0k $9.2m | Unchanged |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 104.5k $9.1m | Reduced -5.7k |
| SOROS FUND MANAGEMENT LLC 0.12% of their portfolio | 100.0k $8.7m | New |
| NEUBERGER BERMAN GROUP LLC 0.01% of their portfolio | 98.5k $8.6m | Reduced -24.9k |
| Swiss National Bank 0.01% of their portfolio | 98.2k $8.6m | Added +2.1k |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 97.8k $8.5m | Added +84.6k |
| CITIGROUP INC 0.01% of their portfolio | 94.9k $8.3m | Reduced -57.7k |
| AXIOM INVESTORS LLC /DE 0.07% of their portfolio | 89.5k $7.8m | Added +9.4k |
| Atika Capital Management LLC 1.05% of their portfolio | 86.0k $7.5m | Added +3.0k |
| Moody Aldrich Partners LLC 1.31% of their portfolio | 80.6k $7.0m | Reduced -62.4k |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 80.6k $7.0m | Reduced -4.9k |
| Informed Momentum Co LLC 0.76% of their portfolio | 78.5k $6.9m | Reduced -1.6k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 76.4k $6.7m | Reduced -6.5k |
| GREAT LAKES ADVISORS, LLC 0.05% of their portfolio | 74.0k $6.5m | Reduced -15.2k |
| HighVista Strategies LLC 1.65% of their portfolio | 73.5k $6.4m | Reduced -48.1k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 73.2k $6.4m | Reduced -187.6k |
| Knott David M Jr 2.95% of their portfolio | 73.0k $6.4m | Reduced -10.0k |
| EFG International AG 0.12% of their portfolio | 72.6k $6.3m | First filing |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 71.6k $6.3m | Added +23.9k |
| Fisher Asset Management, LLC 0.00% of their portfolio | 65.1k $5.7m | New |
| Rafferty Asset Management, LLC 0.02% of their portfolio | 63.7k $5.6m | Reduced -11.2k |
| STEMPOINT CAPITAL LP 0.89% of their portfolio | 59.4k $5.2m | Added +11.5k |
| Eagle Health Investments LP 1.10% of their portfolio | 57.3k $5.0m | New |
| Quinn Opportunity Partners LLC 0.21% of their portfolio | 55.3k $4.8m | New |
| Birchview Capital, LP 2.81% of their portfolio | 55.0k $4.8m | Added +7.0k |
| BESSEMER GROUP INC 0.01% of their portfolio | 54.2k $4.7m | Added +49.9k |
| SILVERCREST ASSET MANAGEMENT GROUP LLC 0.03% of their portfolio | 53.2k $4.6m | Unchanged |
| KVP Capital Advisors, LP 4.78% of their portfolio | 53.0k $4.6m | First filing |
| Eversept Partners, LP 0.26% of their portfolio | 53.0k $4.6m | New |
| Pentwater Capital Management LP 0.03% of their portfolio | 50.0k $4.4m | New |
| CANADA LIFE ASSURANCE Co 0.01% of their portfolio | 49.6k $4.3m | Added +1.2k |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio | 49.4k $4.3m | Reduced -200 |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 0.00% of their portfolio | 48.9k $4.3m | Reduced -10.0k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 48.0k $4.2m | Added +596 |