PROTAGONIST THERAPEUTICS INC PTGX
COM · Common Stock · CUSIP 74366E102 · ISIN US74366E1029
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNewark, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($2.8m this quarter). Holder counts are more reliable. Shares outstanding: 62.2m as of 2025-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $55.29. Options: 8 managers hold calls ($18.4m notional), 10 hold puts ($20.8m).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 132 |
| Q4 2022 | 138 |
| Q1 2023 | 138 |
| Q2 2023 | 168 |
| Q3 2023 | 145 |
| Q4 2023 | 157 |
| Q1 2024 | 186 |
| Q2 2024 | 189 |
| Q3 2024 | 241 |
| Q4 2024 | 243 |
| Q1 2025 | 277 |
| Q2 2025 | 276 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 83 | 80 |
| Q4 2023 | 65 | 79 |
| Q1 2024 | 110 | 76 |
| Q2 2024 | 90 | 94 |
| Q3 2024 | 153 | 86 |
| Q4 2024 | 130 | 116 |
| Q1 2025 | 150 | 125 |
| Q2 2025 | 169 | 125 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $2.8m | $5.2m | 1.83 |
| Q4 2024 | $8.7m | $9.5m | 1.09 |
| Q1 2025 | $51.1m | $31.9m | 0.63 |
| Q2 2025 | $18.4m | $20.8m | 1.13 |
Biggest buyers
| UBS Group AG | Added | +2.1m |
| Commodore Capital LP | New | +1.1m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Added | +748.8k |
| BVF INC/IL | Added | +636.0k |
| Holocene Advisors, LP | New | +530.3k |
| Driehaus Capital Management LLC | Added | +522.6k |
| STATE STREET CORP | Added | +500.9k |
| Pictet Asset Management Holding SA | Added | +456.4k |
| JANUS HENDERSON GROUP PLC | Added | +425.4k |
| BANK OF AMERICA CORP /DE/ | Added | +380.1k |
Biggest sellers
| Focus Partners Wealth | Sold out | -435.1k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -385.3k |
| New Vernon Capital Holdings II LLC | Reduced | -340.9k |
| Artia Global Partners LP | Reduced | -310.9k |
| Qube Research & Technologies Ltd | Reduced | -274.4k |
| Eversept Partners, LP | Reduced | -269.8k |
| Schonfeld Strategic Advisors LLC | Reduced | -210.2k |
| BURNEY CO/ | Reduced | -195.7k |
| JANE STREET GROUP, LLC | Sold out | -193.3k |
| Soleus Capital Management, L.P. | Sold out | -169.0k |
Biggest calls
| Caption Management, LLC | Reduced | $7.5m135.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $6.7m122.0k shares |
| GROUP ONE TRADING LLC | Reduced | $1.4m25.5k shares |
| JANE STREET GROUP, LLC | Reduced | $1.1m20.3k shares |
| BNP PARIBAS FINANCIAL MARKETS | New | $806.9k146 shares |
| CITADEL ADVISORS LLC | Reduced | $657.7k11.9k shares |
| SIMPLEX TRADING, LLC | Reduced | $182.0k3.3k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| Caption Management, LLC | Reduced | $7.9m143.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $4.8m87.4k shares |
| NOMURA HOLDINGS INC | New | $2.8m50.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $2.1m38.2k shares |
| CITADEL ADVISORS LLC | Reduced | $1.0m18.6k shares |
| GROUP ONE TRADING LLC | Reduced | $768.3k13.9k shares |
| SIG BROKERAGE, LP | Added | $552.7k10.0k shares |
| JANE STREET GROUP, LLC | Reduced | $486.4k8.8k shares |
| JPMORGAN CHASE & CO | New | $331.6k6.0k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution +1.4 pts · filed 2026-10-27 | 15.2% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 13G · institution filed 2026-08-13 | 10.0% |
| Farallon Capital Partners, L.P. 13G · passive investor no change · filed 2026-02-06 | 10.0% |
| RTW INVESTMENTS, LP 13G · institution filed 2026-02-17 | 8.1% |
| VANGUARD PORTFOLIO MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 5.5% |
| STATE STREET CORP 13G · institution +0.3 pts · filed 2026-08-07 | 5.2% |
| WELLINGTON MANAGEMENT GROUP LLP 13G · institution new · filed 2026-02-10 | 5.1% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.1% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD PORTFOLIO MANAGEMENT LLC), BIOTECHNOLOGY VALUE FUND L P (4.1%, 2025-11-14), Deep Track Capital, LP (2.8%, 2025-11-14)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 0 | — | 2 | $1.5m | $1.5m |
| Q1 2024 | 0 | — | 4 | $2.2m | $1.5m |
| Q2 2024 | 0 | — | 3 | $2.3m | $2.2m |
| Q3 2024 | 0 | — | 2 | $1.3m | $680.0k |
| Q4 2024 | 0 | — | 3 | $11.8m | — |
| Q1 2025 | 0 | — | 4 | $3.6m | $217.0k |
| Q2 2025 | 0 | — | 2 | $1.2m | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-06-10 | MOLINA ARTURO MD Chief Medical Officer | Sold | $570.3k10.0k shares |
| 2025-06-09 | MOLINA ARTURO MD Chief Medical Officer | Sold | $555.1k10.0k shares |
| 2025-04-22 | Ali Asif Chief Financial Officer | Sold | $80.8k1.8k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.01% of their portfolio | 9.6m $532.3m | Reduced -106.4k |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 1.56% of their portfolio | 6.2m $341.1m | Added +65.0k |
| RTW INVESTMENTS, LP 4.53% of their portfolio | 5.8m $318.1m | Added +36.9k |
| VANGUARD GROUP INC 0.00% of their portfolio | 4.4m $240.9m | Added +81.4k |
| Deep Track Capital, LP 5.77% of their portfolio | 3.2m $179.4m | Added +245.9k |
| BVF INC/IL 6.34% of their portfolio | 3.2m $177.5m | Added +636.0k |
| STATE STREET CORP 0.01% of their portfolio | 3.2m $177.3m | Added +500.9k |
| UBS Group AG 0.03% of their portfolio | 2.5m $138.2m | Added +2.1m |
| JOHNSON & JOHNSON 40.83% of their portfolio | 2.4m $136.4m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 1.4m $79.8m | Added +20.7k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.10% of their portfolio | 1.1m $60.4m | Added +748.8k |
| Commodore Capital LP 4.19% of their portfolio | 1.1m $59.4m | New |
| PERCEPTIVE ADVISORS LLC 2.23% of their portfolio | 1.1m $59.4m | Reduced -16.8k |
| WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio | 1.0m $57.4m | Added +50.4k |
| ADAR1 Capital Management, LLC 8.51% of their portfolio | 948.1k $52.4m | Added +8.4k |
| Woodline Partners LP 0.28% of their portfolio | 946.9k $52.3m | Added +49.2k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio | 936.7k $51.8m | Reduced -385.3k |
| MORGAN STANLEY 0.00% of their portfolio | 869.0k $48.0m | Added +371.9k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 851.8k $47.1m | Added +380.1k |
| Jefferies Financial Group Inc. 0.75% of their portfolio | 824.0k $45.5m | Added +192.1k |
| AMERICAN CENTURY COMPANIES INC 0.02% of their portfolio | 814.0k $45.0m | Added +128.2k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 777.3k $43.0m | Added +221.8k |
| Driehaus Capital Management LLC 0.34% of their portfolio | 757.7k $41.9m | Added +522.6k |
| Pictet Asset Management Holding SA 0.04% of their portfolio | 752.0k $41.6m | Added +456.4k |
| Lynx1 Capital Management LP 11.70% of their portfolio | 733.0k $40.5m | Unchanged |
| Invesco Ltd. 0.01% of their portfolio | 721.7k $39.9m | Reduced -138.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 615.1k $34.0m | Reduced -24.4k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 575.4k $31.8m | Added +17.6k |
| FMR LLC 0.00% of their portfolio | 538.4k $29.8m | Added +60.1k |
| Holocene Advisors, LP 0.07% of their portfolio | 530.3k $29.3m | New |
| JANUS HENDERSON GROUP PLC 0.01% of their portfolio | 446.8k $24.7m | Added +425.4k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.06% of their portfolio | 446.0k $24.7m | Added +66.4k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 445.7k $24.6m | Reduced -23.2k |
| TORONTO DOMINION BANK 0.05% of their portfolio | 445.4k $24.6m | Unchanged |
| 683 Capital Management, LLC 2.49% of their portfolio | 445.0k $24.6m | Reduced -55.0k |
| Affinity Asset Advisors, LLC 3.60% of their portfolio | 440.0k $24.3m | Added +40.0k |
| JUPITER ASSET MANAGEMENT LTD 0.19% of their portfolio | 405.6k $22.4m | Added +237.6k |
| MANGROVE PARTNERS IM, LLC 2.35% of their portfolio | 395.4k $21.9m | Unchanged |
| Bank of New York Mellon Corp 0.00% of their portfolio | 388.1k $21.4m | Added +11.2k |
| PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio | 330.1k $18.2m | Reduced -17.0k |
| RAYMOND JAMES FINANCIAL INC 0.01% of their portfolio | 312.0k $17.2m | Added +13.2k |
| VOYA INVESTMENT MANAGEMENT LLC 0.02% of their portfolio | 280.4k $15.5m | Added +161.0k |
| Eversept Partners, LP 1.54% of their portfolio | 277.3k $15.3m | Reduced -269.8k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 243.4k $13.5m | Added +34.6k |
| BARCLAYS PLC 0.00% of their portfolio | 212.1k $11.7m | Added +100.7k |
| Public Sector Pension Investment Board 0.05% of their portfolio | 211.3k $11.7m | Added +22.2k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 180.1k $10.0m | Added +58.5k |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 173.1k $9.6m | Reduced -150.4k |
| RHUMBLINE ADVISERS 0.01% of their portfolio | 173.0k $9.6m | Added +11.0k |
| Moody Aldrich Partners LLC 1.82% of their portfolio | 170.6k $9.4m | Added +7.1k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 168.4k $9.3m | Added +31.5k |
| Legal & General Group Plc 0.00% of their portfolio | 166.2k $9.2m | Added +18.1k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 149.5k $8.3m | Added +139.5k |
| PANAGORA ASSET MANAGEMENT INC 0.04% of their portfolio | 148.8k $8.2m | Reduced -1.1k |
| GREAT LAKES ADVISORS, LLC 0.06% of their portfolio | 139.4k $7.7m | Reduced -12.9k |
| NAN FUNG TRINITY (HK) LTD 0.89% of their portfolio | 135.1k $7.5m | New |
| KENNEDY CAPITAL MANAGEMENT LLC 0.18% of their portfolio | 134.9k $7.5m | Reduced -2.6k |
| Nuveen, LLC 0.00% of their portfolio | 129.5k $7.2m | Reduced -23.3k |
| SEGALL BRYANT & HAMILL, LLC 0.09% of their portfolio | 120.2k $6.6m | New |
| TD Asset Management Inc 0.01% of their portfolio | 116.3k $6.4m | Reduced -53.6k |
| Capitolis Liquid Global Markets LLC 0.05% of their portfolio | 116.1k $6.4m | New |
| FIRST TRUST ADVISORS LP 0.01% of their portfolio | 113.9k $6.3m | Added +32.2k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 111.2k $6.1m | Added +45.5k |
| Opaleye Management Inc. 1.17% of their portfolio | 105.0k $5.8m | Unchanged |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 94.8k $5.2m | Reduced -26.0k |
| Swiss National Bank 0.00% of their portfolio | 93.8k $5.2m | Added +6.9k |
| NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio | 93.6k $5.2m | New |
| Assenagon Asset Management S.A. 0.01% of their portfolio | 91.9k $5.1m | Added +47.0k |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 90.9k $5.0m | Reduced -11.5k |
| Skandinaviska Enskilda Banken AB (publ) 0.02% of their portfolio | 82.8k $4.6m | Reduced -166.2k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 82.6k $4.6m | Added +3.5k |
| EFG Asset Management (North America) Corp. 0.64% of their portfolio | 81.7k $4.5m | Added +10.6k |
| Checkpoint Capital L.P. 2.09% of their portfolio | 81.3k $4.5m | Reduced -93.9k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 80.5k $4.5m | Added +36.3k |
| Knott David M Jr 2.00% of their portfolio | 80.0k $4.4m | Added +4.0k |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 0.00% of their portfolio | 78.9k $4.4m | Unchanged |
| CITIGROUP INC 0.00% of their portfolio | 78.0k $4.3m | Reduced -43.9k |
| PRUDENTIAL FINANCIAL INC 0.01% of their portfolio | 77.4k $4.3m | Added +19.1k |
| Schonfeld Strategic Advisors LLC 0.03% of their portfolio | 77.1k $4.3m | Reduced -210.2k |
| DIADEMA PARTNERS LP 2.62% of their portfolio | 76.2k $4.2m | New |
| Informed Momentum Co LLC 0.60% of their portfolio | 72.0k $4.0m | Added +2.8k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 71.2k $3.9m | Reduced -121.0k |
| Global IMC LLC 1.00% of their portfolio | 69.7k $3.9m | Reduced -24 |
| Qube Research & Technologies Ltd 0.01% of their portfolio | 69.0k $3.8m | Reduced -274.4k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 67.9k $3.8m | Unchanged |
| Parkman Healthcare Partners LLC 0.39% of their portfolio | 61.6k $3.4m | New |
| Boxer Capital Management, LLC 1.67% of their portfolio | 60.0k $3.3m | New |
| HighVista Strategies LLC 1.17% of their portfolio | 57.9k $3.2m | Reduced -20.6k |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio | 55.7k $3.1m | Added +8.9k |
| SILVERCREST ASSET MANAGEMENT GROUP LLC 0.02% of their portfolio | 54.7k $3.0m | Unchanged |
| AXIOM INVESTORS LLC /DE 0.02% of their portfolio | 51.2k $2.8m | Reduced -28.7k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 51.2k $2.8m | Added +9.3k |
| CANADA LIFE ASSURANCE Co 0.00% of their portfolio | 50.2k $2.8m | Reduced -713 |
| CAPITAL FUND MANAGEMENT S.A. 0.03% of their portfolio | 49.8k $2.8m | New |
| Birchview Capital, LP 2.63% of their portfolio | 48.0k $2.7m | Reduced -2 |
| EXCHANGE TRADED CONCEPTS, LLC 0.03% of their portfolio | 47.4k $2.6m | Added +20.0k |
| Thrivent Financial for Lutherans 0.01% of their portfolio | 45.6k $2.5m | Added +1.8k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 44.9k $2.5m | Added +7.4k |
| NATIXIS 0.01% of their portfolio | 42.0k $2.3m | New |
| Aquatic Capital Management LLC 0.05% of their portfolio | 42.0k $2.3m | Added +26.9k |