PROTAGONIST THERAPEUTICS INC PTGX
COM · Common Stock · CUSIP 74366E102 · ISIN US74366E1029
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNewark, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($6.0m this quarter). Holder counts are more reliable. Shares outstanding: 58.9m as of 2024-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $34.65. Options: 6 managers hold calls ($955.6k notional), 9 hold puts ($7.6m).
Trends to Q2 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 132 |
| Q4 2022 | 138 |
| Q1 2023 | 138 |
| Q2 2023 | 168 |
| Q3 2023 | 145 |
| Q4 2023 | 157 |
| Q1 2024 | 186 |
| Q2 2024 | 189 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 69 | 59 |
| Q1 2023 | 78 | 74 |
| Q2 2023 | 103 | 62 |
| Q3 2023 | 83 | 80 |
| Q4 2023 | 65 | 79 |
| Q1 2024 | 110 | 76 |
| Q2 2024 | 90 | 94 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2023 | $12.2m | $1.1m | 0.09 |
| Q4 2023 | $14.5m | $2.5m | 0.17 |
| Q1 2024 | $1.1m | $6.8m | 6.03 |
| Q2 2024 | $955.6k | $7.6m | 7.92 |
Biggest buyers
| MILLENNIUM MANAGEMENT LLC | Added | +915.4k |
| Jefferies Financial Group Inc. | Added | +860.0k |
| ADAR1 Capital Management, LLC | Added | +818.3k |
| Qube Research & Technologies Ltd | Added | +391.0k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +390.2k |
| EAGLE ASSET MANAGEMENT INC | New | +357.6k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | +283.8k |
| JPMORGAN CHASE & CO | Added | +278.3k |
| PERCEPTIVE ADVISORS LLC | Added | +274.4k |
| RENAISSANCE TECHNOLOGIES LLC | Added | +264.9k |
Biggest sellers
| MORGAN STANLEY | Reduced | -5.3m |
| STATE STREET CORP | Reduced | -1.2m |
| BVF INC/IL | Reduced | -436.7k |
| MARSHALL WACE, LLP | Reduced | -404.7k |
| COWEN AND COMPANY, LLC | Reduced | -375.4k |
| Kynam Capital Management, LP | Reduced | -344.2k |
| Nuveen Asset Management, LLC | Reduced | -304.2k |
| Point72 Asset Management, L.P. | Reduced | -290.2k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Reduced | -217.5k |
| CIBC WORLD MARKETS CORP | Sold out | -200.0k |
Biggest calls
| CITADEL ADVISORS LLC | Reduced | $256.4k7.4k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $242.6k7.0k shares |
| Belvedere Trading LLC | New | $221.8k6.4k shares |
| SIMPLEX TRADING, LLC | Added | $124.0k3.6k shares |
| GROUP ONE TRADING LLC | Added | $110.9k3.2k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| GROUP ONE TRADING LLC | Reduced | $2.3m66.0k shares |
| Balyasny Asset Management L.P. | New | $2.0m57.5k shares |
| JANE STREET GROUP, LLC | Reduced | $1.5m42.8k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $1.2m34.1k shares |
| PEAK6 Investments LLC | Unchanged | $266.8k7.7k shares |
| CITADEL ADVISORS LLC | Reduced | $263.3k7.6k shares |
| Belvedere Trading LLC | New | $86.6k2.5k shares |
| SIMPLEX TRADING, LLC | Reduced | $3.0k100 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution +1.4 pts · filed 2026-10-27 | 15.2% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 13G · institution filed 2026-08-13 | 10.0% |
| Farallon Capital Partners, L.P. 13G · passive investor no change · filed 2026-02-06 | 10.0% |
| RTW INVESTMENTS, LP 13G · institution filed 2026-02-17 | 8.1% |
| VANGUARD PORTFOLIO MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 5.5% |
| STATE STREET CORP 13G · institution +0.3 pts · filed 2026-08-07 | 5.2% |
| WELLINGTON MANAGEMENT GROUP LLP 13G · institution new · filed 2026-02-10 | 5.1% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.1% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD PORTFOLIO MANAGEMENT LLC), BIOTECHNOLOGY VALUE FUND L P (4.1%, 2025-11-14), Deep Track Capital, LP (2.8%, 2025-11-14)
Insider purchases and sales in Q2 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 0 | — | — |
| Q3 2023 | 0 | — | 0 | — | — |
| Q4 2023 | 0 | — | 2 | $1.5m | $1.5m |
| Q1 2024 | 0 | — | 4 | $2.2m | $1.5m |
| Q2 2024 | 0 | — | 3 | $2.3m | $2.2m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-06-07 | PATEL DINESH V PH D President and CEO, director | Sold plan | $1.2m35.0k shares |
| 2024-06-07 | Waddill William D. Director | Sold plan | $280.0k8.0k shares |
| 2024-04-18 | Ali Asif Chief Financial Officer | Sold | $31.0k1.2k shares |
| 2024-04-01 | PATEL DINESH V PH D President and CEO, director | Sold plan | $707.8k25.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2024
| Manager | Shares | Change |
|---|---|---|
| FARALLON CAPITAL MANAGEMENT, L.L.C. 1.19% of their portfolio | 5.8m $202.4m | Added +101.8k |
| BlackRock Inc. 0.00% of their portfolio | 5.8m $199.5m | Added +188.6k |
| RTW INVESTMENTS, LP 2.84% of their portfolio | 5.3m $183.2m | Reduced -29.1k |
| BVF INC/IL 3.22% of their portfolio | 3.3m $115.0m | Reduced -436.7k |
| VANGUARD GROUP INC 0.00% of their portfolio | 3.2m $112.4m | Added +50.5k |
| JOHNSON & JOHNSON 21.18% of their portfolio | 2.4m $84.9m | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 2.1m $72.2m | Reduced -1.2m |
| Jefferies Financial Group Inc. 1.39% of their portfolio | 2.0m $70.7m | Added +860.0k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.13% of their portfolio | 2.0m $69.3m | Reduced -217.5k |
| ADAR1 Capital Management, LLC 11.19% of their portfolio | 1.6m $55.6m | Added +818.3k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.4m $47.5m | Added +77.4k |
| PERCEPTIVE ADVISORS LLC 1.06% of their portfolio | 1.3m $44.0m | Added +274.4k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio | 1.2m $41.9m | Added +390.2k |
| COWEN AND COMPANY, LLC 1.13% of their portfolio | 1.2m $41.0m | Reduced -375.4k |
| MILLENNIUM MANAGEMENT LLC 0.03% of their portfolio | 958.3k $33.2m | Added +915.4k |
| Fairmount Funds Management LLC 3.65% of their portfolio | 931.9k $32.3m | Unchanged |
| Point72 Asset Management, L.P. 0.10% of their portfolio | 909.7k $31.5m | Reduced -290.2k |
| DEUTSCHE BANK AG\ 0.01% of their portfolio | 908.3k $31.5m | Reduced -2.5k |
| Woodline Partners LP 0.27% of their portfolio | 822.2k $28.5m | Added +185.2k |
| Kynam Capital Management, LP 2.90% of their portfolio | 800.0k $27.7m | Reduced -344.2k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 753.2k $26.1m | Added +278.3k |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 616.2k $21.3m | Reduced -175.2k |
| 683 Capital Management, LLC 2.20% of their portfolio | 604.4k $20.9m | Reduced -95.6k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 590.8k $20.5m | Added +65.7k |
| MARSHALL WACE, LLP 0.03% of their portfolio | 572.2k $19.8m | Reduced -404.7k |
| Driehaus Capital Management LLC 0.19% of their portfolio | 556.8k $19.3m | Reduced -3.7k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 525.7k $18.2m | Added +29.1k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 508.5k $17.6m | Reduced -30.5k |
| Eversept Partners, LP 1.34% of their portfolio | 505.8k $17.5m | Added +94.4k |
| Qube Research & Technologies Ltd 0.03% of their portfolio | 453.2k $15.7m | Added +391.0k |
| MANGROVE PARTNERS IM, LLC 1.22% of their portfolio | 439.3k $15.2m | Unchanged |
| FMR LLC 0.00% of their portfolio | 434.5k $15.1m | Reduced -31.6k |
| Gratus Capital, LLC 0.58% of their portfolio | 418.3k $14.5m | Added +10.2k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 374.0k $13.0m | Reduced -304.2k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 370.0k $12.8m | Added +34.6k |
| EAGLE ASSET MANAGEMENT INC 0.07% of their portfolio | 357.6k $12.6m | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.02% of their portfolio | 355.6k $12.3m | Added +283.8k |
| Checkpoint Capital L.P. 7.42% of their portfolio | 355.0k $12.3m | Added +74.7k |
| MORGAN STANLEY 0.00% of their portfolio | 345.3k $12.0m | Reduced -5.3m |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 300.5k $10.4m | Added +33.9k |
| RENAISSANCE TECHNOLOGIES LLC 0.02% of their portfolio | 297.5k $10.3m | Added +264.9k |
| KENNEDY CAPITAL MANAGEMENT LLC 0.21% of their portfolio | 290.1k $10.1m | Reduced -8.0k |
| Candriam S.C.A. 0.06% of their portfolio | 273.8k $9.5m | Reduced -86.2k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 204.3k $7.1m | Added +17.1k |
| Rubric Capital Management LP 0.18% of their portfolio | 198.1k $6.9m | Unchanged |
| SILVERCREST ASSET MANAGEMENT GROUP LLC 0.05% of their portfolio | 191.2k $6.6m | Added +2.4k |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 169.3k $5.9m | Added +88.0k |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 0.01% of their portfolio | 157.8k $5.5m | New |
| ALGERT GLOBAL LLC 0.18% of their portfolio | 152.1k $5.3m | Added +4.2k |
| TD Asset Management Inc 0.00% of their portfolio | 148.3k $5.1m | Added +39.9k |
| Moody Aldrich Partners LLC 0.91% of their portfolio | 134.2k $4.7m | Added +33.7k |
| FIRST TRUST ADVISORS LP 0.00% of their portfolio | 131.8k $4.6m | Added +71.1k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.02% of their portfolio | 129.0k $4.5m | Unchanged |
| Artia Global Partners LP 1.11% of their portfolio | 124.4k $4.3m | Unchanged |
| SEGALL BRYANT & HAMILL, LLC 0.07% of their portfolio | 118.6k $4.1m | New |
| TWO SIGMA ADVISERS, LP 0.01% of their portfolio | 116.6k $4.0m | Reduced -80.1k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 114.4k $4.0m | Added +24.7k |
| Opaleye Management Inc. 0.83% of their portfolio | 105.0k $3.6m | Reduced -7.7k |
| Birchview Capital, LP 1.54% of their portfolio | 96.0k $3.3m | Unchanged |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 95.2k $3.3m | Added +9.8k |
| GREAT LAKES ADVISORS, LLC 0.03% of their portfolio | 93.5k $3.2m | Reduced -3.7k |
| Invesco Ltd. 0.00% of their portfolio | 88.4k $3.1m | Added +60.1k |
| Swiss National Bank 0.00% of their portfolio | 85.9k $3.0m | Reduced -4.8k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 85.0k $2.9m | Reduced -14 |
| Cubist Systematic Strategies, LLC 0.05% of their portfolio | 84.2k $2.9m | Added +78.2k |
| Connor, Clark & Lunn Investment Management Ltd. 0.01% of their portfolio | 82.8k $2.9m | Reduced -10.4k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 82.6k $2.9m | Reduced -75.0k |
| Trexquant Investment LP 0.04% of their portfolio | 80.6k $2.8m | Reduced -21.8k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 75.3k $2.6m | Reduced -163.9k |
| Cannon Global Investment Management, LLC 11.28% of their portfolio | 69.9k $2.4m | New |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.07% of their portfolio | 68.2k $2.4m | Reduced -41.1k |
| UBS Group AG 0.00% of their portfolio | 67.0k $2.3m | Reduced -110.6k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 65.1k $2.3m | Reduced -4.4k |
| DARK FOREST CAPITAL MANAGEMENT LP 0.39% of their portfolio | 61.0k $2.1m | New |
| OLD MISSION CAPITAL LLC 0.05% of their portfolio | 58.9k $2.0m | New |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 56.0k $1.9m | Added +14.5k |
| Legal & General Group Plc 0.00% of their portfolio | 53.3k $1.8m | Added +2.6k |
| Knott David M Jr 0.72% of their portfolio | 52.4k $1.8m | Unchanged |
| Schonfeld Strategic Advisors LLC 0.01% of their portfolio | 49.1k $1.7m | New |
| Y-Intercept (Hong Kong) Ltd 0.09% of their portfolio | 48.1k $1.7m | Added +26.7k |
| ALPS ADVISORS INC 0.01% of their portfolio | 45.8k $1.6m | Added +4.7k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 43.8k $1.5m | Reduced -3.4k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 41.8k $1.4m | Added +5 |
| BARCLAYS PLC 0.00% of their portfolio | 39.2k $1.4m | Reduced -22.6k |
| Hennion & Walsh Asset Management, Inc. 0.07% of their portfolio | 37.9k $1.3m | Added +3.0k |
| SEVEN EIGHT CAPITAL, LP 0.13% of their portfolio | 36.8k $1.3m | Added +29.8k |
| Catalyst Funds Management Pty Ltd 0.34% of their portfolio | 36.6k $1.3m | Added +29.1k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 35.9k $1.2m | Added +4.1k |
| Jackson Creek Investment Advisors LLC 0.44% of their portfolio | 34.7k $1.2m | Reduced -61 |
| MetLife Investment Management, LLC 0.01% of their portfolio | 33.8k $1.2m | Added +5.2k |
| Capula Management Ltd 0.01% of their portfolio | 33.0k $1.1m | Not comparable |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 32.1k $1.1m | First filing |
| Corebridge Financial, Inc. 0.01% of their portfolio | 31.4k $1.1m | First filing |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 30.8k $1.1m | Unchanged |
| MONTANOVA CAPITAL, LLC 0.04% of their portfolio | 30.5k $1.1m | Unchanged |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 30.2k $1.0m | Added +397 |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 27.3k $946.3k | Reduced -133.0k |
| Ensign Peak Advisors, Inc 0.00% of their portfolio | 27.0k $936.8k | Unchanged |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 25.1k $868.2k | Reduced -56.0k |
| GSA CAPITAL PARTNERS LLP 0.06% of their portfolio | 25.0k $867.0k | Reduced -30.3k |