Vault-13

PROTALIX BIOTHERAPEUTICS INC PLX

COM · Common Stock · CUSIP 74365A309

Israeli pharmaceutical company

102 institutional holders +2 vs Q1 2026
14,447,25614.4m shares reported held*
17.9% of all shares outstanding*
$33.7mreported value*
19 new 38 added 17 reduced 16 sold out net sold ≈ $5.6m (-2.4m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($33.0k this quarter). Holder counts are more reliable. Shares outstanding: 80.6m as of 2026-08-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $2.33. Options: 4 managers hold calls ($747.5k notional), 5 hold puts ($458.8k).

Trends to Q2 2026

Institutional holders

Managers reporting a position, each quarter

050100150Q3 22: 27Q4 22: 27Q1 23: 35Q2 23: 67Q3 23: 62Q4 23: 67Q1 24: 65Q2 24: 67Q3 24: 46Q4 24: 47Q1 25: 64Q2 25: 64Q3 25: 77Q4 25: 83Q1 26: 100Q2 26: 102102Q3 22Q3 23Q3 24Q3 25Q2 26
Numbers
QuarterHolders
Q3 202227
Q4 202227
Q1 202335
Q2 202367
Q3 202362
Q4 202367
Q1 202465
Q2 202467
Q3 202446
Q4 202447
Q1 202564
Q2 202564
Q3 202577
Q4 202583
Q1 2026100
Q2 2026102

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q3 24: 11 bought or addedQ3 24: 46 cut or sold outQ4 24: 21 bought or addedQ4 24: 17 cut or sold outQ4 24Q1 25: 41 bought or addedQ1 25: 15 cut or sold outQ2 25: 50 bought or addedQ2 25: 32 cut or sold outQ2 25Q3 25: 35 bought or addedQ3 25: 23 cut or sold outQ4 25: 40 bought or addedQ4 25: 28 cut or sold outQ4 25Q1 26: 53 bought or addedQ1 26: 29 cut or sold outQ2 26: 57 bought or addedQ2 26: 33 cut or sold outQ2 26
Numbers
QuarterBought or addedCut or sold out
Q3 20241146
Q4 20242117
Q1 20254115
Q2 20255032
Q3 20253523
Q4 20254028
Q1 20265329
Q2 20265733

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$200k$400k$600k$800kQ3 25 calls: $98.6kQ3 25 puts: $268.6kQ3 25P/C 2.72Q4 25 calls: $30.6kQ4 25 puts: $49.7kQ4 25P/C 1.62Q1 26 calls: $651.0kQ1 26 puts: $383.0kQ1 26P/C 0.59Q2 26 calls: $747.5kQ2 26 puts: $458.8kQ2 26P/C 0.61
Numbers
QuarterCallsPutsP/C
Q3 2025$98.6k$268.6k2.72
Q4 2025$30.6k$49.7k1.62
Q1 2026$651.0k$383.0k0.59
Q2 2026$747.5k$458.8k0.61

Biggest buyers

MARSHALL WACE, LLP New +452,757+452.8k
BlackRock, Inc. Added +429,688+429.7k
CITADEL ADVISORS LLC New +334,227+334.2k
STRS OHIO New +296,100+296.1k
GOLDMAN SACHS GROUP INC Added +224,577+224.6k
DIMENSIONAL FUND ADVISORS LP Added +196,581+196.6k
Hillsdale Investment Management Inc. New +185,711+185.7k
MILLENNIUM MANAGEMENT LLC New +171,535+171.5k
AQR CAPITAL MANAGEMENT LLC Added +137,333+137.3k
GEODE CAPITAL MANAGEMENT, LLC Added +114,697+114.7k

Biggest sellers

MAK CAPITAL ONE LLC Sold out -3,544,139-3.5m
Prospera Financial Services Inc Sold out -418,570-418.6k
Opaleye Management Inc. Sold out -340,000-340.0k
MORGAN STANLEY Reduced -250,117-250.1k
Connor, Clark & Lunn Investment Management Ltd. Sold out -207,275-207.3k
Round Rock Advisors LLC Sold out -192,080-192.1k
EVERGREEN CAPITAL MANAGEMENT LLC Sold out -171,338-171.3k
RENAISSANCE TECHNOLOGIES LLC Reduced -128,800-128.8k
UBS Group AG Reduced -126,889-126.9k
Diametric Capital, LP Sold out -124,195-124.2k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $456.9k196.1k shares
GROUP ONE TRADING LLC Added $174.1k74.7k shares
JANE STREET GROUP, LLC Reduced $91.6k39.3k shares
SIMPLEX TRADING, LLC Reduced $24.9k10.7k shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $166.8k71.6k shares
CITADEL ADVISORS LLC Added $105.3k45.2k shares
JANE STREET GROUP, LLC Added $86.0k36.9k shares
SIMPLEX TRADING, LLC Added $64.8k27.8k shares
GROUP ONE TRADING LLC Unchanged $35.9k15.4k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
HOLD Alapkezelo Zrt. 13G · passive new · filed 2026-10-15 5.2% new 4.2m≈ $9.7m 2026-10-15
BlackRock, Inc. 13G · institution new · filed 2026-07-29 5.0% new 4.0m≈ $9.4m 2026-07-29

Fell to 5% or below in the last year: MAK Capital Fund LP (4.5%, 2026-03-30)

Insider purchases and sales since 1 Apr 2026

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
101Q4 24: 0 buyingQ4 24: 0 sellingQ1 25: 0 buyingQ1 25: 0 sellingQ1 25Q2 25: 1 buyingQ2 25: 0 sellingQ3 25: 0 buyingQ3 25: 0 sellingQ3 25Q4 25: 1 buyingQ4 25: 1 sellingQ1 26: 0 buyingQ1 26: 0 sellingQ1 26Q2 26: 0 buyingQ2 26: 0 sellingQ3 26: 0 buyingQ3 26: 0 sellingQ3 26
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q4 20240—0——
Q1 20250—0——
Q2 20251$206.4k0——
Q3 20250—0——
Q4 20251$101.4k1$314—
Q1 20260—0——
Q2 20260—0——
Q3 20260—0——

None reported since 1 Apr 2026.

Holders, Q2 2026

#ManagerLocationShares Value% of their portfolioChangeShares change
1 BlackRock, Inc. 0.00% of their portfolio New York, NY 4,046,6504.0m $9.4m $9.4m 0.00% Added +429.7k +429,688
2 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 1,096,0001.1m $2.6m $2.6m 0.00% Reduced -128.8k -128,800
3 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 983,582983.6k $2.3m $2.3m 0.00% Added +10.8k +10,767
4 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 979,995980.0k $2.3m $2.3m 0.00% Added +114.7k +114,697
5 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 922,340922.3k $2.1m $2.1m 0.00% Added +36.9k +36,892
6 VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio MALVERN, PA 510,639510.6k $1.2m $1.2m 0.00% Added +78.2k +78,154
7 Stratos Wealth Partners, LTD. 0.01% of their portfolio BEACHWOOD, OH 500,000500.0k $1.2m $1.2m 0.01% Unchanged
8 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 493,424493.4k $1.1m $1.1m 0.00% Added +196.6k +196,581
9 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 475,922475.9k $1.1m $1.1m 0.00% Added +224.6k +224,577
10 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 452,757452.8k $1.1m $1.1m 0.00% New
11 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 334,227334.2k $778.7k $778.7k 0.00% New
12 STRS OHIO 0.00% of their portfolio COLUMBUS, OH 296,100296.1k $689.9k $689.9k 0.00% New
13 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 232,992233.0k $542.9k $542.9k 0.00% Added +13.7k +13,685
14 Main Street Financial Solutions, LLC 0.03% of their portfolio NEWTOWN, PA 214,100214.1k $498.9k $498.9k 0.03% Unchanged
15 BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.01% of their portfolio HOUSTON, TX 189,100189.1k $440.6k $440.6k 0.01% Unchanged
16 Hillsdale Investment Management Inc. 0.01% of their portfolio Toronto, A6 185,711185.7k $432.7k $432.7k 0.01% New
17 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 180,381180.4k $420.3k $420.3k 0.00% Added +21.1k +21,070
18 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 171,535171.5k $399.7k $399.7k 0.00% New
19 AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio Greenwich, CT 167,826167.8k $391.0k $391.0k 0.00% Added +137.3k +137,333
20 LAZARD ASSET MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 165,561165.6k $385.8k $385.8k 0.00% Added +78.9k +78,944
21 UBS Group AG 0.00% of their portfolio ZURICH, V8 138,646138.6k $323.0k $323.0k 0.00% Reduced -126.9k -126,889
22 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 132,991133.0k $312.5k $312.5k 0.00% Added +101.3k +101,306
23 Nuveen, LLC 0.00% of their portfolio CHARLOTTE, NC 90,18890.2k $210.1k $210.1k 0.00% Unchanged
24 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 77,53777.5k $180.7k $180.7k 0.00% Added +2.6k +2,552
25 VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio MALVERN, PA 70,27770.3k $163.7k $163.7k 0.00% Added +6.9k +6,926
26 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 67,54967.5k $157.4k $157.4k 0.00% Added +41.0k +41,027
27 BAILARD, INC. 0.00% of their portfolio Foster City, CA 61,10061.1k $142.4k $142.4k 0.00% New
28 State of Wyoming 0.01% of their portfolio CHEYENNE, WY 59,17959.2k $137.9k $137.9k 0.01% New
29 WINTON GROUP Ltd 0.00% of their portfolio LONDON, X0 56,00156.0k $130.5k $130.5k 0.00% New
30 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 53,47853.5k $125.0k $125.0k 0.00% Unchanged
31 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 51,89651.9k $120.9k $120.9k 0.00% Reduced -27.2k -27,183
32 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 51,67651.7k $120.4k $120.4k 0.00% Reduced -250.1k -250,117
33 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 46,22446.2k $107.7k $107.7k 0.00% Added +407 +407
34 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 45,50045.5k $106.0k $106.0k 0.00% Added +1.8k +1,803
35 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 42,51542.5k $99.1k $99.1k 0.00% Added +24.4k +24,386
36 FRANKLIN RESOURCES INC 0.00% of their portfolio San Mateo, CA 41,31441.3k $96.3k $96.3k 0.00% New
37 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 40,94440.9k $95.4k $95.4k 0.00% Reduced -8.1k -8,141
38 Phoenix Financial Ltd. 0.00% of their portfolio Givatayim, L3 40,00040.0k $92.9k $92.9k 0.00% Unchanged
39 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 36,71636.7k $85.5k $85.5k 0.00% Reduced -10.7k -10,686
40 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 34,68934.7k $80.8k $80.8k 0.00% Added +31.7k +31,731
41 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio CAUSEWAY BAY, K3 34,09734.1k $79.4k $79.4k 0.00% Added +35 +35
42 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 31,10031.1k $72.5k $72.5k 0.00% Unchanged
43 Aptus Capital Advisors, LLC 0.00% of their portfolio FAIRHOPE, AL 27,96628.0k $65.2k $65.2k 0.00% Added +735 +735
44 EARNED WEALTH ADVISORS, LLC 0.00% of their portfolio WALNUT CREEK, CA 25,97526.0k $60.5k $60.5k 0.00% Reduced -76 -76
45 Smartleaf Asset Management LLC 0.00% of their portfolio BOSTON, MA 25,97526.0k $61.0k $61.0k 0.00% Unchanged
46 Point72 Asset Management, L.P. 0.00% of their portfolio STAMFORD, CT 25,56625.6k $59.6k $59.6k 0.00% New
47 SIMPLEX TRADING, LLC 0.00% of their portfolio CHICAGO, IL 25,04825.0k $58.4k $58.4k 0.00% Added +2.4k +2,377
48 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 24,76524.8k $57.7k $57.7k 0.00% Added +12.5k +12,515
49 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 24,16024.2k $52.4k $52.4k 0.00% Added +12.4k +12,440
50 PRELUDE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio NEW YORK, NY 22,70022.7k $52.9k $52.9k 0.00% Added +3.8k +3,800
51 State of Alaska, Department of Revenue 0.00% of their portfolio JUNEAU, AK 21,83121.8k $50.0k $50.0k 0.00% Unchanged
52 Walleye Capital LLC 0.00% of their portfolio NEW YORK, NY 19,83919.8k $46.2k $46.2k 0.00% New
53 COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio WALTHAM, MA 19,46119.5k $45.3k $45.3k 0.00% Unchanged
54 Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio TRENTON, NJ 18,55418.6k $43.2k $43.2k 0.00% Unchanged
55 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 18,02018.0k $42.0k $42.0k 0.00% Added +678 +678
56 TWO SIGMA SECURITIES, LLC 0.00% of their portfolio NEW YORK, NY 17,79517.8k $41.5k $41.5k 0.00% New
57 INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio WEST PALM BEACH, FL 16,44616.4k $38.3k $38.3k 0.00% Reduced -3.5k -3,512
58 Lido Advisors, LLC 0.00% of their portfolio Los Angeles, CA 15,56015.6k $36.3k $36.3k 0.00% Added +6 +6
59 IEQ CAPITAL, LLC 0.00% of their portfolio Foster City, CA 13,77413.8k $32.1k $32.1k 0.00% New
60 Equitable Holdings, Inc. 0.00% of their portfolio NEW YORK, NY 13,15013.2k $30.6k $30.6k 0.00% Added +2.0k +2,000
61 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 12,66412.7k $29.5k $29.5k 0.00% Reduced -4.7k -4,679
62 Cascade Financial Partners, LLC 0.00% of their portfolio SAN DIEGO, CA 12,00012.0k $28.0k $28.0k 0.00% Unchanged
63 NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio NEW YORK, NY 11,58011.6k $27.0k $27.0k 0.00% Reduced -49 -49
64 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 11,49011.5k $26.8k $26.8k 0.00% Reduced -3.3k -3,332
65 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 10,71710.7k $25.0k $25.0k 0.00% Reduced -777 -777
66 PRUDENTIAL FINANCIAL INC 0.00% of their portfolio NEWARK, NJ 10,11010.1k $23.6k $23.6k 0.00% Unchanged
67 HARBOUR INVESTMENT MANAGEMENT LLC 0.01% of their portfolio EDMONDS, WA 10,10010.1k $23.5k $23.5k 0.01% Unchanged
68 MCF Advisors LLC 0.00% of their portfolio LEXINGTON, KY 10,00010.0k $23.3k $23.3k 0.00% New
69 Kestra Advisory Services, LLC 0.00% of their portfolio AUSTIN, TX 10,00010.0k $23.3k $23.3k 0.00% Unchanged
70 Orin Green Financial, LLC 0.01% of their portfolio SAN DIEGO, CA 10,00010.0k $23.3k $23.3k 0.01% Reduced -54.4k -54,433
71 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 9,6549.7k $22.0k $22.0k 0.00% Added +2.1k +2,086
72 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 8,6698.7k $20.2k $20.2k 0.00% Added +3.5k +3,511
73 GROUP ONE TRADING LLC 0.00% of their portfolio CHICAGO, IL 7,8727.9k $18.3k $18.3k 0.00% Reduced -5.3k -5,350
74 Altshuler Shaham Ltd 0.00% of their portfolio Tel Aviv, L3 7,7427.7k $18.0k $18.0k 0.00% Unchanged
75 Ameritas Investment Partners, Inc. 0.00% of their portfolio LINCOLN, NE 7,1197.1k $16.6k $16.6k 0.00% Unchanged
76 Legal & General Group Plc 0.00% of their portfolio London, X0 6,3336.3k $14.8k $14.8k 0.00% Unchanged
77 HARBOUR INVESTMENTS, INC. 0.00% of their portfolio MADISON, WI 6,0006.0k $14.0k $14.0k 0.00% Unchanged
78 TD Waterhouse Canada Inc. 0.00% of their portfolio TORONTO, A6 6,0006.0k $13.8k $13.8k 0.00% Unchanged
79 FMR LLC 0.00% of their portfolio BOSTON, MA 2,9893.0k $7.0k $7.0k 0.00% Added +84 +84
80 Integrated Wealth Concepts LLC 0.00% of their portfolio WALTHAM, MA 2,7932.8k $6.5k $6.5k 0.00% New
81 NATIONAL BANK OF CANADA /FI/ 0.00% of their portfolio MONTREAL, A8 2,0002.0k $4.6k $4.6k 0.00% Unchanged
82 Arax Advisory Partners 0.00% of their portfolio NEW YORK, NY 1,1121.1k $2.6k $2.6k 0.00% Added +1.1k +1,057
83 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 1,0201.0k $2.4k $2.4k 0.00% Reduced -2.9k -2,889
84 Investment Research & Advisory Group, Inc. 0.00% of their portfolio ATLANTA, GA 1,0001.0k $2.3k $2.3k 0.00% Unchanged
85 Geneos Wealth Management Inc. 0.00% of their portfolio ENGLEWOOD, CO 800800 $1.9k $1.9k 0.00% New
86 GAMMA Investing LLC 0.00% of their portfolio FOSTER CITY, CA 355355 $827 $827 0.00% Reduced -124 -124
87 Allworth Financial LP 0.00% of their portfolio FOLSOM, CA 304304 $709 $709 0.00% Added +278 +278
88 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 300300 $699 $699 0.00% Unchanged
89 Activest Wealth Management 0.00% of their portfolio AVENTURA, FL 300300 $699 $699 0.00% Unchanged
90 Sterling Capital Management LLC 0.00% of their portfolio CHARLOTTE, NC 260260 $606 $606 0.00% Reduced -193 -193
91 Federation des caisses Desjardins du Quebec 0.00% of their portfolio LEVIS, A8 250250 $583 $583 0.00% Unchanged
92 Y.D. More Investments Ltd 0.00% of their portfolio Ramat Gan, L3 220220 $513 $513 0.00% Unchanged
93 EverSource Wealth Advisors, LLC 0.00% of their portfolio BIRMINGHAM, AL 163163 $380 $380 0.00% Added +152 +152
94 True Wealth Design, LLC 0.00% of their portfolio AKRON, OH 115115 $268 $268 0.00% Added +104 +104
95 Farther Finance Advisors, LLC 0.00% of their portfolio SAN FRANCISCO, CA 108108 $253 $253 0.00% New
96 ROTHSCHILD INVESTMENT LLC 0.00% of their portfolio CHICAGO, IL 8383 $193 $193 0.00% Added +68 +68
97 Essential Partners LLC 0.00% of their portfolio RANCHO SANTA FE, CA 8181 $189 $189 0.00% Added +55 +55
98 SJS Investment Consulting Inc. 0.00% of their portfolio SYLVANIA, OH 3030 $70 $70 0.00% New
99 PNC Financial Services Group, Inc. 0.00% of their portfolio Pittsburgh, PA 2020 $47 $47 0.00% Unchanged
100 IFP Advisors, Inc 0.00% of their portfolio TAMPA, FL 99 $21 $21 0.00% Added +6 +6