PROTALIX BIOTHERAPEUTICS INC PLX
COM · Common Stock · CUSIP 74365A309
Israeli pharmaceutical company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersHackensack, NJ
- Founded1993
- Websiteprotalix.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($33.0k this quarter). Holder counts are more reliable. Shares outstanding: 80.6m as of 2026-08-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $2.33. Options: 4 managers hold calls ($747.5k notional), 5 hold puts ($458.8k).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 27 |
| Q4 2022 | 27 |
| Q1 2023 | 35 |
| Q2 2023 | 67 |
| Q3 2023 | 62 |
| Q4 2023 | 67 |
| Q1 2024 | 65 |
| Q2 2024 | 67 |
| Q3 2024 | 46 |
| Q4 2024 | 47 |
| Q1 2025 | 64 |
| Q2 2025 | 64 |
| Q3 2025 | 77 |
| Q4 2025 | 83 |
| Q1 2026 | 100 |
| Q2 2026 | 102 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 11 | 46 |
| Q4 2024 | 21 | 17 |
| Q1 2025 | 41 | 15 |
| Q2 2025 | 50 | 32 |
| Q3 2025 | 35 | 23 |
| Q4 2025 | 40 | 28 |
| Q1 2026 | 53 | 29 |
| Q2 2026 | 57 | 33 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $98.6k | $268.6k | 2.72 |
| Q4 2025 | $30.6k | $49.7k | 1.62 |
| Q1 2026 | $651.0k | $383.0k | 0.59 |
| Q2 2026 | $747.5k | $458.8k | 0.61 |
Biggest buyers
| MARSHALL WACE, LLP | New | +452.8k |
| BlackRock, Inc. | Added | +429.7k |
| CITADEL ADVISORS LLC | New | +334.2k |
| STRS OHIO | New | +296.1k |
| GOLDMAN SACHS GROUP INC | Added | +224.6k |
| DIMENSIONAL FUND ADVISORS LP | Added | +196.6k |
| Hillsdale Investment Management Inc. | New | +185.7k |
| MILLENNIUM MANAGEMENT LLC | New | +171.5k |
| AQR CAPITAL MANAGEMENT LLC | Added | +137.3k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +114.7k |
Biggest sellers
| MAK CAPITAL ONE LLC | Sold out | -3.5m |
| Prospera Financial Services Inc | Sold out | -418.6k |
| Opaleye Management Inc. | Sold out | -340.0k |
| MORGAN STANLEY | Reduced | -250.1k |
| Connor, Clark & Lunn Investment Management Ltd. | Sold out | -207.3k |
| Round Rock Advisors LLC | Sold out | -192.1k |
| EVERGREEN CAPITAL MANAGEMENT LLC | Sold out | -171.3k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -128.8k |
| UBS Group AG | Reduced | -126.9k |
| Diametric Capital, LP | Sold out | -124.2k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $456.9k196.1k shares |
| GROUP ONE TRADING LLC | Added | $174.1k74.7k shares |
| JANE STREET GROUP, LLC | Reduced | $91.6k39.3k shares |
| SIMPLEX TRADING, LLC | Reduced | $24.9k10.7k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $166.8k71.6k shares |
| CITADEL ADVISORS LLC | Added | $105.3k45.2k shares |
| JANE STREET GROUP, LLC | Added | $86.0k36.9k shares |
| SIMPLEX TRADING, LLC | Added | $64.8k27.8k shares |
| GROUP ONE TRADING LLC | Unchanged | $35.9k15.4k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| HOLD Alapkezelo Zrt. 13G · passive new · filed 2026-10-15 | 5.2% |
| BlackRock, Inc. 13G · institution new · filed 2026-07-29 | 5.0% |
Fell to 5% or below in the last year: MAK Capital Fund LP (4.5%, 2026-03-30)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 1 | $206.4k | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 1 | $101.4k | 1 | $314 | — |
| Q1 2026 | 0 | — | 0 | — | — |
| Q2 2026 | 0 | — | 0 | — | — |
| Q3 2026 | 0 | — | 0 | — | — |
None reported since 1 Apr 2026.
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.00% of their portfolio | 4.0m $9.4m | Added +429.7k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 1.1m $2.6m | Reduced -128.8k |
| STATE STREET CORP 0.00% of their portfolio | 983.6k $2.3m | Added +10.8k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 980.0k $2.3m | Added +114.7k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 922.3k $2.1m | Added +36.9k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 510.6k $1.2m | Added +78.2k |
| Stratos Wealth Partners, LTD. 0.01% of their portfolio | 500.0k $1.2m | Unchanged |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 493.4k $1.1m | Added +196.6k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 475.9k $1.1m | Added +224.6k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 452.8k $1.1m | New |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 334.2k $778.7k | New |
| STRS OHIO 0.00% of their portfolio | 296.1k $689.9k | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 233.0k $542.9k | Added +13.7k |
| Main Street Financial Solutions, LLC 0.03% of their portfolio | 214.1k $498.9k | Unchanged |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 189.1k $440.6k | Unchanged |
| Hillsdale Investment Management Inc. 0.01% of their portfolio | 185.7k $432.7k | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 180.4k $420.3k | Added +21.1k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 171.5k $399.7k | New |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 167.8k $391.0k | Added +137.3k |
| LAZARD ASSET MANAGEMENT LLC 0.00% of their portfolio | 165.6k $385.8k | Added +78.9k |
| UBS Group AG 0.00% of their portfolio | 138.6k $323.0k | Reduced -126.9k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 133.0k $312.5k | Added +101.3k |
| Nuveen, LLC 0.00% of their portfolio | 90.2k $210.1k | Unchanged |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 77.5k $180.7k | Added +2.6k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 70.3k $163.7k | Added +6.9k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 67.5k $157.4k | Added +41.0k |
| BAILARD, INC. 0.00% of their portfolio | 61.1k $142.4k | New |
| State of Wyoming 0.01% of their portfolio | 59.2k $137.9k | New |
| WINTON GROUP Ltd 0.00% of their portfolio | 56.0k $130.5k | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 53.5k $125.0k | Unchanged |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 51.9k $120.9k | Reduced -27.2k |
| MORGAN STANLEY 0.00% of their portfolio | 51.7k $120.4k | Reduced -250.1k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 46.2k $107.7k | Added +407 |
| MetLife Investment Management, LLC 0.00% of their portfolio | 45.5k $106.0k | Added +1.8k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 42.5k $99.1k | Added +24.4k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 41.3k $96.3k | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 40.9k $95.4k | Reduced -8.1k |
| Phoenix Financial Ltd. 0.00% of their portfolio | 40.0k $92.9k | Unchanged |
| Invesco Ltd. 0.00% of their portfolio | 36.7k $85.5k | Reduced -10.7k |
| CITIGROUP INC 0.00% of their portfolio | 34.7k $80.8k | Added +31.7k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 34.1k $79.4k | Added +35 |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 31.1k $72.5k | Unchanged |
| Aptus Capital Advisors, LLC 0.00% of their portfolio | 28.0k $65.2k | Added +735 |
| EARNED WEALTH ADVISORS, LLC 0.00% of their portfolio | 26.0k $60.5k | Reduced -76 |
| Smartleaf Asset Management LLC 0.00% of their portfolio | 26.0k $61.0k | Unchanged |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 25.6k $59.6k | New |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 25.0k $58.4k | Added +2.4k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 24.8k $57.7k | Added +12.5k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 24.2k $52.4k | Added +12.4k |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 22.7k $52.9k | Added +3.8k |
| State of Alaska, Department of Revenue 0.00% of their portfolio | 21.8k $50.0k | Unchanged |
| Walleye Capital LLC 0.00% of their portfolio | 19.8k $46.2k | New |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 19.5k $45.3k | Unchanged |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 18.6k $43.2k | Unchanged |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 18.0k $42.0k | Added +678 |
| TWO SIGMA SECURITIES, LLC 0.00% of their portfolio | 17.8k $41.5k | New |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 16.4k $38.3k | Reduced -3.5k |
| Lido Advisors, LLC 0.00% of their portfolio | 15.6k $36.3k | Added +6 |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 13.8k $32.1k | New |
| Equitable Holdings, Inc. 0.00% of their portfolio | 13.2k $30.6k | Added +2.0k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 12.7k $29.5k | Reduced -4.7k |
| Cascade Financial Partners, LLC 0.00% of their portfolio | 12.0k $28.0k | Unchanged |
| NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio | 11.6k $27.0k | Reduced -49 |
| BARCLAYS PLC 0.00% of their portfolio | 11.5k $26.8k | Reduced -3.3k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 10.7k $25.0k | Reduced -777 |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 10.1k $23.6k | Unchanged |
| HARBOUR INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 10.1k $23.5k | Unchanged |
| MCF Advisors LLC 0.00% of their portfolio | 10.0k $23.3k | New |
| Kestra Advisory Services, LLC 0.00% of their portfolio | 10.0k $23.3k | Unchanged |
| Orin Green Financial, LLC 0.01% of their portfolio | 10.0k $23.3k | Reduced -54.4k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 9.7k $22.0k | Added +2.1k |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 8.7k $20.2k | Added +3.5k |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 7.9k $18.3k | Reduced -5.3k |
| Altshuler Shaham Ltd 0.00% of their portfolio | 7.7k $18.0k | Unchanged |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 7.1k $16.6k | Unchanged |
| Legal & General Group Plc 0.00% of their portfolio | 6.3k $14.8k | Unchanged |
| HARBOUR INVESTMENTS, INC. 0.00% of their portfolio | 6.0k $14.0k | Unchanged |
| TD Waterhouse Canada Inc. 0.00% of their portfolio | 6.0k $13.8k | Unchanged |
| FMR LLC 0.00% of their portfolio | 3.0k $7.0k | Added +84 |
| Integrated Wealth Concepts LLC 0.00% of their portfolio | 2.8k $6.5k | New |
| NATIONAL BANK OF CANADA /FI/ 0.00% of their portfolio | 2.0k $4.6k | Unchanged |
| Arax Advisory Partners 0.00% of their portfolio | 1.1k $2.6k | Added +1.1k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 1.0k $2.4k | Reduced -2.9k |
| Investment Research & Advisory Group, Inc. 0.00% of their portfolio | 1.0k $2.3k | Unchanged |
| Geneos Wealth Management Inc. 0.00% of their portfolio | 800 $1.9k | New |
| GAMMA Investing LLC 0.00% of their portfolio | 355 $827 | Reduced -124 |
| Allworth Financial LP 0.00% of their portfolio | 304 $709 | Added +278 |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 300 $699 | Unchanged |
| Activest Wealth Management 0.00% of their portfolio | 300 $699 | Unchanged |
| Sterling Capital Management LLC 0.00% of their portfolio | 260 $606 | Reduced -193 |
| Federation des caisses Desjardins du Quebec 0.00% of their portfolio | 250 $583 | Unchanged |
| Y.D. More Investments Ltd 0.00% of their portfolio | 220 $513 | Unchanged |
| EverSource Wealth Advisors, LLC 0.00% of their portfolio | 163 $380 | Added +152 |
| True Wealth Design, LLC 0.00% of their portfolio | 115 $268 | Added +104 |
| Farther Finance Advisors, LLC 0.00% of their portfolio | 108 $253 | New |
| ROTHSCHILD INVESTMENT LLC 0.00% of their portfolio | 83 $193 | Added +68 |
| Essential Partners LLC 0.00% of their portfolio | 81 $189 | Added +55 |
| SJS Investment Consulting Inc. 0.00% of their portfolio | 30 $70 | New |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 20 $47 | Unchanged |
| IFP Advisors, Inc 0.00% of their portfolio | 9 $21 | Added +6 |