PRIME MEDICINE INC PRME
COM · Common Stock · CUSIP 74168J101 · ISIN US74168J1016
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersCambridge, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 97.3m as of 2023-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $14.65. Options: 1 managers hold calls ($0 notional), 1 hold puts ($0).
Trends to Q2 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q4 2022 | 68 |
| Q1 2023 | 77 |
| Q2 2023 | 80 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2023 | 48 | 14 |
| Q2 2023 | 52 | 26 |
Biggest buyers
| VANGUARD GROUP INC | Added | +2.5m |
| Sumitomo Mitsui Trust Group, Inc. | Added | +2.1m |
| Amova Asset Management Americas, Inc. | Added | +2.1m |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +1.4m |
| BlackRock Inc. | Added | +1.4m |
| JANUS HENDERSON GROUP PLC | Added | +550.8k |
| ARK Investment Management LLC | Added | +526.9k |
| STATE STREET CORP | Added | +415.8k |
| JANE STREET GROUP, LLC | New | +397.0k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +300.0k |
Biggest sellers
| FMR LLC | Reduced | -13.0m |
| Alphabet Inc. | Reduced | -1.4m |
| Cormorant Asset Management, LP | Sold out | -734.4k |
| Redmile Group, LLC | Reduced | -668.5k |
| Casdin Capital, LLC | Reduced | -367.2k |
| WEXFORD CAPITAL LP | Sold out | -153.7k |
| Greenwich Wealth Management LLC | Reduced | -141.0k |
| OUP Management Co., LLC | Sold out | -121.3k |
| MOORE CAPITAL MANAGEMENT, LP | Reduced | -53.3k |
| MWG Management Ltd. | Reduced | -43.7k |
Biggest calls
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | New | $00 shares |
Biggest puts
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | New | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| GV 2019, L.P. 13G · passive investor filed 2025-11-12 | 12.3% |
| ARCH Venture Fund XII, L.P. 13D · may seek influence filed 2025-08-11 | 10.4% |
Fell to 5% or below in the last year: T. Rowe Price Investment Management, Inc. (3.3%, 2026-02-17)
Insider purchases and sales in Q2 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 0 | — | — |
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 2 | $6.8m | 0 | — | — |
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2023-06-21 | Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC | Sold plan | $284.5k19.0k shares |
| 2023-06-20 | Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC | Sold plan | $563.3k37.4k shares |
| 2023-06-16 | Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC | Sold plan | $98.1k6.5k shares |
| 2023-06-15 | Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC | Sold plan | $994.6k66.7k shares |
| 2023-06-14 | Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC | Sold plan | $430.6k29.0k shares |
| 2023-06-13 | Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC | Sold plan | $425.2k28.1k shares |
| 2023-06-12 | Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC | Sold plan | $240.1k16.0k shares |
| 2023-06-09 | Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC | Sold plan | $226.9k15.7k shares |
| 2023-06-08 | Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC | Sold plan | $78.7k5.0k shares |
| 2023-06-07 | Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC | Sold plan | $253.8k15.0k shares |
| 2023-06-06 | Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC | Sold plan | $510.2k30.0k shares |
| 2023-06-05 | Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC | Sold plan | $374.6k22.4k shares |
| 2023-06-01 | Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC | Sold plan | $649.1k45.2k shares |
| 2023-05-31 | Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC | Sold plan | $227.0k16.6k shares |
| 2023-05-30 | Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC | Sold plan | $230.2k16.8k shares |
| 2023-05-26 | Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC | Sold plan | $172.6k12.6k shares |
| 2023-05-25 | Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC | Sold plan | $309.9k23.2k shares |
| 2023-05-24 | Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC | Sold plan | $107.9k7.9k shares |
| 2023-05-23 | Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC | Sold plan | $647.7k43.9k shares |
| 2023-05-22 | Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC | Sold plan | $1.2m87.9k shares |
| 2023-05-19 | Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC | Sold plan | $877.4k63.2k shares |
| 2023-05-18 | Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC | Sold plan | $183.1k14.0k shares |
| 2023-05-18 | Alphabet Inc. +6 10% owner · By GV 2019, L.P. | Sold plan | $170.1k13.1k shares |
| 2023-05-17 | Alphabet Inc. +6 10% owner · By GV 2019, L.P. | Sold plan | $191.6k15.0k shares |
| 2023-05-16 | Alphabet Inc. +6 10% owner · By GV 2019, L.P. | Sold plan | $637.7k50.6k shares |
| 2023-05-15 | Alphabet Inc. +6 10% owner · By GV 2019, L.P. | Sold plan | $2.0m158.0k shares |
| 2023-05-12 | Alphabet Inc. +6 10% owner · By GV 2019, L.P. | Sold plan | $347.1k27.3k shares |
| 2023-05-11 | Alphabet Inc. +6 10% owner · By GV 2019, L.P. | Sold plan | $349.5k26.6k shares |
| 2023-05-10 | Alphabet Inc. +6 10% owner · By GV 2019, L.P. | Sold plan | $1.2m87.4k shares |
| 2023-05-09 | Alphabet Inc. +6 10% owner · By GV 2019, L.P. | Sold plan | $4.5m321.2k shares |
The latest 30 of 31 trades.
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2023
| Manager | Shares | Change |
|---|---|---|
| Alphabet Inc. 9.34% of their portfolio | 11.9m $173.8m | Reduced -1.4m |
| FMR LLC 0.00% of their portfolio | 4.0m $59.2m | Reduced -13.0m |
| VANGUARD GROUP INC 0.00% of their portfolio | 3.3m $48.9m | Added +2.5m |
| Amova Asset Management Americas, Inc. 0.47% of their portfolio | 3.1m $44.8m | Added +2.1m |
| Sumitomo Mitsui Trust Group, Inc. 0.03% of their portfolio | 3.1m $44.9m | Added +2.1m |
| BlackRock Inc. 0.00% of their portfolio | 2.9m $42.3m | Added +1.4m |
| ARK Investment Management LLC 0.24% of their portfolio | 2.4m $35.9m | Added +526.9k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 2.3m $34.2m | Added +1.4m |
| FIL Ltd 0.03% of their portfolio | 1.8m $26.5m | Unchanged |
| MWG Management Ltd. 15.88% of their portfolio | 1.8m $26.3m | Reduced -43.7k |
| Redmile Group, LLC 0.74% of their portfolio | 1.3m $19.4m | Reduced -668.5k |
| BAKER BROS. ADVISORS LP 0.09% of their portfolio | 1.0m $15.1m | Unchanged |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.28% of their portfolio | 885.3k $13.0m | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 605.2k $8.9m | Added +415.8k |
| EcoR1 Capital, LLC 0.23% of their portfolio | 600.0k $8.8m | Unchanged |
| JANUS HENDERSON GROUP PLC 0.01% of their portfolio | 564.9k $8.3m | Added +550.8k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 540.3k $7.9m | Added +300.0k |
| SAMSARA BIOCAPITAL, LLC 1.21% of their portfolio | 470.3k $6.9m | Unchanged |
| MOORE CAPITAL MANAGEMENT, LP 0.16% of their portfolio | 446.7k $6.5m | Reduced -53.3k |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 397.0k $5.8m | New |
| Casdin Capital, LLC 0.47% of their portfolio | 367.2k $5.4m | Reduced -367.2k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 282.4k $4.1m | Added +192.4k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 256.6k $3.8m | Added +245.8k |
| Greenwich Wealth Management LLC 0.32% of their portfolio | 208.0k $3.0m | Reduced -141.0k |
| Ensign Peak Advisors, Inc 0.00% of their portfolio | 150.0k $2.2m | Unchanged |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 147.5k $2.2m | Reduced -2.8k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 141.1k $2.1m | Added +67.7k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 123.2k $1.8m | Added +109.1k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 103.2k $1.5m | Added +73.1k |
| UBS Group AG 0.00% of their portfolio | 99.0k $1.5m | Added +94.1k |
| TD Asset Management Inc 0.00% of their portfolio | 67.1k $982.6k | Added +43.1k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 58.4k $855.6k | Added +12.8k |
| MORGAN STANLEY 0.00% of their portfolio | 57.9k $848.7k | Added +24.5k |
| Laurion Capital Management LP 0.04% of their portfolio | 55.9k $818.8k | Reduced -4.1k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 47.1k $689.5k | New |
| BRANDYWINE MANAGERS, LLC 0.32% of their portfolio | 33.0k $483.1k | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 30.7k $449.3k | Added +17.8k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 26.5k $388.8k | New |
| HighTower Advisors, LLC 0.00% of their portfolio | 21.3k $310.0k | New |
| MetLife Investment Management, LLC 0.00% of their portfolio | 21.3k $311.5k | Added +15.2k |
| LEVIN CAPITAL STRATEGIES, L.P. 0.03% of their portfolio | 20.0k $293.0k | New |
| AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio | 19.0k $278.9k | Added +14.0k |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 18.9k $276.5k | New |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 18.0k $264.1k | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 17.8k $260.9k | Added +7.0k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 16.3k $238.8k | Added +14.4k |
| Clarius Group, LLC 0.02% of their portfolio | 16.1k $235.6k | Unchanged |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 16.0k $234.2k | Added +8.2k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 15.7k $230.6k | New |
| OPPENHEIMER & CO INC 0.00% of their portfolio | 15.4k $225.4k | Added +267 |
| RED LIGHTHOUSE INVESTMENT MANAGEMENT, LLC 0.10% of their portfolio | 14.9k $219.0k | Unchanged |
| CITIGROUP INC 0.00% of their portfolio | 14.2k $207.5k | Added +5.3k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 13.2k $192.8k | Reduced -7.8k |
| Green Alpha Advisors, LLC 0.12% of their portfolio | 12.4k $181.5k | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 12.3k $179.5k | New |
| Allspring Global Investments Holdings, LLC 0.00% of their portfolio | 11.4k $167.6k | Added +10.3k |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio | 11.2k $164.5k | New |
| BROWN BROTHERS HARRIMAN & CO 0.00% of their portfolio | 10.1k $147.5k | New |
| Sandia Investment Management LP 0.04% of their portfolio | 10.0k $146.5k | Unchanged |
| Penserra Capital Management LLC 0.00% of their portfolio | 8.1k $118.0k | Added +1.1k |
| BARCLAYS PLC 0.00% of their portfolio | 7.9k $115.4k | Added +2.5k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 6.4k $93.8k | Reduced -28 |
| ORG Partners LLC 0.01% of their portfolio | 5.3k $76.4k | New |
| Legal & General Group Plc 0.00% of their portfolio | 4.8k $70.2k | Added +1.4k |
| AMALGAMATED BANK 0.00% of their portfolio | 4.8k $70.0k | Added +3.5k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 3.6k $53.0k | Added +3.0k |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 3.3k $47.9k | Added +2.4k |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 3.1k $46.0k | Reduced -82 |
| Metropolitan Life Insurance Co/NY 0.00% of their portfolio | 2.2k $32.3k | Added +1.5k |
| LAZARD ASSET MANAGEMENT LLC 0.00% of their portfolio | 1.6k $23.0k | Added +57 |
| First Horizon Advisors, Inc. 0.00% of their portfolio | 1.6k $22.8k | Reduced -143 |
| CHELSEA COUNSEL CO 0.00% of their portfolio | 600 $8.8k | Unchanged |
| Endurance Wealth Management, Inc. 0.00% of their portfolio | 500 $8.0k | Unchanged |
| US BANCORP \DE\ 0.00% of their portfolio | 346 $5.1k | New |
| BENJAMIN EDWARDS INC 0.00% of their portfolio | 321 $5.0k | Added +139 |
| MassMutual Private Wealth & Trust, FSB 0.00% of their portfolio | 34 $498 | New |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 33 $483 | New |
| CWM, LLC 0.00% of their portfolio | 15 $0 | Unchanged |
| Covestor Ltd 0.00% of their portfolio | 9 $0 | Unchanged |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 0 $0 | Unchanged |