Vault-13

PRIME MEDICINE INC PRME

COM · Common Stock · CUSIP 74168J101 · ISIN US74168J1016

80 institutional holders +3 vs Q1 2023
46,131,80846.1m shares reported held*
47.4% of all shares outstanding*
$675.7mreported value*
16 new 36 added 13 reduced 13 sold out net sold ≈ $60.5m (-4.1m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 97.3m as of 2023-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $14.65. Options: 1 managers hold calls ($0 notional), 1 hold puts ($0).

Trends to Q2 2023

Institutional holders

Managers reporting a position, each quarter

050100Q4 22: 68Q1 23: 77Q2 23: 8080Q4 22Q1 23Q2 23
Numbers
QuarterHolders
Q4 202268
Q1 202377
Q2 202380

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q1 23: 48 bought or addedQ1 23: 14 cut or sold outQ1 23Q2 23: 52 bought or addedQ2 23: 26 cut or sold outQ2 23
Numbers
QuarterBought or addedCut or sold out
Q1 20234814
Q2 20235226

Biggest buyers

VANGUARD GROUP INC Added +2,450,037+2.5m
Sumitomo Mitsui Trust Group, Inc. Added +2,066,179+2.1m
Amova Asset Management Americas, Inc. Added +2,065,283+2.1m
PRICE T ROWE ASSOCIATES INC /MD/ Added +1,430,090+1.4m
BlackRock Inc. Added +1,375,093+1.4m
JANUS HENDERSON GROUP PLC Added +550,763+550.8k
ARK Investment Management LLC Added +526,922+526.9k
STATE STREET CORP Added +415,771+415.8k
JANE STREET GROUP, LLC New +397,004+397.0k
GEODE CAPITAL MANAGEMENT, LLC Added +299,963+300.0k

Biggest sellers

FMR LLC Reduced -12,995,039-13.0m
Alphabet Inc. Reduced -1,422,190-1.4m
Cormorant Asset Management, LP Sold out -734,350-734.4k
Redmile Group, LLC Reduced -668,493-668.5k
Casdin Capital, LLC Reduced -367,175-367.2k
WEXFORD CAPITAL LP Sold out -153,705-153.7k
Greenwich Wealth Management LLC Reduced -141,000-141.0k
OUP Management Co., LLC Sold out -121,255-121.3k
MOORE CAPITAL MANAGEMENT, LP Reduced -53,267-53.3k
MWG Management Ltd. Reduced -43,666-43.7k

Biggest calls

Biggest puts

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
GV 2019, L.P. 13G · passive investor filed 2025-11-12 12.3% 16.6m≈ $61.1m 2025-11-12
ARCH Venture Fund XII, L.P. 13D · may seek influence filed 2025-08-11 10.4% 18.6m≈ $68.6m 2025-08-11

Fell to 5% or below in the last year: T. Rowe Price Investment Management, Inc. (3.3%, 2026-02-17)

Insider purchases and sales in Q2 2023

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
202Q3 21: 0 buyingQ3 21: 0 sellingQ4 21: 0 buyingQ4 21: 0 sellingQ4 21Q1 22: 0 buyingQ1 22: 0 sellingQ2 22: 0 buyingQ2 22: 0 sellingQ2 22Q3 22: 0 buyingQ3 22: 0 sellingQ4 22: 2 buyingQ4 22: 0 sellingQ4 22Q1 23: 0 buyingQ1 23: 0 sellingQ2 23: 0 buyingQ2 23: 0 sellingQ2 23
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q3 20210—0——
Q4 20210—0——
Q1 20220—0——
Q2 20220—0——
Q3 20220—0——
Q4 20222$6.8m0——
Q1 20230—0——
Q2 20230—0——
DateInsiderTradeSharesPrice ValueTheir holding
2023-06-21 Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC Sold plan 19,003 $14.97 $284.5k19.0k shares -100%
2023-06-20 Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC Sold plan 37,405 $15.06 $563.3k37.4k shares -100%
2023-06-16 Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC Sold plan 6,532 $15.02 $98.1k6.5k shares -100%
2023-06-15 Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC Sold plan 66,659 $14.92 $994.6k66.7k shares -100%
2023-06-14 Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC Sold plan 28,960 $14.87 $430.6k29.0k shares -100%
2023-06-13 Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC Sold plan 28,100 $15.13 $425.2k28.1k shares -100%
2023-06-12 Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC Sold plan 16,031 $14.98 $240.1k16.0k shares -100%
2023-06-09 Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC Sold plan 15,672 $14.48 $226.9k15.7k shares -100%
2023-06-08 Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC Sold plan 5,000 $15.74 $78.7k5.0k shares -100%
2023-06-07 Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC Sold plan 15,000 $16.92 $253.8k15.0k shares -100%
2023-06-06 Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC Sold plan 29,975 $17.02 $510.2k30.0k shares -100%
2023-06-05 Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC Sold plan 22,434 $16.70 $374.6k22.4k shares -100%
2023-06-01 Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC Sold plan 45,223 $14.35 $649.1k45.2k shares -100%
2023-05-31 Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC Sold plan 16,633 $13.65 $227.0k16.6k shares -100%
2023-05-30 Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC Sold plan 16,805 $13.70 $230.2k16.8k shares -100%
2023-05-26 Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC Sold plan 12,602 $13.70 $172.6k12.6k shares -100%
2023-05-25 Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC Sold plan 23,161 $13.38 $309.9k23.2k shares -100%
2023-05-24 Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC Sold plan 7,900 $13.66 $107.9k7.9k shares -100%
2023-05-23 Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC Sold plan 43,939 $14.74 $647.7k43.9k shares -100%
2023-05-22 Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC Sold plan 87,922 $14.13 $1.2m87.9k shares -100%
2023-05-19 Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC Sold plan 63,212 $13.88 $877.4k63.2k shares -100%
2023-05-18 Alphabet Inc. +6 10% owner · By Alphabet Holdings LLC Sold plan 14,022 $13.06 $183.1k14.0k shares -100%
2023-05-18 Alphabet Inc. +6 10% owner · By GV 2019, L.P. Sold plan 13,076 $13.01 $170.1k13.1k shares -<1%
2023-05-17 Alphabet Inc. +6 10% owner · By GV 2019, L.P. Sold plan 15,000 $12.77 $191.6k15.0k shares -<1%
2023-05-16 Alphabet Inc. +6 10% owner · By GV 2019, L.P. Sold plan 50,649 $12.59 $637.7k50.6k shares -0%
2023-05-15 Alphabet Inc. +6 10% owner · By GV 2019, L.P. Sold plan 157,952 $12.74 $2.0m158.0k shares -1%
2023-05-12 Alphabet Inc. +6 10% owner · By GV 2019, L.P. Sold plan 27,290 $12.72 $347.1k27.3k shares -<1%
2023-05-11 Alphabet Inc. +6 10% owner · By GV 2019, L.P. Sold plan 26,626 $13.13 $349.5k26.6k shares -<1%
2023-05-10 Alphabet Inc. +6 10% owner · By GV 2019, L.P. Sold plan 87,397 $14.03 $1.2m87.4k shares -1%
2023-05-09 Alphabet Inc. +6 10% owner · By GV 2019, L.P. Sold plan 321,238 $14.08 $4.5m321.2k shares -3%

The latest 30 of 31 trades.

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q2 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Alphabet Inc. 9.34% of their portfolio Mountain View, CA 11,862,49811.9m $173.8m $173.8m 9.34% Reduced -1.4m -1,422,190
2 FMR LLC 0.00% of their portfolio BOSTON, MA 4,039,2194.0m $59.2m $59.2m 0.00% Reduced -13.0m -12,995,039
3 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 3,334,4833.3m $48.9m $48.9m 0.00% Added +2.5m +2,450,037
4 Amova Asset Management Americas, Inc. 0.47% of their portfolio New York, NY 3,064,6163.1m $44.8m $44.8m 0.47% Added +2.1m +2,065,283
5 Sumitomo Mitsui Trust Group, Inc. 0.03% of their portfolio CHIYODA-KU, TOKYO, M0 3,063,7513.1m $44.9m $44.9m 0.03% Added +2.1m +2,066,179
6 BlackRock Inc. 0.00% of their portfolio New York, NY 2,889,2162.9m $42.3m $42.3m 0.00% Added +1.4m +1,375,093
7 ARK Investment Management LLC 0.24% of their portfolio ST. PETERSBURG, FL 2,449,1992.4m $35.9m $35.9m 0.24% Added +526.9k +526,922
8 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 2,333,8312.3m $34.2m $34.2m 0.00% Added +1.4m +1,430,090
9 FIL Ltd 0.03% of their portfolio HAMILTON, D0 1,805,5581.8m $26.5m $26.5m 0.03% Unchanged
10 MWG Management Ltd. 15.88% of their portfolio Washington, DC 1,792,2101.8m $26.3m $26.3m 15.88% Reduced -43.7k -43,666
11 Redmile Group, LLC 0.74% of their portfolio LARKSPUR, CA 1,324,3501.3m $19.4m $19.4m 0.74% Reduced -668.5k -668,493
12 BAKER BROS. ADVISORS LP 0.09% of their portfolio NEW YORK, NY 1,028,4661.0m $15.1m $15.1m 0.09% Unchanged
13 DEERFIELD MANAGEMENT COMPANY, L.P. 0.28% of their portfolio New York, NY 885,314885.3k $13.0m $13.0m 0.28% Unchanged
14 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 605,199605.2k $8.9m $8.9m 0.00% Added +415.8k +415,771
15 EcoR1 Capital, LLC 0.23% of their portfolio San Francisco, CA 600,000600.0k $8.8m $8.8m 0.23% Unchanged
16 JANUS HENDERSON GROUP PLC 0.01% of their portfolio LONDON, X0 564,854564.9k $8.3m $8.3m 0.01% Added +550.8k +550,763
17 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 540,308540.3k $7.9m $7.9m 0.00% Added +300.0k +299,963
18 SAMSARA BIOCAPITAL, LLC 1.21% of their portfolio PALO ALTO, CA 470,304470.3k $6.9m $6.9m 1.21% Unchanged
19 MOORE CAPITAL MANAGEMENT, LP 0.16% of their portfolio NEW YORK, NY 446,733446.7k $6.5m $6.5m 0.16% Reduced -53.3k -53,267
20 JANE STREET GROUP, LLC 0.01% of their portfolio NEW YORK, NY 397,004397.0k $5.8m $5.8m 0.01% New
21 Casdin Capital, LLC 0.47% of their portfolio New York, NY 367,175367.2k $5.4m $5.4m 0.47% Reduced -367.2k -367,175
22 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 282,431282.4k $4.1m $4.1m 0.00% Added +192.4k +192,352
23 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 256,560256.6k $3.8m $3.8m 0.00% Added +245.8k +245,801
24 Greenwich Wealth Management LLC 0.32% of their portfolio GREENWICH, CT 208,000208.0k $3.0m $3.0m 0.32% Reduced -141.0k -141,000
25 Ensign Peak Advisors, Inc 0.00% of their portfolio SALT LAKE CITY, UT 150,000150.0k $2.2m $2.2m 0.00% Unchanged
26 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 147,515147.5k $2.2m $2.2m 0.00% Reduced -2.8k -2,752
27 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 141,144141.1k $2.1m $2.1m 0.00% Added +67.7k +67,717
28 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 123,195123.2k $1.8m $1.8m 0.00% Added +109.1k +109,067
29 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 103,213103.2k $1.5m $1.5m 0.00% Added +73.1k +73,145
30 UBS Group AG 0.00% of their portfolio ZURICH, V8 99,03999.0k $1.5m $1.5m 0.00% Added +94.1k +94,104
31 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 67,07167.1k $982.6k $982.6k 0.00% Added +43.1k +43,149
32 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 58,40158.4k $855.6k $855.6k 0.00% Added +12.8k +12,770
33 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 57,92957.9k $848.7k $848.7k 0.00% Added +24.5k +24,544
34 Laurion Capital Management LP 0.04% of their portfolio NEW YORK, NY 55,88855.9k $818.8k $818.8k 0.04% Reduced -4.1k -4,112
35 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 47,06347.1k $689.5k $689.5k 0.00% New
36 BRANDYWINE MANAGERS, LLC 0.32% of their portfolio HOCKESSIN, DE 32,97733.0k $483.1k $483.1k 0.32% Unchanged
37 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 30,67230.7k $449.3k $449.3k 0.00% Added +17.8k +17,775
38 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 26,54026.5k $388.8k $388.8k 0.00% New
39 HighTower Advisors, LLC 0.00% of their portfolio CHICAGO, IL 21,32221.3k $310.0k $310.0k 0.00% New
40 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 21,26221.3k $311.5k $311.5k 0.00% Added +15.2k +15,171
41 LEVIN CAPITAL STRATEGIES, L.P. 0.03% of their portfolio NEW YORK, NY 20,00020.0k $293.0k $293.0k 0.03% New
42 AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio New York, NY 19,04019.0k $278.9k $278.9k 0.00% Added +14.0k +13,953
43 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 18,87118.9k $276.5k $276.5k 0.00% New
44 PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio DES MOINES, IA 18,02918.0k $264.1k $264.1k 0.00% New
45 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 17,81217.8k $260.9k $260.9k 0.00% Added +7.0k +6,952
46 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 16,29716.3k $238.8k $238.8k 0.00% Added +14.4k +14,361
47 Clarius Group, LLC 0.02% of their portfolio SEATTLE, WA 16,08016.1k $235.6k $235.6k 0.02% Unchanged
48 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 15,98416.0k $234.2k $234.2k 0.00% Added +8.2k +8,191
49 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 15,74315.7k $230.6k $230.6k 0.00% New
50 OPPENHEIMER & CO INC 0.00% of their portfolio NEW YORK, NY 15,38515.4k $225.4k $225.4k 0.00% Added +267 +267
51 RED LIGHTHOUSE INVESTMENT MANAGEMENT, LLC 0.10% of their portfolio HILLSDALE, NY 14,95014.9k $219.0k $219.0k 0.10% Unchanged
52 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 14,16114.2k $207.5k $207.5k 0.00% Added +5.3k +5,302
53 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 13,15913.2k $192.8k $192.8k 0.00% Reduced -7.8k -7,808
54 Green Alpha Advisors, LLC 0.12% of their portfolio NIWOT, CO 12,38612.4k $181.5k $181.5k 0.12% New
55 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 12,25412.3k $179.5k $179.5k 0.00% New
56 Allspring Global Investments Holdings, LLC 0.00% of their portfolio CHARLOTTE, NC 11,44111.4k $167.6k $167.6k 0.00% Added +10.3k +10,290
57 STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio TALLAHASSEE, FL 11,23011.2k $164.5k $164.5k 0.00% New
58 BROWN BROTHERS HARRIMAN & CO 0.00% of their portfolio NEW YORK, NY 10,06510.1k $147.5k $147.5k 0.00% New
59 Sandia Investment Management LP 0.04% of their portfolio BOSTON, MA 10,00010.0k $146.5k $146.5k 0.04% Unchanged
60 Penserra Capital Management LLC 0.00% of their portfolio ORINDA, CA 8,1078.1k $118.0k $118.0k 0.00% Added +1.1k +1,107
61 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 7,8797.9k $115.4k $115.4k 0.00% Added +2.5k +2,543
62 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 6,4036.4k $93.8k $93.8k 0.00% Reduced -28 -28
63 ORG Partners LLC 0.01% of their portfolio ROANOKE, IN 5,2705.3k $76.4k $76.4k 0.01% New
64 Legal & General Group Plc 0.00% of their portfolio London, X0 4,7914.8k $70.2k $70.2k 0.00% Added +1.4k +1,364
65 AMALGAMATED BANK 0.00% of their portfolio NEW YORK, NY 4,7524.8k $70.0k $70.0k 0.00% Added +3.5k +3,488
66 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 3,5793.6k $53.0k $53.0k 0.00% Added +3.0k +2,989
67 Ameritas Investment Partners, Inc. 0.00% of their portfolio LINCOLN, NE 3,2673.3k $47.9k $47.9k 0.00% Added +2.4k +2,436
68 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 3,1433.1k $46.0k $46.0k 0.00% Reduced -82 -82
69 Metropolitan Life Insurance Co/NY 0.00% of their portfolio New York, NY 2,2032.2k $32.3k $32.3k 0.00% Added +1.5k +1,485
70 LAZARD ASSET MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 1,6041.6k $23.0k $23.0k 0.00% Added +57 +57
71 First Horizon Advisors, Inc. 0.00% of their portfolio MEMPHIS, TN 1,5551.6k $22.8k $22.8k 0.00% Reduced -143 -143
72 CHELSEA COUNSEL CO 0.00% of their portfolio Woodland Hills, CA 600600 $8.8k $8.8k 0.00% Unchanged
73 Endurance Wealth Management, Inc. 0.00% of their portfolio Providence, RI 500500 $8.0k $8.0k 0.00% Unchanged
74 US BANCORP \DE\ 0.00% of their portfolio MINNEAPOLIS, MN 346346 $5.1k $5.1k 0.00% New
75 BENJAMIN EDWARDS INC 0.00% of their portfolio Clayton, MO 321321 $5.0k $5.0k 0.00% Added +139 +139
76 MassMutual Private Wealth & Trust, FSB 0.00% of their portfolio Windsor, CT 3434 $498 $498 0.00% New
77 NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio ST. LOUIS, MO 3333 $483 $483 0.00% New
78 CWM, LLC 0.00% of their portfolio OMAHA, NE 1515 $0 $0 0.00% Unchanged
79 Covestor Ltd 0.00% of their portfolio LONDON, X0 99 $0 $0 0.00% Unchanged
80 CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio BIRMINGHAM, AL 00 $0 $0 0.00% Unchanged