PRAXIS PRECISION MEDICINES I
COM · CUSIP 74006W108
79
institutional holders
-9 vs Q1 2023
117.1m
shares reported held*
$134.6mreported value*
22 new
19 added
25 reduced
31 sold out
net bought ≈ $73.4m (+63.8m shares)
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $1.15. Options: 5 managers hold calls ($50.7k notional), 2 hold puts ($0).
Trends to Q2 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 108 |
| Q4 2022 | 104 |
| Q1 2023 | 88 |
| Q2 2023 | 79 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Bought or addedCut or sold out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 41 | 63 |
| Q1 2023 | 52 | 48 |
| Q2 2023 | 41 | 56 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
CallsPuts
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $541.0k | $0 | 0.00 |
| Q4 2022 | $4.0k | $476 | 0.12 |
| Q1 2023 | $17.5k | $203.7k | 11.65 |
| Q2 2023 | $50.7k | $0 | 0.00 |
Biggest buyers
| Point72 Asset Management, L.P. | Added | +10.5m |
| Cormorant Asset Management, LP | New | +9.5m |
| SPHERA FUNDS MANAGEMENT LTD. | New | +8.8m |
| Verition Fund Management LLC | Added | +7.5m |
| PFM Health Sciences, LP | Added | +6.7m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Added | +6.0m |
| Venrock Adviser, LLC | New | +5.3m |
| ACUTA CAPITAL PARTNERS, LLC | New | +4.2m |
| SILVERARC CAPITAL MANAGEMENT, LLC | New | +3.5m |
| Ally Bridge Group (NY) LLC | New | +3.2m |
Biggest sellers
| Avidity Partners Management LP | Sold out | -4.3m |
| BlackRock Inc. | Reduced | -2.3m |
| GREAT POINT PARTNERS LLC | Sold out | -2.0m |
| STATE STREET CORP | Reduced | -758.0k |
| GOLDMAN SACHS GROUP INC | Reduced | -607.2k |
| MORGAN STANLEY | Reduced | -585.5k |
| GEODE CAPITAL MANAGEMENT, LLC | Reduced | -392.3k |
| NORTHERN TRUST CORP | Reduced | -285.7k |
| MARSHALL WACE, LLP | Sold out | -283.7k |
| LOS ANGELES CAPITAL MANAGEMENT LLC | Sold out | -263.9k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $22.5k19.6k shares |
| SIMPLEX TRADING, LLC | Added | $16.0k14.3k shares |
| CITADEL ADVISORS LLC | Added | $12.2k10.6k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
| Cutler Group LLC / CA | Reduced | $0100 shares |
Biggest puts
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
| SIMPLEX TRADING, LLC | New | $0200 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Holders, Q2 2023
| Manager | Shares | Change |
|---|---|---|
| Point72 Asset Management, L.P. 0.04% of their portfolio | 10.6m $12.1m | Added +10.5m |
| Verition Fund Management LLC 0.19% of their portfolio | 10.5m $12.1m | Added +7.5m |
| Cormorant Asset Management, LP 0.62% of their portfolio | 9.5m $10.9m | New |
| PFM Health Sciences, LP 0.41% of their portfolio | 8.9m $10.2m | Added +6.7m |
| SPHERA FUNDS MANAGEMENT LTD. 2.16% of their portfolio | 8.8m $10.1m | New |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.02% of their portfolio | 7.9m $9.1m | Added +6.0m |
| Venrock Adviser, LLC 0.98% of their portfolio | 5.3m $6.1m | New |
| KINGDON CAPITAL MANAGEMENT, L.L.C. 1.04% of their portfolio | 5.2m $6.0m | Added +500.0k |
| Velan Capital Investment Management LP 5.60% of their portfolio | 5.2m $6.0m | Unchanged |
| Tri Locum Partners LP 2.09% of their portfolio | 4.9m $5.6m | Added +2.4m |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 4.5m $5.1m | Added +426.4k |
| ACUTA CAPITAL PARTNERS, LLC 3.31% of their portfolio | 4.2m $4.9m | New |
| SILVERARC CAPITAL MANAGEMENT, LLC 1.35% of their portfolio | 3.5m $4.0m | New |
| Ally Bridge Group (NY) LLC 4.46% of their portfolio | 3.2m $3.7m | New |
| VANGUARD GROUP INC 0.00% of their portfolio | 2.4m $2.7m | Added +224.7k |
| Soleus Capital Management, L.P. 0.27% of their portfolio | 2.1m $2.4m | New |
| BAKER BROS. ADVISORS LP 0.01% of their portfolio | 1.9m $2.2m | Unchanged |
| ACADIAN ASSET MANAGEMENT LLC 0.01% of their portfolio | 1.5m $1.8m | Added +146.8k |
| CIBC Asset Management Inc 0.01% of their portfolio | 1.5m $1.8m | Added +246.0k |
| Vida Ventures Advisors, LLC 2.21% of their portfolio | 1.5m $1.7m | Unchanged |
| Altium Capital Management LLC 1.28% of their portfolio | 1.4m $1.6m | New |
| Maven Securities LTD 0.22% of their portfolio | 1.4m $1.6m | New |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.01% of their portfolio | 1.3m $1.5m | New |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 1.2m $1.4m | Added +1.1m |
| Blackstone Inc. 0.01% of their portfolio | 1.1m $1.2m | Unchanged |
| 72 Investment Holdings, LLC 8.86% of their portfolio | 989.0k $1.1m | Unchanged |
| Schonfeld Strategic Advisors LLC 0.01% of their portfolio | 719.8k $827.7k | Added +188.1k |
| HARVARD MANAGEMENT CO INC 0.08% of their portfolio | 692.6k $797.0k | Reduced -85.9k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 659.2k $758.1k | Added +35.4k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 655.8k $754.0k | Added +275.8k |
| BlackRock Inc. 0.00% of their portfolio | 603.9k $694.5k | Reduced -2.3m |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.01% of their portfolio | 583.5k $671.1k | Added +76.3k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 443.3k $509.8k | Reduced -392.3k |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 365.7k $420.5k | Reduced -22.1k |
| J. Goldman & Co LP 0.02% of their portfolio | 270.0k $310.5k | Added +135.0k |
| MORGAN STANLEY 0.00% of their portfolio | 243.0k $279.4k | Reduced -585.5k |
| STATE STREET CORP 0.00% of their portfolio | 210.6k $242.2k | Reduced -758.0k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 153.5k $176.6k | Reduced -607.2k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 151.6k $174.4k | Added +47.3k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 120.5k $138.6k | Reduced -285.7k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 101.7k $117.0k | Reduced -54.1k |
| CVI Holdings, LLC 0.11% of their portfolio | 89.2k $102.5k | New |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 75.7k $87.1k | New |
| Tekla Capital Management LLC 0.00% of their portfolio | 75.0k $86.2k | Unchanged |
| PEAK6 Investments LLC 0.01% of their portfolio | 74.5k $85.6k | Reduced -15.0k |
| Y-Intercept (Hong Kong) Ltd 0.01% of their portfolio | 67.2k $77.3k | New |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 38.7k $44.5k | New |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 31.8k $36.5k | Added +12.7k |
| Alta Wealth Advisors LLC 0.02% of their portfolio | 31.0k $35.7k | Unchanged |
| OLD MISSION CAPITAL LLC 0.00% of their portfolio | 25.0k $28.8k | New |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 24.8k $28.5k | Reduced -147.1k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 21.2k $24.3k | Reduced -108.1k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 21.1k $24.3k | Reduced -226.5k |
| Engineers Gate Manager LP 0.00% of their portfolio | 19.5k $22.4k | New |
| XTX Topco Ltd 0.00% of their portfolio | 18.1k $20.9k | New |
| NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio | 16.1k $18.5k | New |
| Ergoteles LLC 0.00% of their portfolio | 15.2k $17.4k | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 14.7k $16.9k | Reduced -112.2k |
| GSA CAPITAL PARTNERS LLP 0.00% of their portfolio | 12.3k $14.0k | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 12.1k $13.9k | Reduced -40.7k |
| Cetera Advisors LLC 0.00% of their portfolio | 11.2k $12.9k | Unchanged |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 11.2k $12.9k | Reduced -1.1k |
| Zuckerman Investment Group, LLC 0.00% of their portfolio | 10.5k $12.1k | Unchanged |
| Quantum Private Wealth, LLC 0.01% of their portfolio | 10.4k $12.0k | Reduced -247 |
| Balyasny Asset Management L.P. 0.00% of their portfolio | 10.3k $11.9k | New |
| UBS Group AG 0.00% of their portfolio | 7.6k $8.8k | Reduced -12.1k |
| FMR LLC 0.00% of their portfolio | 3.8k $4.3k | Added +2.5k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 3.6k $4.1k | Reduced -59.8k |
| Cutler Group LLC / CA 0.00% of their portfolio | 2.4k $2.0k | Unchanged |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 2.3k $2.6k | Reduced -24.0k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.5k $1.7k | Reduced -36.5k |
| TORONTO DOMINION BANK 0.00% of their portfolio | 800 $0 | New |
| Allworth Financial LP 0.00% of their portfolio | 632 $727 | Unchanged |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 362 $416 | Reduced -8.1k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 327 $376 | Reduced -5.5k |
| CITIGROUP INC 0.00% of their portfolio | 186 $214 | Reduced -1.6k |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 179 $206 | Reduced -37.5k |
| NFSG Corp 0.00% of their portfolio | 23 $26 | Unchanged |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 0 $0 | Unchanged |