PLIANT THERAPEUTICS INC PLRX
COM · Common Stock · CUSIP 729139105
Company in South San Francisco, United States
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersSouth San Francisco, CA
- Founded2016
- Websitepliantrx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 61.9m as of 2026-08-07, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.14. Options: 3 managers hold calls ($79.9k notional), 3 hold puts ($172.1k).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 110 |
| Q4 2022 | 126 |
| Q1 2023 | 143 |
| Q2 2023 | 147 |
| Q3 2023 | 138 |
| Q4 2023 | 136 |
| Q1 2024 | 137 |
| Q2 2024 | 146 |
| Q3 2024 | 153 |
| Q4 2024 | 163 |
| Q1 2025 | 142 |
| Q2 2025 | 115 |
| Q3 2025 | 100 |
| Q4 2025 | 98 |
| Q1 2026 | 91 |
| Q2 2026 | 86 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 80 | 49 |
| Q4 2024 | 73 | 56 |
| Q1 2025 | 71 | 88 |
| Q2 2025 | 53 | 90 |
| Q3 2025 | 34 | 66 |
| Q4 2025 | 40 | 48 |
| Q1 2026 | 35 | 42 |
| Q2 2026 | 25 | 40 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $107.4k | $161.0k | 1.50 |
| Q4 2025 | $230.7k | $247.3k | 1.07 |
| Q1 2026 | $89.0k | $238.4k | 2.68 |
| Q2 2026 | $79.9k | $172.1k | 2.15 |
Biggest buyers
| ADAR1 Capital Management, LLC | Added | +2.9m |
| Lynx1 Capital Management LP | New | +1.8m |
| Ikarian Capital, LLC | New | +1.0m |
| BOOTHBAY FUND MANAGEMENT, LLC | New | +303.0k |
| RENAISSANCE TECHNOLOGIES LLC | Added | +197.0k |
| Verdad Advisers, LP | Added | +183.0k |
| Marquette Asset Management, LLC | New | +174.5k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +161.3k |
| VANGUARD CAPITAL MANAGEMENT LLC | Added | +97.2k |
| BlackRock, Inc. | Added | +54.8k |
Biggest sellers
| Blue Owl Capital Holdings LP | Sold out | -3.0m |
| CITADEL ADVISORS LLC | Reduced | -1.1m |
| MILLENNIUM MANAGEMENT LLC | Reduced | -621.1k |
| UBS Group AG | Reduced | -486.2k |
| Centiva Capital, LP | Sold out | -432.5k |
| GOLDMAN SACHS GROUP INC | Reduced | -388.3k |
| Woodline Partners LP | Reduced | -370.3k |
| BANK OF AMERICA CORP /DE/ | Sold out | -352.7k |
| TORNO CAPITAL, LLC | Reduced | -348.6k |
| Prosight Management, LP | Reduced | -297.4k |
Biggest calls
| JANE STREET GROUP, LLC | New | $70.6k61.9k shares |
| SIMPLEX TRADING, LLC | Reduced | $9.2k8.1k shares |
| GROUP ONE TRADING LLC | Reduced | $114100 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $93.4k81.9k shares |
| SIMPLEX TRADING, LLC | Reduced | $65.0k57.0k shares |
| JANE STREET GROUP, LLC | Reduced | $13.8k12.1k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
TANG CAPITAL MANAGEMENT LLC
13D · may seek influence
new · filed 2025-03-10
Stated purposeThe Reporting Persons purchased the Common Stock reported hereunder for investment purposes, and such purchases were made in the Reporting Persons' ordinary course of business. As with their other investments, the Reporting Persons continuously evaluate the Issuer, including, but not limited to, its businesses, operations and prospects. The Reporting Persons may engage in discussions with the Issuer and its representatives and/or other stockholders, seek to enter into a confidentiality agreement with the Issuer and/or discuss with the Issuer different strategic alternatives or changes to the Issuer's operations. There can be no certainty as to whether discussions with the Issuer will occur, the outcome of any such discussions or whether the Reporting Persons will take any actions relating… Full filing |
9.6% |
| ADAR1 Capital Management, LLC 13G · institution new · filed 2026-08-14 | 8.9% |
Fell to 5% or below in the last year: CITADEL ADVISORS LLC (3.5%, 2026-08-14), Point72 Asset Management, L.P. (0.1%, 2026-02-17), Woodline Partners LP (3.3%, 2026-02-17), MORGAN STANLEY (0.9%, 2026-01-08), Deep Track Capital, LP (0.0%, 2025-11-14)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 6 | $1.5m | $1.5m |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 0 | — | — |
| Q1 2026 | 0 | — | 4 | $163.6k | $163.6k |
| Q2 2026 | 0 | — | 0 | — | — |
| Q3 2026 | 0 | — | 0 | — | — |
None reported since 1 Apr 2026.
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| TANG CAPITAL MANAGEMENT LLC 0.32% of their portfolio | 6.1m $7.0m | Reduced -1.9k |
| ADAR1 Capital Management, LLC 0.30% of their portfolio | 5.5m $6.3m | Added +2.9m |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 2.4m $2.8m | Added +97.2k |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 2.4m $2.7m | Unchanged |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 2.3m $2.6m | Added +9.7k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 2.1m $2.4m | Reduced -1.1m |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 2.0m $2.3m | Added +197.0k |
| Monaco Asset Management SAM 0.82% of their portfolio | 1.9m $2.2m | Unchanged |
| Lynx1 Capital Management LP 0.24% of their portfolio | 1.8m $2.0m | New |
| BML Capital Management, LLC 1.01% of their portfolio | 1.5m $1.8m | Unchanged |
| Prosight Management, LP 0.27% of their portfolio | 1.4m $1.6m | Reduced -297.4k |
| Peapod Lane Capital LLC 1.01% of their portfolio | 1.3m $1.5m | Added +20.4k |
| Woodline Partners LP 0.00% of their portfolio | 1.3m $1.5m | Reduced -370.3k |
| BlackRock, Inc. 0.00% of their portfolio | 1.2m $1.3m | Added +54.8k |
| Ikarian Capital, LLC 0.19% of their portfolio | 1.0m $1.1m | New |
| Eversept Partners, LP 0.06% of their portfolio | 891.4k $1.0m | Unchanged |
| MARSHALL WACE, LLP 0.00% of their portfolio | 835.1k $952.0k | Reduced -160.8k |
| Redmile Group, LLC 0.06% of their portfolio | 772.1k $880.2k | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 681.6k $783.9k | Reduced -180.2k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.00% of their portfolio | 643.1k $733.2k | Reduced -75.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 578.6k $660.0k | Added +161.3k |
| UBS Group AG 0.00% of their portfolio | 571.8k $651.8k | Reduced -486.2k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 559.4k $637.8k | Reduced -621.1k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 553.6k $631.1k | Unchanged |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 536.1k $611.1k | Added +18.6k |
| BESSEMER GROUP INC 0.00% of their portfolio | 532.1k $606.0k | Unchanged |
| DAFNA Capital Management LLC 0.11% of their portfolio | 487.0k $555.2k | Unchanged |
| XTX Topco Ltd 0.01% of their portfolio | 440.8k $502.6k | Reduced -60.0k |
| Laurion Capital Management LP 0.03% of their portfolio | 412.8k $470.6k | Unchanged |
| TORNO CAPITAL, LLC 0.03% of their portfolio | 351.4k $400.6k | Reduced -348.6k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 341.8k $389.6k | Added +2.2k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.01% of their portfolio | 303.0k $345.4k | New |
| MORGAN STANLEY 0.00% of their portfolio | 299.0k $340.8k | Reduced -206.8k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 297.3k $338.9k | Unchanged |
| Verdad Advisers, LP 0.31% of their portfolio | 281.3k $320.7k | Added +183.0k |
| ArrowMark Colorado Holdings LLC 0.01% of their portfolio | 281.2k $320.6k | Unchanged |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P 0.24% of their portfolio | 275.0k $313.5k | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 253.4k $288.9k | Unchanged |
| Stonepine Capital Management, LLC 0.20% of their portfolio | 230.5k $262.8k | Added +5.9k |
| Rangeley Capital, LLC 0.24% of their portfolio | 225.0k $256.5k | Unchanged |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 208.6k $237.8k | Reduced -388.3k |
| Marquette Asset Management, LLC 0.03% of their portfolio | 174.5k $198.9k | New |
| HighMark Wealth Management LLC 0.06% of their portfolio | 166.2k $189.5k | Unchanged |
| GSA CAPITAL PARTNERS LLP 0.01% of their portfolio | 162.2k $185.0k | Reduced -239.9k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 153.7k $175.2k | Reduced -98 |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 130.0k $148.1k | Reduced -226.8k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 125.1k $142.6k | Reduced -29.1k |
| ALGERT GLOBAL LLC 0.00% of their portfolio | 123.4k $140.7k | Added +39.0k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 114.9k $131.0k | Unchanged |
| Invesco Ltd. 0.00% of their portfolio | 104.7k $119.3k | Reduced -10.5k |
| Bond & Devick Financial Network, Inc. 0.03% of their portfolio | 100.2k $114.2k | Unchanged |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 99.8k $113.8k | Unchanged |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 55.1k $62.8k | Unchanged |
| Squarepoint Ops LLC 0.00% of their portfolio | 40.8k $46.5k | Reduced -122.4k |
| Headlands Technologies LLC 0.00% of their portfolio | 33.7k $38.4k | New |
| Quadrature Capital Ltd 0.00% of their portfolio | 33.3k $37.9k | Reduced -17.7k |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 29.7k $33.9k | Unchanged |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 29.1k $33.1k | Reduced -33.6k |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 0.00% of their portfolio | 28.5k $32.5k | Unchanged |
| Spark Investment Management LLC 0.05% of their portfolio | 22.6k $25.8k | New |
| Blackstone Inc. 0.00% of their portfolio | 22.2k $25.3k | Unchanged |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 20.1k $22.9k | Reduced -27.0k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 19.5k $22.2k | Unchanged |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.00% of their portfolio | 18.1k $20.6k | Unchanged |
| Bank of New York Mellon Corp 0.00% of their portfolio | 16.0k $18.3k | Added +208 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 15.5k $17.6k | Reduced -37.5k |
| NewEdge Advisors, LLC 0.00% of their portfolio | 15.0k $17.1k | New |
| Fiduciary Trust Co 0.00% of their portfolio | 11.6k $13.2k | Unchanged |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 10.0k $11.4k | Reduced -933 |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 4.9k $5.6k | Reduced -43.1k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 995 $2.0k | Reduced -2 |
| Rockefeller Capital Management L.P. 0.00% of their portfolio | 660 $752 | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 657 $749 | Unchanged |
| HARBOUR INVESTMENTS, INC. 0.00% of their portfolio | 590 $672 | Added +102 |
| BARCLAYS PLC 0.00% of their portfolio | 426 $486 | Added +392 |
| FMR LLC 0.00% of their portfolio | 419 $478 | Reduced -105 |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 300 $342 | Unchanged |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 50 $57 | Unchanged |
| Truvestments Capital LLC 0.00% of their portfolio | 50 $57 | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio | 36 $41 | Unchanged |
| Capital Advisors, Ltd. LLC 0.00% of their portfolio | 31 $0 | Added +11 |
| Caitong International Asset Management Co., Ltd 0.00% of their portfolio | 8 $9 | Added +4 |
| Farther Finance Advisors, LLC 0.00% of their portfolio | 5 $6 | Unchanged |
| FIFTH THIRD BANCORP 0.00% of their portfolio | 4 $5 | Unchanged |
| IFG Advisory, LLC 0.00% of their portfolio | 4 $5 | New |
| Global Retirement Partners, LLC 0.00% of their portfolio | 4 $5 | First filing |