PTC THERAPEUTICS INC PTCT
COM · Common Stock · CUSIP 69366J200 · ISIN US69366J2006
Pharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersWarren, NJ
- Founded1998
- Websiteptcbio.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($7.7m this quarter). Holder counts are more reliable. Shares outstanding: 80.3m as of 2025-11-03, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $75.95. Options: 10 managers hold calls ($22.4m notional), 8 hold puts ($17.4m).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 213 |
| Q4 2022 | 203 |
| Q1 2023 | 203 |
| Q2 2023 | 207 |
| Q3 2023 | 182 |
| Q4 2023 | 174 |
| Q1 2024 | 185 |
| Q2 2024 | 200 |
| Q3 2024 | 204 |
| Q4 2024 | 242 |
| Q1 2025 | 263 |
| Q2 2025 | 286 |
| Q3 2025 | 295 |
| Q4 2025 | 354 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 83 | 90 |
| Q2 2024 | 119 | 88 |
| Q3 2024 | 98 | 95 |
| Q4 2024 | 123 | 95 |
| Q1 2025 | 131 | 118 |
| Q2 2025 | 167 | 115 |
| Q3 2025 | 153 | 142 |
| Q4 2025 | 206 | 133 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $15.8m | $12.5m | 0.79 |
| Q2 2025 | $13.1m | $7.7m | 0.59 |
| Q3 2025 | $50.2m | $13.8m | 0.27 |
| Q4 2025 | $22.4m | $17.4m | 0.78 |
Biggest buyers
| BlackRock, Inc. | Added | +5.6m |
| JANUS HENDERSON GROUP PLC | Added | +1.1m |
| STATE STREET CORP | Added | +1.1m |
| TORONTO DOMINION BANK | Added | +891.7k |
| BNP PARIBAS FINANCIAL MARKETS | Added | +808.5k |
| SG Americas Securities, LLC | Added | +764.4k |
| Avoro Capital Advisors LLC | New | +685.0k |
| VANGUARD GROUP INC | Added | +514.2k |
| UBS Group AG | Added | +512.4k |
| MORGAN STANLEY | Added | +485.8k |
Biggest sellers
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -1.1m |
| MILLENNIUM MANAGEMENT LLC | Reduced | -1.0m |
| JPMORGAN CHASE & CO | Reduced | -625.8k |
| CITADEL ADVISORS LLC | Reduced | -576.6k |
| ARMISTICE CAPITAL, LLC | Reduced | -475.4k |
| Qube Research & Technologies Ltd | Sold out | -430.9k |
| D. E. Shaw & Co., Inc. | Reduced | -429.6k |
| Pictet Asset Management Holding SA | Reduced | -429.0k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -319.7k |
| Pacer Advisors, Inc. | Reduced | -268.3k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $9.8m129.2k shares |
| Caption Management, LLC | Added | $7.6m100.0k shares |
| JPMORGAN CHASE & CO | New | $2.1m27.0k shares |
| CITIGROUP INC | New | $1.1m15.0k shares |
| CITADEL ADVISORS LLC | Reduced | $888.7k11.7k shares |
| JANE STREET GROUP, LLC | Reduced | $364.6k4.8k shares |
| Walleye Trading LLC | Added | $296.2k3.9k shares |
| SIMPLEX TRADING, LLC | Reduced | $129.1k1.7k shares |
| Walleye Capital LLC | New | $60.8k800 shares |
| GROUP ONE TRADING LLC | Reduced | $30.4k400 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $9.8m128.7k shares |
| JANE STREET GROUP, LLC | Added | $2.4m31.9k shares |
| JPMORGAN CHASE & CO | New | $2.1m27.0k shares |
| CITIGROUP INC | New | $1.1m15.0k shares |
| Walleye Trading LLC | Added | $615.3k8.1k shares |
| CITADEL ADVISORS LLC | Reduced | $577.3k7.6k shares |
| Walleye Capital LLC | Added | $448.2k5.9k shares |
| SIMPLEX TRADING, LLC | Added | $379.8k5.0k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution +6.8 pts · filed 2025-12-04 | 14.8% |
| JANUS HENDERSON GROUP PLC 13G · institution +2.7 pts · filed 2026-05-15 | 8.7% |
| ARMISTICE CAPITAL, LLC 13G · institution -1.4 pts · filed 2025-05-15 | 6.9% |
| VANGUARD PORTFOLIO MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 5.9% |
| STATE STREET CORP 13G · institution new · filed 2026-02-09 | 5.2% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.2% |
Fell to 5% or below in the last year: TORONTO DOMINION BANK (3.7%, 2026-05-15), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD PORTFOLIO MANAGEMENT LLC), WELLINGTON MANAGEMENT GROUP LLP (4.8%, 2026-02-10)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 0 | — | 8 | $1.3m | $1.3m |
| Q2 2024 | 0 | — | 4 | $921.8k | $887.1k |
| Q3 2024 | 0 | — | 1 | $77.2k | $77.2k |
| Q4 2024 | 0 | — | 5 | $11.3m | $11.3m |
| Q1 2025 | 0 | — | 9 | $7.8m | $7.5m |
| Q2 2025 | 0 | — | 3 | $308.5k | $178.8k |
| Q3 2025 | 0 | — | 7 | $7.7m | $6.9m |
| Q4 2025 | 0 | — | 6 | $27.4m | $27.4m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2025-12-30 | Klein Matthew B. CHIEF EXECUTIVE OFFICER, director | Sold plan | $619.9k8.1k shares |
| 2025-12-19 | Pauwels Eric CHIEF BUSINESS OFFICER | Sold plan | $1.6m20.5k shares |
| 2025-12-18 | Pauwels Eric CHIEF BUSINESS OFFICER | Sold plan | $240.4k3.2k shares |
| 2025-12-17 | Pauwels Eric CHIEF BUSINESS OFFICER | Sold plan | $3.0m40.3k shares |
| 2025-12-03 | Reeve Emma Director | Sold plan | $57.6k733 shares |
| 2025-12-02 | Klein Matthew B. CHIEF EXECUTIVE OFFICER, director | Sold plan | $271.1k3.4k shares |
| 2025-11-25 | Almstead Neil Gregory CHIEF TECHNICAL OPS OFFICER | Sold plan | $6.0m71.9k shares |
| 2025-11-25 | Jacobson Allan Steven Director | Sold plan | $1.2m14.2k shares |
| 2025-11-24 | Almstead Neil Gregory CHIEF TECHNICAL OPS OFFICER | Sold plan | $2.9m35.6k shares |
| 2025-11-24 | Jacobson Allan Steven Director | Sold plan | $945.7k11.8k shares |
| 2025-11-21 | Reeve Emma Director | Sold plan | $795.0k10.0k shares |
| 2025-11-17 | Boulding Mark Elliott EXEC. VP AND CLO | Sold plan | $213.7k2.8k shares |
| 2025-11-12 | Reeve Emma Director | Sold plan | $546.3k7.3k shares |
| 2025-10-30 | Reeve Emma Director | Sold plan | $1.1m15.7k shares |
| 2025-10-07 | Boulding Mark Elliott EXEC. VP AND CLO | Sold plan | $214.1k3.4k shares |
| 2025-10-06 | Boulding Mark Elliott EXEC. VP AND CLO | Sold plan | $147.4k2.3k shares |
| 2025-10-03 | Almstead Neil Gregory CHIEF TECHNICAL OPS OFFICER | Sold plan | $3.6m55.0k shares |
| 2025-10-03 | Reeve Emma Director | Sold plan | $1.7m25.6k shares |
| 2025-10-03 | Boulding Mark Elliott EXEC. VP AND CLO | Sold plan | $1.5m22.7k shares |
| 2025-10-03 | Jacobson Allan Steven Director | Sold plan | $780.0k12.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.02% of their portfolio | 12.8m $970.7m | Added +5.6m |
| VANGUARD GROUP INC 0.01% of their portfolio | 8.8m $668.7m | Added +514.2k |
| RTW INVESTMENTS, LP 5.89% of their portfolio | 7.7m $588.4m | Unchanged |
| JANUS HENDERSON GROUP PLC 0.17% of their portfolio | 4.9m $368.6m | Added +1.1m |
| STATE STREET CORP 0.01% of their portfolio | 4.2m $319.5m | Added +1.1m |
| TORONTO DOMINION BANK 0.55% of their portfolio | 4.1m $314.3m | Added +891.7k |
| WELLINGTON MANAGEMENT GROUP LLP 0.05% of their portfolio | 3.9m $293.8m | Reduced -1.1m |
| ARMISTICE CAPITAL, LLC 5.21% of their portfolio | 2.8m $212.8m | Reduced -475.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 2.0m $153.2m | Added +65.2k |
| D. E. Shaw & Co., Inc. 0.10% of their portfolio | 1.7m $132.5m | Reduced -429.6k |
| FMR LLC 0.01% of their portfolio | 1.7m $127.7m | Added +69.4k |
| Jefferies Financial Group Inc. 1.03% of their portfolio | 1.7m $126.0m | Added +73.8k |
| TANG CAPITAL MANAGEMENT LLC 5.63% of their portfolio | 1.5m $113.9m | Unchanged |
| BANK OF AMERICA CORP /DE/ 0.01% of their portfolio | 1.4m $108.7m | Reduced -85.5k |
| FRANKLIN RESOURCES INC 0.02% of their portfolio | 1.3m $97.7m | Added +129.7k |
| CITADEL ADVISORS LLC 0.06% of their portfolio | 1.2m $87.7m | Reduced -576.6k |
| Driehaus Capital Management LLC 0.59% of their portfolio | 1.1m $86.3m | Added +4.4k |
| Point72 Asset Management, L.P. 0.13% of their portfolio | 1.1m $85.7m | Reduced -92.1k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 1.0m $77.7m | Added +146.7k |
| Hood River Capital Management LLC 0.84% of their portfolio | 1.0m $76.2m | Added +7.3k |
| Pictet Asset Management Holding SA 0.07% of their portfolio | 979.0k $74.8m | Reduced -429.0k |
| UBS Group AG 0.01% of their portfolio | 964.7k $73.3m | Added +512.4k |
| MORGAN STANLEY 0.00% of their portfolio | 905.2k $68.8m | Added +485.8k |
| Palo Alto Investors LP 9.56% of their portfolio | 903.9k $68.7m | Added +41.3k |
| SG Americas Securities, LLC 0.09% of their portfolio | 894.5k $67.9m | Added +764.4k |
| BNP PARIBAS FINANCIAL MARKETS 0.04% of their portfolio | 828.7k $62.9m | Added +808.5k |
| NORTHERN TRUST CORP 0.01% of their portfolio | 769.4k $58.4m | Added +31.9k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 734.9k $55.8m | Added +32.2k |
| Nuveen, LLC 0.01% of their portfolio | 699.2k $53.1m | Reduced -22.0k |
| Avoro Capital Advisors LLC 0.51% of their portfolio | 685.0k $52.0m | New |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.06% of their portfolio | 647.6k $49.2m | Reduced -153.3k |
| LORD, ABBETT & CO. LLC 0.15% of their portfolio | 627.1k $47.6m | Added +249.1k |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 627.1k $47.6m | Reduced -146.1k |
| RENAISSANCE TECHNOLOGIES LLC 0.07% of their portfolio | 607.6k $46.2m | Reduced -319.7k |
| Woodline Partners LP 0.17% of their portfolio | 571.6k $43.4m | Added +465.9k |
| Bank of New York Mellon Corp 0.01% of their portfolio | 514.7k $39.1m | Added +241.6k |
| Boston Partners 0.04% of their portfolio | 488.0k $37.1m | Added +126.3k |
| PRINCIPAL FINANCIAL GROUP INC 0.02% of their portfolio | 478.9k $36.4m | Added +411.2k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 460.1k $35.0m | Added +1.8k |
| Invesco Ltd. 0.00% of their portfolio | 434.3k $33.0m | Added +121.2k |
| MPM BIOIMPACT LLC 3.74% of their portfolio | 430.0k $32.7m | Reduced -8.5k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.03% of their portfolio | 426.5k $32.4m | Added +1.5k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.02% of their portfolio | 406.4k $30.9m | Added +82.9k |
| Rockefeller Capital Management L.P. 0.06% of their portfolio | 405.5k $30.8m | Reduced -68.2k |
| Legal & General Group Plc 0.01% of their portfolio | 366.3k $27.8m | Added +124.9k |
| JUPITER ASSET MANAGEMENT LTD 0.22% of their portfolio | 361.2k $27.4m | New |
| PANAGORA ASSET MANAGEMENT INC 0.10% of their portfolio | 359.8k $27.3m | Added +11.5k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 356.0k $27.0m | Reduced -625.8k |
| AQR CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 341.9k $26.0m | Added +10.7k |
| VOYA INVESTMENT MANAGEMENT LLC 0.03% of their portfolio | 339.1k $25.8m | Added +54.3k |
| Public Sector Pension Investment Board 0.08% of their portfolio | 324.6k $24.7m | New |
| Ensign Peak Advisors, Inc 0.04% of their portfolio | 280.6k $21.3m | Reduced -8.2k |
| Russell Investments Group, Ltd. 0.02% of their portfolio | 270.7k $20.6m | Added +23.3k |
| Empowered Funds, LLC 0.32% of their portfolio | 250.4k $19.0m | Added +206.7k |
| MARSHALL WACE, LLP 0.02% of their portfolio | 247.7k $18.8m | Added +90.0k |
| MACKENZIE FINANCIAL CORP 0.02% of their portfolio | 236.9k $18.0m | Added +35.1k |
| Pacer Advisors, Inc. 0.05% of their portfolio | 235.7k $17.9m | Reduced -268.3k |
| DEUTSCHE BANK AG\ 0.01% of their portfolio | 231.3k $17.6m | Added +151.4k |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main 0.01% of their portfolio | 220.8k $16.8m | Reduced -16.3k |
| BARCLAYS PLC 0.01% of their portfolio | 220.2k $16.7m | Reduced -19.5k |
| RHUMBLINE ADVISERS 0.01% of their portfolio | 207.9k $15.8m | Added +94.0k |
| Boxer Capital Management, LLC 3.33% of their portfolio | 200.0k $15.2m | Unchanged |
| PRUDENTIAL FINANCIAL INC 0.02% of their portfolio | 183.2k $13.9m | Added +95.7k |
| Parkman Healthcare Partners LLC 1.16% of their portfolio | 160.2k $12.2m | Reduced -42.2k |
| BI Asset Management Fondsmaeglerselskab A/S 0.11% of their portfolio | 159.5k $12.1m | Added +64.5k |
| FIRST TRUST ADVISORS LP 0.01% of their portfolio | 155.6k $11.8m | Added +33.7k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.02% of their portfolio | 151.4k $11.5m | Added +19.3k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 147.6k $11.2m | Added +137.0k |
| Swiss National Bank 0.01% of their portfolio | 141.1k $10.7m | Added +2.8k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.02% of their portfolio | 141.0k $10.7m | Reduced -150.0k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 131.9k $10.0m | Added +2.0k |
| Ikarian Capital, LLC 1.17% of their portfolio | 118.7k $9.0m | Reduced -161.9k |
| FEDERATED HERMES, INC. 0.01% of their portfolio | 112.6k $8.6m | Added +97.8k |
| NEUBERGER BERMAN GROUP LLC 0.01% of their portfolio | 111.6k $8.5m | Added +108.0k |
| WCM INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio | 110.3k $8.4m | Reduced -36.8k |
| CASTLEARK MANAGEMENT LLC 0.22% of their portfolio | 96.9k $7.4m | New |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 94.3k $7.2m | Added +2.3k |
| SEI INVESTMENTS CO 0.01% of their portfolio | 92.1k $7.0m | Added +33.7k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 86.9k $6.6m | Added +35.5k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 86.0k $6.5m | Added +2.9k |
| PINNACLE ASSOCIATES LTD 0.08% of their portfolio | 83.4k $6.3m | Reduced -5.2k |
| ROYCE & ASSOCIATES LP 0.06% of their portfolio | 80.8k $6.1m | Added +48.0k |
| Rafferty Asset Management, LLC 0.02% of their portfolio | 78.5k $6.0m | Reduced -22.5k |
| CANADA LIFE ASSURANCE Co 0.01% of their portfolio | 78.2k $5.9m | Added +44.2k |
| Abacus FCF Advisors LLC 0.75% of their portfolio | 75.8k $5.8m | New |
| Hillsdale Investment Management Inc. 0.16% of their portfolio | 75.7k $5.8m | Reduced -15.4k |
| CANADA PENSION PLAN INVESTMENT BOARD 0.00% of their portfolio | 75.4k $5.7m | New |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 72.6k $5.5m | Added +38.5k |
| Alyeska Investment Group, L.P. 0.02% of their portfolio | 72.3k $5.5m | New |
| Informed Momentum Co LLC 0.61% of their portfolio | 71.7k $5.4m | New |
| ACADIAN ASSET MANAGEMENT LLC 0.01% of their portfolio | 69.5k $5.3m | Added +45.4k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio | 68.3k $5.2m | Added +3.8k |
| HRT FINANCIAL LP 0.02% of their portfolio | 67.1k $5.1m | Added +55.3k |
| SECTOR GAMMA AS 1.07% of their portfolio | 61.9k $4.7m | Reduced -56.2k |
| Rock Springs Capital Management LP 0.24% of their portfolio | 61.9k $4.7m | New |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 56.6k $4.3m | Reduced -19.5k |
| Thrivent Financial for Lutherans 0.01% of their portfolio | 55.2k $4.2m | New |
| Assenagon Asset Management S.A. 0.01% of their portfolio | 54.2k $4.1m | Reduced -53.5k |
| NORGES BANK 0.00% of their portfolio | 53.8k $4.1m | Not comparable |
| SEGALL BRYANT & HAMILL, LLC 0.05% of their portfolio | 50.4k $3.8m | Added +13.0k |