OPKO HEALTH INC OPK
COM · Common Stock · CUSIP 68375N103 · ISIN US68375N1037
Medical test and medication company
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.8k this quarter). Holder counts are more reliable. Shares outstanding: 755.1m as of 2026-04-17, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.14. Options: 6 managers hold calls ($516.6k notional), 3 hold puts ($111.9k).
Trends to Q1 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 221 |
| Q4 2022 | 222 |
| Q1 2023 | 227 |
| Q2 2023 | 230 |
| Q3 2023 | 226 |
| Q4 2023 | 220 |
| Q1 2024 | 227 |
| Q2 2024 | 234 |
| Q3 2024 | 235 |
| Q4 2024 | 237 |
| Q1 2025 | 256 |
| Q2 2025 | 223 |
| Q3 2025 | 233 |
| Q4 2025 | 221 |
| Q1 2026 | 236 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2024 | 76 | 98 |
| Q3 2024 | 85 | 95 |
| Q4 2024 | 93 | 87 |
| Q1 2025 | 116 | 81 |
| Q2 2025 | 68 | 114 |
| Q3 2025 | 105 | 67 |
| Q4 2025 | 66 | 110 |
| Q1 2026 | 94 | 85 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2025 | $3.8m | $568.8k | 0.15 |
| Q3 2025 | $4.3m | $209.0k | 0.05 |
| Q4 2025 | $2.0m | $100.2k | 0.05 |
| Q1 2026 | $516.6k | $111.9k | 0.22 |
Biggest buyers
| GOLDMAN SACHS GROUP INC | Added | +1.7m |
| BlackRock, Inc. | Added | +1.4m |
| OP Asset Management Ltd | New | +1.1m |
| UBS Group AG | Added | +718.6k |
| STATE STREET CORP | Added | +549.6k |
| BANK OF AMERICA CORP /DE/ | Added | +523.6k |
| FIRST TRUST ADVISORS LP | New | +500.3k |
| Kovack Advisors, Inc. | New | +459.7k |
| Qube Research & Technologies Ltd | Added | +301.6k |
| MORGAN STANLEY | Added | +278.7k |
Biggest sellers
| AQR CAPITAL MANAGEMENT LLC | Reduced | -1.3m |
| CITADEL ADVISORS LLC | Reduced | -777.9k |
| JANE STREET GROUP, LLC | Reduced | -661.0k |
| HRT FINANCIAL LP | Reduced | -584.7k |
| TWO SIGMA INVESTMENTS, LP | Reduced | -564.7k |
| BARCLAYS PLC | Reduced | -524.9k |
| TWO SIGMA SECURITIES, LLC | Sold out | -374.5k |
| CAPITAL ADVISORS INC/OK | Reduced | -350.0k |
| WELLS FARGO & COMPANY/MN | Reduced | -305.9k |
| MILLENNIUM MANAGEMENT LLC | Sold out | -265.3k |
Biggest calls
| SIMPLEX TRADING, LLC | Reduced | $191.7k168.2k shares |
| CITADEL ADVISORS LLC | Added | $108.4k95.1k shares |
| IMC-Chicago, LLC | New | $91.9k80.6k shares |
| GROUP ONE TRADING LLC | Reduced | $60.8k53.3k shares |
| JANE STREET GROUP, LLC | Added | $56.3k49.4k shares |
| Raiffeisen Bank International AG | Unchanged | $7.4k6.5k shares |
Biggest puts
| CITADEL ADVISORS LLC | Reduced | $68.9k60.4k shares |
| IMC-Chicago, LLC | New | $39.4k34.6k shares |
| GROUP ONE TRADING LLC | Added | $3.6k3.2k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FROST PHILLIP MD ET AL 13D · may seek influence +1.3 pts · filed 2026-07-01 | 34.1% |
| Rubric Capital Management LP 13G · institution filed 2025-07-09 | 6.0% |
Insider purchases and sales in Q1 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2024 | 1 | $338.6k | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 1 | $2.0m | 0 | — | — |
| Q1 2025 | 1 | $1.7m | 0 | — | — |
| Q2 2025 | 1 | $520.0k | 0 | — | — |
| Q3 2025 | 1 | $891.0k | 0 | — | — |
| Q4 2025 | 1 | $3.2m | 0 | — | — |
| Q1 2026 | 1 | $11.4k | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-03-20 | PAGANELLI JOHN A Director | Bought | $11.4k10.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2026
| Manager | Shares | Change |
|---|---|---|
| Rubric Capital Management LP 0.67% of their portfolio | 47.8m $54.5m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 36.2m $41.3m | Added +1.4m |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 14.8m $16.8m | First filing |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 14.5m $16.5m | First filing |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 11.3m $12.9m | Added +240.2k |
| STATE STREET CORP 0.00% of their portfolio | 9.5m $10.8m | Added +549.6k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 7.7m $8.7m | Added +1.7m |
| UBS Group AG 0.00% of their portfolio | 6.1m $6.9m | Added +718.6k |
| Whitefort Capital Management, LP 1.48% of their portfolio | 4.3m $4.8m | Unchanged |
| NORTHERN TRUST CORP 0.00% of their portfolio | 3.6m $4.1m | Added +181.0k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 3.6m $4.1m | Reduced -118.6k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 2.7m $3.1m | First filing |
| AWM Investment Company, Inc. 0.27% of their portfolio | 2.1m $2.4m | Unchanged |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 2.1m $2.4m | Reduced -777.9k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 1.6m $1.8m | Reduced -51.3k |
| WASHINGTON GROWTH STRATEGIES LLC 1.01% of their portfolio | 1.4m $1.5m | Unchanged |
| Y.D. More Investments Ltd 0.06% of their portfolio | 1.3m $1.5m | Reduced -7.0k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 1.3m $1.5m | Reduced -30.1k |
| MORGAN STANLEY 0.00% of their portfolio | 1.2m $1.4m | Added +278.7k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 1.2m $1.3m | Added +58.8k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.1m $1.3m | Added +523.6k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 1.1m $1.3m | Reduced -661.0k |
| PFG Investments, LLC 0.06% of their portfolio | 1.1m $1.3m | Reduced -207.6k |
| OP Asset Management Ltd 0.01% of their portfolio | 1.1m $1.3m | New |
| Clearstead Advisors, LLC 0.01% of their portfolio | 884.1k $1.0m | Added +1.8k |
| Tejara Capital Ltd 0.33% of their portfolio | 877.9k $1.0m | Unchanged |
| Nuveen, LLC 0.00% of their portfolio | 847.0k $965.6k | Added +5.2k |
| Swiss National Bank 0.00% of their portfolio | 845.8k $964.2k | Unchanged |
| Invesco Ltd. 0.00% of their portfolio | 793.2k $904.2k | Added +11.5k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 763.6k $870.5k | Reduced -1.3m |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 674.8k $769.3k | Added +1.3k |
| GSA CAPITAL PARTNERS LLP 0.05% of their portfolio | 663.7k $757.0k | Added +42.4k |
| Assenagon Asset Management S.A. 0.00% of their portfolio | 652.1k $740.3k | Unchanged |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 522.9k $596.1k | Added +92.3k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 508.5k $559.3k | Reduced -71.3k |
| FIRST TRUST ADVISORS LP 0.00% of their portfolio | 500.3k $570.3k | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 497.2k $566.8k | Reduced -14.2k |
| Kovack Advisors, Inc. 0.03% of their portfolio | 459.7k $524.1k | New |
| XTX Topco Ltd 0.01% of their portfolio | 431.0k $491.3k | Added +88.2k |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 430.9k $491.2k | Reduced -210.6k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 423.2k $533.2k | Reduced -25.0k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 414.0k $472.0k | Reduced -3.1k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 404.7k $462.0k | Added +37.5k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 404.4k $461.0k | Added +301.6k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 391.5k $446.3k | Reduced -45.8k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 370.9k $422.9k | Added +45.1k |
| Legal & General Group Plc 0.00% of their portfolio | 343.5k $391.6k | Reduced -109.8k |
| EntryPoint Capital, LLC 0.11% of their portfolio | 342.2k $390.1k | Added +33.1k |
| ZAZOVE ASSOCIATES LLC 0.02% of their portfolio | 300.0k $360.0k | Added +150.0k |
| VANGUARD ASSET MANAGEMENT, Ltd 0.00% of their portfolio | 294.0k $335.2k | First filing |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 244.8k $279.1k | Unchanged |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 238.3k $272.8k | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 220.0k $251.0k | Reduced -41.0k |
| JANUS HENDERSON GROUP PLC 0.00% of their portfolio | 206.3k $236.2k | Unchanged |
| MetLife Investment Management, LLC 0.00% of their portfolio | 204.7k $233.4k | Added +29.1k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 197.9k $225.6k | Added +6.8k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 181.8k $207.2k | First filing |
| Creative Planning 0.00% of their portfolio | 177.0k $201.8k | Added +118.9k |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio | 176.3k $200.9k | Unchanged |
| GAMCO INVESTORS, INC. ET AL 0.00% of their portfolio | 175.0k $199.5k | Unchanged |
| GABELLI FUNDS LLC 0.00% of their portfolio | 170.0k $193.8k | Unchanged |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 170.0k $193.8k | Reduced -564.7k |
| State of Wyoming 0.02% of their portfolio | 167.0k $190.4k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 162.6k $185.4k | Reduced -305.9k |
| VAN ECK ASSOCIATES CORP 0.00% of their portfolio | 160.1k $183.0k | Added +23.1k |
| ProShare Advisors LLC 0.00% of their portfolio | 140.7k $160.3k | Reduced -15.7k |
| Teton Advisors, LLC 0.11% of their portfolio | 140.0k $159.6k | Unchanged |
| BARCLAYS PLC 0.00% of their portfolio | 138.3k $157.7k | Reduced -524.9k |
| U.S. Capital Wealth Advisors, LLC 0.00% of their portfolio | 133.3k $151.9k | New |
| FIFTH THIRD BANCORP 0.00% of their portfolio | 128.8k $146.8k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 128.7k $146.7k | Added +119.6k |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 125.8k $143.4k | Reduced -33.8k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 122.1k $139.2k | Reduced -107.5k |
| HIGHLINE WEALTH PARTNERS LLC 0.03% of their portfolio | 116.7k $133.0k | Reduced -1 |
| ARIZONA STATE RETIREMENT SYSTEM 0.00% of their portfolio | 116.0k $132.2k | Added +2.1k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 114.3k $130.3k | Unchanged |
| GLENMEDE TRUST CO NA 0.00% of their portfolio | 112.8k $128.5k | Reduced -733 |
| Vanguard Investments Australia, Ltd. 0.00% of their portfolio | 111.0k $126.5k | First filing |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 109.5k $124.9k | New |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 102.4k $116.7k | Unchanged |
| 360 Financial, Inc. 0.03% of their portfolio | 97.3k $110.9k | Added +10.0k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 96.7k $110.3k | Added +480 |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 93.3k $106.4k | New |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 93.2k $106.3k | Reduced -64.6k |
| HRT FINANCIAL LP 0.00% of their portfolio | 90.8k $103.0k | Reduced -584.7k |
| KLP KAPITALFORVALTNING AS 0.00% of their portfolio | 90.7k $103.4k | Unchanged |
| Cambridge Investment Research Advisors, Inc. 0.00% of their portfolio | 90.3k $103.0k | Added +558 |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 89.7k $102.3k | Reduced -701 |
| Quadrature Capital Ltd 0.00% of their portfolio | 88.9k $101.4k | Reduced -2.8k |
| RPg Family Wealth Advisory, LLC 0.02% of their portfolio | 88.6k $101.0k | Reduced -10.4k |
| SG Americas Securities, LLC 0.00% of their portfolio | 87.8k $100.0k | Added +33.8k |
| CWM, LLC 0.00% of their portfolio | 69.8k $79.6k | Added +687 |
| World Investment Advisors 0.00% of their portfolio | 66.5k $75.8k | Unchanged |
| Cascade Financial Partners, LLC 0.01% of their portfolio | 66.5k $75.8k | Unchanged |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 65.6k $74.7k | Added +39.2k |
| Pictet Asset Management Holding SA 0.00% of their portfolio | 65.5k $74.7k | Unchanged |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 62.4k $71.1k | Added +4.8k |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO 0.00% of their portfolio | 61.5k $70.0k | Unchanged |
| Cetera Investment Advisers 0.00% of their portfolio | 59.4k $67.7k | Added +189 |
| KESTRA PRIVATE WEALTH SERVICES, LLC 0.00% of their portfolio | 58.5k $66.6k | Unchanged |