OPKO HEALTH INC OPK
COM · Common Stock · CUSIP 68375N103 · ISIN US68375N1037
Medical test and medication company
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 772.7m as of 2022-10-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.25. Options: 10 managers hold calls ($3.9m notional), 9 hold puts ($2.1m).
Trends to Q4 2022
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 221 |
| Q4 2022 | 222 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $6.5m | $9.4m | 1.44 |
| Q4 2022 | $3.9m | $2.1m | 0.55 |
Biggest buyers
| MILLENNIUM MANAGEMENT LLC | Added | +1.6m |
| BANK OF AMERICA CORP /DE/ | Added | +990.3k |
| GOLDMAN SACHS GROUP INC | Added | +979.2k |
| BlackRock Inc. | Added | +968.9k |
| VANGUARD GROUP INC | Added | +835.7k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | Added | +561.1k |
| Graham Capital Management, L.P. | Added | +373.4k |
| Hennion & Walsh Asset Management, Inc. | Added | +347.6k |
| Nuveen Asset Management, LLC | Added | +239.4k |
| CITADEL ADVISORS LLC | Added | +225.4k |
Biggest sellers
| Invesco Ltd. | Reduced | -2.6m |
| ORACLE INVESTMENT MANAGEMENT INC | Reduced | -1.9m |
| DIMENSIONAL FUND ADVISORS LP | Reduced | -1.9m |
| Phoenix Financial Ltd. | Reduced | -1.5m |
| JPMORGAN CHASE & CO | Reduced | -1.1m |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -968.6k |
| GROUP ONE TRADING LLC | Sold out | -835.8k |
| TWO SIGMA INVESTMENTS, LP | Reduced | -618.4k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -549.8k |
| Bank of New York Mellon Corp | Reduced | -502.9k |
Biggest calls
| GROUP ONE TRADING LLC | Reduced | $1.9m1.5m shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $798.8k639.0k shares |
| SIMPLEX TRADING, LLC | Added | $614.0k491.3k shares |
| JANE STREET GROUP, LLC | Reduced | $316.5k253.2k shares |
| CITADEL ADVISORS LLC | Reduced | $205.2k164.2k shares |
| WOLVERINE TRADING, LLC | Reduced | $36.0k28.5k shares |
| Marathon Trading Investment Management LLC | Unchanged | $26.4k20.0k shares |
| HAP Trading, LLC | Reduced | $2.0k38.9k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
| Cutler Group LLC / CA | Reduced | $013.1k shares |
Biggest puts
| WOLVERINE ASSET MANAGEMENT LLC | Unchanged | $1.5m1.2m shares |
| CITADEL ADVISORS LLC | Reduced | $191.8k153.4k shares |
| SIMPLEX TRADING, LLC | Reduced | $177.0k142.3k shares |
| GROUP ONE TRADING LLC | Reduced | $146.5k117.2k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $73.1k58.5k shares |
| WOLVERINE TRADING, LLC | Added | $25.0k19.8k shares |
| JPMORGAN CHASE & CO | Unchanged | $3.0k2.7k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
| Cutler Group LLC / CA | Reduced | $0300 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FROST PHILLIP MD ET AL 13D · may seek influence +1.3 pts · filed 2026-07-01 | 34.1% |
| Rubric Capital Management LP 13G · institution filed 2025-07-09 | 6.0% |
Insider purchases and sales in Q4 2022
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2021 | 0 | — | 0 | — | — |
| Q2 2021 | 0 | — | 0 | — | — |
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 0 | — | — |
| Q1 2022 | 1 | $4.8m | 0 | — | — |
| Q2 2022 | 2 | $5.9m | 0 | — | — |
| Q3 2022 | 1 | $2.5m | 0 | — | — |
| Q4 2022 | 1 | $1.8m | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2022-11-22 | FROST PHILLIP MD ET AL +1 CEO & Chairman, director · See Footnote | Bought | $447.3k300.0k shares |
| 2022-11-09 | FROST PHILLIP MD ET AL +1 CEO & Chairman, director · See Footnote | Bought | $314.0k196.5k shares |
| 2022-11-09 | FROST PHILLIP MD ET AL +1 CEO & Chairman, director · Frost Gamma | Bought | $5.6k3.5k shares |
| 2022-10-27 | FROST PHILLIP MD ET AL +1 CEO & Chairman, director · See Footnote | Bought | $182.3k100.0k shares |
| 2022-10-19 | FROST PHILLIP MD ET AL +1 CEO & Chairman, director · See Footnote | Bought | $172.1k100.0k shares |
| 2022-10-14 | FROST PHILLIP MD ET AL +1 CEO & Chairman, director · See Footnote | Bought | $172.1k100.0k shares |
| 2022-10-13 | FROST PHILLIP MD ET AL +1 CEO & Chairman, director · See Footnote | Bought | $179.5k100.0k shares |
| 2022-10-12 | FROST PHILLIP MD ET AL +1 CEO & Chairman, director · See Footnote | Bought | $172.8k100.0k shares |
| 2022-10-07 | FROST PHILLIP MD ET AL +1 CEO & Chairman, director · See Footnote | Bought | $132.7k75.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q4 2022
| Manager | Shares | Change |
|---|---|---|
| VANGUARD GROUP INC 0.00% of their portfolio | 41.1m $51.4m | Added +835.7k |
| BlackRock Inc. 0.00% of their portfolio | 35.5m $44.3m | Added +968.9k |
| STATE STREET CORP 0.00% of their portfolio | 10.4m $13.1m | Added +71.0k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 9.0m $11.2m | Reduced -1.9m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 8.0m $10.0m | Added +158.2k |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 5.8m $7.2m | Reduced -182.1k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 4.4m $5.5m | Added +561.1k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 3.9m $4.8m | Reduced -52.1k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 3.8m $4.7m | Added +979.2k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 3.7m $4.7m | Added +1.6m |
| NORGES BANK 0.00% of their portfolio | 3.2m $4.0m | Unchanged |
| ORACLE INVESTMENT MANAGEMENT INC 3.51% of their portfolio | 3.2m $4.0m | Reduced -1.9m |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 2.4m $3.1m | Added +239.4k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 2.3m $2.9m | Added +40.3k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 2.3m $2.9m | Reduced -549.8k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 2.3m $2.8m | Reduced -618.4k |
| TWO SIGMA ADVISERS, LP 0.01% of their portfolio | 2.3m $2.8m | Added +140.6k |
| CITIGROUP INC 0.00% of their portfolio | 2.1m $2.7m | Reduced -9.9k |
| Numerai GP LLC 1.61% of their portfolio | 1.9m $2.4m | First filing |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 1.6m $2.1m | Added +23.5k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 1.5m $1.9m | Reduced -502.9k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.3m $1.6m | Reduced -1.1m |
| NORDEA INVESTMENT MANAGEMENT AB 0.00% of their portfolio | 1.3m $1.5m | Reduced -26.0k |
| Swiss National Bank 0.00% of their portfolio | 1.2m $1.5m | Added +164.4k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.1m $1.4m | Added +990.3k |
| MORGAN STANLEY 0.00% of their portfolio | 1.1m $1.4m | Reduced -250.9k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 1.1m $1.3m | Added +225.4k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 1.0m $1.3m | Reduced -41.9k |
| AWM Investment Company, Inc. 0.18% of their portfolio | 1.0m $1.2m | Added +200.0k |
| Graham Capital Management, L.P. 0.04% of their portfolio | 824.0k $1.0m | Added +373.4k |
| Connor, Clark & Lunn Investment Management Ltd. 0.01% of their portfolio | 818.6k $1.0m | Added +61.4k |
| JUPITER ASSET MANAGEMENT LTD 0.01% of their portfolio | 765.2k $948.8k | Unchanged |
| Invesco Ltd. 0.00% of their portfolio | 728.8k $911.0k | Reduced -2.6m |
| Candriam S.C.A. 0.01% of their portfolio | 654.6k $818.2k | Added +202.3k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 643.4k $804.0k | Reduced -5.3k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 639.8k $799.8k | Reduced -446.9k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 619.5k $774.3k | Added +13.5k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 597.0k $746.2k | Added +56.4k |
| Hennion & Walsh Asset Management, Inc. 0.04% of their portfolio | 569.5k $712.0k | Added +347.6k |
| CREDIT SUISSE AG/ 0.00% of their portfolio | 541.0k $676.3k | Added +131.7k |
| ALPS ADVISORS INC 0.01% of their portfolio | 524.6k $655.7k | Added +103.2k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 430.4k $538.0k | Reduced -19.9k |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 404.0k $504.0k | Reduced -3.6k |
| Legal & General Group Plc 0.00% of their portfolio | 399.0k $498.7k | Added +22.6k |
| OCCUDO QUANTITATIVE STRATEGIES LP 0.05% of their portfolio | 365.3k $456.6k | Added +15.7k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 357.8k $447.0k | Added +85.7k |
| Schonfeld Strategic Advisors LLC 0.00% of their portfolio | 356.0k $444.9k | Reduced -122.4k |
| TUDOR INVESTMENT CORP ET AL 0.01% of their portfolio | 341.1k $426.0k | Unchanged |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 334.1k $417.6k | Unchanged |
| Engineers Gate Manager LP 0.02% of their portfolio | 316.3k $395.4k | Added +3.2k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 313.4k $392.0k | Added +66.4k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 267.4k $334.2k | Reduced -968.6k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 261.7k $327.1k | Unchanged |
| UBS Group AG 0.00% of their portfolio | 224.2k $280.2k | Added +5.6k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 210.6k $263.3k | Added +180.4k |
| X-Square Capital, LLC 0.15% of their portfolio | 204.3k $256.0k | Reduced -1.1k |
| GAMCO INVESTORS, INC. ET AL 0.00% of their portfolio | 200.0k $250.0k | Unchanged |
| ETF MANAGERS GROUP, LLC 0.01% of their portfolio | 192.6k $240.8k | Reduced -35.2k |
| AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio | 191.0k $238.7k | Reduced -695 |
| GABELLI FUNDS LLC 0.00% of their portfolio | 190.0k $237.5k | Reduced -10.0k |
| Teton Advisors, Inc. 0.06% of their portfolio | 190.0k $237.5k | Reduced -20.0k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 183.3k $229.2k | Reduced -31.0k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 181.7k $227.0k | Added +30.4k |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio | 176.0k $220.0k | Unchanged |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 174.3k $217.9k | Added +3.6k |
| New York Life Investment Management LLC 0.00% of their portfolio | 164.9k $206.1k | Added +18.6k |
| CAPITAL ADVISORS INC/OK 0.01% of their portfolio | 164.6k $205.8k | Unchanged |
| SG Americas Securities, LLC 0.00% of their portfolio | 150.1k $188.0k | Added +12.5k |
| Phoenix Financial Ltd. 0.00% of their portfolio | 148.8k $186.0k | Reduced -1.5m |
| VAN ECK ASSOCIATES CORP 0.00% of their portfolio | 144.2k $180.0k | Added +2.2k |
| ARIZONA STATE RETIREMENT SYSTEM 0.00% of their portfolio | 141.6k $177.0k | Added +21.2k |
| Cambridge Investment Research Advisors, Inc. 0.00% of their portfolio | 135.0k $169.0k | Reduced -75.3k |
| Csenge Advisory Group 0.01% of their portfolio | 117.0k $146.2k | Unchanged |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 116.9k $146.0k | Reduced -14.4k |
| WILBANKS SMITH & THOMAS ASSET MANAGEMENT LLC 0.01% of their portfolio | 108.5k $135.6k | Reduced -27.5k |
| BARCLAYS PLC 0.00% of their portfolio | 108.4k $135.5k | First filing |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 107.9k $134.8k | Reduced -95.7k |
| HIGHLINE WEALTH PARTNERS LLC 0.10% of their portfolio | 106.7k $133.3k | Unchanged |
| Sequoia Financial Advisors, LLC 0.00% of their portfolio | 104.0k $130.0k | New |
| Virtu Financial LLC 0.02% of their portfolio | 102.9k $129.0k | New |
| Handelsbanken Fonder AB 0.00% of their portfolio | 101.6k $127.0k | Unchanged |
| INTREPID CAPITAL MANAGEMENT INC 0.11% of their portfolio | 100.0k $125.0k | Unchanged |
| Creative Planning 0.00% of their portfolio | 98.0k $122.5k | Added +3.3k |
| JANUS HENDERSON GROUP PLC 0.00% of their portfolio | 87.9k $109.4k | Reduced -87.9k |
| GSA CAPITAL PARTNERS LLP 0.01% of their portfolio | 87.7k $110.0k | New |
| Weiss Multi-Strategy Advisers LLC 0.00% of their portfolio | 85.0k $106.0k | Unchanged |
| HOLLENCREST CAPITAL MANAGEMENT 0.01% of their portfolio | 84.0k $105.0k | Unchanged |
| LEVIN CAPITAL STRATEGIES, L.P. 0.01% of their portfolio | 80.0k $100.0k | Added +10.0k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 79.9k $99.9k | Added +27.6k |
| State of Wyoming 0.03% of their portfolio | 78.7k $98.4k | Added +15.9k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 78.3k $97.9k | Reduced -252.9k |
| AE Wealth Management LLC 0.00% of their portfolio | 75.3k $94.1k | Reduced -3.1k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 70.8k $88.5k | Reduced -2.6k |
| BDO Wealth Advisors, LLC 0.01% of their portfolio | 70.0k $87.5k | Unchanged |
| PICTET ASSET MANAGEMENT SA 0.00% of their portfolio | 65.5k $82.0k | Added +30.9k |
| SHELL ASSET MANAGEMENT CO 0.00% of their portfolio | 65.3k $82.0k | Reduced -13.3k |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO 0.00% of their portfolio | 61.5k $77.0k | Unchanged |
| Raymond James Financial Services Advisors, Inc. 0.00% of their portfolio | 61.4k $76.7k | Added +3.0k |
| TWO SIGMA SECURITIES, LLC 0.01% of their portfolio | 60.6k $75.8k | New |
| Bayesian Capital Management, LP 0.01% of their portfolio | 57.7k $72.1k | New |