OPKO HEALTH INC OPK
COM · Common Stock · CUSIP 68375N103 · ISIN US68375N1037
Medical test and medication company
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($14.5k this quarter). Holder counts are more reliable. Shares outstanding: 746.3m as of 2026-07-17, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $1.50. Options: 8 managers hold calls ($759.2k notional), 3 hold puts ($156.9k).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 221 |
| Q4 2022 | 222 |
| Q1 2023 | 227 |
| Q2 2023 | 230 |
| Q3 2023 | 226 |
| Q4 2023 | 220 |
| Q1 2024 | 227 |
| Q2 2024 | 234 |
| Q3 2024 | 235 |
| Q4 2024 | 237 |
| Q1 2025 | 256 |
| Q2 2025 | 223 |
| Q3 2025 | 233 |
| Q4 2025 | 221 |
| Q1 2026 | 236 |
| Q2 2026 | 223 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 85 | 95 |
| Q4 2024 | 93 | 87 |
| Q1 2025 | 116 | 81 |
| Q2 2025 | 68 | 114 |
| Q3 2025 | 105 | 67 |
| Q4 2025 | 66 | 110 |
| Q1 2026 | 94 | 85 |
| Q2 2026 | 97 | 82 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $4.3m | $209.0k | 0.05 |
| Q4 2025 | $2.0m | $100.2k | 0.05 |
| Q1 2026 | $516.6k | $111.9k | 0.22 |
| Q2 2026 | $759.2k | $156.9k | 0.21 |
Biggest buyers
| HIGHBRIDGE CAPITAL MANAGEMENT LLC | New | +3.6m |
| STATE STREET CORP | Added | +807.7k |
| MORGAN STANLEY | Added | +778.9k |
| BlackRock, Inc. | Added | +746.7k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | Added | +547.4k |
| AQR CAPITAL MANAGEMENT LLC | Added | +475.8k |
| VANGUARD CAPITAL MANAGEMENT LLC | Added | +469.8k |
| ALGERT GLOBAL LLC | New | +397.0k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +279.5k |
| VAN ECK ASSOCIATES CORP | Added | +278.5k |
Biggest sellers
| UBS Group AG | Reduced | -1.1m |
| JANE STREET GROUP, LLC | Reduced | -884.9k |
| Tejara Capital Ltd | Sold out | -877.9k |
| GSA CAPITAL PARTNERS LLP | Sold out | -663.7k |
| CITADEL ADVISORS LLC | Reduced | -658.6k |
| GOLDMAN SACHS GROUP INC | Reduced | -639.5k |
| PFG Investments, LLC | Reduced | -502.3k |
| FIRST TRUST ADVISORS LP | Sold out | -500.3k |
| Qube Research & Technologies Ltd | Sold out | -404.4k |
| BANK OF AMERICA CORP /DE/ | Reduced | -346.1k |
Biggest calls
| SIMPLEX TRADING, LLC | Added | $253.7k169.1k shares |
| IMC-Chicago, LLC | Added | $158.2k105.5k shares |
| CITADEL ADVISORS LLC | Added | $156.2k104.1k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $89.2k59.5k shares |
| GROUP ONE TRADING LLC | Reduced | $53.9k35.9k shares |
| JANE STREET GROUP, LLC | Reduced | $38.2k25.5k shares |
| Raiffeisen Bank International AG | Unchanged | $9.8k6.5k shares |
| FNY Investment Advisers, LLC | New | $02 shares |
Biggest puts
| CITADEL ADVISORS LLC | Added | $91.0k60.7k shares |
| IMC-Chicago, LLC | Reduced | $47.1k31.4k shares |
| GROUP ONE TRADING LLC | Added | $18.8k12.5k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FROST PHILLIP MD ET AL 13D · may seek influence +1.3 pts · filed 2026-07-01 | 34.1% |
| Rubric Capital Management LP 13G · institution filed 2025-07-09 | 6.0% |
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 1 | $2.0m | 0 | — | — |
| Q1 2025 | 1 | $1.7m | 0 | — | — |
| Q2 2025 | 1 | $520.0k | 0 | — | — |
| Q3 2025 | 1 | $891.0k | 0 | — | — |
| Q4 2025 | 1 | $3.2m | 0 | — | — |
| Q1 2026 | 1 | $11.4k | 0 | — | — |
| Q2 2026 | 0 | — | 0 | — | — |
| Q3 2026 | 0 | — | 0 | — | — |
None reported since 1 Apr 2026.
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| Rubric Capital Management LP 0.66% of their portfolio | 47.8m $71.7m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 37.0m $55.5m | Added +746.7k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 15.0m $22.5m | Added +469.8k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 14.9m $22.4m | Added +165.2k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 11.6m $17.4m | Added +279.5k |
| STATE STREET CORP 0.00% of their portfolio | 10.3m $15.5m | Added +807.7k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 7.0m $10.6m | Reduced -639.5k |
| UBS Group AG 0.00% of their portfolio | 5.0m $7.5m | Reduced -1.1m |
| Whitefort Capital Management, LP 1.67% of their portfolio | 4.5m $6.8m | Added +258.1k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 3.8m $5.6m | Added +136.8k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 3.6m $5.4m | Added +22.9k |
| HIGHBRIDGE CAPITAL MANAGEMENT LLC 0.19% of their portfolio | 3.6m $5.4m | New |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 2.7m $4.1m | Reduced -35.8k |
| AWM Investment Company, Inc. 0.27% of their portfolio | 2.1m $3.2m | Added +10.0k |
| MORGAN STANLEY 0.00% of their portfolio | 2.0m $3.0m | Added +778.9k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 1.4m $2.1m | Reduced -658.6k |
| WASHINGTON GROWTH STRATEGIES LLC 1.13% of their portfolio | 1.4m $2.0m | Unchanged |
| Bank of New York Mellon Corp 0.00% of their portfolio | 1.3m $2.0m | Added +49.9k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 1.3m $1.9m | Reduced -292.3k |
| Y.D. More Investments Ltd 0.06% of their portfolio | 1.3m $1.9m | Reduced -41.9k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 1.2m $1.9m | Added +475.8k |
| OP Asset Management Ltd 0.02% of their portfolio | 1.2m $1.7m | Added +57.4k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 1.1m $1.6m | Reduced -66.8k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 961.5k $1.4m | Added +547.4k |
| Clearstead Advisors, LLC 0.01% of their portfolio | 883.3k $1.3m | Reduced -831 |
| Nuveen, LLC 0.00% of their portfolio | 863.0k $1.3m | Added +16.0k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 795.7k $1.2m | Reduced -346.1k |
| Swiss National Bank 0.00% of their portfolio | 761.5k $1.1m | Reduced -84.3k |
| Invesco Ltd. 0.00% of their portfolio | 685.1k $1.0m | Reduced -108.1k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 623.6k $935.3k | Added +232.0k |
| PFG Investments, LLC 0.04% of their portfolio | 610.5k $915.7k | Reduced -502.3k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 574.1k $861.2k | Reduced -100.7k |
| Assenagon Asset Management S.A. 0.00% of their portfolio | 570.7k $851.0k | Reduced -81.4k |
| Kovack Advisors, Inc. 0.04% of their portfolio | 536.2k $804.3k | Added +76.5k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 498.9k $748.3k | Added +1.6k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 455.7k $684.0k | Added +51.1k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 442.7k $504.7k | Added +19.5k |
| VAN ECK ASSOCIATES CORP 0.00% of their portfolio | 438.6k $658.0k | Added +278.5k |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 431.9k $647.8k | Added +988 |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 412.1k $618.1k | Reduced -110.9k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 398.6k $597.9k | Added +27.7k |
| ALGERT GLOBAL LLC 0.01% of their portfolio | 397.0k $595.5k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 354.0k $531.1k | Added +191.4k |
| Legal & General Group Plc 0.00% of their portfolio | 346.8k $520.2k | Added +3.3k |
| VANGUARD ASSET MANAGEMENT, Ltd 0.00% of their portfolio | 294.0k $441.0k | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 289.8k $435.0k | Added +69.8k |
| XTX Topco Ltd 0.01% of their portfolio | 286.2k $429.3k | Reduced -144.8k |
| Creative Planning 0.00% of their portfolio | 246.1k $369.1k | Added +69.1k |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 244.8k $367.2k | Unchanged |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 229.5k $344.2k | Reduced -884.9k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 226.8k $340.2k | Added +22.1k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 215.8k $323.7k | Added +184.0k |
| Jupiter Topco LLC 0.00% of their portfolio | 206.3k $310.5k | First filing |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 200.0k $298.9k | Reduced -38.3k |
| CITIGROUP INC 0.00% of their portfolio | 199.8k $299.7k | Added +166.1k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 185.6k $278.3k | Reduced -12.3k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 181.8k $272.6k | Unchanged |
| RPg Family Wealth Advisory, LLC 0.02% of their portfolio | 177.2k $265.9k | Added +88.6k |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio | 176.3k $264.4k | Unchanged |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 175.8k $263.7k | Added +5.8k |
| GAMCO INVESTORS, INC. ET AL 0.00% of their portfolio | 175.0k $262.5k | Unchanged |
| FIFTH THIRD BANCORP 0.00% of their portfolio | 170.0k $255.0k | Added +41.2k |
| GABELLI FUNDS LLC 0.00% of their portfolio | 170.0k $255.0k | Unchanged |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 169.4k $254.1k | Added +76.2k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 168.3k $254.1k | Reduced -340.2k |
| Cambridge Investment Research Advisors, Inc. 0.00% of their portfolio | 167.3k $252.0k | Added +77.1k |
| 360 Financial, Inc. 0.06% of their portfolio | 150.3k $225.4k | Added +53.0k |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 145.2k $217.9k | Added +51.9k |
| Teton Advisors, LLC 0.12% of their portfolio | 140.0k $210.0k | Unchanged |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 132.5k $198.7k | Added +30.1k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 119.1k $178.7k | Reduced -3.0k |
| HIGHLINE WEALTH PARTNERS LLC 0.04% of their portfolio | 116.7k $175.0k | Unchanged |
| State of Wyoming 0.02% of their portfolio | 116.5k $174.7k | Reduced -50.5k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 114.3k $171.5k | Unchanged |
| SG Americas Securities, LLC 0.00% of their portfolio | 113.8k $171.0k | Added +26.0k |
| GLENMEDE TRUST CO NA 0.00% of their portfolio | 112.8k $169.1k | Unchanged |
| Vanguard Investments Australia, Ltd. 0.00% of their portfolio | 111.0k $166.4k | Unchanged |
| Headlands Technologies LLC 0.02% of their portfolio | 108.0k $162.0k | Added +51.5k |
| ARIZONA STATE RETIREMENT SYSTEM 0.00% of their portfolio | 104.7k $157.1k | Reduced -11.3k |
| ZAZOVE ASSOCIATES LLC 0.01% of their portfolio | 100.0k $150.0k | Reduced -200.0k |
| BARCLAYS PLC 0.00% of their portfolio | 99.6k $149.4k | Reduced -38.7k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 94.1k $141.1k | Reduced -2.7k |
| Arax Advisory Partners 0.00% of their portfolio | 93.6k $140.4k | Added +93.3k |
| Allied Private Wealth LLC 0.08% of their portfolio | 91.1k $128.5k | First filing |
| Cerity Partners LLC 0.00% of their portfolio | 91.1k $136.7k | Added +67.6k |
| KLP KAPITALFORVALTNING AS 0.00% of their portfolio | 90.7k $136.1k | Unchanged |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 85.9k $128.8k | Reduced -39.9k |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 84.0k $113.4k | Added +21.6k |
| MERCER GLOBAL ADVISORS INC /ADV 0.00% of their portfolio | 76.8k $115.2k | Added +24.0k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 72.3k $108.5k | New |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 69.6k $104.3k | Added +21.9k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 69.0k $103.5k | Added +3.4k |
| Cascade Financial Partners, LLC 0.01% of their portfolio | 66.5k $99.7k | Unchanged |
| Pictet Asset Management Holding SA 0.00% of their portfolio | 65.5k $98.2k | Unchanged |
| CAPTRUST FINANCIAL ADVISORS 0.00% of their portfolio | 63.7k $95.6k | Added +23.4k |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO 0.00% of their portfolio | 61.5k $92.0k | Unchanged |
| Cetera Investment Advisers 0.00% of their portfolio | 60.9k $91.4k | Added +1.6k |
| KESTRA PRIVATE WEALTH SERVICES, LLC 0.00% of their portfolio | 58.5k $87.7k | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 57.5k $86.3k | Reduced -32.2k |
| Private Advisor Group, LLC 0.00% of their portfolio | 55.3k $83.0k | Unchanged |