OMEROS CORP OMER
COM · Common Stock · CUSIP 682143102 · ISIN US6821431029
Company in Seattle, United States
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersSeattle, WA
- Founded1994
- Websiteomeros.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($409.0k this quarter). Holder counts are more reliable. Shares outstanding: 70.9m as of 2025-11-12, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $17.16. Options: 17 managers hold calls ($77.1m notional), 15 hold puts ($64.5m).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 94 |
| Q4 2022 | 99 |
| Q1 2023 | 92 |
| Q2 2023 | 104 |
| Q3 2023 | 101 |
| Q4 2023 | 98 |
| Q1 2024 | 100 |
| Q2 2024 | 105 |
| Q3 2024 | 109 |
| Q4 2024 | 129 |
| Q1 2025 | 138 |
| Q2 2025 | 129 |
| Q3 2025 | 133 |
| Q4 2025 | 151 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 41 | 45 |
| Q2 2024 | 39 | 44 |
| Q3 2024 | 40 | 42 |
| Q4 2024 | 72 | 38 |
| Q1 2025 | 55 | 61 |
| Q2 2025 | 61 | 61 |
| Q3 2025 | 72 | 40 |
| Q4 2025 | 92 | 48 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $4.1m | $6.3m | 1.53 |
| Q2 2025 | $1.4m | $3.2m | 2.22 |
| Q3 2025 | $10.4m | $10.9m | 1.05 |
| Q4 2025 | $77.1m | $64.5m | 0.84 |
Biggest buyers
| UBS Group AG | Added | +1.5m |
| Corient Private Wealth LP | Added | +766.6k |
| VANGUARD GROUP INC | Added | +666.4k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | +631.3k |
| NOMURA HOLDINGS INC | Added | +611.3k |
| BlackRock, Inc. | Added | +610.3k |
| STATE STREET CORP | Added | +333.8k |
| Jump Financial, LLC | New | +228.0k |
| Informed Momentum Co LLC | New | +207.5k |
| JANE STREET GROUP, LLC | Added | +182.5k |
Biggest sellers
| MORGAN STANLEY | Reduced | -1.6m |
| Polar Asset Management Partners Inc. | Reduced | -1.4m |
| JPMORGAN CHASE & CO | Reduced | -795.1k |
| INGALLS & SNYDER LLC | Reduced | -657.9k |
| TWO SIGMA ADVISERS, LP | Reduced | -502.1k |
| MARSHALL WACE, LLP | Sold out | -464.2k |
| TWO SIGMA INVESTMENTS, LP | Reduced | -408.6k |
| RENAISSANCE TECHNOLOGIES LLC | Sold out | -344.5k |
| D. E. Shaw & Co., Inc. | Reduced | -250.2k |
| BANK OF AMERICA CORP /DE/ | Reduced | -160.6k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $19.9m1.2m shares |
| BANK OF MONTREAL /CAN/ | New | $10.3m600.0k shares |
| Ikarian Capital, LLC | New | $9.4m550.0k shares |
| Caption Management, LLC | New | $8.2m475.7k shares |
| CITADEL ADVISORS LLC | Added | $6.8m394.6k shares |
| GROUP ONE TRADING LLC | Added | $4.8m277.3k shares |
| KOTLER KEVIN | First filing | $3.8m218.7k shares |
| Polar Asset Management Partners Inc. | Reduced | $3.4m200.0k shares |
| BOOTHBAY FUND MANAGEMENT, LLC | New | $2.4m141.3k shares |
| SIMPLEX TRADING, LLC | Added | $2.2m129.5k shares |
Biggest puts
| Ikarian Capital, LLC | New | $16.3m950.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $10.2m593.5k shares |
| CITADEL ADVISORS LLC | Added | $7.0m408.4k shares |
| BANK OF MONTREAL /CAN/ | New | $5.5m320.4k shares |
| TORONTO DOMINION BANK | Added | $5.5m317.9k shares |
| BOOTHBAY FUND MANAGEMENT, LLC | New | $4.2m247.0k shares |
| Kynam Capital Management, LP | New | $3.4m200.0k shares |
| GROUP ONE TRADING LLC | Added | $3.1m178.6k shares |
| JANE STREET GROUP, LLC | Added | $2.9m171.1k shares |
| SIMPLEX TRADING, LLC | Added | $2.1m119.7k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2026-07-29 | 8.2% |
Fell to 5% or below in the last year: INGALLS & SNYDER LLC (4.8%, 2026-04-23), VANGUARD GROUP INC (0.0%, 2026-03-27)
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
None reported in Q4 2025.
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.00% of their portfolio | 5.1m $86.9m | Added +610.3k |
| VANGUARD GROUP INC 0.00% of their portfolio | 4.0m $68.9m | Added +666.4k |
| INGALLS & SNYDER LLC 2.18% of their portfolio | 3.4m $59.2m | Reduced -657.9k |
| UBS Group AG 0.01% of their portfolio | 2.2m $38.2m | Added +1.5m |
| STIFEL FINANCIAL CORP 0.03% of their portfolio | 1.8m $31.1m | Reduced -2.5k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.6m $28.0m | Added +96.0k |
| STATE STREET CORP 0.00% of their portfolio | 1.6m $27.0m | Added +333.8k |
| Corient Private Wealth LP 0.02% of their portfolio | 1.4m $23.6m | Added +766.6k |
| KOTLER KEVIN 11.49% of their portfolio | 905.6k $15.6m | First filing |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 755.0k $13.0m | Reduced -250.2k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.02% of their portfolio | 741.9k $12.7m | Added +631.3k |
| NOMURA HOLDINGS INC 0.03% of their portfolio | 655.0k $11.2m | Added +611.3k |
| BANK OF MONTREAL /CAN/ 0.00% of their portfolio | 601.6k $10.3m | Added +38.5k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 593.2k $10.2m | Added +39.8k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 526.7k $9.0m | Reduced -9.0k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 524.8k $9.0m | Reduced -408.6k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 498.4k $8.6m | Reduced -45.3k |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 463.6k $8.0m | Added +182.5k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 441.8k $7.6m | Added +40.0k |
| MORGAN STANLEY 0.00% of their portfolio | 386.2k $6.6m | Reduced -1.6m |
| Badgley Phelps Wealth Managers, LLC 0.08% of their portfolio | 263.6k $4.5m | Unchanged |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 240.4k $4.1m | Reduced -152.9k |
| Jump Financial, LLC 0.05% of their portfolio | 228.0k $3.9m | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 227.3k $3.9m | Reduced -108.8k |
| Informed Momentum Co LLC 0.40% of their portfolio | 207.5k $3.6m | New |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 202.6k $3.5m | Added +8.2k |
| Itau Unibanco Holding S.A. 0.07% of their portfolio | 180.0k $3.1m | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 165.8k $2.8m | Added +3.4k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 165.3k $2.8m | Added +31.2k |
| Invesco Ltd. 0.00% of their portfolio | 154.8k $2.7m | Added +32.7k |
| Nuveen, LLC 0.00% of their portfolio | 153.2k $2.6m | Added +65.6k |
| Clutterbuck Capital Management LLC 2.20% of their portfolio | 150.0k $2.6m | First filing |
| GROUP ONE TRADING LLC 0.07% of their portfolio | 133.3k $2.3m | Added +35.0k |
| SIMPLEX TRADING, LLC 0.06% of their portfolio | 124.0k $2.1m | Added +101.8k |
| BARCLAYS PLC 0.00% of their portfolio | 120.5k $2.1m | Reduced -11.5k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 117.0k $2.0m | Added +468 |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 114.8k $2.0m | Reduced -160.6k |
| Walleye Capital LLC 0.01% of their portfolio | 110.0k $1.9m | Added +95.0k |
| HighTower Advisors, LLC 0.00% of their portfolio | 104.1k $1.8m | Added +8.9k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 100.1k $1.7m | Reduced -5.8k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 96.9k $1.7m | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 95.7k $1.6m | Added +6.2k |
| Susquehanna Portfolio Strategies, LLC 0.02% of their portfolio | 92.8k $1.6m | Reduced -78.3k |
| AlphaQuest LLC 0.08% of their portfolio | 82.6k $1.4m | Added +82.6k |
| Cambridge Investment Research Advisors, Inc. 0.00% of their portfolio | 81.6k $1.4m | Added +63.4k |
| MML INVESTORS SERVICES, LLC 0.00% of their portfolio | 77.9k $1.3m | Added +18.7k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 76.1k $1.3m | Reduced -502.1k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 73.5k $1.3m | Added +5.9k |
| Walleye Trading LLC 0.02% of their portfolio | 69.7k $1.2m | Added +56.0k |
| Polar Asset Management Partners Inc. 0.02% of their portfolio | 68.8k $1.2m | Reduced -1.4m |
| Brevan Howard Capital Management LP 0.02% of their portfolio | 65.0k $1.1m | Reduced -64.4k |
| AMERICAN FINANCIAL GROUP INC 0.40% of their portfolio | 64.1k $1.1m | Unchanged |
| Verition Fund Management LLC 0.01% of their portfolio | 63.5k $1.1m | New |
| Ancora Advisors LLC 0.02% of their portfolio | 59.2k $1.0m | Added +56.2k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 56.7k $974.1k | Unchanged |
| COLDSTREAM CAPITAL MANAGEMENT INC 0.01% of their portfolio | 53.6k $920.7k | Added +27.8k |
| MINDSET WEALTH MANAGEMENT, LLC 0.23% of their portfolio | 52.0k $893.1k | Reduced -8.0k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 48.7k $836.6k | Added +7.9k |
| Cypress Capital Group 0.08% of their portfolio | 42.0k $721.4k | Unchanged |
| COMERICA BANK 0.00% of their portfolio | 38.0k $652.6k | Added +3.0k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 37.2k $638.8k | Reduced -795.1k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 36.2k $621.7k | Added +15.7k |
| NFSG Corp 0.09% of their portfolio | 34.3k $589.3k | Reduced -100.2k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 31.8k $545.6k | Added +18.7k |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 31.7k $429.3k | Added +2.6k |
| Focus Partners Wealth 0.00% of their portfolio | 31.0k $533.0k | New |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 30.9k $232.5k | New |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 30.6k $525.3k | Added +399 |
| Cerity Partners LLC 0.00% of their portfolio | 30.4k $523.0k | Added +1.8k |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 30.0k $514.7k | Added +4.3k |
| AXQ CAPITAL, LP 0.11% of their portfolio | 29.2k $500.7k | New |
| CITIGROUP INC 0.00% of their portfolio | 27.5k $472.1k | Added +22.0k |
| Man Group plc 0.00% of their portfolio | 27.1k $465.4k | New |
| Virtus Investment Advisers, LLC 0.12% of their portfolio | 26.2k $450.2k | New |
| Quantinno Capital Management LP 0.00% of their portfolio | 25.1k $430.6k | Added +6.9k |
| ADAR1 Capital Management, LLC 0.03% of their portfolio | 25.0k $429.4k | New |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 0.00% of their portfolio | 23.0k $395.0k | New |
| Stordahl Capital Management, Inc. 0.08% of their portfolio | 22.9k $392.6k | Unchanged |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 22.8k $392.2k | Added +1.5k |
| HARBOUR INVESTMENTS, INC. 0.01% of their portfolio | 21.8k $375.0k | Added +8.4k |
| CANADA PENSION PLAN INVESTMENT BOARD 0.00% of their portfolio | 21.7k $372.7k | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 20.7k $355.7k | Added +9.3k |
| Engineers Gate Manager LP 0.00% of their portfolio | 20.1k $344.9k | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 19.9k $340.9k | Reduced -48 |
| SG Americas Securities, LLC 0.00% of their portfolio | 18.8k $323.0k | Reduced -26.5k |
| FMR LLC 0.00% of their portfolio | 18.1k $310.3k | Added +4.9k |
| AlphaCore Capital LLC 0.01% of their portfolio | 17.6k $303.1k | New |
| Breakwater Investment Management 0.11% of their portfolio | 17.0k $292.8k | Unchanged |
| Creative Planning 0.00% of their portfolio | 16.9k $290.5k | New |
| China Universal Asset Management Co., Ltd. 0.02% of their portfolio | 16.6k $284.3k | Reduced -5.4k |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 16.4k $281.0k | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 16.4k $280.8k | Reduced -71.8k |
| ProShare Advisors LLC 0.00% of their portfolio | 15.2k $260.6k | Added +1.6k |
| PROFUND ADVISORS LLC 0.01% of their portfolio | 14.3k $246.1k | New |
| Apella Capital, LLC 0.00% of their portfolio | 14.3k $245.4k | Unchanged |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 14.0k $240.7k | Added +3.3k |
| Graham Capital Management, L.P. 0.01% of their portfolio | 13.2k $227.1k | Reduced -21.2k |
| Avantax Planning Partners, Inc. 0.01% of their portfolio | 13.2k $226.7k | Added +3.1k |
| Schonfeld Strategic Advisors LLC 0.00% of their portfolio | 12.7k $217.6k | New |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 12.2k $210.3k | New |